{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T04:41:11Z","timestamp":1787892071686,"version":"build-2784847793"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:00:00Z","timestamp":1734652800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:00:00Z","timestamp":1734652800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["grant no. 82271329"],"award-info":[{"award-number":["grant no. 82271329"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Beijing Hospitals Authority Youth Programme","award":["code: QML20230503"],"award-info":[{"award-number":["code: QML20230503"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Radiol"],"DOI":"10.1007\/s00330-024-11310-5","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T16:11:25Z","timestamp":1734711085000},"page":"4141-4151","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Pathway plaques and diffusion-weighted lesion analysis after endovascular treatment of unruptured intracranial aneurysms: a prospective study"],"prefix":"10.1007","volume":"35","author":[{"given":"Qianmei","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhu","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinjian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomeng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sili","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaobin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4238-4842","authenticated-orcid":false,"given":"Lian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,20]]},"reference":[{"key":"11310_CR1","doi-asserted-by":"publisher","unstructured":"Etminan N, de Sousa DA, Tiseo C et al (2022) European Stroke Organisation (ESO) guidelines on management of unruptured intracranial aneurysms. Eur Stroke J. https:\/\/doi.org\/10.1177\/23969873221099736","DOI":"10.1177\/23969873221099736"},{"key":"11310_CR2","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1001\/jamaneurol.2018.4165","volume":"76","author":"AM Algra","year":"2019","unstructured":"Algra AM, Lindgren A, Vergouwen MDI et al (2019) Procedural clinical complications, case-fatality risks, and risk factors in endovascular and neurosurgical treatment of unruptured intracran ial aneurysms: a systematic review and meta-analysis. JAMA Neurol 76:282\u2013293. https:\/\/doi.org\/10.1001\/jamaneurol.2018.4165","journal-title":"JAMA Neurol"},{"key":"11310_CR3","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.3174\/ajnr.A8024","volume":"44","author":"AB Habtezghi","year":"2023","unstructured":"Habtezghi AB, Ghozy S, Bilgin C et al (2023) DWI-detected ischemic lesions after endovascular treatment for cerebral aneurysms: an updated systematic review and meta-analysis. AJNR Am J Neuroradiol 44:1256\u20131261. https:\/\/doi.org\/10.3174\/ajnr.A8024","journal-title":"AJNR Am J Neuroradiol"},{"key":"11310_CR4","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1016\/S0140-6736(19)31795-7","volume":"394","author":"M Mrkobrada","year":"2019","unstructured":"Mrkobrada M, Chan MTV, Cowan D et al (2019) Perioperative covert stroke in patients undergoing non-cardiac surgery (NeuroVISION): a prospective cohort study. Lancet 394:1022\u20131029. https:\/\/doi.org\/10.1016\/S0140-6736(19)31795-7","journal-title":"Lancet"},{"key":"11310_CR5","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1007\/s00234-020-02616-4","volume":"63","author":"E Higashi","year":"2021","unstructured":"Higashi E, Hatano T, Ando M et al (2021) Factors associated with the new appearance of cerebral microbleeds after endovascular treatment for unruptured intracranial aneurysms. Neuroradiology 63:1079\u20131085. https:\/\/doi.org\/10.1007\/s00234-020-02616-4","journal-title":"Neuroradiology"},{"key":"11310_CR6","doi-asserted-by":"publisher","first-page":"982","DOI":"10.3171\/2016.11.JNS161020","volume":"128","author":"C Iosif","year":"2018","unstructured":"Iosif C, Lecomte J-C, Pedrolo-Silveira E et al (2018) Evaluation of ischemic lesion prevalence after endovascular treatment of intracranial aneurysms, as documented by 3-T diffusion-weighted imaging: a 2-year, single-center cohort study. J Neurosurg 128:982\u2013991. https:\/\/doi.org\/10.3171\/2016.11.JNS161020","journal-title":"J Neurosurg"},{"key":"11310_CR7","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1177\/1591019918758493","volume":"24","author":"YK Ihn","year":"2018","unstructured":"Ihn YK, Shin SH, Baik SK, Choi IS (2018) Complications of endovascular treatment for intracranial aneurysms: Management and prevention. Interv Neuroradiol 24:237\u2013245. https:\/\/doi.org\/10.1177\/1591019918758493","journal-title":"Interv Neuroradiol"},{"key":"11310_CR8","doi-asserted-by":"publisher","first-page":"708","DOI":"10.3174\/ajnr.A2840","volume":"33","author":"D