{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T07:48:27Z","timestamp":1782373707714,"version":"3.54.5"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T00:00:00Z","timestamp":1693612800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T00:00:00Z","timestamp":1693612800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100013003","name":"Universit\u00e0 degli Studi di Cagliari","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100013003","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Radiol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objective<\/jats:title>\n                <jats:p>The aims of our study were to investigate the effect of the extent and location of late gadolinium enhancement (LGE) on the left atrium (LA) function in patients with acute myocarditis (AM) using cardiovascular magnetic resonance (CMR).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Method<\/jats:title>\n                <jats:p>This retrospective study performed CMR scans in 113 consecutive patients (89 males, 24 females; mean age 45.8\u2009\u00b1\u200917.3\u00a0years) with AM that met the updated Lake Louise criteria. Reservoir, conduit, and booster LA functions were analyzed by CMR feature tracking using dedicated software. Besides LA strain measurements, myocardial scar location and extent were assigned and quantified by LGE imaging.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>AM patients with septal LGE had impaired reservoir, conduit, and conduit strain rate function in comparison with AM patients with non-septal LGE (<jats:italic>p<\/jats:italic>\u2009=\u20090.001, for all). In fully adjusted multivariable linear regression, reservoir and conduit were significantly associated with left ventricle (LV) LGE location (<jats:italic>\u03b2<\/jats:italic> coefficient\u2009=\u20098.205, <jats:italic>p<\/jats:italic>\u2009=\u20090.007; <jats:italic>\u03b2<\/jats:italic> coefficient\u2009=\u20095.185, <jats:italic>p<\/jats:italic>\u2009=\u20090.026; respectively). In addition, LA parameters decreased according to the increase in the extent of LV fibrosis (LGE\u2009\u2264\u200910%; LGE 11\u201319%; LGE\u2009\u2265\u200920%). After adjustment in multivariable linear regression, the association with LV LGE extent was no longer statistically significant.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>In patients with acute myocarditis, LA function abnormalities are significantly associated with LV LGE location, but not with LGE extent. Septal LGE is paralleled by a deterioration of LA reservoir and conduit function.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Clinical relevance statement<\/jats:title>\n                <jats:p>Left atrium dysfunction is associated with the presence of late gadolinium enhancement in the left ventricle septum and can be useful in the clinical prognostication of patients with acute myocarditis, allowing individually tailored treatment.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Key Points<\/jats:title>\n                <jats:p><jats:italic>\u2022 Myocardial fibrosis is related to atrial impairment.<\/jats:italic><\/jats:p>\n                <jats:p><jats:italic>\u2022 The location of myocardial fibrosis is the main determinant of atrial dysfunction in myocarditis patients.<\/jats:italic><\/jats:p>\n                <jats:p><jats:italic>\u2022 The quantification of atrial mechanisms may provide more in-depth insight into myocarditis pathophysiology.<\/jats:italic><\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00330-023-10176-3","type":"journal-article","created":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T09:01:57Z","timestamp":1693645317000},"page":"1846-1853","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Effect of late gadolinium enhancement on left atrial impairment in myocarditis patients"],"prefix":"10.1007","volume":"34","author":[{"given":"Riccardo","family":"Cau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Muscogiuri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Pisu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Mannelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandro","family":"Sironi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasjit