{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T15:32:38Z","timestamp":1788449558526,"version":"build-2803163510"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T00:00:00Z","timestamp":1738108800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T00:00:00Z","timestamp":1738108800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Radiol"],"DOI":"10.1007\/s00330-025-11377-8","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T13:24:52Z","timestamp":1738157092000},"page":"4587-4598","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["A radiopathomics model for predicting large-number cervical lymph node metastasis in clinical N0 papillary thyroid carcinoma"],"prefix":"10.1007","volume":"35","author":[{"given":"Weihan","family":"Xiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmei","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanding","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianjun","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8669-3308","authenticated-orcid":false,"given":"Xiachuan","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,29]]},"reference":[{"key":"11377_CR1","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/S2213-8587(21)00027-9","volume":"9","author":"A Miranda-Filho","year":"2021","unstructured":"Miranda-Filho A, Lortet-Tieulent J, Bray F et al (2021) Thyroid cancer incidence trends by histology in 25 countries: a population-based study. Lancet Diabetes Endocrinol 9:225\u2013234","journal-title":"Lancet Diabetes Endocrinol"},{"key":"11377_CR2","doi-asserted-by":"publisher","first-page":"3801","DOI":"10.1002\/cncr.24416","volume":"115","author":"AY Chen","year":"2009","unstructured":"Chen AY, Jemal A, Ward EM (2009) Increasing incidence of differentiated thyroid cancer in the United States, 1988\u20132005. Cancer 115:3801\u20133807","journal-title":"Cancer"},{"key":"11377_CR3","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21387","volume":"67","author":"RL Siegel","year":"2017","unstructured":"Siegel RL, Miller KD, Jemal A (2017) Cancer statistics, 2017. CA Cancer J Clin 67:7\u201330","journal-title":"CA Cancer J Clin"},{"key":"11377_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1089\/thy.2015.0020","volume":"26","author":"BR Haugen","year":"2016","unstructured":"Haugen BR, Alexander EK, Bible KC et al (2016) 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: the American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid 26:1\u2013133","journal-title":"Thyroid"},{"key":"11377_CR5","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.ijsu.2018.09.004","volume":"59","author":"B Yan","year":"2018","unstructured":"Yan B, Hou Y, Chen D, He J, Jiang Y (2018) Risk factors for contralateral central lymph node metastasis in unilateral cN0 papillary thyroid carcinoma: a meta-analysis. Int J Surg 59:90\u201398","journal-title":"Int J Surg"},{"key":"11377_CR6","doi-asserted-by":"publisher","first-page":"7211","DOI":"10.2147\/CMAR.S199921","volume":"11","author":"BD Chen","year":"2019","unstructured":"Chen BD, Zhang Z, Wang KK et al (2019) A multivariable model of BRAF(V600E) and ultrasonographic features for predicting the risk of central lymph node metastasis in cN0 papillary thyroid microcarcinoma. Cancer Manag Res 11:7211\u20137217","journal-title":"Cancer Manag Res"},{"key":"11377_CR7","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1007\/s00405-016-4302-0","volume":"274","author":"LS Liu","year":"2017","unstructured":"Liu LS, Liang J, Li JH et al (2017) The incidence and risk factors for central lymph node metastasis in cN0 papillary thyroid microcarcinoma: a meta-analysis. Eur Arch Otorhinolaryngol 274:1327\u20131338","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"11377_CR8","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1001\/archotol.130.1.110","volume":"130","author":"TS Wang","year":"2004","unstructured":"Wang TS, Dubner S, Sznyter LA, Heller KS (2004) Incidence of metastatic well-differentiated thyroid cancer in cervical lymph nodes. Arch Otolaryngol Head Neck Surg 130:110\u2013113","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"11377_CR9","doi-asserted-by":"publisher","first-page":"2370","DOI":"10.1200\/JCO.2014.59.8391","volume":"33","author":"MA Adam","year":"2015","unstructured":"Adam MA, Pura J, Goffredo P et al (2015) Presence