Stojanov","year":"2012","unstructured":"Stojanov D, Ilic M, Bosnjakovic P et al (2012) New ischemic brain lesions on diffusion-weighted MRI after carotid artery stenting with filter protection: frequency and relationship with plaque morphology. AJNR Am J Neuroradiol 33:708\u2013714. https:\/\/doi.org\/10.3174\/ajnr.A2840","journal-title":"AJNR Am J Neuroradiol"},{"key":"11310_CR9","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1177\/1591019916633242","volume":"22","author":"P Szikra","year":"2016","unstructured":"Szikra P, Boda K, Rarosi F et al (2016) Aortic arch and common carotid artery plaques with soft components pose a substantial risk of cerebral embolization during carotid stenting. Interv Neuroradiol 22:438\u2013444. https:\/\/doi.org\/10.1177\/1591019916633242","journal-title":"Interv Neuroradiol"},{"key":"11310_CR10","doi-asserted-by":"publisher","first-page":"e457","DOI":"10.1016\/j.wneu.2019.06.114","volume":"130","author":"K Tokunaga","year":"2019","unstructured":"Tokunaga K, Hatano T, Nakahara I et al (2019) Factors associated with postprocedural diffusion-weighted imaging-positive lesions in endovascular treatment for unruptured cerebral aneurysms. World Neurosurg 130:e457\u2013e462. https:\/\/doi.org\/10.1016\/j.wneu.2019.06.114","journal-title":"World Neurosurg"},{"key":"11310_CR11","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1007\/s00234-010-0730-5","volume":"53","author":"S Yamatogi","year":"2011","unstructured":"Yamatogi S, Furukawa M, Iida E et al (2011) Evaluation of small ischemic lesions after carotid artery stenting: the usefulness of thin-slice diffusion-weighted MR imaging. Neuroradiology 53:255\u2013260. https:\/\/doi.org\/10.1007\/s00234-010-0730-5","journal-title":"Neuroradiology"},{"key":"11310_CR12","doi-asserted-by":"publisher","first-page":"777","DOI":"10.3171\/2015.3.JNS142835","volume":"124","author":"JC Park","year":"2016","unstructured":"Park JC, Lee DH, Kim JK et al (2016) Microembolism after endovascular coiling of unruptured cerebral aneurysms: incidence and risk factors. J Neurosurg 124:777\u2013783. https:\/\/doi.org\/10.3171\/2015.3.JNS142835","journal-title":"J Neurosurg"},{"key":"11310_CR13","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1136\/neurintsurg-2013-010820","volume":"6","author":"ML Hahnemann","year":"2014","unstructured":"Hahnemann ML, Ringelstein A, Sandalcioglu IE et al (2014) Silent embolism after stent-assisted coiling of cerebral aneurysms: diffusion-weighted MRI study of 75 cases. J Neurointerv Surg 6:461\u2013465. https:\/\/doi.org\/10.1136\/neurintsurg-2013-010820","journal-title":"J Neurointerv Surg"},{"key":"11310_CR14","doi-asserted-by":"publisher","first-page":"e661","DOI":"10.1161\/CIR.0000000000000567","volume":"137","author":"CJ Eskey","year":"2018","unstructured":"Eskey CJ, Meyers PM, Nguyen TN et al (2018) Indications for the performance of intracranial endovascular neurointerventional procedures: a scientific statement from the American Heart Association. Circulation 137:e661\u2013e689. https:\/\/doi.org\/10.1161\/CIR.0000000000000567","journal-title":"Circulation"},{"key":"11310_CR15","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1016\/S0140-6736(07)61602-X","volume":"370","author":"E von Elm","year":"2007","unstructured":"von Elm E, Altman DG, Egger M et al (2007) The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. Lancet 370:1453\u20131457. https:\/\/doi.org\/10.1016\/S0140-6736(07)61602-X","journal-title":"Lancet"},{"key":"11310_CR16","doi-asserted-by":"publisher","unstructured":"Schirmer CM, Bulsara KR, Al-Mufti F et al (2023) Antiplatelets and antithrombotics in neurointerventional procedures: guideline update. J Neurointerv Surg. https:\/\/doi.org\/10.1136\/jnis-2022-019844","DOI":"10.1136\/jnis-2022-019844"},{"key":"11310_CR17","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.3171\/2016.4.JNS16147","volume":"126","author":"L Rangel-Castilla","year":"2017","unstructured":"Rangel-Castilla L, Munich SA, Jaleel N et al (2017) Patency of anterior circulation branch vessels after Pipeline emboliza tion: longer-term results from 82 aneurysm cases. J Neurosurg 126:1064\u20131069. https:\/\/doi.org\/10.3171\/2016.4.JNS16147","journal-title":"J Neurosurg"},{"key":"11310_CR18","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1136\/neurintsurg-2019-015363","volume":"12","author":"S Pikis","year":"2020","unstructured":"Pikis S, Mantziaris G, Mamalis V et al (2020) Diffusion weighted image documented cerebral ischemia in the postprocedural period following pipeline embolization device with shield technology treatment of unruptured intracranial aneurysms: