{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T21:33:03Z","timestamp":1784151183106,"version":"3.55.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T00:00:00Z","timestamp":1693785600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T00:00:00Z","timestamp":1693785600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum Hamburg-Eppendorf (UKE)"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Radiol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objectives<\/jats:title>\n                <jats:p>Parametric mapping constitutes a novel cardiac magnetic resonance (CMR) technique enabling quantitative assessment of pathologic alterations of left ventricular (LV) myocardium. This study aimed to investigate the clinical utility of mapping techniques with and without contrast agent compared to standard CMR to predict adverse LV remodeling following acute myocardial infarction (AMI).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Materials and methods<\/jats:title>\n                <jats:p>A post hoc analysis was performed on sixty-four consecutively enrolled patients (57 \u00b1 12 years, 54 men) with first-time reperfused AMI. Baseline CMR was obtained at 8 \u00b1 5 days post-AMI, and follow-up CMR at 6 \u00b1 1.4 months. T1\/T2 mapping, T2-weighted, and late gadolinium enhancement (LGE) acquisitions were performed at baseline and cine imaging was used to determine adverse LV remodeling, defined as end-diastolic volume increase by 20% at 6 months.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A total of 11 (17%) patients developed adverse LV remodeling. At baseline, patients with LV remodeling showed larger edema (30 \u00b1 11 vs. 22 \u00b1 10%LV; <jats:italic>p<\/jats:italic> &lt; 0.05), infarct size (24 \u00b1 11 vs. 14 \u00b1 8%LV; <jats:italic>p<\/jats:italic> &lt; 0.001), extracellular volume (ECV<jats:sub>infarct<\/jats:sub>; 63 \u00b1 12 vs. 47 \u00b1 11%; <jats:italic>p<\/jats:italic> &lt; 0.001), and native T2<jats:sub>infarct<\/jats:sub> (95 \u00b1 16 vs. 78 \u00b1 17 ms; <jats:italic>p<\/jats:italic> &lt; 0.01). ECV<jats:sub>infarct<\/jats:sub> and infarct size by LGE were the best predictors of LV remodeling with areas under the curve (AUCs) of 0.843 and 0.789, respectively (all <jats:italic>p<\/jats:italic> &lt; 0.01). Native T1<jats:sub>infarct<\/jats:sub> had the lowest AUC of 0.549 (<jats:italic>p<\/jats:italic> = 0.668) and was inferior to edema size by T2-weighted imaging (AUC = 0.720; <jats:italic>p<\/jats:italic> &lt; 0.05) and native T2<jats:sub>infarct<\/jats:sub> (AUC = 0.766; <jats:italic>p<\/jats:italic> &lt; 0.01).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>In this study, ECV<jats:sub>infarct<\/jats:sub> and infarct size by LGE were the best predictors for the development of LV remodeling within 6 months after AMI, with a better discriminative performance than non-contrast mapping CMR.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Clinical relevance statement<\/jats:title>\n                <jats:p>This study demonstrates the predictive value of contrast-enhanced and non-contrast as well as conventional and novel CMR techniques for the development of LV remodeling following AMI, which might help define precise CMR endpoints in experimental and clinical myocardial infarction trials.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Key Points<\/jats:title>\n                <jats:p><jats:italic>\u2022 Multiparametric CMR provides insights into left ventricular remodeling at 6 months following an acute myocardial infarction.<\/jats:italic><\/jats:p>\n                <jats:p><jats:italic>\u2022 Extracellular volume fraction and infarct size are the best predictors for adverse left ventricular remodeling.<\/jats:italic><\/jats:p>\n                <jats:p><jats:italic>\u2022 Contrast-enhanced T1 mapping has a better predictive performance than non-contrast standard CMR and T1\/T2 mapping.<\/jats:italic><\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00330-023-10100-9","type":"journal-article","created":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T07:02:43Z","timestamp":1693810963000},"page":"1863-1874","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Contrast-enhanced cardiac MRI is superior to non-contrast mapping to predict left ventricular remodeling at 6 months after acute myocardial infarction"],"prefix":"10.1007","volume":"34","author":[{"given":"Hang","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Erley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Muellerleile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Saering","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Jahnke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ersin","family":"Cavus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan N.","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Blankenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar K.","family":"Lund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Adam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6999-2787","authenticated-orcid":false,"given":"Enver","family":"Tahir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Sinn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,9,4]]},"reference":[{"key":"10100_CR1","doi-asserted-by":"publisher","first-page":"2351","DOI":"10.1161\/01.CIR.0000036014.90197.FA","volume":"106","author":"L Bolognese","year":"2002","unstructured":"Bolognese L, Neskovic AN, Parodi G et al (2002) Left ventricular remodeling after primary coronary angioplasty: patterns of left ventricular dilation and long-term prognostic implications. 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Acute versus Chronic Myocardial Infarction: Diagnostic Accuracy of Quantitative Native T1 and T2 Mapping versus Assessment of Edema on Standard T2-weighted Cardiovascular MR Images for Differentiation. Radiology. 2017 Oct;285(1):83\u201391. doi:10.1148\/radiol.2017162338.\u00a0Epub 2017 Jul 3. PMID: 28678672.Erley J, Starekova J, Sinn M, Muellerleile K, Chen H, Harms P, Naimi L, Meyer M, Cavus E, Schneider J, Blankenberg S, Lund GK, Adam G, Tahir E. Cardiac magnetic resonance feature tracking global and segmental strain in acute and chronic ST-elevation myocardial infarction. Sci Rep. 2022 Dec 31;12(1):22644. doi:10.1038\/s41598-022-26968-4. PMID: 36587037; PMCID: PMC9805431.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Study subjects or cohorts overlap"}},{"value":"\u2022 prospective\u2022\u00a0observational\u2022 performed at one institution","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Methodology"}}]}}