and number of lymph node metastases are associated with compromised survival for patients younger than age 45 years with papillary thyroid cancer. J Clin Oncol 33:2370\u20132375","journal-title":"J Clin Oncol"},{"key":"11377_CR10","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1016\/j.surg.2008.08.034","volume":"144","author":"V Zaydfudim","year":"2008","unstructured":"Zaydfudim V, Feurer ID, Griffin MR, Phay JE (2008) The impact of lymph node involvement on survival in patients with papillary and follicular thyroid carcinoma. Surgery 144:1070\u20131077","journal-title":"Surgery"},{"key":"11377_CR11","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1507\/endocrj.K09E-025","volume":"56","author":"Y Ito","year":"2009","unstructured":"Ito Y, Fukushima M, Tomoda C et al (2009) Prognosis of patients with papillary thyroid carcinoma having clinically apparent metastasis to the lateral compartment. Endocr J 56:759\u2013766","journal-title":"Endocr J"},{"key":"11377_CR12","doi-asserted-by":"publisher","unstructured":"Yu Y, Ouyang W, Huang Y et al (2024) AI-based multimodal multi-tasks analysis reveals tumor molecular heterogeneity, predicts preoperative lymph node metastasis and prognosis in papillary thyroid carcinoma: a retrospective study. Int J Surg. https:\/\/doi.org\/10.1097\/js9.0000000000001875","DOI":"10.1097\/js9.0000000000001875"},{"key":"11377_CR13","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1089\/thy.2012.0043","volume":"22","author":"GW Randolph","year":"2012","unstructured":"Randolph GW, Duh QY, Heller KS et al (2012) The prognostic significance of nodal metastases from papillary thyroid carcinoma can be stratified based on the size and number of metastatic lymph nodes, as well as the presence of extranodal extension. Thyroid 22:1144\u20131152","journal-title":"Thyroid"},{"key":"11377_CR14","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1089\/thy.2014.0294","volume":"25","author":"SC Londero","year":"2015","unstructured":"Londero SC, Krogdahl A, Bastholt L et al (2015) Papillary thyroid carcinoma in Denmark, 1996-2008: outcome and evaluation of established prognostic scoring systems in a prospective national cohort. Thyroid 25:78\u201384","journal-title":"Thyroid"},{"key":"11377_CR15","first-page":"1139","volume":"112","author":"ID Hay","year":"1992","unstructured":"Hay ID, Grant CS, van Heerden JA, Goellner JR, Ebersold JR, Bergstralh EJ (1992) Papillary thyroid microcarcinoma: a study of 535 cases observed in a 50-year period. Surgery 112:1139\u20131146","journal-title":"Surgery"},{"key":"11377_CR16","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1007\/s12020-020-02456-5","volume":"72","author":"M Raffaelli","year":"2021","unstructured":"Raffaelli M, De Crea C, Sessa L et al (2021) Modulating the extension of thyroidectomy in patients with papillary thyroid carcinoma pre-operatively eligible for lobectomy: reliability of ipsilateral central neck dissection. Endocrine 72:437\u2013444","journal-title":"Endocrine"},{"key":"11377_CR17","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.surg.2020.04.043","volume":"169","author":"M Raffaelli","year":"2021","unstructured":"Raffaelli M, Sessa L, De Crea C et al (2021) Is it possible to intraoperatively modulate the extent of thyroidectomy in small papillary thyroid carcinoma? Surgery 169:77\u201381","journal-title":"Surgery"},{"key":"11377_CR18","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.1002\/hed.27451","volume":"45","author":"AL Albuck","year":"2023","unstructured":"Albuck AL, Issa PP, Hussein M et al (2023) A combination of computed tomography scan and ultrasound provides optimal detection of cervical lymph node metastasis in papillary thyroid carcinomas: a systematic review and meta-analysis. Head Neck 45:2173\u20132184","journal-title":"Head Neck"},{"key":"11377_CR19","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1080\/07435800.2023.2249090","volume":"48","author":"W Xiao","year":"2023","unstructured":"Xiao W, Hu X, Zhang C, Qin X (2023) Ultrasonic feature prediction of large-number central lymph node metastasis in clinically node-negative solitary papillary thyroid carcinoma. Endocr Res 48:112\u2013119","journal-title":"Endocr Res"},{"key":"11377_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2020.109103","volume":"129","author":"Z