{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:19:46Z","timestamp":1786979986590,"version":"build-2736575974"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T00:00:00Z","timestamp":1720483200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T00:00:00Z","timestamp":1720483200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Radiol"],"DOI":"10.1007\/s00330-024-10885-3","type":"journal-article","created":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T12:02:10Z","timestamp":1720526530000},"page":"7765-7775","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Specific brain MRI features of constitutional mismatch repair deficiency syndrome in children with high-grade gliomas"],"prefix":"10.1007","volume":"34","author":[{"given":"Magali","family":"Raveneau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e9a","family":"Guerrini-Rousseau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Levy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles-Joris","family":"Roux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Bolle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Doz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franck","family":"Bourdeaut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chrystelle","family":"Colas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Blauwblomme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Beccaria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnault","family":"Tauzi\u00e8de-Espariat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Varlet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christelle","family":"Dufour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Grill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Boddaert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1260-5886","authenticated-orcid":false,"given":"Volodia","family":"Dangouloff-Ros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,9]]},"reference":[{"key":"10885_CR1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/S0300-483X(03)00287-7","volume":"193","author":"M Christmann","year":"2003","unstructured":"Christmann M, Tomicic MT, Roos WP, Kaina B (2003) Mechanisms of human DNA repair: an update. Toxicology 193:3\u201334. https:\/\/doi.org\/10.1016\/S0300-483X(03)00287-7","journal-title":"Toxicology"},{"key":"10885_CR2","first-page":"808","volume":"57","author":"MF Kane","year":"1997","unstructured":"Kane MF, Loda M, Gaida GM et al (1997) Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines. Cancer Res 57:808\u2013811","journal-title":"Cancer Res"},{"key":"10885_CR3","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.dnarep.2019.03.009","volume":"78","author":"D Gupta","year":"2019","unstructured":"Gupta D, Heinen CD (2019) The mismatch repair-dependent DNA damage response: mechanisms and implications. DNA Repair (Amst) 78:60\u201369. https:\/\/doi.org\/10.1016\/j.dnarep.2019.03.009","journal-title":"Repair (Amst)"},{"key":"10885_CR4","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.29859","volume":"69","author":"S Scollon","year":"2022","unstructured":"Scollon S, Eldomery MK, Reuther J et al (2022) Clinical and molecular features of pediatric cancer patients with Lynch syndrome. Pediatr Blood Cancer 69:e29859. https:\/\/doi.org\/10.1002\/pbc.29859","journal-title":"Pediatr Blood Cancer"},{"key":"10885_CR5","doi-asserted-by":"publisher","first-page":"2304","DOI":"10.1001\/jama.2011.743","volume":"305","author":"V Bonadona","year":"2011","unstructured":"Bonadona V, Bona\u00efti B, Olschwang S et al (2011) Cancer risks associated with germline mutations in MLH1, MSH2, and MSH6 genes in Lynch syndrome. JAMA 305:2304\u20132310. https:\/\/doi.org\/10.1001\/jama.2011.743","journal-title":"JAMA"},{"key":"10885_CR6","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1016\/j.ejca.2013.12.005","volume":"50","author":"D Bakry","year":"2014","unstructured":"Bakry D, Aronson M, Durno C et al (2014) Genetic and clinical determinants of constitutional mismatch repair deficiency syndrome: report from the constitutional mismatch repair deficiency consortium. Eur J Cancer Oxf Engl 50:987\u2013996. https:\/\/doi.org\/10.1016\/j.ejca.2013.12.005","journal-title":"Eur J Cancer Oxf Engl"},{"key":"10885_CR7","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1038\/ajg.2015.392","volume":"111","author":"M Aronson","year":"2016","unstructured":"Aronson M, Gallinger S, Cohen Z et al (2016) Gastrointestinal findings in the largest series of patients with hereditary biallelic mismatch repair deficiency syndrome: report from the international consortium. Am J Gastroenterol 111:275\u2013284. https:\/\/doi.org\/10.1038\/ajg.2015.392","journal-title":"Am J Gastroenterol"},{"key":"10885_CR8","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1136\/jmedgenet-2015-103299","volume":"52","author":"N Lavoine","year":"2015","unstructured":"Lavoine N, Colas C, Muleris M et al (2015) Constitutional mismatch repair deficiency syndrome: clinical description in a French cohort. J Med Genet 52:770\u2013778. https:\/\/doi.org\/10.1136\/jmedgenet-2015-103299","journal-title":"J Med Genet"},{"key":"10885_CR9","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1136\/jmedgenet-2014-102284","volume":"51","author":"K Wimmer","year":"2014","unstructured":"Wimmer K, Kratz CP, Vasen HFA et al (2014) Diagnostic criteria for constitutional mismatch repair deficiency syndrome: suggestions of the European consortium \u201ccare for CMMRD\u201d (C4CMMRD). J Med Genet 51:355\u2013365. https:\/\/doi.org\/10.1136\/jmedgenet-2014-102284","journal-title":"J Med Genet"},{"key":"10885_CR10","doi-asserted-by":"publisher","first-page":"2779","DOI":"10.1200\/JCO.20.02636","volume":"39","author":"C Durno","year":"2021","unstructured":"Durno C, Ercan AB, Bianchi V et al (2021) Survival benefit for individuals with constitutional mismatch repair deficiency undergoing surveillance. J Clin Oncol 39:2779\u20132790. https:\/\/doi.org\/10.1200\/JCO.20.02636","journal-title":"J Clin Oncol"},{"key":"10885_CR11","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1136\/jmedgenet-2018-105664","volume":"56","author":"M Suerink","year":"2019","unstructured":"Suerink M, Ripperger T, Messiaen L et al (2019) Constitutional mismatch repair deficiency as a differential diagnosis of neurofibromatosis type 1: consensus guidelines for testing a child without malignancy. J Med Genet 56:53\u201362. https:\/\/doi.org\/10.1136\/jmedgenet-2018-105664","journal-title":"J Med Genet"},{"key":"10885_CR12","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1111\/cge.12904","volume":"91","author":"K Wimmer","year":"2017","unstructured":"Wimmer K, Rosenbaum T, Messiaen L (2017) Connections between constitutional mismatch repair deficiency syndrome and neurofibromatosis type 1. Clin Genet 91:507\u2013519. https:\/\/doi.org\/10.1111\/cge.12904","journal-title":"Clin Genet"},{"key":"10885_CR13","doi-asserted-by":"publisher","first-page":"E30","DOI":"10.3174\/ajnr.A6058","volume":"40","author":"L Guerrini-Rousseau","year":"2019","unstructured":"Guerrini-Rousseau L, Suerink M, Grill J et al (2019) Patients with high-grade gliomas and caf\u00e9-au-lait macules: is neurofibromatosis type 1 the only diagnosis? AJNR Am J Neuroradiol 40:E30\u2013E31. https:\/\/doi.org\/10.3174\/ajnr.A6058","journal-title":"AJNR Am J Neuroradiol"},{"key":"10885_CR14","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1111\/cge.13656","volume":"97","author":"M Shapira Rootman","year":"2020","unstructured":"Shapira Rootman M, Goldberg Y, Cohen R et al (2020) The great mimicker: phenotypic overlap between constitutional mismatch repair deficiency and Tuberous Sclerosis complex. Clin Genet 97:296\u2013304. https:\/\/doi.org\/10.1111\/cge.13656","journal-title":"Clin Genet"},{"key":"10885_CR15","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1136\/jmedgenet-2013-102238","volume":"51","author":"HFA