{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:48:59Z","timestamp":1791938939846,"version":"4.3.4"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T00:00:00Z","timestamp":1783123200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T00:00:00Z","timestamp":1783123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971615"],"award-info":[{"award-number":["81971615"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Henan Clinical Medical Scientist Program","award":["HNCMS202506"],"award-info":[{"award-number":["HNCMS202506"]}]},{"name":"the Henan Provincial Selective Research Funding Program for Returned Scholar Studying Abroad","award":["HNLX202625"],"award-info":[{"award-number":["HNLX202625"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Radiol"],"DOI":"10.1007\/s00330-026-12727-w","type":"journal-article","created":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T18:08:33Z","timestamp":1783188513000},"page":"8249-8263","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Spectral CT-based habitat analysis for predicting pathologic response to neoadjuvant therapy in gastric cancer"],"prefix":"10.1007","volume":"36","author":[{"given":"Yaru","family":"You","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengchen","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinjin","family":"Dang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6844-130X","authenticated-orcid":false,"given":"Jianbo","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,4]]},"reference":[{"key":"12727_CR1","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1002\/cac2.12516","volume":"44","author":"FH Wang","year":"2024","unstructured":"Wang FH, Zhang XT, Tang L et al (2024) The Chinese Society of Clinical Oncology (CSCO): clinical guidelines for the diagnosis and treatment of gastric cancer, 2023. Cancer Commun 44:127\u2013172","journal-title":"Cancer Commun"},{"key":"12727_CR2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-40480-x","volume":"14","author":"J Wei","year":"2023","unstructured":"Wei J, Lu X, Liu Q et al (2023) Neoadjuvant sintilimab in combination with concurrent chemoradiotherapy for locally advanced gastric or gastroesophageal junction adenocarcinoma: a single-arm phase 2 trial. Nat Commun 14:4904","journal-title":"Nat Commun"},{"key":"12727_CR3","doi-asserted-by":"publisher","first-page":"6469","DOI":"10.1007\/s00330-025-11601-5","volume":"35","author":"X Lin","year":"2025","unstructured":"Lin X, Xu S, Wang Y et al (2025) Sequential dual-energy CT for longitudinal assessment of pathologic response to neoadjuvant immuno-chemotherapy in locally advanced gastric cancer. Eur Radiol 35:6469\u20136481","journal-title":"Eur Radiol"},{"key":"12727_CR4","doi-asserted-by":"publisher","first-page":"3547","DOI":"10.1007\/s00330-024-11290-6","volume":"35","author":"Y Chen","year":"2025","unstructured":"Chen Y, Liu X, Zeng H et al (2025) The clinical applications of dual-layer spectral detector CT in digestive system diseases. Eur Radiol 35:3547\u20133557","journal-title":"Eur Radiol"},{"key":"12727_CR5","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1186\/s13244-023-01490-x","volume":"14","author":"Y Zhu","year":"2023","unstructured":"Zhu Y, Wang P, Wang B et al (2023) Dual-layer spectral-detector CT for predicting microsatellite instability status and prognosis in locally advanced gastric cancer. Insights Imaging 14:151","journal-title":"Insights Imaging"},{"key":"12727_CR6","doi-asserted-by":"publisher","first-page":"8948","DOI":"10.1007\/s00330-023-09875-8","volume":"33","author":"M Luo","year":"2023","unstructured":"Luo M, Chen G, Xie H et al (2023) Preoperative diagnosis of metastatic lymph nodes by CT-histopathologic matching analysis in gastric adenocarcinoma using dual-layer spectral detector CT. Eur Radiol 33:8948\u20138956","journal-title":"Eur Radiol"},{"key":"12727_CR7","doi-asserted-by":"publisher","first-page":"7517","DOI":"10.1097\/JS9.0000000000002912","volume":"111","author":"Y Wu","year":"2025","unstructured":"Wu Y, Lin Y, Xiong M et al (2025) Dual-layer spectral detector CT-based scoring system for noninvasive TP53 expression assessment and adjuvant chemotherapy response prediction in gastric cancer: a multicenter cross-sectional study. Int J Surg 111:7517\u20137532","journal-title":"Int J Surg"},{"key":"12727_CR8","doi-asserted-by":"publisher","first-page":"4775","DOI":"10.1007\/s00330-018-5502-3","volume":"28","author":"HJ Kang","year":"2018","unstructured":"Kang HJ, Kim SH, Bae JS, Jeon SK, Han JK (2018) Can quantitative iodine parameters on DECT replace perfusion CT parameters in colorectal cancers? Eur Radiol 28:4775\u20134782","journal-title":"Eur Radiol"},{"key":"12727_CR9","doi-asserted-by":"publisher","first-page":"1666","DOI":"10.3748\/wjg.v23.i9.1666","volume":"23","author":"XH Chen","year":"2017","unstructured":"Chen XH, Ren K, Liang P, Chai YR, Chen KS, Gao JB (2017) Spectral computed tomography in advanced gastric cancer: Can iodine