{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T01:25:24Z","timestamp":1790213124705,"version":"4.1.0"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100006095","name":"Helse S\u00f8r-\u00d8st RHF","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006095","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012446","name":"Akershus Universitetssykehus","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012446","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Radiol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the diagnostic accuracy of magnetic resonance imaging (MRI) compared to histopathology for detecting extramural venous invasion (EMVI) in rectal cancer, and to assess their prognostic value for long-term recurrence-free survival (RFS) and overall survival (OS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>In a prospective cohort of 150 patients with biopsy-confirmed rectal adenocarcinoma, EMVI was assessed via high-resolution 1.5-T MRI and histopathological examination. Interobserver agreement, clinical correlations, and survival outcomes were analyzed. Kaplan\u2013Meier and Cox regression analyses were used to evaluate recurrence-free survival (RFS) and overall survival (OS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      mrEMVI was detected in 52.7% of patients and showed good interobserver agreement (\u03ba\u2009=\u20090.68). pEMVI was confirmed in 45.9% of surgical cases, with fair agreement with mrEMVI (\u03ba\u2009=\u20090.40). mrEMVI was significantly associated with advanced tumor stage, larger tumor volume, synchronous metastases, and elevated CEA levels. mrEMVI positivity predicted poorer RFS (HR 5.22,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and OS (HR 3.40,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01), while pEMVI showed no significant prognostic value.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>mrEMVI is a more reliable imaging biomarker strongly correlated with long-term oncologic events compared to histopathological EMVI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Points<\/jats:title>\n                    <jats:p>\n                      <jats:bold>\n                        <jats:italic>Question<\/jats:italic>\n                      <\/jats:bold>\n                      <jats:italic>Reliable preoperative markers are lacking for accurate EMVI detection in rectal cancer, creating uncertainty in risk stratification and treatment decisions due to inconsistent MRI\u2013pathology concordance.<\/jats:italic>\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:bold>\n                        <jats:italic>Findings<\/jats:italic>\n                      <\/jats:bold>\n                      <jats:italic>mrEMVI showed strong prognostic value for recurrence and survival, whereas pEMVI did not, and MRI offered higher reliability and reproducibility than histopathology.<\/jats:italic>\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:bold>\n                        <jats:italic>Clinical relevance<\/jats:italic>\n                      <\/jats:bold>\n                      <jats:italic>Identifying mrEMVI preoperatively enables more accurate risk stratification, helping clinicians tailor treatment intensity and potentially improve survival, while highlighting MRI as a more reliable tool than pathology for guiding management decisions in rectal cancer.<\/jats:italic>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00330-026-12658-6","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T14:19:45Z","timestamp":1781101185000},"page":"7974-7984","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["MRI versus histopathology in EMVI detection for rectal cancer: prognostic relevance and survival outcomes"],"prefix":"10.1007","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3904-2430","authenticated-orcid":false,"given":"Aida Kapic","family":"Lunder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Meltzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elin Agathe","family":"Fr\u00f8yen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars Gustav","family":"Lyckander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole Jacob","family":"Grandal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Hansen","family":"Ree","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrine R\u00f8e","family":"Redalen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Neg\u00e5rd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,10]]},"reference":[{"key":"12658_CR1","first-page":"177","volume":"67","author":"RL Siegel","year":"2017","unstructured":"Siegel RL, Miller KD, Fedewa SA et al (2017) Colorectal cancer statistics, 2017. 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