{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T04:03:24Z","timestamp":1788581004211,"version":"build-2803163510"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T00:00:00Z","timestamp":1757635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T00:00:00Z","timestamp":1757635200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Radiol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To compare 40\u2009keV virtual monochromatic images (VMIs) with conventionally acquired polychromatic multi-detector CT images (CONV) in patients with acute bowel ischaemia (ABI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>We retrospectively included 48 consecutive patients (38 males, mean age 69 years) with pathologically proven ABI over 40 months. They underwent portovenous dual-energy multi-detector CT followed by surgery within &lt; 48\u2009h. Nineteen patients had VMIs, and 29 had CONV after non-enhanced acquisition. After dividing the small and large bowel into 10 segments, two radiologists blinded to the exact localisation of the ABI read the VMIs and CONV images separately. After this qualitative analysis, bowel wall density was assessed quantitatively on (virtual) non-enhanced and portovenous images.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Qualitative analysis showed good overall sensitivity (75.9\u201382%) and specificity (85.9\u201388.7%) for localising ABI on VMIs and CONV images without significant differences. Inter-observer agreement was important or near perfect (kappa 0.61\u20130.83). Quantitative analysis revealed significant differences in wall density between healthy and pathological bowel segments for nearly all VMIs and CONV images, not only when analysing the (virtual) non-enhanced and portovenous phases separately, but also when subtracting wall density (portovenous minus (virtual) non-enhanced phase). Wall density delta (healthy minus pathological wall) showed no significant differences between VMIs and CONV images.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>VMIs and CONV images had good diagnostic value and important inter-reader agreement for localising ABI using (virtual) non-enhanced and portovenous phases, without significant qualitative or quantitative differences. Therefore, we can rely on the virtual non-enhanced phase instead of additionally acquiring a non-enhanced phase, enabling considerable dose reduction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Points<\/jats:title>\n                    <jats:p>\n                      <jats:bold>\n                        <jats:italic>Question<\/jats:italic>\n                      <\/jats:bold>\n                      <jats:italic>Can we rely on virtual monochromatic CT images to detect reduced or absent bowel wall enhancement in acute bowel ischaemia?<\/jats:italic>\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:bold>\n                        <jats:italic>Findings<\/jats:italic>\n                      <\/jats:bold>\n                      <jats:italic>Virtual monochromatic CT images have equal diagnostic value for detecting acute bowel ischaemia as conventionally acquired polychromatic CT images without significant qualitative or quantitative differences.<\/jats:italic>\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:bold>\n                        <jats:italic>Clinical relevance<\/jats:italic>\n                      <\/jats:bold>\n                      <jats:italic>Significant differences in bowel wall density between healthy and pathological segments on subtraction virtual monochromatic images allow us to rely on the virtual non-enhanced phase instead of acquiring an additional non-enhanced phase in acute bowel ischaemia, leading to dose reduction.<\/jats:italic>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphical Abstract<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1007\/s00330-025-11995-2","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T16:13:23Z","timestamp":1757693603000},"page":"2343-2352","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Virtual monochromatic versus conventional polychromatic CT images in patients with acute bowel ischaemia"],"prefix":"10.1007","volume":"36","author":[{"given":"Kilian","family":"Rothenbuehler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Sayadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renaud","family":"Troxler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Sempoux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alban","family":"Denys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Rotzinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2631-3032","authenticated-orcid":false,"given":"Sabine","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,12]]},"reference":[{"key":"11995_CR1","doi-asserted-by":"publisher","first-page":"29","DOI":"10.2214\/AJR.19.22625","volume":"215","author":"L Garzelli","year":"2020","unstructured":"Garzelli L, Nuzzo A, Copin P et al (2020) Contrast-enhanced CT for the diagnosis of acute mesenteric ischemia. 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The remaining authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"One of the authors, David Rotzinger, has significant statistical expertise. No complex statistical methods were necessary for this paper.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statistics and biometry"}},{"value":"Written informed consent was waived by the Institutional Review Board.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"Institutional Review Board approval was obtained.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"No study subjects or cohorts have been previously reported.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Study subjects or cohorts overlap"}},{"order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Methodology"}}]}}