{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:07:46Z","timestamp":1786122466902,"version":"build-2736575974"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Radiol"],"DOI":"10.1007\/s00330-026-12553-0","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:07:41Z","timestamp":1777399661000},"page":"7329-7340","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Utility of multi-echo MRI for differentiating neonatal hemochromatosis from other causes of neonatal liver failure"],"prefix":"10.1007","volume":"36","author":[{"given":"Diana","family":"Veiga-Canuto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar","family":"Miserachs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iram","family":"Siddiqui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Tomlinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Logi","family":"Vidarsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1111-2457","authenticated-orcid":false,"given":"Govind B.","family":"Chavhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,28]]},"reference":[{"key":"12553_CR1","doi-asserted-by":"crossref","unstructured":"Staicu A, Popa-Stanila R, Albu C et al (2023) Neonatal hemochromatosis: systematic review of prenatal ultrasound findings\u2014is there a place for MRI in the diagnostic process? J Clin Med 12:2679","DOI":"10.3390\/jcm12072679"},{"key":"12553_CR2","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1097\/MPG.0000000000001880","volume":"66","author":"K Alenezi","year":"2018","unstructured":"Alenezi K, Kamath BM, Siddiqui I, Tomlinson C, Chavhan GB (2018) Magnetic resonance imaging findings in neonatal hemochromatosis. J Pediatr Gastroenterol Nutr 66:581\u2013587","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"12553_CR3","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.jceh.2013.10.004","volume":"3","author":"AG Feldman","year":"2013","unstructured":"Feldman AG, Whitington PF (2013) Neonatal hemochromatosis. J Clin Exp Hepatol 3:313\u2013320","journal-title":"J Clin Exp Hepatol"},{"key":"12553_CR4","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1055\/s-2007-985069","volume":"27","author":"P Whitington","year":"2007","unstructured":"Whitington P (2007) Neonatal hemochromatosis: a congenital alloimmune hepatitis. Semin Liver Dis 27:243\u2013250","journal-title":"Semin Liver Dis"},{"key":"12553_CR5","doi-asserted-by":"publisher","first-page":"2061","DOI":"10.1002\/hep.23581","volume":"51","author":"X Pan","year":"2010","unstructured":"Pan X, Kelly S, Melin-Aldana H, Malladi P, Whitington PF (2010) Novel mechanism of fetal hepatocyte injury in congenital alloimmune hepatitis involves the terminal complement cascade. Hepatology 51:2061\u20132068","journal-title":"Hepatology"},{"key":"12553_CR6","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1891\/0730-0832.37.5.271","volume":"37","author":"O Kasko","year":"2018","unstructured":"Kasko O, Klose E, Rama G, Newberry D, Jnah A (2018) Gestational alloimmune liver disease: a case study. Neonatal Netw 37:271\u2013280","journal-title":"Neonatal Netw"},{"key":"12553_CR7","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1097\/MPG.0000000000001202","volume":"64","author":"R Bitar","year":"2017","unstructured":"Bitar R, Thwaites R, Davison S, Rajwal S, McClean P (2017) Liver failure in early infancy: aetiology, presentation, and outcome. J Pediatr Gastroenterol Nutr 64:70\u201375","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"12553_CR8","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.jpeds.2017.12.054","volume":"196","author":"SA Taylor","year":"2018","unstructured":"Taylor SA, Kelly S, Alonso EM, Whitington PF (2018) The effects of gestational alloimmune liver disease on fetal and infant morbidity and mortality. J Pediatr 196:123\u2013128.e1","journal-title":"J Pediatr"},{"key":"12553_CR9","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1016\/j.jpeds.2009.04.012","volume":"155","author":"EB Rand","year":"2009","unstructured":"Rand EB, Karpen SJ, Kelly S et al (2009) Treatment of neonatal hemochromatosis with exchange transfusion and intravenous immunoglobulin. J Pediatr 155:566\u2013571.e1","journal-title":"J Pediatr"},{"key":"12553_CR10","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1097\/MPG.0000000000002593","volume":"70","author":"HS Fischer","year":"2020","unstructured":"Fischer HS, Staufner C, Sallmon H, Henning S, B\u00fchrer C (2020) Early exchange transfusion to treat neonates with gestational alloimmune liver disease: an 11-year cohort study. J Pediatr Gastroenterol Nutr 70:444\u2013449","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"12553_CR11","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.jpeds.2014.09.030","volume":"166","author":"S Heissat","year":"2015","unstructured":"Heissat S, Collardeau-Frachon S, Baruteau J et al (2015) Neonatal hemochromatosis: diagnostic work-up based on a series of 56 cases of fetal death and neonatal liver failure. J Pediatr 166:66\u201373","journal-title":"J Pediatr"},{"key":"12553_CR12","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-43909-w","volume":"9","author":"J Dong","year":"2019","unstructured":"Dong J, Xie F, Jia L et al (2019) Clinical characteristics of liver failure with hemophagocytic lymphohistiocytosis. Sci Rep 9:8125","journal-title":"Sci Rep"},{"key":"12553_CR13","doi-asserted-by":"publisher","first-page":"e26","DOI":"10.1097\/MPG.0000000000002554","volume":"70","author":"KS Lone","year":"2020","unstructured":"Lone KS, AlSaleem B, Asery A, Bashir MS, Al-Hussaini A (2020) Liver failure among young Saudi infants: etiology, clinical presentation, and outcome. J Pediatr Gastroenterol Nutr 70:e26\u2013e32","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"12553_CR14","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1007\/s00247-021-05008-9","volume":"52","author":"GB Chavhan","year":"2022","unstructured":"Chavhan GB, Kamath BM, Siddiqui I, Tomlinson C (2022) Magnetic resonance imaging of neonatal hemochromatosis. Pediatr Radiol 52:334\u2013339","journal-title":"Pediatr Radiol"},{"key":"12553_CR15","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.221856","volume":"307","author":"SB