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J.K.F reports receiving grants\/contracts from NIH (USA), EU Horizon, CRUK, Elypta, and Alchemab, consulting fees from Elypta, Qure.ai, iDNA, and Astra Zeneca, and support for meeting attendance from IASLC. M.P.A.D. reports receiving consulting fees from Brainomix, Boehringer Ingelheim, and AstraZeneca, and stock\/stock options with Brainomix. M.S. reports receiving support for a lecture at the ESTI congress from Coreline LTD. M.O. and C.M.vdA. reports receiving support from the EU Horizon grant as part of the ongoing 4ITLR screening implementation trial. J.Y. is an employee of Coreline Soft, the developer of the AI software (AVIEW LCS) evaluated in this study. A.N.H.W. is affiliated with the Medimaps group SA. All other authors declare that they have no conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"No complex statistical methods were necessary for this paper.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statistics and biometry"}},{"value":"Written informed consent was waived by the Institutional Review Board for this retrospective analysis.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"Institutional Review Board approval was obtained for the original UK Lung Screening (UKLS) Trial. This retrospective analysis of the curated dataset was performed in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The study cohort is a subset of the UKLS trial cohort, which has been previously reported in: Lancaster HL et al [\n                      \n                      ];\n                      \n                      .","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Study subjects or cohorts overlap"}},{"order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Methodology"}}]}}