{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T14:26:23Z","timestamp":1793715983585,"version":"4.6.1"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Colorectal Cancer Research Center at Memorial Sloan Kettering Cancer Center"},{"DOI":"10.13039\/501100002322","name":"Coordination for the Improvement of Higher Education Personnel","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Radiol"],"DOI":"10.1007\/s00330-025-11967-6","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T08:39:43Z","timestamp":1756197583000},"page":"1838-1850","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Mucin quantity on MRI and outcomes following total neoadjuvant therapy in patients with rectal cancer"],"prefix":"10.1007","volume":"36","author":[{"given":"Sidra","family":"Javed-Tayyab","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joao","family":"Miranda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thais","family":"Reif de Paula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Nevin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Victor","family":"Alves Pinto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junting","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Canan","family":"Firat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"El Homsi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marinela","family":"Capanu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin R.","family":"Weiser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinru","family":"Shia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc J.","family":"Gollub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8849-5789","authenticated-orcid":false,"given":"Natally","family":"Horvat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,26]]},"reference":[{"key":"11967_CR1","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/s40880-019-0361-0","volume":"39","author":"C Luo","year":"2019","unstructured":"Luo C, Cen S, Ding G, Wu W (2019) Mucinous colorectal adenocarcinoma: clinical pathology and treatment options. Cancer Commun 39:13","journal-title":"Cancer Commun"},{"key":"11967_CR2","unstructured":"Bosman FT, Carneiro F, Hruban RH, Theise ND (2010) WHO Classification of Tumours of the Digestive System. World Health Organization, International Agency for Research on Cancer"},{"key":"11967_CR3","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.620146","volume":"11","author":"YT Lan","year":"2021","unstructured":"Lan YT, Chang SC, Lin PC et al (2021) Clinicopathological and molecular features of colorectal cancer patients with mucinous and non-mucinous adenocarcinoma. Front Oncol 11:620146","journal-title":"Front Oncol"},{"key":"11967_CR4","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1245\/s10434-007-9757-1","volume":"15","author":"S Leopoldo","year":"2008","unstructured":"Leopoldo S, Lorena B, Cinzia A et al (2008) Two subtypes of mucinous adenocarcinoma of the colorectum: clinicopathological and genetic features. Ann Surg Oncol 15:1429\u20131439","journal-title":"Ann Surg Oncol"},{"key":"11967_CR5","first-page":"745","volume":"26","author":"GA Song","year":"2005","unstructured":"Song GA, Deng G, Bell I, Kakar S, Sleisenger MH, Kim YS (2005) Mucinous carcinomas of the colorectum have distinct molecular genetic characteristics. Int J Oncol 26:745\u2013750","journal-title":"Int J Oncol"},{"key":"11967_CR6","doi-asserted-by":"publisher","unstructured":"Stanietzky N, Morani A, Surabhi V, Jensen C, Horvat N, Vikram R (2024) Mucinous rectal adenocarcinoma-challenges in magnetic resonance imaging interpretation. J Comput Assist Tomogr. https:\/\/doi.org\/10.1097\/RCT.0000000000001599","DOI":"10.1097\/RCT.0000000000001599"},{"key":"11967_CR7","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1136\/jclinpath-2011-200340","volume":"65","author":"J Verhulst","year":"2012","unstructured":"Verhulst J, Ferdinande L, Demetter P, Ceelen W (2012) Mucinous subtype as prognostic factor in colorectal cancer: a systematic review and meta-analysis. J Clin