S.","family":"Suri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Pontone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2870-3771","authenticated-orcid":false,"given":"Luca","family":"Saba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,9,2]]},"reference":[{"issue":"11","key":"10176_CR1","doi-asserted-by":"publisher","first-page":"e007405","DOI":"10.1161\/CIRCHEARTFAILURE.120.007405","volume":"13","author":"E Ammirati","year":"2020","unstructured":"Ammirati E, Frigerio M, Adler ED et al (2020) Management of acute myocarditis and chronic inflammatory cardiomyopathy: an expert consensus document. Circ Heart Fail 13(11):e007405\u2013e007405. https:\/\/doi.org\/10.1161\/CIRCHEARTFAILURE.120.007405","journal-title":"Circ Heart Fail"},{"issue":"33","key":"10176_CR2","doi-asserted-by":"publisher","first-page":"2636","DOI":"10.1093\/eurheartj\/eht210","volume":"34","author":"ALP Caforio","year":"2013","unstructured":"Caforio ALP, Pankuweit S, Arbustini E et al (2013) Current state of knowledge on aetiology, diagnosis, management, and therapy of myocarditis: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases. Eur Heart J. 34(33):2636\u20132648. https:\/\/doi.org\/10.1093\/eurheartj\/eht210","journal-title":"Eur Heart J."},{"issue":"3","key":"10176_CR3","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1038\/s41569-020-00435-x","volume":"18","author":"C Tsch\u00f6pe","year":"2021","unstructured":"Tsch\u00f6pe C, Ammirati E, Bozkurt B et al (2021) Myocarditis and inflammatory cardiomyopathy: current evidence and future directions. Nat Rev Cardiol 18(3):169\u2013193. https:\/\/doi.org\/10.1038\/s41569-020-00435-x","journal-title":"Nat Rev Cardiol"},{"issue":"16","key":"10176_CR4","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.1136\/heartjnl-2014-306363","volume":"101","author":"ALP Caforio","year":"2015","unstructured":"Caforio ALP, Marcolongo R, Basso C, Iliceto S (2015) Clinical presentation and diagnosis of myocarditis. Heart 101(16):1332\u20131344","journal-title":"Heart"},{"issue":"3","key":"10176_CR5","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1161\/CIRCRESAHA.115.306573","volume":"118","author":"G Fung","year":"2016","unstructured":"Fung G, Luo H, Qiu Y, Yang D, McManus B (2016) Myocarditis. Circ Res 118(3):496\u2013514. https:\/\/doi.org\/10.1161\/CIRCRESAHA.115.306573","journal-title":"Circ Res"},{"issue":"24","key":"10176_CR6","doi-asserted-by":"publisher","first-page":"3158","DOI":"10.1016\/j.jacc.2018.09.072","volume":"72","author":"VM Ferreira","year":"2018","unstructured":"Ferreira VM, Schulz-Menger J, Holmvang G et al (2018) Cardiovascular magnetic resonance in nonischemic myocardial inflammation: expert recommendations. J Am Coll Cardiol 72(24):3158\u20133176. https:\/\/doi.org\/10.1016\/j.jacc.2018.09.072","journal-title":"J Am Coll Cardiol"},{"key":"10176_CR7","doi-asserted-by":"publisher","unstructured":"Cau R, Bassareo P, Deidda M et al (2022) Could CMR tissue-tracking and parametric mapping distinguish between Takotsubo syndrome and acute myocarditis? A pilot study. Acad Radiol 29(Suppl 4):S33\u2013S39. https:\/\/doi.org\/10.1016\/j.acra.2021.01.009","DOI":"10.1016\/j.acra.2021.01.009"},{"key":"10176_CR8","doi-asserted-by":"publisher","unstructured":"Cau R, Solinas C, De Silva P et al (2022) Role of cardiac MRI in the diagnosis of immune checkpoint inhibitor-inhibitorassociated\nmyocarditis. Int J Cancer 151(11):1860\u20131873. https:\/\/doi.org\/10.1002\/ijc.34169","DOI":"10.1002\/ijc.34169"},{"issue":"1","key":"10176_CR9","doi-asserted-by":"publisher","first-page":"e011492","DOI":"10.1161\/CIRCIMAGING.120.011492","volume":"14","author":"G Georgiopoulos","year":"2021","unstructured":"Georgiopoulos G, Figliozzi S, Sanguineti F et al (2021) Prognostic impact of late gadolinium enhancement by cardiovascular magnetic resonance in myocarditis. Circ Cardiovasc Imaging 14(1):e011492. https:\/\/doi.org\/10.1161\/CIRCIMAGING.120.011492","journal-title":"Circ Cardiovasc