Vasen","year":"2014","unstructured":"Vasen HFA, Ghorbanoghli Z, Bourdeaut F et al (2014) Guidelines for surveillance of individuals with constitutional mismatch repair-deficiency proposed by the European Consortium \u201cCare for CMMR-D\u201d (C4CMMR-D). J Med Genet 51:283\u2013293. https:\/\/doi.org\/10.1136\/jmedgenet-2013-102238","journal-title":"J Med Genet"},{"key":"10885_CR16","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1136\/jmedgenet-2020-107627","volume":"59","author":"M Aronson","year":"2022","unstructured":"Aronson M, Colas C, Shuen A et al (2022) Diagnostic criteria for constitutional mismatch repair deficiency (CMMRD): recommendations from the international consensus working group. J Med Genet 59:318\u2013327. https:\/\/doi.org\/10.1136\/jmedgenet-2020-107627","journal-title":"J Med Genet"},{"key":"10885_CR17","doi-asserted-by":"publisher","first-page":"1943","DOI":"10.3174\/ajnr.A5766","volume":"39","author":"SI Shiran","year":"2018","unstructured":"Shiran SI, Ben-Sira L, Elhasid R et al (2018) Multiple brain developmental venous anomalies as a marker for constitutional mismatch repair deficiency syndrome. AJNR Am J Neuroradiol 39:1943\u20131946. https:\/\/doi.org\/10.3174\/ajnr.A5766","journal-title":"AJNR Am J Neuroradiol"},{"key":"10885_CR18","doi-asserted-by":"publisher","first-page":"904","DOI":"10.3174\/ajnr.A6512","volume":"41","author":"A Kerpel","year":"2020","unstructured":"Kerpel A, Yalon M, Soudack M et al (2020) Neuroimaging findings in children with constitutional mismatch repair deficiency syndrome. AJNR Am J Neuroradiol 41:904\u2013910. https:\/\/doi.org\/10.3174\/ajnr.A6512","journal-title":"AJNR Am J Neuroradiol"},{"key":"10885_CR19","doi-asserted-by":"publisher","DOI":"10.1093\/noajnl\/vdz033","volume":"1","author":"L Guerrini-Rousseau","year":"2019","unstructured":"Guerrini-Rousseau L, Varlet P, Colas C et al (2019) Constitutional mismatch repair deficiency-associated brain tumors: report from the European C4CMMRD consortium. Neurooncol Adv 1:vdz033. https:\/\/doi.org\/10.1093\/noajnl\/vdz033","journal-title":"Neurooncol Adv"},{"key":"10885_CR20","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.24953\/turkjped.2021.3921","volume":"64","author":"B Kara","year":"2022","unstructured":"Kara B, Paksoy Y, \u00c7a\u011flayan AO et al (2022) Cerebral developmental venous anomalies in children with mismatch repair deficiency. Turk J Pediatr 64:1106\u20131116. https:\/\/doi.org\/10.24953\/turkjped.2021.3921","journal-title":"Turk J Pediatr"},{"key":"10885_CR21","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.3174\/ajnr.A6740","volume":"41","author":"S Calvez","year":"2020","unstructured":"Calvez S, Levy R, Calvez R et al (2020) Focal areas of high signal intensity in children with neurofibromatosis type 1: expected evolution on MRI. AJNR Am J Neuroradiol 41:1733\u20131739. https:\/\/doi.org\/10.3174\/ajnr.A6740","journal-title":"AJNR Am J Neuroradiol"},{"key":"10885_CR22","doi-asserted-by":"crossref","unstructured":"(1988) Neurofibromatosis. Conference statement. National Institutes of Health consensus development conference. Arch Neurol 45:575\u2013578. https:\/\/pubmed.ncbi.nlm.nih.gov\/3128965\/","DOI":"10.1001\/archneur.1988.00520290115023"},{"key":"10885_CR23","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1038\/gim.2015.30","volume":"17","author":"S Richards","year":"2015","unstructured":"Richards S, Aziz N, Bale S et al (2015) Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology. Genet Med 17:405\u2013424. https:\/\/doi.org\/10.1038\/gim.2015.30","journal-title":"Genet Med"},{"key":"10885_CR24","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1053\/j.gastro.2015.06.013","volume":"149","author":"S Bodo","year":"2015","unstructured":"Bodo S, Colas C, Buhard O et al (2015) Diagnosis of constitutional mismatch repair-deficiency syndrome based on microsatellite instability and lymphocyte tolerance to