Pathol 65:381\u2013388","journal-title":"J Clin Pathol"},{"key":"11967_CR8","doi-asserted-by":"crossref","unstructured":"Enblad M, Hammarstr\u00f6m K, Folkesson J, Imam I, Golubovik M, Glimelius B (2022) Mucinous rectal cancers: clinical features and prognosis in a population-based cohort. BJS Open 6:zrac039","DOI":"10.1093\/bjsopen\/zrac039"},{"key":"11967_CR9","doi-asserted-by":"publisher","first-page":"2341","DOI":"10.1111\/codi.15760","volume":"23","author":"T Ko\u00ebter","year":"2021","unstructured":"Ko\u00ebter T, Stijns RCH, van Koeverden S et al (2021) Poor response at restaging MRI and high incomplete resection rates of locally advanced mucinous rectal cancer after chemoradiation therapy. Colorectal Dis 23:2341\u20132347","journal-title":"Colorectal Dis"},{"key":"11967_CR10","doi-asserted-by":"publisher","first-page":"1378","DOI":"10.1016\/j.acra.2023.10.031","volume":"31","author":"J Liu","year":"2024","unstructured":"Liu J, Miao G, Deng L et al (2024) Should the baseline MRI staging criteria differentiate between mucinous and classical rectal adenocarcinoma?. Acad Radiol 31:1378\u20131387","journal-title":"Acad Radiol"},{"key":"11967_CR11","doi-asserted-by":"publisher","first-page":"1576","DOI":"10.1245\/s10434-015-5029-7","volume":"23","author":"I Tarantino","year":"2016","unstructured":"Tarantino I, H\u00fcttner FJ, Warschkow R, Schmied BM, Diener MK, Ulrich A (2016) Prognostic relevance of mucinous subtype in a population-based propensity score analysis of 40,083 rectal cancer patients. Ann Surg Oncol 23:1576\u20131586","journal-title":"Ann Surg Oncol"},{"key":"11967_CR12","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1007\/s00595-016-1419-0","volume":"47","author":"K Kaneko","year":"2017","unstructured":"Kaneko K, Kawai K, Kazama S et al (2017) Clinical significance of mucinous components in rectal cancer after preoperative chemoradiotherapy. Surg Today 47:697\u2013704","journal-title":"Surg Today"},{"key":"11967_CR13","doi-asserted-by":"publisher","first-page":"206","DOI":"10.2214\/AJR.23.29002","volume":"221","author":"J Miranda","year":"2023","unstructured":"Miranda J, Pinto PVA, Kinochita F et al (2023) Mucinous degeneration on MRI after neoadjuvant therapy in patients with rectal adenocarcinoma: frequency and association with clinical outcomes. AJR Am J Roentgenol 221:206\u2013216","journal-title":"AJR Am J Roentgenol"},{"key":"11967_CR14","doi-asserted-by":"publisher","unstructured":"Garcia-Aguilar J, Patil S, Gollub MJ et al (2022) Organ preservation in patients with rectal adenocarcinoma treated with total neoadjuvant therapy. J Clin Oncol. https:\/\/doi.org\/10.1200\/JCO.22.00032:JCO2200032","DOI":"10.1200\/JCO.22.00032:JCO2200032"},{"key":"11967_CR15","doi-asserted-by":"publisher","unstructured":"Horvat N, Hope TA, Pickhardt PJ, Petkovska I (2019) Mucinous rectal cancer: concepts and imaging challenges. Abdom Radiol (NY). https:\/\/doi.org\/10.1007\/s00261-019-02019-x","DOI":"10.1007\/s00261-019-02019-x"},{"key":"11967_CR16","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-015-1632-z","volume":"15","author":"JJ Smith","year":"2015","unstructured":"Smith JJ, Chow OS, Gollub MJ et al (2015) Organ preservation in rectal adenocarcinoma: a phase II randomized controlled trial evaluating 3-year disease-free survival in patients with locally advanced rectal cancer treated with chemoradiation plus induction or consolidation chemotherapy, and total mesorectal excision or nonoperative management. BMC Cancer 15:767","journal-title":"BMC Cancer"},{"key":"11967_CR17","doi-asserted-by":"publisher","first-page":"e180071","DOI":"10.1001\/jamaoncol.2018.0071","volume":"4","author":"A Cercek","year":"2018","unstructured":"Cercek A, Roxburgh CSD, Strombom P et al (2018) Adoption of total neoadjuvant therapy for locally advanced rectal cancer. JAMA Oncol 4:e180071","journal-title":"JAMA Oncol"},{"key":"11967_CR18","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1007\/978-3-642-71967-7_12","volume":"146","author":"P Hohenberger","year":"1998","unstructured":"Hohenberger