{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T06:04:52Z","timestamp":1789452292076,"version":"build-2803163510"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100006775","name":"GE Healthcare","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100006775","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Korean Society of Breast Imaging and Korean Society for Breast Screening"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Radiol"],"DOI":"10.1007\/s00330-026-12678-2","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T18:18:55Z","timestamp":1781115535000},"page":"7874-7886","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Comparison of automated breast ultrasound and hand-held breast ultrasound in preoperative evaluation of early-stage breast cancer: a multicenter prospective study"],"prefix":"10.1007","volume":"36","author":[{"given":"Ji Soo","family":"Choi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nami","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun-Young","family":"Baek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyunga","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeoung Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myoung Kyoung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boo-Kyung","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Sook","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haejung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surin","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jai Min","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung Joo","family":"Chae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6679-9650","authenticated-orcid":false,"given":"Eun Young","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,10]]},"reference":[{"key":"12678_CR1","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1093\/jbi\/wbac088","volume":"5","author":"DM Christensen","year":"2023","unstructured":"Christensen DM, Shehata MN, Javid SH, Rahbar H, Lam DL (2023) Preoperative breast MRI: current evidence and patient selection. J Breast Imaging 5:112\u2013124","journal-title":"J Breast Imaging"},{"key":"12678_CR2","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.3348\/kjr.2021.0967","volume":"23","author":"H Kim","year":"2022","unstructured":"Kim H, Yang SY, Ahn JH et al (2022) Digital breast tomosynthesis versus MRI as an adjunct to full-field digital mammography for preoperative evaluation of breast cancer according to mammographic density. Korean J Radiol 23:1031\u20131043","journal-title":"Korean J Radiol"},{"key":"12678_CR3","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1148\/radiol.2019182947","volume":"292","author":"RM Mann","year":"2019","unstructured":"Mann RM, Cho N, Moy L (2019) Breast MRI: state of the art. Radiology 292:520\u2013536","journal-title":"Radiology"},{"key":"12678_CR4","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1148\/radiol.2333031484","volume":"233","author":"WA Berg","year":"2004","unstructured":"Berg WA, Gutierrez L, NessAiver MS et al (2004) Diagnostic accuracy of mammography, clinical examination, US, and MR imaging in preoperative assessment of breast cancer. Radiology 233:830\u2013849","journal-title":"Radiology"},{"key":"12678_CR5","doi-asserted-by":"publisher","first-page":"3669","DOI":"10.1007\/s00330-015-3807-z","volume":"25","author":"RM Mann","year":"2015","unstructured":"Mann RM, Balleyguier C, Baltzer PA et al (2015) Breast MRI: EUSOBI recommendations for women\u2019s information. Eur Radiol 25:3669\u20133678","journal-title":"Eur Radiol"},{"key":"12678_CR6","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1007\/s10549-017-4324-3","volume":"165","author":"N Houssami","year":"2017","unstructured":"Houssami N, Turner RM, Morrow M (2017) Meta-analysis of pre-operative magnetic resonance imaging (MRI) and surgical treatment for breast cancer. Breast Cancer Res Treat 165:273\u2013283","journal-title":"Breast Cancer Res Treat"},{"key":"12678_CR7","doi-asserted-by":"publisher","first-page":"743","DOI":"10.3348\/kjr.2025.0338","volume":"26","author":"N Chotai","year":"2025","unstructured":"Chotai N, Renganathan R, Uematsu T et al (2025) Breast cancer screening in Asian countries: epidemiology, screening practices, outcomes, challenges, and future directions. Korean J Radiol 26:743\u2013758","journal-title":"Korean J Radiol"},{"key":"12678_CR8","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.2214\/AJR.13.12311","volume":"203","author":"DL