Imaging"},{"issue":"8","key":"10176_CR10","doi-asserted-by":"publisher","first-page":"1851","DOI":"10.1007\/s10554-022-02601-3","volume":"38","author":"L Weber","year":"2022","unstructured":"Weber L, Sokolska JM, Nadarevic T et al (2022) Impact of myocardial injury on regional left ventricular function in the course of acute myocarditis with preserved ejection fraction: insights from segmental feature tracking strain analysis using cine cardiac MRI. Int J Cardiovasc Imaging 38(8):1851\u20131861. https:\/\/doi.org\/10.1007\/s10554-022-02601-3","journal-title":"Int J Cardiovasc Imaging"},{"issue":"7","key":"10176_CR11","doi-asserted-by":"publisher","first-page":"4384","DOI":"10.1007\/s00330-022-08598-6","volume":"32","author":"R Cau","year":"2022","unstructured":"Cau R, Bassareo P, Suri JS, Pontone G, Saba L (2022) The emerging role of atrial strain assessed by cardiac MRI in different cardiovascular settings: an up-to-date review. Eur Radiol 32(7):4384\u20134394. https:\/\/doi.org\/10.1007\/s00330-022-08598-6","journal-title":"Eur Radiol"},{"issue":"2","key":"10176_CR12","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.hfc.2018.12.001","volume":"15","author":"KY Kebed","year":"2019","unstructured":"Kebed KY, Addetia K, Lang RM (2019) Importance of the left atrium: more than a bystander? Heart Fail Clin 15(2):191\u2013204. https:\/\/doi.org\/10.1016\/j.hfc.2018.12.001","journal-title":"Heart Fail Clin"},{"issue":"1","key":"10176_CR13","doi-asserted-by":"publisher","first-page":"29","DOI":"10.21037\/cdt.2017.06.08","volume":"8","author":"GCH Gan","year":"2018","unstructured":"Gan GCH, Ferkh A, Boyd A, Thomas L (2018) Left atrial function: evaluation by strain analysis. Cardiovasc Diagn Ther 8(1):29\u201346","journal-title":"Cardiovasc Diagn Ther"},{"key":"10176_CR14","doi-asserted-by":"publisher","unstructured":"Cau R, Bassareo P, Caredda G, Suri JS, Esposito A, Saba L (2022) Atrial strain by feature-tracking cardiac magnetic resonance imaging in Takotsubo cardiomyopathy. Features, feasibility, and reproducibility. Can Assoc Radiol J 73(3):573\u2013580. https:\/\/doi.org\/10.1177\/08465371211042497","DOI":"10.1177\/08465371211042497"},{"key":"10176_CR15","doi-asserted-by":"publisher","unstructured":"Cau R, Pisu F, Porcu M et al (2022) Machine learning approach in diagnosing Takotsubo cardiomyopathy: the role of the combined evaluation of atrial and ventricular strain, and parametric mapping. Int J Cardiol 373:124\u2013133. https:\/\/doi.org\/10.1016\/j.ijcard.2022.11.021","DOI":"10.1016\/j.ijcard.2022.11.021"},{"issue":"5","key":"10176_CR16","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1016\/j.jcmg.2022.10.011","volume":"16","author":"SF Nagueh","year":"2023","unstructured":"Nagueh SF, Khan SU (2023) Left atrial strain for assessment of left ventricular diastolic function: focus on populations with normal LVEF. JACC Cardiovasc Imaging 16(5):691\u2013707. https:\/\/doi.org\/10.1016\/j.jcmg.2022.10.011","journal-title":"JACC Cardiovasc Imaging"},{"key":"10176_CR17","doi-asserted-by":"crossref","unstructured":"Cau R, Bassareo P, Suri JS, Pontone G, Saba L, Saba L (2022) The emerging role of atrial strain assessed by cardiac MRI in different cardiovascular settings: an up-to-date review. Eur Radiol 32(7):4384\u20134394","DOI":"10.1007\/s00330-022-08598-6"},{"issue":"May","key":"10176_CR18","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.ejrad.2018.05.012","volume":"104","author":"J Doerner","year":"2018","unstructured":"Doerner J, Bunck AC, Michels G, Maintz D, Bae\u00dfler B (2018) Incremental value of cardiovascular magnetic resonance feature tracking derived atrial and ventricular strain parameters in a comprehensive approach for the diagnosis of acute myocarditis. Eur J Radiol 104(May):120\u2013128. https:\/\/doi.org\/10.1016\/j.ejrad.2018.05.012","journal-title":"Eur J Radiol"},{"key":"10176_CR19","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.ejrad.2017.01.028","volume":"89","author":"A Dick","year":"2017","unstructured":"Dick A, Schmidt B, Michels G, Bunck AC, Maintz D, Bae\u00dfler B (2017) Left and right atrial