a prospective, single center study. J NeuroIntervent Surg 12:407\u2013411. https:\/\/doi.org\/10.1136\/neurintsurg-2019-015363","journal-title":"J NeuroIntervent Surg"},{"key":"11310_CR19","doi-asserted-by":"publisher","first-page":"1986","DOI":"10.1161\/STROKEAHA.117.017147","volume":"48","author":"J Bj\u00f6rkman","year":"2017","unstructured":"Bj\u00f6rkman J, Fr\u00f6sen J, T\u00e4htinen O et al (2017) Irregular shape identifies ruptured intracranial aneurysm in subarachnoid hemorrhage patients with multiple aneurysms. Stroke 48:1986\u20131989. https:\/\/doi.org\/10.1161\/STROKEAHA.117.017147","journal-title":"Stroke"},{"key":"11310_CR20","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.jcmg.2023.09.005","volume":"17","author":"L Saba","year":"2024","unstructured":"Saba L, Cau R, Murgia A et al (2024) Carotid plaque-RADS: a novel stroke risk classification system. JACC Cardiovasc Imaging 17:62\u201375. https:\/\/doi.org\/10.1016\/j.jcmg.2023.09.005","journal-title":"JACC Cardiovasc Imaging"},{"key":"11310_CR21","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1136\/svn-2022-002071","volume":"8","author":"D Wang","year":"2023","unstructured":"Wang D, Shang Z-Y, Cui Y et al (2023) Characteristics of intracranial plaque in patients with non-cardioembolic stroke and intracranial large vessel occlusion. Stroke Vasc Neurol 8:387\u2013398. https:\/\/doi.org\/10.1136\/svn-2022-002071","journal-title":"Stroke Vasc Neurol"},{"key":"11310_CR22","doi-asserted-by":"publisher","first-page":"e1698","DOI":"10.1212\/WNL.0000000000007294","volume":"92","author":"AP Liberato","year":"2019","unstructured":"Liberato AP, Mallack EJ, Aziz-Bose R et al (2019) MRI brain lesions in asymptomatic boys with X-linked adrenoleukodystrophy. Neurology 92:e1698\u2013e1708. https:\/\/doi.org\/10.1212\/WNL.0000000000007294","journal-title":"Neurology"},{"key":"11310_CR23","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1093\/brain\/awv011","volume":"138","author":"C Mainero","year":"2015","unstructured":"Mainero C, Louapre C, Govindarajan ST et al (2015) A gradient in cortical pathology in multiple sclerosis by in vivo quantitative 7 T imaging. Brain 138:932\u2013945. https:\/\/doi.org\/10.1093\/brain\/awv011","journal-title":"Brain"},{"key":"11310_CR24","doi-asserted-by":"publisher","first-page":"e221499","DOI":"10.1148\/radiol.221499","volume":"307","author":"Z Hou","year":"2023","unstructured":"Hou Z, Jing J, Yan L et al (2023) New diffusion abnormalities following endovascular treatment for intracranial atherosclerosis. Radiology 307:e221499. https:\/\/doi.org\/10.1148\/radiol.221499","journal-title":"Radiology"},{"key":"11310_CR25","doi-asserted-by":"publisher","first-page":"108","DOI":"10.2176\/nmc.48.108","volume":"48","author":"T Sorimachi","year":"2008","unstructured":"Sorimachi T, Ito Y, Morita K, Fujii Y (2008) Thin-section diffusion-weighted imaging of the infratentorium in patients with acute cerebral ischemia without apparent lesion on conventional diffusion-weighted imaging. Neurol Med Chir 48:108\u2013113. https:\/\/doi.org\/10.2176\/nmc.48.108","journal-title":"Neurol Med Chir"},{"key":"11310_CR26","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.clinimag.2010.04.004","volume":"35","author":"H Isoda","year":"2011","unstructured":"Isoda H, Arizono S, Shimada K et al (2011) Contrast behavior of high-spatial-resolution T1-weighted MR imaging at 3.0 T vs. 1.5 T. Clin Imaging 35:133\u2013138. https:\/\/doi.org\/10.1016\/j.clinimag.2010.04.004","journal-title":"Clin Imaging"},{"key":"11310_CR27","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1177\/1747493016647736","volume":"13","author":"JS Kim","year":"2018","unstructured":"Kim JS, Kim Y-J, Ahn S-H, Kim BJ (2018) Location of cerebral atherosclerosis: Why is there a difference between east and west? Int J Stroke 13:35\u201346. https:\/\/doi.org\/10.1177\/1747493016647736","journal-title":"Int J Stroke"},{"key":"11310_CR28","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.1161\/STROKEAHA.120.033984","volume":"52","author":"M Goyal","year":"2021","unstructured":"Goyal M, Ganesh A, Tymianski M et al (2021) Iatrogenic diffusion-weighted imaging lesions: What is their impact and how can it be measured? Stroke 52:1929\u20131936. https:\/\/doi.org\/10.1161\/STROKEAHA.120.033984","journal-title":"Stroke"},{"key":"11310_CR29","doi-asserted-by":"publisher","first-page":"1484","DOI":"10.1161\/STROKEAHA.122.041553","volume":"54","author":"Z Yin","year":"2023","unstructured":"Yin Z, Zhang Q, Zhao Y et al (2023) Prevalence and procedural risk of intracranial atherosclerotic stenosis coexisting with unruptured intracranial aneurysm. Stroke 