Lane","year":"2014","unstructured":"Lane DL, Adeyefa MM, Yang WT (2014) Role of sonography for the locoregional staging of breast cancer. AJR Am J Roentgenol 203:1132\u20131141","journal-title":"AJR Am J Roentgenol"},{"key":"12678_CR9","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1148\/radiol.13121606","volume":"268","author":"RJ Hooley","year":"2013","unstructured":"Hooley RJ, Scoutt LM, Philpotts LE (2013) Breast ultrasonography: state of the art. Radiology 268:642\u2013659","journal-title":"Radiology"},{"key":"12678_CR10","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1148\/radiol.2242011215","volume":"224","author":"WK Moon","year":"2002","unstructured":"Moon WK, Noh DY, Im JG (2002) Multifocal, multicentric, and contralateral breast cancers: bilateral whole-breast US in the preoperative evaluation of patients. Radiology 224:569\u2013576","journal-title":"Radiology"},{"key":"12678_CR11","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1148\/radiol.2412051710","volume":"241","author":"WA Berg","year":"2006","unstructured":"Berg WA, Blume JD, Cormack JB, Mendelson EB (2006) Operator dependence of physician-performed whole-breast US: lesion detection and characterization. Radiology 241:355\u2013365","journal-title":"Radiology"},{"key":"12678_CR12","doi-asserted-by":"publisher","first-page":"e230023","DOI":"10.1148\/rg.230023","volume":"43","author":"AI Huppe","year":"2023","unstructured":"Huppe AI, Inciardi MF, Aripoli AM, Peterson JK, Smith CB, Winblad OD (2023) Pearls and pitfalls of interpretation of automated breast US. Radiographics 43:e230023","journal-title":"Radiographics"},{"key":"12678_CR13","doi-asserted-by":"publisher","first-page":"15","DOI":"10.3348\/kjr.2019.0176","volume":"21","author":"SH Kim","year":"2020","unstructured":"Kim SH, Kim HH, Moon WK (2020) Automated breast ultrasound screening for dense breasts. Korean J Radiol 21:15\u201324","journal-title":"Korean J Radiol"},{"key":"12678_CR14","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1093\/jbi\/wbz055","volume":"1","author":"WA Berg","year":"2019","unstructured":"Berg WA, Vourtsis A (2019) Screening breast ultrasound using handheld or automated technique in women with dense breasts. J Breast Imaging 1:283\u2013296","journal-title":"J Breast Imaging"},{"key":"12678_CR15","doi-asserted-by":"publisher","first-page":"e222435","DOI":"10.1148\/radiol.222435","volume":"307","author":"MR Kwon","year":"2023","unstructured":"Kwon MR, Choi JS, Lee MY et al (2023) Screening outcomes of supplemental automated breast US in Asian women with dense and nondense breasts. Radiology 307:e222435","journal-title":"Radiology"},{"key":"12678_CR16","doi-asserted-by":"publisher","first-page":"1554","DOI":"10.1016\/j.ejrad.2016.06.004","volume":"85","author":"B Wilczek","year":"2016","unstructured":"Wilczek B, Wilczek HE, Rasouliyan L, Leifland K (2016) Adding 3D automated breast ultrasound to mammography screening in women with heterogeneously and extremely dense breasts: report from a hospital-based, high-volume, single-center breast cancer screening program. Eur J Radiol 85:1554\u20131563","journal-title":"Eur J Radiol"},{"key":"12678_CR17","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1148\/radiol.14132832","volume":"274","author":"RF Brem","year":"2015","unstructured":"Brem RF, Tabar L, Duffy SW et al (2015) Assessing improvement in detection of breast cancer with three-dimensional automated breast US in women with dense breast tissue: the SomoInsight Study. Radiology 274:663\u2013673","journal-title":"Radiology"},{"key":"12678_CR18","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1148\/radiol.2020192534","volume":"295","author":"JM Chang","year":"2020","unstructured":"Chang JM, Leung JWT, Moy L, Ha SM, Moon WK (2020) Axillary nodal evaluation in breast cancer: state of the art. Radiology 295:500\u2013515","journal-title":"Radiology"},{"key":"12678_CR19","doi-asserted-by":"publisher","DOI":"10.1186\/s40644-019-0191-y","volume":"19","author":"WH Kim","year":"2019","unstructured":"Kim WH, Kim HJ, Lee SM et al (2019) Prediction of high nodal burden with ultrasound and magnetic resonance imaging in clinically node-negative breast cancer patients. Cancer Imaging 19:4","journal-title":"Cancer Imaging"},{"key":"12678_CR20","doi-asserted-by":"publisher","first-page":"696","DOI":"10.2214\/AJR.12.9036","volume":"200","author":"H