P (1998) Locoregional recurrence of rectal cancer: biological and technical aspects of surgical failure. Recent Results Cancer Res 146:127\u2013140","journal-title":"Recent Results Cancer Res"},{"key":"11967_CR19","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1038\/s41571-021-00538-5","volume":"18","author":"E Fokas","year":"2021","unstructured":"Fokas E, Appelt A, Glynne-Jones R et al (2021) International consensus recommendations on key outcome measures for organ preservation after (chemo)radiotherapy in patients with rectal cancer. Nat Rev Clin Oncol 18:805\u2013816","journal-title":"Nat Rev Clin Oncol"},{"key":"11967_CR20","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1097\/DCR.0000000000001984","volume":"64","author":"KM Hardiman","year":"2021","unstructured":"Hardiman KM, Felder SI, Friedman G, Migaly J, Paquette IM, Feingold DL (2021) The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Surveillance and Survivorship Care of Patients After Curative Treatment of Colon and Rectal Cancer. Dis Colon Rectum 64:517\u2013533","journal-title":"Dis Colon Rectum"},{"key":"11967_CR21","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1001\/jamaoncol.2023.5098","volume":"10","author":"J Nors","year":"2024","unstructured":"Nors J, Iversen LH, Erichsen R, Gotschalck KA, Andersen CL (2024) Incidence of recurrence and time to recurrence in stage I to III colorectal cancer: A Nationwide Danish Cohort Study. JAMA Oncol 10:54\u201362","journal-title":"JAMA Oncol"},{"key":"11967_CR22","unstructured":"National Comprehensive Cancer Network (2024) NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines\u00ae) for Rectal Cancer V.1.2024. Available via https:\/\/www.nccn.org\/guidelines\/guidelines-detail?category=1&id=1461. Accessed Feb 29, 2024"},{"key":"11967_CR23","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.1093\/jnci\/djae152","volume":"116","author":"SJ Judge","year":"2024","unstructured":"Judge SJ, Malekzadeh P, Corines MJ et al (2024) Watch and wait in rectal cancer patients with residual mucin on magnetic resonance imaging following neoadjuvant therapy. J Natl Cancer Inst 116:1761\u20131766","journal-title":"J Natl Cancer Inst"},{"key":"11967_CR24","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1038\/modpathol.3800093","volume":"17","author":"S Kakar","year":"2004","unstructured":"Kakar S, Aksoy S, Burgart LJ, Smyrk TC (2004) Mucinous carcinoma of the colon: correlation of loss of mismatch repair enzymes with clinicopathologic features and survival. Mod Pathol 17:696\u2013700","journal-title":"Mod Pathol"},{"key":"11967_CR25","doi-asserted-by":"publisher","first-page":"513","DOI":"10.6004\/jnccn.2014.0056","volume":"12","author":"A Cercek","year":"2014","unstructured":"Cercek A, Goodman KA, Hajj C et al (2014) Neoadjuvant chemotherapy first, followed by chemoradiation and then surgery, in the management of locally advanced rectal cancer. J Natl Compr Canc Netw 12:513\u2013519","journal-title":"J Natl Compr Canc Netw"},{"key":"11967_CR26","doi-asserted-by":"publisher","first-page":"3588","DOI":"10.1002\/1097-0142(19931215)72:12<3588::AID-CNCR2820721207>3.0.CO;2-I","volume":"72","author":"M Younes","year":"1993","unstructured":"Younes M, Katikaneni PR, Lechago J (1993) The value of the preoperative mucosal biopsy in the diagnosis of colorectal mucinous adenocarcinoma. Cancer 72:3588\u20133592","journal-title":"Cancer"},{"key":"11967_CR27","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1186\/1477-7819-10-109","volume":"10","author":"M Numata","year":"2012","unstructured":"Numata M, Shiozawa M, Watanabe T et al (2012) The clinicopathological features of colorectal mucinous adenocarcinoma and a therapeutic strategy for the disease. World J Surg Oncol 10:109","journal-title":"World J Surg Oncol"},{"key":"11967_CR28","first-page":"S41","volume":"94","author":"P Jivapaisarnpong","year":"2011","unstructured":"Jivapaisarnpong P, Boonthongtho K (2011) Clinicopathological characteristics of mucinous and non-mucinous