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Lemstra.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Guarantor"}},{"value":"H.R.M. performs contract research for Combinostics; all funding is paid to her institution. Research programs of W.F. have been funded by ZonMW, NWO, EU-FP7, EU-JPND, Alzheimer Nederland, Hersenstichting CardioVascular Onderzoek Nederland, Health\u223cHolland, Topsector Life Sciences&Health, stichting Dioraphte, Gieskes-Strijbis fonds, stichting Equilibrio, Edwin Bouw fonds, Pasman stichting, stichting Alzheimer & Neuropsychiatrie Foundation, Philips, Biogen MA Inc, Novartis-NL, Life-MI, AVID, Roche BV, Fujifilm, Combinostics. W.F. has performed contract research for Biogen MA Inc., and Boehringer Ingelheim. W.F. has been an invited speaker at Boehringer Ingelheim, BiogenMAInc, Danone, Eisai, WebMD Neurology (Medscape), Springer Healthcare. W.F. is consultant to Oxford Health Policy Forum CIC, Roche, and BiogenMAInc. W.F. participated in advisory boards of Biogen MA Inc and Roche. All funding is paid to her institution. W.F. was associate editor of Alzheimer, Research & Therapy in 2020\/2021 and is associate editor at Brain. A.G. received a travel grant from Alzheimer Nederland for a research visit to Combinostics. J.L. reports that Combinostics owns the following IPR related to the article: 1. J. Koikkalainen and J. L\u00f6tj\u00f6nen. A method for inferring the state of a system, US 7,840,510 B2. 2. J. L\u00f6tj\u00f6nen, J. Koikkalainen, and J. Mattila. State Inference in a heterogeneous system, US 10,372,786 B2. J.L. is shareholder at Combinostics. F.B. is steering committee or Data Safety Monitoring Board member for Biogen, Merck, Eisai and Prothena. F.B. is advisory board member for Combinostics, Scottish Brain Sciences. Consultant for Roche, Celltrion, Rewind Therapeutics, Merck, Bracco. F.B. has research agreements with ADDI, Merck, Biogen, GE Healthcare, Roche. F.B. is co-founder and shareholder of Queen Square Analytics LTD. The other authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"One of the authors (A.J.T.) has significant statistical expertise.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statistics and biometry"}},{"value":"Written informed consent was obtained from all subjects (patients) in this study.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"Institutional Review Board approval was obtained.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Some study subjects or cohorts have been previously reported in studies using the ADC, ADNI and\/or PDPB cohorts.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Study subjects or cohorts overlap"}},{"order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Methodology"}}]}}