Reeder","year":"2023","unstructured":"Reeder SB, Yokoo T, Fran\u00e7a M et al (2023) Quantification of liver iron overload with MRI: review and guidelines from the ESGAR and SAR. Radiology 307:e221856","journal-title":"Radiology"},{"key":"12553_CR16","doi-asserted-by":"publisher","first-page":"167","DOI":"10.2463\/mrms.2013-0096","volume":"13","author":"BP Schoennagel","year":"2014","unstructured":"Schoennagel BP, Remus CC, Wedegaertner U et al (2014) Quantification of prenatal liver and spleen iron in a sheep model and assessment of iron stores in a human neonate with neonatal hemochromatosis using r2* mapping. Magn Reson Med Sci 13:167\u2013173","journal-title":"Magn Reson Med Sci"},{"key":"12553_CR17","doi-asserted-by":"publisher","first-page":"1460","DOI":"10.1182\/blood-2004-10-3982","volume":"106","author":"JC Wood","year":"2005","unstructured":"Wood JC, Enriquez C, Ghugre N, Tyzka JM, Carson S, Coates TD (2005) MRI R2 and R2* mapping accurately estimates hepatic iron concentration in transfusion-dependent thalassemia and sickle cell disease patients. Blood 106:1460\u20131465","journal-title":"Blood"},{"key":"12553_CR18","doi-asserted-by":"publisher","first-page":"159","DOI":"10.2307\/2529310","volume":"33","author":"JR Landis","year":"1977","unstructured":"Landis JR, Koch GG (1977) The measurement of observer agreement for categorical data. Biometrics 33:159\u2013174","journal-title":"Biometrics"},{"key":"12553_CR19","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1002\/jmri.20816","volume":"25","author":"P Storey","year":"2007","unstructured":"Storey P, Thompson AA, Carqueville CL, Wood JC, De Freitas RA, Rigsby CK (2007) R2* imaging of transfusional iron burden at 3T and comparison with 1.5T. J Magn Reson Imaging 25:540\u2013547","journal-title":"J Magn Reson Imaging"},{"key":"12553_CR20","doi-asserted-by":"publisher","first-page":"450","DOI":"10.2350\/12-02-1155-OA.1","volume":"15","author":"S Collardeau-Frachon","year":"2012","unstructured":"Collardeau-Frachon S, Heissat S, Bouvier R et al (2012) French Retrospective Multicentric Study of neonatal hemochromatosis: importance of autopsy and autoimmune maternal manifestations. Pediatr Dev Pathol 15:450\u2013470","journal-title":"Pediatr Dev Pathol"},{"key":"12553_CR21","first-page":"1312","volume":"143","author":"MM Silver","year":"1993","unstructured":"Silver MM, Valberg LS, Cutz E, Lines LD, Phillips MJ (1993) Hepatic morphology and iron quantitation in perinatal hemochromatosis. Comparison with a large perinatal control population, including cases with chronic liver disease. Am J Pathol 143:1312\u20131325","journal-title":"Am J Pathol"},{"key":"12553_CR22","doi-asserted-by":"publisher","first-page":"2505","DOI":"10.1007\/s00261-020-02912-w","volume":"46","author":"E Aslan","year":"2021","unstructured":"Aslan E, Luo JW, Lesage A et al (2021) MRI-based R2* mapping in patients with suspected or known iron overload. Abdom Radiol (NY) 46:2505\u20132515","journal-title":"Abdom Radiol (NY)"},{"key":"12553_CR23","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-74968-z","volume":"10","author":"M Obrzut","year":"2020","unstructured":"Obrzut M, Atamaniuk V, Glaser KJ et al (2020) Value of liver iron concentration in healthy volunteers assessed by MRI. Sci Rep 10:17887","journal-title":"Sci Rep"},{"key":"12553_CR24","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1182\/asheducation-2011.1.443","volume":"2011","author":"JC Wood","year":"2011","unstructured":"Wood JC (2011) Impact of iron assessment by MRI. Hematology 2011:443\u2013450","journal-title":"Hematology"},{"key":"12553_CR25","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1186\/s13244-022-01280-x","volume":"13","author":"BM Raief Mosaad","year":"2022","unstructured":"Raief Mosaad BM, Ibrahim AS, Mansour MG, ElAlfy MS, Ebeid FSE, Abdeldayem EH (2022) The role of MRI-R2* in the detection of subclinical pancreatic iron loading among transfusion-dependent sickle cell disease patients and correlation with hepatic and cardiac iron loading. Insights Imaging 13:140","journal-title":"Insights Imaging"}],"container-title":["European Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-026-12553-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00330-026-12553-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-026-12553-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T10:09:41Z","timestamp":1786097381000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00330-026-12553-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,28]]},"references-count":25,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["12553"],"URL":"https:\/\/doi.org\/10.1007\/s00330-026-12553-0","relation":{},"ISSN":["1432-1084"],"issn-type":[{"value":"1432-1084","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,28]]},"assertion":[{"value":"24 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 February 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 March 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 April 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The scientific guarantor of this publication is Govind B. Chavhan.","order":1,"name":"Ethics","label":"Guarantor","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.","order":2,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"One of the authors has significant statistical expertise.","order":3,"name":"Ethics","label":"Statistics and biometry","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Written informed consent was waived by the Institutional Review Board.","order":4,"name":"Ethics","label":"Informed consent","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Institutional Review Board approval was obtained.","order":5,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"No study subjects or cohorts have been previously reported.","order":6,"name":"Ethics","label":"Study subjects or cohorts overlap","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"order":7,"name":"Ethics","label":"Methodology","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}}]}}