adenocarcinoma in the colon and rectum in Rajavithi Hospital, Thailand. J Med Assoc Thai 94:S41\u2013S45","journal-title":"J Med Assoc Thai"},{"key":"11967_CR29","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1097\/DCR.0000000000002145","volume":"65","author":"JB Yuval","year":"2022","unstructured":"Yuval JB, Thompson HM, Firat C et al (2022) MRI at restaging after neoadjuvant therapy for rectal cancer overestimates circumferential resection margin proximity as determined by comparison with whole-mount pathology. Dis Colon Rectum 65:489\u2013496","journal-title":"Dis Colon Rectum"},{"key":"11967_CR30","doi-asserted-by":"publisher","first-page":"111986","DOI":"10.1016\/j.ejrad.2025.111986","volume":"184","author":"MJ Corines","year":"2025","unstructured":"Corines MJ, Ibrahim A, Baheti A et al (2025) Can MRI radiomics distinguish residual adenocarcinoma from acellular mucin in treated rectal cancer?. Eur J Radiol 184:111986","journal-title":"Eur J Radiol"},{"key":"11967_CR31","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1097\/00004728-200301000-00010","volume":"27","author":"MJ Kim","year":"2003","unstructured":"Kim MJ, Park JS, Park SI et al (2003) Accuracy in differentiation of mucinous and nonmucinous rectal carcinoma on MR imaging. J Comput Assist Tomogr 27:48\u201355","journal-title":"J Comput Assist Tomogr"},{"key":"11967_CR32","doi-asserted-by":"publisher","first-page":"593","DOI":"10.2463\/mrms.mp.2021-0067","volume":"21","author":"J Zhang","year":"2022","unstructured":"Zhang J, Ge Y, Zhang H, Wang Z, Dou W, Hu S (2022) Quantitative T2 mapping to discriminate mucinous from nonmucinous adenocarcinoma in rectal cancer: comparison with diffusion-weighted imaging. Magn Reson Med Sci 21:593\u2013598","journal-title":"Magn Reson Med Sci"}],"container-title":["European Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-025-11967-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00330-025-11967-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-025-11967-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T13:20:01Z","timestamp":1772716801000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00330-025-11967-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,26]]},"references-count":32,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,3]]}},"alternative-id":["11967"],"URL":"https:\/\/doi.org\/10.1007\/s00330-025-11967-6","relation":{},"ISSN":["1432-1084"],"issn-type":[{"value":"1432-1084","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,26]]},"assertion":[{"value":"11 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 June 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 August 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 August 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The scientific guarantor of this publication is Natally Horvat, MD, PhD.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Guarantor"}},{"value":"The authors of this manuscript declare relationships with the following companies: Jinru Shia reports professional services and activities with Paige AI, Inc., Marc J. Gollub reports being a consultant for GSK, and Natally Horvat reports being a consultant for Guerbet, receiving travel support from Guerbet, and giving a lecture to Bayer. The remaining authors have nothing to disclose.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Two of the authors (Junting Zheng, MS, and Marinela Capanu, PhD) have significant statistical expertise.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statistics and biometry"}},{"value":"Written informed consent was waived by the Institutional Review Board at Memorial Sloan Kettering Cancer Center.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"Institutional Review Board approval was obtained from Memorial Sloan Kettering Cancer Center.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"None.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Study subjects or cohorts overlap"}},{"order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Methodology"}}]}}