{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T06:17:12Z","timestamp":1791958632041,"version":"4.3.4"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T00:00:00Z","timestamp":1737504000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T00:00:00Z","timestamp":1737504000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Radiol"],"DOI":"10.1007\/s00330-024-11340-z","type":"journal-article","created":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T08:29:54Z","timestamp":1737534594000},"page":"3917-3926","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Myocardial microvascular function assessed by cardiovascular magnetic resonance first-pass perfusion in patients with Takotsubo syndrome"],"prefix":"10.1007","volume":"35","author":[{"given":"Riccardo","family":"Cau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Pitzalis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Pisu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesare","family":"Mantini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Pontone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Francesca","family":"Marchetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Montisci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Salgado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Esposito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2870-3771","authenticated-orcid":false,"given":"Luca","family":"Saba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,22]]},"reference":[{"key":"11340_CR1","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1002\/ejhf.424","volume":"18","author":"AR Lyon","year":"2016","unstructured":"Lyon AR, Bossone E, Schneider B et al (2016) Current state of knowledge on Takotsubo syndrome: a Position Statement from the Taskforce on Takotsubo Syndrome of the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail 18:8\u201327. https:\/\/doi.org\/10.1002\/ejhf.424","journal-title":"Eur J Heart Fail"},{"key":"11340_CR2","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.echo.2007.05.024","volume":"21","author":"P Meimoun","year":"2008","unstructured":"Meimoun P, Malaquin D, Sayah S et al (2008) The coronary flow reserve is transiently impaired in tako-tsubo cardiomyopathy: a prospective study using serial Doppler transthoracic echocardiography. J Am Soc Echocardiogr 21:72\u201377","journal-title":"J Am Soc Echocardiogr"},{"key":"11340_CR3","doi-asserted-by":"publisher","first-page":"2430","DOI":"10.1016\/j.jacc.2011.08.046","volume":"58","author":"HS Kim","year":"2011","unstructured":"Kim HS, Tremmel JA, Nam CW et al (2011) Quantitative comparison of microcirculatory dysfunction in patients with stress cardiomyopathy and ST-segment elevation myocardial infarction. J Am Coll Cardiol 58:2430\u20132431","journal-title":"J Am Coll Cardiol"},{"key":"11340_CR4","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1001\/jamacardio.2016.5993","volume":"2","author":"F Rivero","year":"2017","unstructured":"Rivero F, Cuesta J, Garc\u00eda-Guimaraes M et al (2017) Time-related microcirculatory dysfunction in patients with Takotsubo cardiomyopathy. JAMA Cardiol 2:699\u2013700","journal-title":"JAMA Cardiol"},{"key":"11340_CR5","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1093\/eurheartj\/ehq039","volume":"31","author":"L Galiuto","year":"2010","unstructured":"Galiuto L, De Caterina AR, Porfidia A et al (2010) Reversible coronary microvascular dysfunction: a common pathogenetic mechanism in apical ballooning or Tako-Tsubo syndrome. Eur Heart J 31:1319\u20131327","journal-title":"Eur Heart J"},{"key":"11340_CR6","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.jcmg.2018.11.036","volume":"13","author":"TH Schindler","year":"2020","unstructured":"Schindler TH, Dilsizian V (2020) Coronary microvascular dysfunction: clinical considerations and noninvasive diagnosis. JACC Cardiovasc Imaging 13:140\u2013155. https:\/\/doi.org\/10.1016\/j.jcmg.2018.11.036","journal-title":"JACC Cardiovasc Imaging"},{"key":"11340_CR7","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1007\/s11897-021-00518-x","volume":"18","author":"PJ Jensch","year":"2021","unstructured":"Jensch PJ, Stiermaier T, Eitel I (2021) Takotsubo syndrome-is there a need for CMR? Curr Heart Fail Rep. 18:200\u2013210. https:\/\/doi.org\/10.1007\/s11897-021-00518-x","journal-title":"Curr Heart Fail Rep."