concentration non-invasively assess angiogenesis? World J Gastroenterol 23:1666\u20131675","journal-title":"World J Gastroenterol"},{"key":"12727_CR10","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1007\/s00261-005-0386-5","volume":"31","author":"CA Cuenod","year":"2006","unstructured":"Cuenod CA, Fournier L, Balvay D, Guinebreti\u00e8re JM (2006) Tumor angiogenesis: pathophysiology and implications for contrast-enhanced MRI and CT assessment. Abdom Imaging 31:188\u2013193","journal-title":"Abdom Imaging"},{"key":"12727_CR11","doi-asserted-by":"publisher","first-page":"6193","DOI":"10.1007\/s00330-024-10642-6","volume":"34","author":"J Li","year":"2024","unstructured":"Li J, Xu S, Wang Y, Ma F, Chen X, Qu J (2024) Spectral CT vs. diffusion-weighted imaging for the quantitative prediction of pathologic response to neoadjuvant chemotherapy in locally advanced gastric cancer. Eur Radiol 34:6193\u20136204","journal-title":"Eur Radiol"},{"key":"12727_CR12","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/s00330-024-10737-0","volume":"35","author":"Y Chen","year":"2025","unstructured":"Chen Y, Jiang J, Yan C et al (2025) Prediction of tumor regression grade in far-advanced gastric cancer after preoperative immuno-chemotherapy using dual-energy CT-derived extracellular volume fraction. Eur Radiol 35:93\u2013104","journal-title":"Eur Radiol"},{"key":"12727_CR13","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.crad.2023.08.023","volume":"79","author":"J Deng","year":"2024","unstructured":"Deng J, Zhang W, Xu M et al (2024) Value of spectral CT parameters in predicting the efficacy of neoadjuvant chemotherapy for gastric cancer. Clin Radiol 79:51\u201359","journal-title":"Clin Radiol"},{"key":"12727_CR14","doi-asserted-by":"publisher","DOI":"10.1148\/ryai.230118","volume":"6","author":"O Prior","year":"2024","unstructured":"Prior O, Macarro C, Navarro V et al (2024) Identification of precise 3D CT radiomics for habitat computation by machine learning in cancer. Radiol Artif Intell 6:e230118","journal-title":"Radiol Artif Intell"},{"key":"12727_CR15","doi-asserted-by":"publisher","unstructured":"Cai W, Zhu Y, Li D, Wang B, Ma X, Zhao X (2025) Intratumoral heterogeneity of CT enhancement for component prediction and prognostic significance in combined hepatocellular carcinoma\u2011cholangiocarcinoma. Eur Radiol. https:\/\/doi.org\/10.1007\/s00330-025-12034-w","DOI":"10.1007\/s00330-025-12034-w"},{"key":"12727_CR16","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.242993","volume":"317","author":"Q Wang","year":"2025","unstructured":"Wang Q, Zhang Y, Wang T et al (2025) MRI-based habitat analysis for the prediction of progression-free survival in primary spinal tumors. Radiology 317:e242993","journal-title":"Radiology"},{"key":"12727_CR17","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.241805","volume":"315","author":"Y Huang","year":"2025","unstructured":"Huang Y, Wang X, Cao Y et al (2025) Nomogram for predicting neoadjuvant chemotherapy response in breast cancer using MRI-based intratumoral heterogeneity quantification. Radiology 315:e241805","journal-title":"Radiology"},{"key":"12727_CR18","doi-asserted-by":"publisher","first-page":"4448","DOI":"10.1007\/s00330-025-11430-6","volume":"35","author":"J Li","year":"2025","unstructured":"Li J, Li Z, Wang Y et al (2025) CT radiomics-based intratumoral and intertumoral heterogeneity indicators for prognosis prediction in gastric cancer patients receiving neoadjuvant chemotherapy. Eur Radiol 35:4448\u20134460","journal-title":"Eur Radiol"},{"key":"12727_CR19","first-page":"93","volume":"67","author":"MB Amin","year":"2017","unstructured":"Amin MB, Greene FL, Edge SB et al (2017) The Eighth Edition AJCC Cancer Staging Manual: Continuing to build a bridge from a population-based to a more \u201cpersonalized\u201d approach to cancer staging. CA Cancer J Clin 67:93\u201399","journal-title":"CA Cancer J Clin"},{"key":"12727_CR20","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1007\/s00330-022-09055-0","volume":"33","author":"J Li","year":"2023","unstructured":"Li J, Qiu Z, Zhang C et al (2023) ITHscore: comprehensive quantification of intra-tumor heterogeneity in NSCLC by multi-scale radiomic features. Eur Radiol 33:893\u2013903","journal-title":"Eur Radiol"},{"key":"12727_CR21","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1097\/RLI.0000000000001064","volume":"59","author":"M Graf","year":"2024","unstructured":"Graf M, Gawlitza J, Makowski M, Meurer F, Huber T, Ziegelmayer S (2024) Evaluating treatment response in GEJ adenocarcinoma: the role of pretherapeutic and posttherapeutic iodine mapping. Invest Radiol 59:583\u2013588","journal-title":"Invest Radiol"},{"key":"12727_CR22","doi-asserted-by":"publisher","first-page":"5748","DOI":"10.1007\/s00330-025-11508-1","volume":"35","author":"Y Lin","year":"2025","unstructured":"Lin Y, Lan Y, Zheng Y, Ma M (2025) Dual-energy CT for evaluating the tumor regression grade of gastric