{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:49:22Z","timestamp":1791938962750,"version":"4.3.4"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T00:00:00Z","timestamp":1783728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T00:00:00Z","timestamp":1783728000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Radiol"],"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n \n Post-treatment surveillance after locally treated colorectal liver metastases involves CEA measurement and contrast-enhanced CT (CECT) scans. However, reactive tissue around ablated lesions can appear similar to viable tumor tissue on CECT, complicating the detection of local tumor progression (LTP). Therefore, a new imaging protocol was initiated, which incorporates [\n 18<\/jats:sup>\n F]FDG-PET\/CT to complement CECT. This study evaluated the diagnostic accuracy of [\n 18<\/jats:sup>\n F]FDG-PET\/CECT for early detection of disease progression after resection or thermal ablation, compared to CECT alone.\n <\/jats:p>\n <\/jats:sec>\n \n Materials and methods<\/jats:title>\n \n The study analyzed a prospective cohort of patients undergoing thermal ablation or resection, who received CECT and [\n 18<\/jats:sup>\n F]FDG-PET\/CT scans 3\u20135 months post-treatment. Disease progression was confirmed by histology, consensus during a multidisciplinary team meeting or after extended follow-up. Diagnostic accuracy of [\n 18<\/jats:sup>\n F]FDG-PET\/CECT was compared to standard practice (CEA serum levels and CECT).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The final analysis included 64 patients with 154 lesions. 37 patients underwent ablation, 14 patients underwent resection, and 13 patients underwent combination therapy, resulting in 93 (60%) lesions being treated with thermal ablation and 61 (40%) lesions with resection. Disease progression was found in 66% of patients, with LTP detected in 25% of treated lesions. Compared to CECT, [\n 18<\/jats:sup>\n F]FDG-PET\/CECT had a higher diagnostic accuracy for detecting local progression after thermal ablation (AUC 0.97 vs. 0.73,\n p<\/jats:italic>\n \u2009=\u20090.001) and hepatic resection (AUC 0.96 vs. 0.69,\n p<\/jats:italic>\n \u2009=\u20090.03), and for detection of extrahepatic disease (AUC 0.91 vs. 0.79,\n p<\/jats:italic>\n \u2009=\u20090.03). CEA serum levels had low diagnostic accuracy for detecting disease progression (AUC 0.60).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n [\n 18<\/jats:sup>\n F]FDG-PET\/CECT improves diagnostic accuracy in the early follow-up of patients with locally treated colorectal liver metastases.\n <\/jats:p>\n <\/jats:sec>\n \n Key Points<\/jats:title>\n \n \n Question<\/jats:italic>\n <\/jats:bold>\n : Interpreting CECT scans after local treatment of colorectal liver metastases can be challenging because reactive tissue around treated lesions can appear similar to viable tumor tissue<\/jats:italic>\n .\n <\/jats:p>\n \n \n Findings<\/jats:italic>\n <\/jats:bold>\n : [<\/jats:italic>\n \n 18<\/jats:italic>\n <\/jats:sup>\n F]FDG-PET\/CECT improves the diagnostic accuracy of detecting local tumor progression after thermal ablation and resection of colorectal liver metastases<\/jats:italic>\n .\n <\/jats:p>\n \n \n Clinical relevance<\/jats:italic>\n <\/jats:bold>\n : [<\/jats:italic>\n \n 18<\/jats:italic>\n <\/jats:sup>\n F]FDG-PET\/CECT should be considered during follow-up after local treatment of colorectal liver metastases to identify and treat local tumor progression earlier<\/jats:italic>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1007\/s00330-026-12726-x","type":"journal-article","created":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T10:39:58Z","timestamp":1783766398000},"page":"8197-8205","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Improved detection of local tumor progression after ablation or resection of colorectal liver metastases using [18F]FDG-PET\/contrast-enhanced CT versus contrast-enhanced CT alone: results from a Dutch prospective cohort"],"prefix":"10.1007","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9069-500X","authenticated-orcid":false,"given":"O. 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Mieog.","order":1,"name":"Ethics","label":"Guarantor","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.","order":2,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"No complex statistical methods were necessary for this paper.","order":3,"name":"Ethics","label":"Statistics and biometry","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Written informed consent was waived by the Institutional Review Board.","order":4,"name":"Ethics","label":"Informed consent","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Institutional Review Board approval was obtained\u2014METC Leiden-Den Haag-Delft.","order":5,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"order":6,"name":"Ethics","label":"Methodology","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}}]}}