methylating agents. Gastroenterology 149:1017\u20131029.e3. https:\/\/doi.org\/10.1053\/j.gastro.2015.06.013","journal-title":"Gastroenterology"},{"key":"10885_CR25","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1053\/j.gastro.2022.12.017","volume":"164","author":"R Gallon","year":"2023","unstructured":"Gallon R, Phelps R, Hayes C et al (2023) Constitutional microsatellite instability, genotype, and phenotype correlations in constitutional mismatch repair deficiency. Gastroenterology 164:579\u2013592.e8. https:\/\/doi.org\/10.1053\/j.gastro.2022.12.017","journal-title":"Gastroenterology"},{"key":"10885_CR26","doi-asserted-by":"publisher","DOI":"10.1200\/PO.22.00525","volume":"7","author":"PR Benusiglio","year":"2023","unstructured":"Benusiglio PR, Elder F, Touat M et al (2023) Mismatch repair deficiency and lynch syndrome among adult patients with glioma. JCO Precis Oncol 7:e2200525. https:\/\/doi.org\/10.1200\/PO.22.00525","journal-title":"JCO Precis Oncol"},{"key":"10885_CR27","unstructured":"R Core Team (2020) R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. https:\/\/www.R-project.org\/"},{"key":"10885_CR28","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1148\/radiology.195.3.7754001","volume":"195","author":"DP DiPaolo","year":"1995","unstructured":"DiPaolo DP, Zimmerman RA, Rorke LB et al (1995) Neurofibromatosis type 1: pathologic substrate of high-signal-intensity foci in the brain. Radiology 195:721\u2013724. https:\/\/doi.org\/10.1148\/radiology.195.3.7754001","journal-title":"Radiology"},{"key":"10885_CR29","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1007\/s00062-013-0235-9","volume":"24","author":"E G\u00f6k\u00e7e","year":"2014","unstructured":"G\u00f6k\u00e7e E, Acu B, Beyhan M et al (2014) Magnetic resonance imaging findings of developmental venous anomalies. Clin Neuroradiol 24:135\u2013143. https:\/\/doi.org\/10.1007\/s00062-013-0235-9","journal-title":"Clin Neuroradiol"},{"key":"10885_CR30","doi-asserted-by":"publisher","unstructured":"Dangouloff-Ros V, Roux C-J, Boulouis G et al (2019) Incidental brain MRI findings in children: a systematic review and meta-analysis. AJNR Am J Neuroradiol. https:\/\/doi.org\/10.3174\/ajnr.A6281","DOI":"10.3174\/ajnr.A6281"},{"key":"10885_CR31","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1093\/neuros\/nyz298","volume":"86","author":"A Roux","year":"2020","unstructured":"Roux A, Boddaert N, Grill J et al (2020) High prevalence of developmental venous anomaly in diffuse intrinsic pontine gliomas: a pediatric control study. Neurosurgery 86:517\u2013523. https:\/\/doi.org\/10.1093\/neuros\/nyz298","journal-title":"Neurosurgery"},{"key":"10885_CR32","doi-asserted-by":"publisher","first-page":"1782","DOI":"10.3174\/ajnr.A4352","volume":"36","author":"BV Jones","year":"2015","unstructured":"Jones BV, Linscott L, Koberlein G et al (2015) Increased prevalence of developmental venous anomalies in children with intracranial neoplasms. AJNR Am J Neuroradiol 36:1782\u20131785. https:\/\/doi.org\/10.3174\/ajnr.A4352","journal-title":"AJNR Am J Neuroradiol"},{"key":"10885_CR33","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.1212\/wnl.43.9.1683","volume":"43","author":"F Fazekas","year":"1993","unstructured":"Fazekas F, Kleinert R, Offenbacher H et al (1993) Pathologic correlates of incidental MRI white matter signal hyperintensities. Neurology 43:1683\u20131689. https:\/\/doi.org\/10.1212\/wnl.43.9.1683","journal-title":"Neurology"},{"key":"10885_CR34","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1177\/0333102413480955","volume":"33","author":"T Eidlitz-Markus","year":"2013","unstructured":"Eidlitz-Markus T, Zeharia A, Haimi-Cohen Y, Konen O (2013) MRI white matter lesions in pediatric migraine. Cephalalgia Int J Headache 33:906\u2013913. https:\/\/doi.org\/10.1177\/0333102413480955","journal-title":"Cephalalgia Int J Headache"},{"key":"10885_CR35","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1007\/s00401-022-02478-5","volume":"144","author":"C-HG