{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T14:31:52Z","timestamp":1772721112942,"version":"3.50.1"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:00:00Z","timestamp":1756944000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:00:00Z","timestamp":1756944000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Radiol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of this study was to describe the imaging features on dynamic CT and MRI of a series of pathologically confirmed low-grade vascular neoplasia of the liver (LGVNL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>In this retrospective multicenter study, patients diagnosed with pathologically proven LGVNL between January 2014 and August 2024 and with cross-sectional imaging (CT or MRI) were included. Based on prior studies, we divided the patients into two groups: a group with typical LGVNL features and a group with atypical tumors. Univariable analysis and the logistic regression model were used to evaluate the outcome of typical and atypical LGVNL features.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty-eight patients were included (20 men, mean age 53.7\u2009\u00b1\u200913.4 [SD] years old). The median size of tumors at diagnosis was 22\u2009mm [IQR, 10\u201380]. A typical LGVNL pattern including thick continuous peripheral arterial phase \u201cflower petal shape\u201d enhancement was found on MRI in 67% (18\/27) with lobulated lesions (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001), a marked hypersignal on T2-weighted images (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003) and a high apparent diffusion coefficient (ADC) (mean tumor ADC, 2.1\u2009\u00d7\u200910\n                      <jats:sup>\u22123<\/jats:sup>\n                      \u2009\u00b1\u20090.3 [SD] mm\n                      <jats:sup>2<\/jats:sup>\n                      \/s) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006) with portal and delayed phase filling following contrast administration. An atypical LGVNL pattern was found in 33% (9\/27), including homogeneous arterial phase enhancement that persisted during the portal and delayed phases. After a median follow-up of 16 months, tumor growth was observed in 42% (8\/19) and was faster in patients with the atypical LGVNL pattern (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.013).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The typical imaging pattern of LGVNL that includes arterial phase \u201cflower petal shape\u201d enhancement with a marked hypersignal on T2-weighted images and a high ADC was seen in most cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Points<\/jats:title>\n                    <jats:p>\n                      <jats:bold>\n                        <jats:italic>Question<\/jats:italic>\n                      <\/jats:bold>\n                      <jats:italic>Low-grade vascular neoplasia of the liver, including hepatic small vessel neoplasms and anastomosing hemangioma, is a new entity of vascular tumors with few radiological descriptions.<\/jats:italic>\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:bold>\n                        <jats:italic>Findings<\/jats:italic>\n                      <\/jats:bold>\n                      <jats:italic>Diagnostic imaging criteria include the \u201cflower petal shape\u201d enhancement pattern on arterial phase, a marked hypersignal on T2-weighted images and high ADC values.<\/jats:italic>\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:bold>\n                        <jats:italic>Clinical relevance<\/jats:italic>\n                      <\/jats:bold>\n                      <jats:italic>This multicenter study provides clinical, pathological and imaging data on low-grade vascular neoplasia of the liver and highlights specific imaging features for its diagnosis. Knowledge of these imaging features helps eliminate differential diagnoses.<\/jats:italic>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphical Abstract<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1007\/s00330-025-11915-4","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T11:16:22Z","timestamp":1756984582000},"page":"1887-1898","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Imaging features of recently identified low-grade vascular neoplasia of the liver: hepatic small vessel neoplasm and anastomosing hemangioma"],"prefix":"10.1007","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9450-8096","authenticated-orcid":false,"given":"Ma\u00eft\u00e9","family":"Lewin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rauda","family":"Aldhaheri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aur\u00e9lie","family":"Beaufr\u00e8re","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe","family":"Desterke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"Paisant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Bricault","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Borde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel","family":"Simon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Micka\u00ebl","family":"Lesurtel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Cherqui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clara","family":"Prud\u2019Homme","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9rie","family":"Vilgrain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Astrid","family":"Laurent-Bellue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,9,4]]},"reference":[{"key":"11915_CR1","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.humpath.2016.03.018","volume":"54","author":"RM Gill","year":"2016","unstructured":"Gill RM, Buelow B, Mather C et al (2016) Hepatic small vessel neoplasm, a rare infiltrative vascular neoplasm of uncertain malignant potential. 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Institution: INSERM U1310, University Paris-Saclay, Medicine Faculty, Paul Brousse University Hospital, Villejuif, France.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statistics and biometry"}},{"value":"Written informed consent was obtained from all subjects (patients) in this study.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"Institutional Review Board approval was obtained (ClinicalTrials.gov number NCT06067035).","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Study subjects or cohorts overlap"}},{"order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Methodology"}}]}}