54:1484\u20131493. https:\/\/doi.org\/10.1161\/STROKEAHA.122.041553","journal-title":"Stroke"},{"key":"11310_CR30","doi-asserted-by":"publisher","first-page":"964191","DOI":"10.3389\/fsurg.2022.964191","volume":"9","author":"L Mo","year":"2023","unstructured":"Mo L, Yue J, Yu W et al (2023) Diffusion-weighted imaging lesions after endovascular treatment of cerebral aneurysms: a network meta-analysis. Front Surg 9:964191. https:\/\/doi.org\/10.3389\/fsurg.2022.964191","journal-title":"Front Surg"},{"key":"11310_CR31","doi-asserted-by":"publisher","first-page":"304","DOI":"10.3174\/ajnr.A4989","volume":"38","author":"KM Bond","year":"2017","unstructured":"Bond KM, Brinjikji W, Murad MH et al (2017) Diffusion-weighted imaging-detected ischemic lesions following endovas cular treatment of cerebral aneurysms: a systematic review and meta-analysis. AJNR Am J Neuroradiol 38:304\u2013309. https:\/\/doi.org\/10.3174\/ajnr.A4989","journal-title":"AJNR Am J Neuroradiol"},{"key":"11310_CR32","doi-asserted-by":"publisher","first-page":"713","DOI":"10.3174\/ajnr.A6996","volume":"42","author":"Y Xiang","year":"2021","unstructured":"Xiang Y, Zhao H, Ding C et al (2021) The prophylactic use of tirofiban versus oral antiplatelet medications in stent-assisted coiling of intracranial aneurysms: a meta-analysis. AJNR Am J Neuroradiol 42:713\u2013719. https:\/\/doi.org\/10.3174\/ajnr.A6996","journal-title":"AJNR Am J Neuroradiol"},{"key":"11310_CR33","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1136\/neurintsurg-2020-016878","volume":"13","author":"Q Wu","year":"2021","unstructured":"Wu Q, Shao Q, Li L et al (2021) Prophylactic administration of tirofiban for preventing thromboembolic events in flow diversion treatment of intracranial aneurysms. J Neurointerv Surg 13:835\u2013840. https:\/\/doi.org\/10.1136\/neurintsurg-2020-016878","journal-title":"J Neurointerv Surg"},{"key":"11310_CR34","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1136\/neurintsurg-2015-012091","volume":"8","author":"LBC Brasiliense","year":"2016","unstructured":"Brasiliense LBC, Stanley MA, Grewal SS et al (2016) Silent ischemic events after pipeline embolization device: a prospective evaluation with MR diffusion-weighted imaging. J Neurointerv Surg 8:1136\u20131139. https:\/\/doi.org\/10.1136\/neurintsurg-2015-012091","journal-title":"J Neurointerv Surg"}],"container-title":["European Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-024-11310-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00330-024-11310-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-024-11310-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T15:42:09Z","timestamp":1749829329000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00330-024-11310-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,20]]},"references-count":34,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,7]]}},"alternative-id":["11310"],"URL":"https:\/\/doi.org\/10.1007\/s00330-024-11310-5","relation":{},"ISSN":["1432-1084"],"issn-type":[{"value":"1432-1084","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,20]]},"assertion":[{"value":"18 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 November 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 November 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 December 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The scientific guarantor of this publication is Lian Liu.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Guarantor"}},{"value":"Dr. Shuo Chen is an employee of Shanghai United Imaging Healthcare. The other authors have no conflicts of interest to be disclosed related to this article. The Tiantan Hospital holds a research agreement with Shanghai United Imaging Healthcare, which provided the thin-slice diffusion-weighted imaging (2\u2009mm) and the 3D joint intra-and extracranial vessel wall MRI.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"No complex statistical methods were necessary for this paper.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statistics and biometry"}},{"value":"The Institutional Scientific Board and the Institutional Board of Directors approved the study design.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Written informed consent was obtained from all individuals participating in the study.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"Institutional Review Board approval was obtained.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The study subjects or cohorts have not been previously reported elsewhere.","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Study subjects or cohorts overlap"}},{"order":9,"name":"Ethics","group":{"name":"EthicsHeading","label":"Methodology"}}]}}