},{"key":"11340_CR8","doi-asserted-by":"crossref","unstructured":"Cau R, Bassareo P, Deidda M et al (2021) Could CMR tissue-tracking and parametric mapping distinguish between Takotsubo syndrome and acute myocarditis? A pilot study. Acad Radiol http:\/\/www.sciencedirect.com\/science\/article\/pii\/S1076633221000155","DOI":"10.1016\/j.acra.2021.01.009"},{"key":"11340_CR9","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1007\/s00330-009-1549-5","volume":"20","author":"I Eitel","year":"2010","unstructured":"Eitel I, L\u00fccke C, Grothoff M et al (2010) Inflammation in takotsubo cardiomyopathy: insights from cardiovascular magnetic resonance imaging. Eur Radiol 20:422\u2013431. https:\/\/doi.org\/10.1007\/s00330-009-1549-5","journal-title":"Eur Radiol"},{"key":"11340_CR10","doi-asserted-by":"publisher","unstructured":"Cau R, Muscogiuri G, Palmisano V et al (2023) Base-to-apex gradient pattern assessed by cardiovascular magnetic resonance in takotsubo cardiomyopathy. J Thorac Imaging https:\/\/doi.org\/10.1097\/RTI.0000000000000761","DOI":"10.1097\/RTI.0000000000000761"},{"key":"11340_CR11","doi-asserted-by":"publisher","first-page":"W78","DOI":"10.1097\/RTI.0000000000000650","volume":"37","author":"R Cau","year":"2022","unstructured":"Cau R, Loewe C, Cherchi V et al (2022) Atrial impairment as a marker in discriminating between Takotsubo and acute myocarditis using cardiac magnetic resonance. J Thorac Imaging 37:W78\u2013W84. https:\/\/doi.org\/10.1097\/RTI.0000000000000650","journal-title":"J Thorac Imaging"},{"key":"11340_CR12","doi-asserted-by":"publisher","unstructured":"Cau R, Bassareo P, Caredda G, Suri JS, Esposito A, Saba L (2021) Atrial strain by feature-tracking cardiac magnetic resonance imaging in Takotsubo cardiomyopathy. features, feasibility, and reproducibility. Can Assoc Radiol J 2021:8465371211042497. https:\/\/doi.org\/10.1177\/08465371211042497","DOI":"10.1177\/08465371211042497"},{"key":"11340_CR13","doi-asserted-by":"publisher","unstructured":"Cau R, Pisu F, Porcu M et al (2022) Machine learning approach in diagnosing Takotsubo cardiomyopathy: The role of the combined evaluation of atrial and ventricular strain, and parametric mapping. Int J Cardiol https:\/\/doi.org\/10.1016\/j.ijcard.2022.11.021","DOI":"10.1016\/j.ijcard.2022.11.021"},{"key":"11340_CR14","doi-asserted-by":"publisher","unstructured":"Cau R, Palmisano A, Suri JS, Pisu F, Esposito A, Saba L (2024) Prognostic role of cardiovascular magnetic resonance in Takotsubo syndrome: a systematic review. Eur J Radiol. 177. https:\/\/doi.org\/10.1016\/j.ejrad.2024.111576","DOI":"10.1016\/j.ejrad.2024.111576"},{"key":"11340_CR15","doi-asserted-by":"publisher","unstructured":"Muscogiuri G, Guglielmo M, Serra A et al (2022) Multimodality imaging in ischemic chronic cardiomyopathy. J Imaging. 8. https:\/\/doi.org\/10.3390\/jimaging8020035","DOI":"10.3390\/jimaging8020035"},{"key":"11340_CR16","doi-asserted-by":"publisher","first-page":"e15949","DOI":"10.1111\/echo.15949","volume":"41","author":"R Cau","year":"2024","unstructured":"Cau R, Masala S, Manelli L et al (2024) Cardiovascular magnetic resonance imaging of takotsubo syndrome: evolving diagnostic and prognostic perspectives. Echocardiography 41:e15949. https:\/\/doi.org\/10.1111\/echo.15949","journal-title":"Echocardiography"},{"key":"11340_CR17","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1016\/j.crad.2014.12.018","volume":"70","author":"A Chiribiri","year":"2015","unstructured":"Chiribiri