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We aimed to assess the association between embolic agent choice and early rebleeding and intestinal ischemia after TAE for CDB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>We conducted a nationwide retrospective cohort study using the Japanese Diagnosis Procedure Combination database between July 2010 and March 2022. Adults who underwent a first TAE for CDB with coils, gelatin sponge (GS) particles, or n\u2011butyl\u20112\u2011cyanoacrylate (NBCA) were included. Multivariate logistic regression analyses were performed to evaluate the association of embolic agent choice with early rebleeding requiring intervention and intestinal ischemic complications, while adjusting for covariates and within-hospital clustering.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The cohort comprised 5625 patients (mean age 72 years \u00b1 12 [standard deviation], 4020 men). Coils, GS particles, and NBCA were used in 59%, 30%, and 11%, respectively. The overall early incidence of rebleeding and intestinal ischemia was 12% and 1.0%, respectively. With coils as the reference, the adjusted odds ratio for GS particles was 1.38 (95% CI: 1.15\u20131.66;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) for early rebleeding and 2.64 (95% CI: 1.43\u20134.90;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002) for intestinal ischemia, and those for NBCA were 0.69 (95% CI: 0.50\u20130.95;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03) for early rebleeding and 3.53 (95% CI: 1.72\u20137.22;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) for intestinal ischemia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Compared with coils, GS particles were associated with an increase in both early rebleeding and intestinal ischemia, whereas NBCA was associated with decreased rebleeding and increased ischemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Points<\/jats:title>\n                    <jats:p>\n                      <jats:bold>\n                        <jats:italic>Question<\/jats:italic>\n                      <\/jats:bold>\n                      <jats:italic>Transcatheter arterial embolization (TAE) is one of the mainstay treatments for colonic diverticular bleeding, but outcome differences among embolic agents remain unclear.<\/jats:italic>\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:bold>\n                        <jats:italic>Findings<\/jats:italic>\n                      <\/jats:bold>\n                      <jats:italic>Gelatin sponge particles increased both early rebleeding and intestinal ischemic risks, while coils reduced intestinal ischemic risk and n\u2011butyl\u20112\u2011cyanoacrylate reduced early rebleeding risk.<\/jats:italic>\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:bold>\n                        <jats:italic>Clinical relevance<\/jats:italic>\n                      <\/jats:bold>\n                      <jats:italic>Embolic material selection should be individualized for TAE in colonic diverticular bleeding. Coils may be safer in ischemia-prone patients, while n\u2011butyl\u20112\u2011cyanoacrylate may be suitable for those at high risk of rebleeding.<\/jats:italic>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphical Abstract<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1007\/s00330-025-12210-y","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T14:43:26Z","timestamp":1766155406000},"page":"3960-3968","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between embolic agent choice and complications after transcatheter arterial embolization for colonic diverticular bleeding"],"prefix":"10.1007","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3512-1980","authenticated-orcid":false,"given":"Takatoshi","family":"Kubo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayato","family":"Yamana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shotaro","family":"Aso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Matsui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyohide","family":"Fushimi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideo","family":"Yasunaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Abe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,12,19]]},"reference":[{"key":"12210_CR1","doi-asserted-by":"crossref","unstructured":"Nagata N, Niikura R, Aoki T et al (2014) Increase in colonic diverticulosis and diverticular hemorrhage in an aging society: lessons from a 9-year colonoscopic study of 28,192 patients in Japan. 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