Xing","year":"2020","unstructured":"Xing Z, Qiu Y, Yang Q et al (2020) Thyroid cancer neck lymph nodes metastasis: meta-analysis of US and CT diagnosis. Eur J Radiol 129:109103","journal-title":"Eur J Radiol"},{"key":"11377_CR21","doi-asserted-by":"publisher","first-page":"319","DOI":"10.21037\/gs-20-618","volume":"10","author":"Y Zhu","year":"2021","unstructured":"Zhu Y, Ren W, Song Y et al (2021) Cytomorphologic features as predictors of aggressiveness in patients with pT1 papillary thyroid carcinoma: a retrospective study of associations with clinicopathological parameters in 226 fine-needle aspirates. Gland Surg 10:319\u2013327","journal-title":"Gland Surg"},{"key":"11377_CR22","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1038\/s41571-019-0252-y","volume":"16","author":"K Bera","year":"2019","unstructured":"Bera K, Schalper KA, Rimm DL, Velcheti V, Madabhushi A (2019) Artificial intelligence in digital pathology\u2014new tools for diagnosis and precision oncology. Nat Rev Clin Oncol 16:703\u2013715","journal-title":"Nat Rev Clin Oncol"},{"key":"11377_CR23","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1038\/nrclinonc.2017.141","volume":"14","author":"P Lambin","year":"2017","unstructured":"Lambin P, Leijenaar RTH, Deist TM et al (2017) Radiomics: the bridge between medical imaging and personalised medicine. Nat Rev Clin Oncol 14:749\u2013762","journal-title":"Nat Rev Clin Oncol"},{"key":"11377_CR24","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1007\/s11030-021-10217-3","volume":"25","author":"R Gupta","year":"2021","unstructured":"Gupta R, Srivastava D, Sahu M, Tiwari S, Ambasta RK, Kumar P (2021) Artificial intelligence to deep learning: machine intelligence approach for drug discovery. Mol Divers 25:1315\u20131360","journal-title":"Mol Divers"},{"key":"11377_CR25","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1089\/thy.2017.0500","volume":"27","author":"ES Cibas","year":"2017","unstructured":"Cibas ES, Ali SZ (2017) The 2017 Bethesda system for reporting thyroid cytopathology. Thyroid 27:1341\u20131346","journal-title":"Thyroid"},{"key":"11377_CR26","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/j.jacr.2017.01.046","volume":"14","author":"FN Tessler","year":"2017","unstructured":"Tessler FN, Middleton WD, Grant EG et al (2017) ACR thyroid imaging, reporting and data system (TI-RADS): white paper of the ACR TI-RADS Committee. J Am Coll Radiol 14:587\u2013595","journal-title":"J Am Coll Radiol"},{"key":"11377_CR27","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1038\/s41591-020-1037-7","volume":"26","author":"S Cruz Rivera","year":"2020","unstructured":"Cruz Rivera S, Liu X, Chan AW et al (2020) Guidelines for clinical trial protocols for interventions involving artificial intelligence: the SPIRIT-AI extension. Nat Med 26:1351\u20131363","journal-title":"Nat Med"},{"key":"11377_CR28","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1097\/MNM.0000000000001119","volume":"41","author":"G Shen","year":"2020","unstructured":"Shen G, Ma H, Huang R, Kuang A (2020) Predicting large-volume lymph node metastasis in the clinically node-negative papillary thyroid microcarcinoma: a retrospective study. Nucl Med Commun 41:5\u201310","journal-title":"Nucl Med Commun"},{"key":"11377_CR29","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/S0039-6060(03)00384-2","volume":"135","author":"I Sugitani","year":"2004","unstructured":"Sugitani I, Kasai N, Fujimoto Y, Yanagisawa A (2004) A novel classification system for patients with PTC: addition of the new variables of large (3 cm or greater) nodal metastases and reclassification during the follow-up period. Surgery 135:139\u2013148","journal-title":"Surgery"},{"key":"11377_CR30","doi-asserted-by":"publisher","first-page":"5723","DOI":"10.1210\/jc.2005-0285","volume":"90","author":"S Leboulleux","year":"2005","unstructured":"Leboulleux S, Rubino C, Baudin E et al (2005) Prognostic factors for persistent or recurrent disease of papillary thyroid carcinoma with neck lymph node metastases and\/or tumor extension beyond the thyroid capsule at initial diagnosis. J Clin Endocrinol Metab 90:5723\u20135729","journal-title":"J Clin Endocrinol Metab"},{"key":"11377_CR31","doi-asserted-by":"publisher","first-page":"2063","DOI":"10.1007\/s00405-023-08219-y","volume":"281","author":"JR