A, Leuzzi S, Conte MR et al (2015) Rest perfusion abnormalities in hypertrophic cardiomyopathy: correlation with myocardial fibrosis and risk factors for sudden cardiac death. Clin Radiol 70:495\u2013501. https:\/\/doi.org\/10.1016\/j.crad.2014.12.018","journal-title":"Clin Radiol"},{"key":"11340_CR18","doi-asserted-by":"publisher","unstructured":"Unger T, Borghi C, Charchar F et al (2020) 2020 International Society of Hypertension Global Hypertension Practice Guidelines. Hypertension 75:1334\u20131357. https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.120.15026","DOI":"10.1161\/HYPERTENSIONAHA.120.15026"},{"key":"11340_CR19","unstructured":"Organization WH (2006) Definition and diagnosis of diabetes mellitus and intermediate hyperglycaemia: report of a WHO\/IDF consultation. WHO. Published online 2006"},{"key":"11340_CR20","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1038\/sj.ijo.0800541","volume":"22","author":"KM Flegal","year":"1998","unstructured":"Flegal KM, Carroll MD, Kuczmarski RJ, Johnson CL (1998) Overweight and obesity in the United States: prevalence and trends, 1960\u20131994. Int J Obes 22:39\u201347","journal-title":"Int J Obes"},{"key":"11340_CR21","doi-asserted-by":"publisher","first-page":"6850","DOI":"10.1007\/s00330-022-08823-2","volume":"32","author":"MX Yang","year":"2022","unstructured":"Yang MX, Li QL, Wang DQ et al (2022) Myocardial microvascular function assessed by CMR first-pass perfusion in patients treated with chemotherapy for gynecologic malignancies. Eur Radiol 32:6850\u20136858. https:\/\/doi.org\/10.1007\/s00330-022-08823-2","journal-title":"Eur Radiol"},{"key":"11340_CR22","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.ijcard.2020.07.013","volume":"320","author":"L Jiang","year":"2020","unstructured":"Jiang L, Wang J, Liu X et al (2020) The combined effects of cardiac geometry, microcirculation, and tissue characteristics on cardiac systolic and diastolic function in subclinical diabetes mellitus-related cardiomyopathy. Int J Cardiol 320:112\u2013118. https:\/\/doi.org\/10.1016\/j.ijcard.2020.07.013","journal-title":"Int J Cardiol"},{"key":"11340_CR23","doi-asserted-by":"publisher","unstructured":"Schulz-Menger J, Bluemke DA, Bremerich J et al (2020) Standardized image interpretation and post-processing in cardiovascular magnetic resonance\u20142020 update. J Cardiovascular Magn Reson 22:19. https:\/\/doi.org\/10.1186\/s12968-020-00610-6","DOI":"10.1186\/s12968-020-00610-6"},{"key":"11340_CR24","doi-asserted-by":"publisher","first-page":"110706","DOI":"10.1016\/j.ejrad.2023.110706","volume":"160","author":"R Cau","year":"2023","unstructured":"Cau R, Bassareo P, Cademartiri F et al (2023) Epicardial fat volume assessed with cardiac magnetic resonance imaging in patients with Takotsubo cardiomyopathy. Eur J Radiol 160:110706. https:\/\/doi.org\/10.1016\/j.ejrad.2023.110706","journal-title":"Eur J Radiol"},{"key":"11340_CR25","doi-asserted-by":"publisher","unstructured":"Couch LS, Thomas KE, Marin F et al (2024) The role of coronary blood flow and myocardial edema in the pathophysiology of Takotsubo syndrome. JACC Cardiovasc Imaging. https:\/\/doi.org\/10.1016\/j.jcmg.2024.02.017","DOI":"10.1016\/j.jcmg.2024.02.017"},{"key":"11340_CR26","doi-asserted-by":"publisher","first-page":"2395","DOI":"10.1002\/ehf2.14394","volume":"10","author":"C Ekenb\u00e4ck","year":"2023","unstructured":"Ekenb\u00e4ck C, Nickander J, Jokhaji F et al (2023) Coronary microvascular dysfunction in Takotsubo syndrome and associations with left ventricular function. ESC Heart Fail 10:2395\u20132405. https:\/\/doi.org\/10.1002\/ehf2.14394","journal-title":"ESC Heart Fail"},{"key":"11340_CR27","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.hrtlng.2024.06.007","volume":"68","author":"A Shetrit","year":"2024","unstructured":"Shetrit A, Freund O, Banai A et al (2024) Coronary microvascular dysfunction in patients with Takotsubo