feature tracking in acute myocarditis: a feasibility study. Eur J Radiol 89:72\u201380. https:\/\/doi.org\/10.1016\/j.ejrad.2017.01.028","journal-title":"Eur J Radiol"},{"issue":"6","key":"10176_CR20","doi-asserted-by":"publisher","first-page":"W78","DOI":"10.1097\/RTI.0000000000000650","volume":"37","author":"R Cau","year":"2022","unstructured":"Cau R, Loewe C, Cherchi V et al (2022) Atrial impairment as a marker in discriminating between Takotsubo and acute myocarditis using cardiac magnetic resonance. J Thorac Imaging 37(6):W78\u2013W84. https:\/\/doi.org\/10.1097\/RTI.0000000000000650","journal-title":"J Thorac Imaging"},{"key":"10176_CR21","doi-asserted-by":"publisher","unstructured":"Chen Y, Zhao W, Zhang N et al Prognostic significance of cardiac magnetic resonance in left atrial and biventricular strain analysis during the follow-up of suspected myocarditis. J Clin Med. 2023;12(2). https:\/\/doi.org\/10.3390\/jcm12020457","DOI":"10.3390\/jcm12020457"},{"key":"10176_CR22","doi-asserted-by":"publisher","unstructured":"Meindl C, Paulus M, Poschenrieder F et al (2023) Left atrial strain parameters derived by echocardiography are impaired in patients with acute myocarditis and preserved systolic left ventricular function. Int J Cardiovasc Imaging 39(6):1157\u20131165. https:\/\/doi.org\/10.1007\/s10554-023-02827-9","DOI":"10.1007\/s10554-023-02827-9"},{"issue":"9","key":"10176_CR23","doi-asserted-by":"publisher","first-page":"2003","DOI":"10.1007\/s10554-022-02576-1","volume":"38","author":"JN Schneider","year":"2022","unstructured":"Schneider JN, Jahnke C, Cavus E et al (2022) Feature tracking cardiovascular magnetic resonance reveals recovery of atrial function after acute myocarditis. Int J Cardiovasc Imaging 38(9):2003\u20132012. https:\/\/doi.org\/10.1007\/s10554-022-02576-1","journal-title":"Int J Cardiovasc Imaging"},{"issue":"23","key":"10176_CR24","doi-asserted-by":"publisher","first-page":"e579","DOI":"10.1161\/CIR.0000000000000455","volume":"134","author":"B Bozkurt","year":"2016","unstructured":"Bozkurt B, Colvin M, Cook J et al (2016) Current diagnostic and treatment strategies for specific dilated cardiomyopathies: a scientific statement from the American Heart Association. Circulation 134(23):e579\u2013e646","journal-title":"Circulation"},{"issue":"6","key":"10176_CR25","doi-asserted-by":"publisher","first-page":"e69","DOI":"10.1161\/CIR.0000000000000745","volume":"141","author":"RD Kociol","year":"2020","unstructured":"Kociol RD, Cooper LT, Fang JC et al (2020) Recognition and initial management of fulminant myocarditis. Circulation 141(6):e69\u2013e92. https:\/\/doi.org\/10.1161\/CIR.0000000000000745","journal-title":"Circulation"},{"key":"10176_CR26","unstructured":"World Health Organization & International Diabetes Federation (2006) Definition and diagnosis of diabetes mellitus and intermediate hyperglycaemia: report of a WHO\/IDF consultation. World Health Organization. https:\/\/apps.who.int\/iris\/handle\/10665\/43588"},{"issue":"1","key":"10176_CR27","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1038\/sj.ijo.0800541","volume":"22","author":"KM Flegal","year":"1998","unstructured":"Flegal KM, Carroll MD, Kuczmarski RJ, Johnson CL (1998) Overweight and obesity in the United States: prevalence and trends, 1960\u20131994. Int J Obes 22(1):39\u201347","journal-title":"Int J Obes"},{"issue":"2","key":"10176_CR28","doi-asserted-by":"publisher","first-page":"e005379","DOI":"10.1161\/CIRCIMAGING.116.005379","volume":"10","author":"F Zemrak","year":"2017","unstructured":"Zemrak F, Ambale-Venkatesh B, Captur G et al (2017) Left atrial structure in relationship to age, sex, ethnicity, and cardiovascular risk factors. Circ Cardiovasc Imaging 10(2):e005379. https:\/\/doi.org\/10.1161\/CIRCIMAGING.116.005379","journal-title":"Circ Cardiovasc Imaging"},{"issue":"1","key":"10176_CR29","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s12968-020-00610-6","volume":"22","author":"J Schulz-Menger","year":"2020","unstructured":"Schulz-Menger J, Bluemke DA, Bremerich J et al (2020) Standardized image interpretation and post-processing