Lechien","year":"2024","unstructured":"Lechien JR, Maniaci A, Gengler I, Hans S, Chiesa-Estomba CM, Vaira LA (2024) Validity and reliability of an instrument evaluating the performance of intelligent chatbot: the artificial intelligence performance instrument (AIPI). Eur Arch Otorhinolaryngol 281:2063\u20132079","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"11377_CR32","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1159114","volume":"13","author":"M Zhang","year":"2023","unstructured":"Zhang M, Zhang Y, Wei H et al (2023) Ultrasound radiomics nomogram for predicting large-number cervical lymph node metastasis in papillary thyroid carcinoma. Front Oncol 13:1159114","journal-title":"Front Oncol"},{"key":"11377_CR33","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/7133972","volume":"2022","author":"W Zhu","year":"2022","unstructured":"Zhu W, Huang X, Qi Q et al (2022) Artificial neural network-based ultrasound radiomics can predict large-volume lymph node metastasis in clinical N0 papillary thyroid carcinoma patients. J Oncol 2022:7133972","journal-title":"J Oncol"},{"key":"11377_CR34","doi-asserted-by":"publisher","DOI":"10.5812\/ijem.8156","volume":"11","author":"E Skoura","year":"2013","unstructured":"Skoura E (2013) Depicting medullary thyroid cancer recurrence: the past and the future of nuclear medicine imaging. Int J Endocrinol Metab 11:e8156","journal-title":"Int J Endocrinol Metab"},{"key":"11377_CR35","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1002\/lary.21227","volume":"121","author":"HS Hwang","year":"2011","unstructured":"Hwang HS, Orloff LA (2011) Efficacy of preoperative neck ultrasound in the detection of cervical lymph node metastasis from thyroid cancer. Laryngoscope 121:487\u2013491","journal-title":"Laryngoscope"},{"key":"11377_CR36","doi-asserted-by":"publisher","first-page":"387","DOI":"10.3348\/kjr.2019.0752","volume":"21","author":"HJ Park","year":"2020","unstructured":"Park HJ, Park B, Lee SS (2020) Radiomics and deep learning: hepatic applications. Korean J Radiol 21:387\u2013401","journal-title":"Korean J Radiol"},{"key":"11377_CR37","doi-asserted-by":"publisher","first-page":"5843","DOI":"10.1007\/s00330-022-08662-1","volume":"32","author":"MD Li","year":"2022","unstructured":"Li MD, Cheng MQ, Chen LD et al (2022) Reproducibility of radiomics features from ultrasound images: influence of image acquisition and processing. Eur Radiol 32:5843\u20135851","journal-title":"Eur Radiol"}],"container-title":["European Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-025-11377-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00330-025-11377-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-025-11377-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T12:16:44Z","timestamp":1751545004000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00330-025-11377-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,29]]},"references-count":37,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2025,8]]}},"alternative-id":["11377"],"URL":"https:\/\/doi.org\/10.1007\/s00330-025-11377-8","relation":{},"ISSN":["1432-1084"],"issn-type":[{"value":"1432-1084","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,29]]},"assertion":[{"value":"7 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 November 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 December 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 January 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The scientific guarantor of this publication is Xiachaun Qin.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Guarantor"}},{"value":"The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"No complex statistical methods were necessary for this paper.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statistics and biometry"}},{"value":"Written informed consent was waived by the Institutional Review Board.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"This retrospective study was approved by the institutional review board of Nanchong Central Hospital, the approval number was review no. 2023-109.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not available.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Study subjects or cohorts overlap"}},{"order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Methodology"}}]}}