syndrome. Heart Lung 68:46\u201351. https:\/\/doi.org\/10.1016\/j.hrtlng.2024.06.007","journal-title":"Heart Lung"},{"key":"11340_CR28","doi-asserted-by":"publisher","first-page":"2244","DOI":"10.1093\/eurheartj\/ehad274","volume":"44","author":"F Dong","year":"2023","unstructured":"Dong F, Yin L, Sisakian H et al (2023) Takotsubo syndrome is a coronary microvascular disease: experimental evidence. Eur Heart J 44:2244\u20132253. https:\/\/doi.org\/10.1093\/eurheartj\/ehad274","journal-title":"Eur Heart J"},{"key":"11340_CR29","doi-asserted-by":"publisher","unstructured":"Cau R, Muscogiuri G, Pisu F et al (2023) Exploring the EVolution in PrognOstic CapabiLity of MUltisequence Cardiac MagneTIc ResOnance in PatieNts Affected by Takotsubo Cardiomyopathy Based on Machine Learning Analysis Design and Rationale of the EVOLUTION Study. J Thorac Imaging 2023;00:1\u20138. https:\/\/doi.org\/10.1097\/RTI.0000000000000709","DOI":"10.1097\/RTI.0000000000000709"},{"key":"11340_CR30","doi-asserted-by":"publisher","unstructured":"Arbelo E, Protonotarios A, Gimeno JR et al (2023) 2023 ESC Guidelines for the management of cardiomyopathies: developed by the task force on the management of cardiomyopathies of the European Society of Cardiology (ESC). Eur Heart J 44:3503\u20133626. https:\/\/doi.org\/10.1093\/eurheartj\/ehad194","DOI":"10.1093\/eurheartj\/ehad194"},{"key":"11340_CR31","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s12933-023-02106-w","volume":"23","author":"L Jiang","year":"2024","unstructured":"Jiang L, Yan W, Zhang L et al (2024) Early left ventricular microvascular dysfunction in diabetic pigs: a longitudinal quantitative myocardial perfusion CMR study. Cardiovasc Diabetol 23:9. https:\/\/doi.org\/10.1186\/s12933-023-02106-w","journal-title":"Cardiovasc Diabetol"},{"key":"11340_CR32","doi-asserted-by":"crossref","unstructured":"Zhao Y, Huang L, Li C et al (2023) Improvement in coronary microvascular dysfunction evaluated by cardiac magnetic resonance in patients with hypertrophic obstructive cardiomyopathy after transapical beating-heart septal myectomy. Front Cardiovasc Med. 10. https:\/\/www.frontiersin.org\/journals\/cardiovascular-medicine\/articles\/10.3389\/fcvm.2023.1233004","DOI":"10.3389\/fcvm.2023.1233004"},{"key":"11340_CR33","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1093\/bjr\/tqad016","volume":"97","author":"L Xie","year":"2024","unstructured":"Xie L, Cai X, Guo Y et al (2024) Novel implementation of cardiac magnetic resonance first-pass perfusion imaging for semi-quantitatively evaluating microvascular dysfunction in paediatric patients with Duchenne muscular dystrophy. Br J Radiol 97:249\u2013257. https:\/\/doi.org\/10.1093\/bjr\/tqad016","journal-title":"Br J Radiol"},{"key":"11340_CR34","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.ijcard.2017.07.032","volume":"250","author":"E Verna","year":"2018","unstructured":"Verna E, Provasoli S, Ghiringhelli S, Morandi F, Salerno-Uriarte J (2018) Abnormal coronary vasoreactivity in transient left ventricular apical ballooning (tako-tsubo) syndrome. Int J Cardiol 250:4\u201310. https:\/\/doi.org\/10.1016\/j.ijcard.2017.07.032","journal-title":"Int J Cardiol"},{"key":"11340_CR35","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1016\/j.jacc.2020.10.060","volume":"77","author":"AR Lyon","year":"2021","unstructured":"Lyon AR, Citro R, Schneider B et al (2021) Pathophysiology of Takotsubo syndrome: JACC state-of-the-art review. J Am Coll Cardiol 77:902\u2013921. https:\/\/doi.org\/10.1016\/j.jacc.2020.10.060","journal-title":"J Am Coll Cardiol"},{"key":"11340_CR36","doi-asserted-by":"publisher","first-page":"H818","DOI":"10.1152\/ajpheart.00347.2022","volume":"323","author":"NL Bonfig","year":"2022","unstructured":"Bonfig NL, Soukup CR, Shah AA et al (2022) Increasing myocardial edema is associated with greater microvascular obstruction in ST-segment elevation myocardial infarction. Am