Abe","year":"2013","unstructured":"Abe H, Schacht D, Sennett CA, Newstead GM, Schmidt RA (2013) Utility of preoperative ultrasound for predicting pN2 or higher stage axillary lymph node involvement in patients with newly diagnosed breast cancer. AJR Am J Roentgenol 200:696\u2013702","journal-title":"AJR Am J Roentgenol"},{"key":"12678_CR21","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1200\/JCO.2016.71.0947","volume":"35","author":"GH Lyman","year":"2017","unstructured":"Lyman GH, Somerfield MR, Bosserman LD, Perkins CL, Weaver DL, Giuliano AE (2017) Sentinel lymph node biopsy for patients with early-stage breast cancer: American Society of Clinical Oncology clinical practice guideline update. J Clin Oncol 35:561\u2013564","journal-title":"J Clin Oncol"},{"key":"12678_CR22","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1148\/radiol.10100296","volume":"257","author":"CH Neal","year":"2010","unstructured":"Neal CH, Daly CP, Nees AV, Helvie MA (2010) Can preoperative axillary US help exclude N2 and N3 metastatic breast cancer? Radiology 257:335\u2013341","journal-title":"Radiology"},{"key":"12678_CR23","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.amjsurg.2024.03.011","volume":"231","author":"K Jiang","year":"2024","unstructured":"Jiang K, Ma C, Yang Y et al (2024) Axillary ultrasonography for early-stage invasive breast cancer. Am J Surg 231:86\u201390","journal-title":"Am J Surg"},{"key":"12678_CR24","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1001\/jama.2017.11470","volume":"318","author":"AE Giuliano","year":"2017","unstructured":"Giuliano AE, Ballman KV, McCall L et al (2017) Effect of axillary dissection vs no axillary dissection on 10-year overall survival among women with invasive breast cancer and sentinel node metastasis: the ACOSOG Z0011 (Alliance) randomized clinical trial. JAMA 318:918\u2013926","journal-title":"JAMA"},{"key":"12678_CR25","doi-asserted-by":"crossref","unstructured":"Mun HS, Ko EY, Han BK et al (2025) Comparative analysis of automated and handheld breast ultrasound findings for small (\u22641 cm) breast cancers based on BI-RADS category. Diagnostics 15:212","DOI":"10.3390\/diagnostics15020212"},{"key":"12678_CR26","doi-asserted-by":"publisher","first-page":"97","DOI":"10.3348\/kjr.2025.1249","volume":"27","author":"MK Kim","year":"2026","unstructured":"Kim MK, Kim H, Baek SY et al (2026) Association of breast tissue composition on preoperative automated breast ultrasound with accuracy of cancer multiplicity evaluation and recurrence-free survival in patients with early-stage breast cancer. Korean J Radiol 27:97\u2013110","journal-title":"Korean J Radiol"},{"key":"12678_CR27","unstructured":"D\u2019Orsi CJ SE, Mendelson EB, Morris EA et al (2013) ACR BI-RADS\u00ae Atlas, Breast Imaging Reporting and Data System, 5th edn. American College of Radiology, Reston, VA"},{"key":"12678_CR28","doi-asserted-by":"publisher","first-page":"452","DOI":"10.6004\/jnccn.2020.0016","volume":"18","author":"WJ Gradishar","year":"2020","unstructured":"Gradishar WJ, Anderson BO, Abraham J et al (2020) Breast cancer, version 3.2020, NCCN clinical practice guidelines in oncology. J Natl Compr Cancer Netw 18:452\u2013478","journal-title":"J Natl Compr Cancer Netw"},{"key":"12678_CR29","doi-asserted-by":"publisher","first-page":"118","DOI":"10.6004\/jnccn.2019.0009","volume":"17","author":"MP Goetz","year":"2019","unstructured":"Goetz MP, Gradishar WJ, Anderson BO et al (2019) NCCN guidelines insights: breast cancer, Version 3.2018: featured updates to the NCCN guidelines. J Natl Compr Cancer Netw 17:118\u2013126","journal-title":"J Natl Compr Cancer Netw"},{"key":"12678_CR30","doi-asserted-by":"publisher","first-page":"2246","DOI":"10.1016\/j.ultrasmedbio.2013.07.005","volume":"39","author":"EY Chae","year":"2013","unstructured":"Chae EY, Shin HJ, Kim HJ et al (2013) Diagnostic performance of automated breast ultrasound as a replacement for a hand-held second-look ultrasound for breast lesions detected initially on magnetic resonance imaging. Ultrasound Med Biol 39:2246\u20132254","journal-title":"Ultrasound Med Biol"},{"key":"12678_CR31","doi-asserted-by":"publisher","first-page":"2880","DOI":"10.1016\/j.csda.2011.04.020","volume":"55","author":"JM Nam","year":"2011","unstructured":"Nam JM (2011) Power and sample size requirements for non-inferiority in studies comparing two matched proportions where the events are correlated. Comput Stat Data Anal 