{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T14:08:05Z","timestamp":1765980485601,"version":"3.48.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Radiol"],"DOI":"10.1007\/s00330-025-11754-3","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T21:26:00Z","timestamp":1751405160000},"page":"163-171","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cost-effective integration of dynamic myocardial CT perfusion in the assessment of symptomatic coronary artery disease"],"prefix":"10.1007","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7167-2587","authenticated-orcid":false,"given":"Carlos","family":"Gonz\u00e1lez-Freixa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesc","family":"Altadill Balsells","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lidia","family":"Bos Real","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mart\u00edn","family":"Descalzo Buey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Fern\u00e1ndez Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Salido Iniesta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konrad","family":"Pieszko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruben","family":"Leta Petracca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Vilad\u00e9s Medel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,7,2]]},"reference":[{"key":"11754_CR1","doi-asserted-by":"crossref","unstructured":"Knuuti J, Wijns W, Saraste A et al (2020) 2019 ESC guidelines for the diagnosis and management of chronic coronary syndromes. Eur Heart J 41:407\u2013477","DOI":"10.1093\/eurheartj\/ehz425"},{"key":"11754_CR2","first-page":"e368","volume":"144","author":"M Gulati","year":"2021","unstructured":"Gulati M, Levy PD, Mukherjee D et al (2021) 2021 AHA\/ACC\/ASE\/CHEST\/SAEM\/SCCT\/SCMR guideline for the evaluation and diagnosis of chest pain: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation 144:e368\u2013e454","journal-title":"Circulation"},{"key":"11754_CR3","doi-asserted-by":"publisher","first-page":"e9","DOI":"10.1161\/CIR.0000000000001168","volume":"148","author":"SS Virani","year":"2023","unstructured":"Virani SS, Newby LK, Arnold SV et al (2023) 2023 AHA\/ACC\/ACCP\/ASPC\/NLA\/PCNA guideline for the management of patients with chronic coronary disease: a report of the American Heart Association\/American College of Cardiology Joint Committee on Clinical Practice Guidelines. Circulation 148:e9\u2013e119","journal-title":"Circulation"},{"key":"11754_CR4","doi-asserted-by":"publisher","first-page":"1724","DOI":"10.1016\/j.jacc.2008.07.031","volume":"52","author":"MJ Budoff","year":"2008","unstructured":"Budoff MJ, Dowe D, Jollis JG et al (2008) Diagnostic performance of 64-multidetector row coronary computed tomographic angiography for evaluation of coronary artery stenosis in individuals without known coronary artery disease: results from the prospective multicenter ACCURACY trial. J Am Coll Cardiol 52:1724\u20131732","journal-title":"J Am Coll Cardiol"},{"key":"11754_CR5","doi-asserted-by":"publisher","first-page":"1916","DOI":"10.1093\/eurheartj\/ehq072","volume":"31","author":"SP Chao","year":"2010","unstructured":"Chao SP, Law WY, Kuo CJ et al (2010) The diagnostic accuracy of 256-row computed tomographic angiography compared with invasive coronary angiography in patients with suspected coronary artery disease. Eur Heart J 31:1916\u20131923","journal-title":"Eur Heart J"},{"key":"11754_CR6","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1016\/j.jacc.2008.05.024","volume":"52","author":"WB Meijboom","year":"2008","unstructured":"Meijboom WB, Van Mieghem CAG, van Pelt N et al (2008) Comprehensive assessment of coronary artery stenoses: computed tomography coronary angiography versus conventional coronary angiography and correlation with fractional flow reserve in patients with stable angina. J Am Coll Cardiol 52:636\u2013643","journal-title":"J Am Coll Cardiol"},{"key":"11754_CR7","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1056\/NEJMoa0807611","volume":"360","author":"PAL Tonino","year":"2009","unstructured":"Tonino PAL, De Bruyne B, Pijls NHJ et al (2009) Fractional flow reserve versus angiography for guiding percutaneous coronary intervention. N Engl J Med 360:213\u2013224","journal-title":"N Engl J Med"},{"key":"11754_CR8","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.jcmg.2021.07.021","volume":"15","author":"FMA Nous","year":"2022","unstructured":"Nous FMA, Geisler T, Kruk MBP et al (2022) Dynamic myocardial perfusion CT for the detection of hemodynamically significant coronary artery disease. JACC Cardiovasc Imaging 15:75\u201387","journal-title":"JACC Cardiovasc Imaging"},{"key":"11754_CR9","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.jcmg.2013.06.008","volume":"7","author":"F Bamberg","year":"2014","unstructured":"Bamberg F, Marcus RP, Becker A et al (2014) Dynamic myocardial CT perfusion imaging for evaluation of myocardial ischemia as determined by MR imaging. JACC