{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:57:36Z","timestamp":1793041056258,"version":"4.5.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Health~Holland and Siemens Healthineers","award":["LSHM20103"],"award-info":[{"award-number":["LSHM20103"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Radiol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine whether AI-reconstructed prostate MRI at reduced acquisition times maintains prostate cancer (PCa) detection performance comparable to conventional scans.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>This multicenter, retrospective, consecutive-cohort study included 120 multi-coil T2-weighted prostate MRI scans from the University Medical Center Groningen (UMCG) and 312 publicly available scans from New York University (NYU). An AI model trained on the NYU data was tested on retrospectively undersampled UMCG scans at acceleration factors R\u2009=\u20093 and R\u2009=\u20096 (i.e., data reduction in k-space). Eight experienced radiologists participated in a multi-reader multi-case PCa detection study. Diagnostic performance was assessed using the area under the receiver operating characteristic curve (AUROC). Histopathology and PI-RADS\u2009\u2264\u20092 findings served as reference standards. Multiple image quality metrics were subjectively evaluated using a 4-point Likert scale.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      No statistically significant reduction in PCa detection was observed at an MRI acceleration up to R\u2009=\u20096 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.08). AUROC values were 0.86 (95% CI: 0.74\u20130.90) for R\u2009=\u20091, 0.82 (0.72\u20130.88) for R\u2009=\u20093, and 0.80 (0.70\u20130.86) for R\u2009=\u20096. Compared to R\u2009=\u20091, R\u2009=\u20093 scans were rated by radiologists to have significantly improved sharpness (+0.2,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) and lower noise (+0.1,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Overall visual quality at R\u2009=\u20096 remained comparable to R\u2009=\u20091 (2.81 at R6 vs. 2.74 at R1).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>AI-driven reconstruction enabled a sixfold acceleration of T2-weighted prostate MRI (0:33\u20131:27\u2009min) without a statistically significant reduction in PCa detection, while preserving perceived image quality. However, the decreasing diagnostic performance at higher accelerations warrants further prospective evaluation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Points<\/jats:title>\n                    <jats:p>\n                      <jats:bold>\n                        <jats:italic>Question<\/jats:italic>\n                      <\/jats:bold>\n                      <jats:italic>This study investigated whether deep learning reconstruction enables three- to sixfold acceleration without reducing radiologists\u2019 detection of clinically significant prostate cancer<\/jats:italic>\n                      .\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:bold>\n                        <jats:italic>Findings<\/jats:italic>\n                      <\/jats:bold>\n                      <jats:italic>In a multi-reader multi-case study with eight radiologists, three- and sixfold acceleration showed no significant change in area under the receiver operating characteristic curve<\/jats:italic>\n                      .\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:bold>\n                        <jats:italic>Clinical relevance<\/jats:italic>\n                      <\/jats:bold>\n                      <jats:italic>Deep learning reconstruction shortened T2-weighted acquisition times at sixfold acceleration while preserving perceived image quality and diagnostic performance across acceleration factors<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00330-026-12479-7","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T13:30:04Z","timestamp":1775136604000},"page":"6440-6449","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Diagnostic assessment of artificial intelligence reconstruction on accelerated prostate MRI: a retrospective, paired, multi-reader multi-case study"],"prefix":"10.1007","volume":"36","author":[{"given":"Quintin","family":"van Lohuizen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5454-5052","authenticated-orcid":false,"given":"Stefan Johannes","family":"Fransen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Yiasemis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasper Jonathan","family":"Twilt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Roest","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Arita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Borstlap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurgen J.","family":"F\u00fctterer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten","family":"de Rooij","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis B.","family":"Rouw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivo G.","family":"Schoots","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baris","family":"Turkbey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel Joseph","family":"Withey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank F. 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The remaining authors of this manuscript declare relationships with the following companies: Siemens Healthineers.","order":2,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"No complex statistical methods were necessary for this paper.","order":3,"name":"Ethics","label":"Statistics and biometry","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Written informed consent was waived by the Institutional Review Board.","order":4,"name":"Ethics","label":"Informed consent","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Institutional Review Board approval was obtained.","order":5,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"No study subjects or cohorts have been previously reported.","order":6,"name":"Ethics","label":"Study subjects or cohorts overlap","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"order":7,"name":"Ethics","label":"Methodology","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}}]}}