J Physiol Heart Circ Physiol 323:H818\u2013H824. https:\/\/doi.org\/10.1152\/ajpheart.00347.2022","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"11340_CR37","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1093\/cvr\/cvq145","volume":"87","author":"RM Dongaonkar","year":"2010","unstructured":"Dongaonkar RM, Stewart RH, Geissler HJ, Laine GA (2010) Myocardial microvascular permeability, interstitial oedema, and compromised cardiac function. Cardiovasc Res 87:331\u2013339. https:\/\/doi.org\/10.1093\/cvr\/cvq145","journal-title":"Cardiovasc Res"},{"key":"11340_CR38","doi-asserted-by":"publisher","unstructured":"Schweiger V, Gilhofer T, Fang R et al (2023) Coronary microvascular dysfunction in Takotsubo syndrome: an analysis using angiography-derived index of microcirculatory resistance. Clin Res Cardiol https:\/\/doi.org\/10.1007\/s00392-023-02329-7","DOI":"10.1007\/s00392-023-02329-7"},{"key":"11340_CR39","doi-asserted-by":"publisher","first-page":"1784","DOI":"10.1016\/j.jcmg.2022.03.030","volume":"15","author":"J Sans-Rosell\u00f3","year":"2022","unstructured":"Sans-Rosell\u00f3 J, Fern\u00e1ndez-Peregrina E, Duran-Cambra A et al (2022) Prognostic value of microvascular resistance at rest in patients with Takotsubo syndrome. JACC Cardiovasc Imaging 15:1784\u20131795. https:\/\/doi.org\/10.1016\/j.jcmg.2022.03.030","journal-title":"JACC Cardiovasc Imaging"},{"key":"11340_CR40","doi-asserted-by":"publisher","unstructured":"Hoffman JI (2000) Problems of coronary flow reserve. Ann Biomed Eng. 28:884\u2013896 https:\/\/doi.org\/10.1114\/1.1308503","DOI":"10.1114\/1.1308503"},{"key":"11340_CR41","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1016\/j.jcmg.2020.10.015","volume":"14","author":"H Rahman","year":"2021","unstructured":"Rahman H, Scannell CM, Demir OM et al (2021) High-resolution cardiac magnetic resonance imaging techniques for the identification of coronary microvascular dysfunction. JACC Cardiovasc Imaging 14:978\u2013986. https:\/\/doi.org\/10.1016\/j.jcmg.2020.10.015","journal-title":"JACC Cardiovasc Imaging"}],"container-title":["European Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-024-11340-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00330-024-11340-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-024-11340-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T15:41:58Z","timestamp":1749829318000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00330-024-11340-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,22]]},"references-count":41,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,7]]}},"alternative-id":["11340"],"URL":"https:\/\/doi.org\/10.1007\/s00330-024-11340-z","relation":{},"ISSN":["1432-1084"],"issn-type":[{"value":"1432-1084","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,22]]},"assertion":[{"value":"25 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 October 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 December 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 January 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The scientific guarantor of this publication is the corresponding Author.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Guarantor"}},{"value":"The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"No complex statistical methods were necessary for this paper.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statistics and biometry"}},{"value":"Written informed consent was waived by the Institutional Review Board.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"Institutional Review Board approval was obtained.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Some study subjects or cohorts have been previously reported in our previous studies (; ; ; ).","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Study subjects or cohorts overlap"}},{"order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Methodology"}}]}}