Cardiovasc Imaging 7:267\u2013277","journal-title":"JACC Cardiovasc Imaging"},{"key":"11754_CR10","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.ijcard.2019.10.046","volume":"300","author":"G Pontone","year":"2020","unstructured":"Pontone G, Guaricci AI, Palmer SC et al (2020) Diagnostic performance of non-invasive imaging for stable coronary artery disease: a meta-analysis. Int J Cardiol 300:276\u2013281","journal-title":"Int J Cardiol"},{"key":"11754_CR11","doi-asserted-by":"publisher","first-page":"1974","DOI":"10.1016\/j.jcmg.2022.07.002","volume":"15","author":"RC Cury","year":"2022","unstructured":"Cury RC, Leipsic J, Abbara S et al (2022) CAD-RADS\u2122 2.0\u20142022 coronary artery disease-reporting and data system: an expert consensus document of the Society of Cardiovascular Computed Tomography (SCCT), the American College of Cardiology (ACC), the American College of Radiology (ACR), and the North America Society of Cardiovascular Imaging (NASCI). JACC Cardiovasc Imaging 15:1974\u20132001","journal-title":"JACC Cardiovasc Imaging"},{"key":"11754_CR12","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1056\/NEJMoa1415516","volume":"372","author":"PS Douglas","year":"2015","unstructured":"Douglas PS, Hoffmann U, Patel MR et al (2015) Outcomes of anatomical versus functional testing for coronary artery disease. N Engl J Med 372:1291\u20131300","journal-title":"N Engl J Med"},{"key":"11754_CR13","doi-asserted-by":"publisher","first-page":"2383","DOI":"10.1016\/S0140-6736(15)60291-4","volume":"385","author":"SCOT-HEART investigators","year":"2015","unstructured":"SCOT-HEART investigators (2015) CT coronary angiography in patients with suspected angina due to coronary heart disease (SCOT-HEART): an open-label, parallel-group, multicentre trial. Lancet 385:2383\u20132391","journal-title":"Lancet"},{"key":"11754_CR14","doi-asserted-by":"publisher","first-page":"2508","DOI":"10.1016\/j.jacc.2006.05.080","volume":"48","author":"JD Schuijf","year":"2006","unstructured":"Schuijf JD, Wijns W, Jukema JW et al (2006) Relationship between noninvasive coronary angiography with multi-slice computed tomography and myocardial perfusion imaging. J Am Coll Cardiol 48:2508\u20132514","journal-title":"J Am Coll Cardiol"},{"key":"11754_CR15","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1056\/NEJMoa072771","volume":"359","author":"WS Weintraub","year":"2008","unstructured":"Weintraub WS, Spertus JA, Kolm P et al (2008) Effect of PCI on quality of life in patients with stable coronary disease. N Engl J Med 359:677\u2013687","journal-title":"N Engl J Med"},{"key":"11754_CR16","first-page":"836","volume":"10","author":"A Rossi","year":"2016","unstructured":"Rossi A, Wragg A, Klotz E et al (2016) Dynamic computed tomography myocardial perfusion imaging: comparison of clinical analysis methods for the detection of vessel-specific ischemia. Eur Heart J Cardiovasc Imaging 10:836\u2013844","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"11754_CR17","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1093\/ehjci\/jew044","volume":"17","author":"I Danad","year":"2016","unstructured":"Danad I, Szymonifka J, Schulman-Marcus J, Min JK (2016) Static and dynamic assessment of myocardial perfusion by computed tomography. Eur Heart J Cardiovasc Imaging 17:836\u2013844","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"11754_CR18","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1016\/j.jcmg.2019.05.031","volume":"13","author":"D Andreini","year":"2020","unstructured":"Andreini D, Mushtaq S, Pontone G et al (2020) CT perfusion versus coronary CT angiography in patients with suspected in-stent restenosis or CAD progression. JACC Cardiovasc Imaging 13:732\u2013742","journal-title":"JACC Cardiovasc Imaging"},{"key":"11754_CR19","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1161\/CIRCULATIONAHA.107.688101","volume":"116","author":"AJ Einstein","year":"2007","unstructured":"Einstein AJ, Moser KW, Thompson RC et al (2007) Radiation dose to patients from cardiac diagnostic imaging. Circulation 116:1290\u20131305","journal-title":"Circulation"},{"key":"11754_CR20","doi-asserted-by":"publisher","first-page":"3715","DOI":"10.1093\/eurheartj\/ehy546","volume":"39","author":"TJ Stocker","year":"2018","unstructured":"Stocker TJ, Deseive S, Leipsic J et al (2018) Reduction in radiation exposure in cardiovascular computed tomography imaging: results from the PROspective multicenter registry on radiaTion dose Estimates of cardiac CT angIOgraphy iN daily practice in 2017 (PROTECTION VI). Eur Heart J 39:3715\u20133723","journal-title":"Eur Heart J"},{"key":"11754_CR21","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.1093\/eurheartj\/ehv117","volume":"36","author":"AJ Einstein","year":"2015","unstructured":"Einstein AJ, Pascual TN, Mercuri M et al (2015) Current worldwide nuclear cardiology practices and radiation exposure: results from the 65-country IAEA Nuclear Cardiology Protocols