cancer after neoadjuvant chemotherapy. Eur Radiol 35:5748\u20135759","journal-title":"Eur Radiol"},{"key":"12727_CR23","doi-asserted-by":"crossref","unstructured":"Yun H, Dong F, Wei X et al (2025) Role and value of the tumor microenvironment in the progression and treatment resistance of gastric cancer. Oncol Rep 53:14","DOI":"10.3892\/or.2024.8847"},{"key":"12727_CR24","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1148\/radiol.2021210600","volume":"302","author":"J Dewaguet","year":"2022","unstructured":"Dewaguet J, Copin MC, Duhamel A et al (2022) Dual-energy CT perfusion of invasive tumor front in non-small cell lung cancers. Radiology 302:448\u2013456","journal-title":"Radiology"},{"key":"12727_CR25","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1038\/nrclinonc.2017.166","volume":"15","author":"I Dagogo-Jack","year":"2018","unstructured":"Dagogo-Jack I, Shaw AT (2018) Tumour heterogeneity and resistance to cancer therapies. Nat Rev Clin Oncol 15:81\u201394","journal-title":"Nat Rev Clin Oncol"},{"key":"12727_CR26","doi-asserted-by":"publisher","first-page":"1671","DOI":"10.1007\/s00330-025-11997-0","volume":"36","author":"Q Chen","year":"2026","unstructured":"Chen Q, Zhang Q, Li Z et al (2026) MRI-based habitat analysis for pathologic response prediction after neoadjuvant chemoradiotherapy in rectal cancer: a multicenter study. Eur Radiol 36:1671\u20131685","journal-title":"Eur Radiol"},{"key":"12727_CR27","doi-asserted-by":"crossref","unstructured":"Sch\u00f6mig T, Sabov A, Zopfs D et al (2026) Effect of age and sex on normalized automated DECT-derived pulmonary iodine concentration. Diagnostics (Basel) 16:1134","DOI":"10.3390\/diagnostics16081134"},{"key":"12727_CR28","doi-asserted-by":"publisher","first-page":"4438","DOI":"10.1007\/s00330-020-07611-0","volume":"31","author":"S Lennartz","year":"2021","unstructured":"Lennartz S, Parakh A, Cao J, Zopfs D, Gro\u00dfe Hokamp N, Kambadakone A (2021) Inter-scan and inter-scanner variation of quantitative dual-energy CT: evaluation with three different scanner types. Eur Radiol 31:4438\u20134451","journal-title":"Eur Radiol"},{"key":"12727_CR29","doi-asserted-by":"publisher","first-page":"2340","DOI":"10.1007\/s00330-020-07298-3","volume":"31","author":"D Zopfs","year":"2021","unstructured":"Zopfs D, Graffe J, Reimer RP et al (2021) Quantitative distribution of iodinated contrast media in body computed tomography: data from a large reference cohort. Eur Radiol 31:2340\u20132348","journal-title":"Eur Radiol"},{"key":"12727_CR30","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1097\/SLA.0b013e318216f449","volume":"253","author":"K Becker","year":"2011","unstructured":"Becker K, Langer R, Reim D et al (2011) Significance of histopathological tumor regression after neoadjuvant chemotherapy in gastric adenocarcinomas: a summary of 480 cases. Ann Surg 253:934\u2013939","journal-title":"Ann Surg"}],"container-title":["European Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-026-12727-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00330-026-12727-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-026-12727-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:02:39Z","timestamp":1791936159000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00330-026-12727-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,4]]},"references-count":30,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2026,11]]}},"alternative-id":["12727"],"URL":"https:\/\/doi.org\/10.1007\/s00330-026-12727-w","relation":{},"ISSN":["1432-1084"],"issn-type":[{"value":"1432-1084","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,4]]},"assertion":[{"value":"29 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 May 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 June 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 July 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The scientific guarantor of this publication is Jianbo Gao.","order":1,"name":"Ethics","label":"Guarantor","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"JD is an employee of Philips (China) Investment Co. The remaining authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article.","order":2,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"No complex statistical methods were necessary for this paper.","order":3,"name":"Ethics","label":"Statistics and biometry","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Written informed consent was waived due to the retrospective nature of the study.","order":4,"name":"Ethics","label":"Informed consent","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Institutional Review Board approval was obtained.","order":5,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"None.","order":6,"name":"Ethics","label":"Study subjects or cohorts overlap","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"order":7,"name":"Ethics","label":"Methodology","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}}]}}