55:2880\u20132887","journal-title":"Comput Stat Data Anal"},{"key":"12678_CR32","doi-asserted-by":"publisher","first-page":"550","DOI":"10.3348\/kjr.2019.0525","volume":"21","author":"G Tang","year":"2020","unstructured":"Tang G, An X, Xiang H, Liu L, Li A, Lin X (2020) Automated breast ultrasound: interobserver agreement, diagnostic value, and associated clinical factors of coronal-plane image features. Korean J Radiol 21:550\u2013560","journal-title":"Korean J Radiol"},{"key":"12678_CR33","doi-asserted-by":"publisher","first-page":"146","DOI":"10.3348\/kjr.2023.0100","volume":"25","author":"SM Kim","year":"2024","unstructured":"Kim SM, Jang M, Yun B et al (2024) Automated versus handheld breast ultrasound for evaluating axillary lymph nodes in patients with breast cancer. Korean J Radiol 25:146\u2013156","journal-title":"Korean J Radiol"},{"key":"12678_CR34","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1056\/NEJMoa2412063","volume":"392","author":"T Reimer","year":"2025","unstructured":"Reimer T, Stachs A, Veselinovic K et al (2025) Axillary surgery in breast cancer\u2014primary results of the INSEMA trial. N Engl J Med 392:1051\u20131064","journal-title":"N Engl J Med"},{"key":"12678_CR35","doi-asserted-by":"publisher","first-page":"1557","DOI":"10.1001\/jamaoncol.2023.3759","volume":"9","author":"OD Gentilini","year":"2023","unstructured":"Gentilini OD, Botteri E, Sangalli C et al (2023) Sentinel lymph node biopsy vs no axillary surgery in patients with small breast cancer and negative results on ultrasonography of axillary lymph nodes: the SOUND randomized clinical trial. JAMA Oncol 9:1557\u20131564","journal-title":"JAMA Oncol"}],"container-title":["European Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-026-12678-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00330-026-12678-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-026-12678-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T05:37:28Z","timestamp":1789450648000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00330-026-12678-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,10]]},"references-count":35,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,10]]}},"alternative-id":["12678"],"URL":"https:\/\/doi.org\/10.1007\/s00330-026-12678-2","relation":{},"ISSN":["1432-1084"],"issn-type":[{"value":"1432-1084","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,10]]},"assertion":[{"value":"22 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 March 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 May 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 June 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The scientific guarantors of this publication are Eun Young Ko and Ji Soo Choi.","order":1,"name":"Ethics","label":"Guarantor","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors of this manuscript declare relationships with the following company: GE Healthcare.","order":2,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Two of the authors have significant statistical expertise.","order":3,"name":"Ethics","label":"Statistics and biometry","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Written informed consent was obtained from all patients in this study.","order":4,"name":"Ethics","label":"Informed consent","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Institutional Review Board approval was obtained.","order":5,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Among the included patients, 51 cases were previously reported in a separate study comparing US findings between ABUS and HHUS for small (\u2264\u20091\u2009cm) breast cancers [\n                      \n                      ]. These cases are included within a larger cohort of 409 patients reported in another study investigating breast tissue composition on preoperative ABUS in relation to cancer multiplicity evaluation and recurrence-free survival [\n                      \n                      ]. These retrospective studies differ in their objectives, inclusion criteria, and analytic approaches from the current prospective study. This overlap is also described in the \u201cStudy participants\u201d section of \u201cMaterials and methods.\u201d","order":6,"name":"Ethics","label":"Study subjects or cohorts overlap","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"order":7,"name":"Ethics","label":"Methodology","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}}]}}