{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T07:04:07Z","timestamp":1780383847124,"version":"3.54.1"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:00:00Z","timestamp":1758067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:00:00Z","timestamp":1758067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Radiol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess the effects of a bisacodyl micro-enema on rectal physio-morphology, image quality, and patient acceptance when used as preparation before MRI of rectal tumors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      In this prospective single-center study, we made an intra-individual comparison of patients with suspected early rectal cancer who all completed MRI without (MRex) and with (MRin) a bisacodyl micro-enema. The width and the anal-oral extension of the submucosal edema in the healthy rectal wall, anal-oral extension of luminal fluid, and rectal distension were registered. Image artifacts were recorded with a figurative visual analog scale (fVAS), and patient acceptance with questionnaires at baseline, after MRex, and MRin. Significance levels were calculated with a\n                      <jats:italic>t<\/jats:italic>\n                      -test, the Wilcoxon signed-rank test, or McNemar\u2019s test for paired samples and inter-reader agreement with Gwets AC1 statistics.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Consecutively, 50 patients (mean age, 65 years \u00b1 10, 26 men) were included. The median (iqr) summed width of submucosa (MRex, 26 (12) mm, MRin 39 (13) mm,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01) and anal-oral fluid extension (MRex 0 (0) mm, MRin 134 (91) mm,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) increased. Susceptibility artifacts on diffusion weighted imaging (axial plane\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.04 and parallel plane\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) were reduced. No increase in rectal distension, motion artifacts, or side effects was registered, and the patient-reported acceptance remained unchanged.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Bisacodyl significantly increased the submucosal width and extension of intraluminal fluid, did not lead to distension of the rectum, improved image quality, and was well tolerated by the patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Points<\/jats:title>\n                    <jats:p>\n                      <jats:bold>\n                        <jats:italic>Question<\/jats:italic>\n                      <\/jats:bold>\n                      <jats:italic>Bisacodyl micro-enema can improve MRI of early stage-rectal tumors, but the impact on rectal physio-morphology, image quality, and patient acceptance is unknown.<\/jats:italic>\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:bold>\n                        <jats:italic>Result<\/jats:italic>\n                      <\/jats:bold>\n                      <jats:italic>Bisacodyl micro-enema increased the submucosal width and intraluminal fluid, did not distend the rectum, improved image quality, and was well tolerated by the patients.<\/jats:italic>\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:bold>\n                        <jats:italic>Clinical relevance<\/jats:italic>\n                      <\/jats:bold>\n                      <jats:italic>Bisacodyl micro-enema represents a reliable preparation before MRI of rectal tumors and can improve imaging of early-stage cancer. This is increasingly important because of the shift toward earlier stages due to screening programs and the growing use of organ-saving treatment.<\/jats:italic>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphical Abstract<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1007\/s00330-025-11996-1","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T15:53:47Z","timestamp":1758124427000},"page":"1874-1886","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Bisacodyl micro-enema before MRI of rectal tumors: effects on rectum, image quality and patient acceptance"],"prefix":"10.1007","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7140-2440","authenticated-orcid":false,"given":"Ellen","family":"Viktil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina Andrea","family":"Hanekamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arild","family":"Nesbakken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole Helmer","family":"Sjo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Neg\u00e5rd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johann Baptist","family":"Dormagen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anselm","family":"Schulz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,17]]},"reference":[{"key":"11996_CR1","doi-asserted-by":"publisher","first-page":"3498","DOI":"10.1007\/s00261-019-02251-5","volume":"44","author":"J Krdzalic","year":"2019","unstructured":"Krdzalic J, Maas M, Gollub MJ, Beets-Tan RGH (2019) Guidelines for MR imaging in rectal cancer: Europe versus United States. 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