in cardiovascular magnetic resonance - 2020 update. J Cardiovasc Magn Reson 22(1):19. https:\/\/doi.org\/10.1186\/s12968-020-00610-6","journal-title":"J Cardiovasc Magn Reson"},{"issue":"3","key":"10176_CR30","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1148\/radiol.14131971","volume":"273","author":"M Imai","year":"2014","unstructured":"Imai M, AmbaleVenkatesh B, Samiei S et al (2014) Multi-ethnic study of atherosclerosis: association between left atrial function using tissue tracking from cine MR imaging and myocardial fibrosis. Radiology 273(3):703\u2013713. https:\/\/doi.org\/10.1148\/radiol.14131971","journal-title":"Radiology"},{"issue":"19","key":"10176_CR31","doi-asserted-by":"publisher","first-page":"e016797","DOI":"10.1161\/JAHA.120.016797","volume":"9","author":"I Csecs","year":"2020","unstructured":"Csecs I, Pashakhanloo F, Paskavitz A et al (2020) Association between left ventricular mechanical deformation and myocardial fibrosis in nonischemic cardiomyopathy. J Am Heart Assoc 9(19):e016797. https:\/\/doi.org\/10.1161\/JAHA.120.016797","journal-title":"J Am Heart Assoc"},{"issue":"1","key":"10176_CR32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12968-015-0221-2","volume":"18","author":"RJ Taylor","year":"2016","unstructured":"Taylor RJ, Umar F, Lin ELS et al (2016) Mechanical effects of left ventricular midwall fibrosis in non-ischemic cardiomyopathy. J Cardiovasc Magn Reson 18(1):1. https:\/\/doi.org\/10.1186\/s12968-015-0221-2","journal-title":"J Cardiovasc Magn Reson"},{"key":"10176_CR33","doi-asserted-by":"publisher","unstructured":"HB J, Jichao Z, FV V (2017) Fibrosis and atrial fibrillation: computerized and optical mapping. JACC Clin Electrophysiol 3(6):531\u2013546. https:\/\/doi.org\/10.1016\/j.jacep.2017.05.002","DOI":"10.1016\/j.jacep.2017.05.002"},{"key":"10176_CR34","doi-asserted-by":"publisher","unstructured":"Rohrbeck M, Hoerr V, Piccini I et al (2023) Pathophysiological mechanisms of cardiac dysfunction in transgenic mice with viral myocarditis. Cells 12(4):550. https:\/\/doi.org\/10.3390\/cells12040550","DOI":"10.3390\/cells12040550"}],"container-title":["European Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-023-10176-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00330-023-10176-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-023-10176-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T18:09:59Z","timestamp":1708106999000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00330-023-10176-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,2]]},"references-count":34,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,3]]}},"alternative-id":["10176"],"URL":"https:\/\/doi.org\/10.1007\/s00330-023-10176-3","relation":{},"ISSN":["1432-1084"],"issn-type":[{"value":"1432-1084","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,2]]},"assertion":[{"value":"21 May 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 June 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 July 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 September 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The scientific guarantor of this publication is Luca Saba.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Guarantor"}},{"value":"JSS is affiliated to AtheroPointTM. The authors of this manuscript declare no other relationships.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"No complex statistical methods were necessary for this paper.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statistics and biometry"}},{"value":"Written informed consent was waived by the Institutional Review Board.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"Institutional Review Board approval was obtained (NP\/2022\/788).","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors state that none of its contents have been published previously.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Study subjects or cohorts overlap"}},{"value":"\u2022 retrospective\u2022 observational\u2022 performed at one institution","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Methodology"}}]}}