Cross-Sectional Study (INCAPS). Eur Heart J 36:1689\u20131696","journal-title":"Eur Heart J"},{"key":"11754_CR22","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.118.007565","volume":"11","author":"MC Desiderio","year":"2018","unstructured":"Desiderio MC, Lundbye JB, Baker WL et al (2018) Current status of patient radiation exposure of cardiac positron emission tomography and single-photon emission computed tomographic myocardial perfusion imaging: a report from the Intersocietal Accreditation Commission database. Circ Cardiovasc Imaging 11:e007565","journal-title":"Circ Cardiovasc Imaging"},{"key":"11754_CR23","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.1016\/j.jcmg.2017.10.010","volume":"11","author":"M Lubbers","year":"2018","unstructured":"Lubbers M, Coenen A, Kofflard M et al (2018) Comprehensive Cardiac CT with myocardial perfusion imaging versus functional testing in suspected coronary artery disease: the multicenter, randomized CRESCENT-II trial. JACC Cardiovasc Imaging 11:1625\u20131636","journal-title":"JACC Cardiovasc Imaging"},{"key":"11754_CR24","doi-asserted-by":"crossref","unstructured":"Baggiano A, Baessato F, Mushtaq S et al (2024) Stress CT perfusion and stress cardiac magnetic resonance for the management of suspected or known coronary artery disease: resources and outcomes impact. J Cardiovasc Comput Tomogr 18:553\u2013558","DOI":"10.1016\/j.jocmr.2024.100127"},{"key":"11754_CR25","doi-asserted-by":"publisher","first-page":"8191","DOI":"10.1007\/s00330-023-09787-7","volume":"33","author":"X Dai","year":"2023","unstructured":"Dai X, Lan Z, Ling R et al (2023) Financial and clinical outcomes of CT myocardial perfusion imaging and coronary CT angiography-guided versus coronary CT angiography-guided strategy. Eur Radiol 33:8191\u20138202","journal-title":"Eur Radiol"},{"key":"11754_CR26","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.1093\/eurheartj\/eht488","volume":"35","author":"CE Rochitte","year":"2014","unstructured":"Rochitte CE, George RT, Chen MY et al (2014) Computed tomography angiography and perfusion to assess coronary artery stenosis causing perfusion defects by single photon emission computed tomography: the CORE320 study. Eur Heart J 35:1120\u20131130","journal-title":"Eur Heart J"},{"key":"11754_CR27","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.jcct.2019.02.005","volume":"13","author":"M van Assen","year":"2019","unstructured":"van Assen M, De Cecco CN, Eid M et al (2019) Prognostic value of CT myocardial perfusion imaging and CT-derived fractional flow reserve for major adverse cardiac events in patients with coronary artery disease. J Cardiovasc Comput Tomogr 13:26\u201333","journal-title":"J Cardiovasc Comput Tomogr"},{"key":"11754_CR28","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1136\/bmj.38695.605440.AE","volume":"332","author":"CA Daly","year":"2006","unstructured":"Daly CA, Stavola D, Sendon B (2006) Predicting prognosis in stable angina\u2014results from the Euro Heart Survey of stable angina: prospective observational study. BMJ 332:262\u2013267","journal-title":"BMJ"}],"container-title":["European Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-025-11754-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00330-025-11754-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-025-11754-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T14:03:42Z","timestamp":1765980222000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00330-025-11754-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,2]]},"references-count":28,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1]]}},"alternative-id":["11754"],"URL":"https:\/\/doi.org\/10.1007\/s00330-025-11754-3","relation":{},"ISSN":["1432-1084"],"issn-type":[{"type":"electronic","value":"1432-1084"}],"subject":[],"published":{"date-parts":[[2025,7,2]]},"assertion":[{"value":"25 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 May 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 May 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 July 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The scientific guarantor of this publication is David Vilades Medel.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Guarantor"}},{"value":"The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"No complex statistical methods were necessary for this paper.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statistics and biometry"}},{"value":"Written informed consent was obtained from all subjects (patients) in this study.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"Institutional Review Board approval was not required because it\u2019s an observational retrospective study.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"No study subjects or cohorts have been previously reported.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Study subjects or cohorts overlap"}},{"order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Methodology"}}]}}