Lucas","year":"2022","unstructured":"Lucas C-HG, Sloan EA, Gupta R et al (2022) Multiplatform molecular analyses refine classification of gliomas arising in patients with neurofibromatosis type 1. Acta Neuropathol 144:747\u2013765. https:\/\/doi.org\/10.1007\/s00401-022-02478-5","journal-title":"Acta Neuropathol"},{"key":"10885_CR36","doi-asserted-by":"publisher","first-page":"366","DOI":"10.3174\/ajnr.A5888","volume":"40","author":"CD Spyris","year":"2019","unstructured":"Spyris CD, Castellino RC, Schniederjan MJ, Kadom N (2019) High-grade gliomas in children with neurofibromatosis type 1: literature review and illustrative cases. AJNR Am J Neuroradiol 40:366\u2013369. https:\/\/doi.org\/10.3174\/ajnr.A5888","journal-title":"AJNR Am J Neuroradiol"},{"key":"10885_CR37","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1007\/s00381-009-1024-2","volume":"26","author":"A Rosenfeld","year":"2010","unstructured":"Rosenfeld A, Listernick R, Charrow J, Goldman S (2010) Neurofibromatosis type 1 and high-grade tumors of the central nervous system. Childs Nerv Syst 26:663\u2013667. https:\/\/doi.org\/10.1007\/s00381-009-1024-2","journal-title":"Childs Nerv Syst"},{"key":"10885_CR38","doi-asserted-by":"publisher","unstructured":"Kim B, Tabori U, Hawkins C (2020) An update on the CNS manifestations of brain tumor polyposis syndromes. Acta Neuropathol. https:\/\/doi.org\/10.1007\/s00401-020-02124-y","DOI":"10.1007\/s00401-020-02124-y"},{"key":"10885_CR39","doi-asserted-by":"publisher","unstructured":"Guerrini-Rousseau L, Pasmant E, Muleris M et al (2023) Neurofibromatosis type 1 mosaicism in patients with constitutional mismatch repair deficiency. J Med Genet jmg-2023-109235. https:\/\/doi.org\/10.1136\/jmg-2023-109235","DOI":"10.1136\/jmg-2023-109235"}],"container-title":["European Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-024-10885-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00330-024-10885-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-024-10885-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T18:04:11Z","timestamp":1731434651000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00330-024-10885-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,9]]},"references-count":39,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["10885"],"URL":"https:\/\/doi.org\/10.1007\/s00330-024-10885-3","relation":{},"ISSN":["1432-1084"],"issn-type":[{"value":"1432-1084","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,9]]},"assertion":[{"value":"10 February 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 March 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 May 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 July 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The scientific guarantor of this publication is V.D.R.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Guarantor"}},{"value":"The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"One of the authors has significant statistical expertise.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statistics and biometry"}},{"value":"Parental agreement on behalf of the patients was prospectively obtained to perform molecular testing of tumor samples. Parental consent for MR imaging analysis was waived for this retrospective observational study.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"Ethical committee approval was obtained to study the multimodal imaging of children\u2019s brain tumors (EDRACT 2014-A-00541-46).","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"26\/30 CMMRD patients have been previously published with clinical or biological descriptions, but without in-depth imaging analysis (see Supplementary Table with related published articles).","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Study subjects or cohorts overlap"}},{"order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Methodology"}}]}}