{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:48:40Z","timestamp":1791938920470,"version":"4.3.4"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:00:00Z","timestamp":1784332800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:00:00Z","timestamp":1784332800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100020050","name":"Japan Intractable Diseases Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Radiol"],"DOI":"10.1007\/s00330-026-12741-y","type":"journal-article","created":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T13:07:09Z","timestamp":1784380029000},"page":"8332-8346","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A CT-based score for predicting histopathological usual interstitial pneumonia features and predicting disease progression in smokers with fibrotic idiopathic interstitial pneumonia"],"prefix":"10.1007","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7566-546X","authenticated-orcid":false,"given":"Ryoko","family":"Egashira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiminori","family":"Fujimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kensuke","family":"Kataoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Fukihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikiko","family":"Hashisako","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Fujisawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiko","family":"Nakazono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takafumi","family":"Suda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Kawaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Kondoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junya","family":"Fukuoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Irie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Johkoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Togao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the CRPJD research group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Arakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiki","family":"Fukuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuya","family":"Ichikado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae","family":"Iwasawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosaku","family":"Komiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makiko","family":"Murota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Ogura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumikazu","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromitsu","family":"Sumikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Taniguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junya","family":"Tominaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunori","family":"Tobino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriyuki","family":"Tomiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomonori","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Midori","family":"Ueno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,18]]},"reference":[{"key":"12741_CR1","doi-asserted-by":"publisher","unstructured":"Ryerson CJ, Adegunsoye A, Piciucchi S et al (2025) Update of the International Multidisciplinary Classification of the Interstitial Pneumonias: an ERS\/ATS Statement. Eur Respir J. https:\/\/doi.org\/10.1183\/13993003.00158-2025","DOI":"10.1183\/13993003.00158-2025"},{"key":"12741_CR2","doi-asserted-by":"publisher","first-page":"e18","DOI":"10.1164\/rccm.202202-0399ST","volume":"205","author":"G Raghu","year":"2022","unstructured":"Raghu G, Remy-Jardin M, Richeldi L et al (2022) Idiopathic pulmonary fibrosis (an update) and progressive pulmonary fibrosis in adults: an official ATS\/ERS\/JRS\/ALAT clinical practice guideline. Am J Respir Crit Care Med 205:e18\u2013e47","journal-title":"Am J Respir Crit Care Med"},{"key":"12741_CR3","doi-asserted-by":"publisher","first-page":"1722","DOI":"10.1164\/ajrccm.164.9.2103074","volume":"164","author":"KR Flaherty","year":"2001","unstructured":"Flaherty KR, Travis WD, Colby TV et al (2001) Histopathologic variability in usual and nonspecific interstitial pneumonias. Am J Respir Crit Care Med 164:1722\u20131727","journal-title":"Am J Respir Crit Care Med"},{"key":"12741_CR4","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1378\/chest.125.2.522","volume":"125","author":"H Monaghan","year":"2004","unstructured":"Monaghan H, Wells AU, Colby TV, du Bois RM, Hansell DM, Nicholson AG (2004) Prognostic implications of histologic patterns in multiple surgical lung biopsies from patients with idiopathic interstitial pneumonias. Chest 125:522\u2013526","journal-title":"Chest"},{"key":"12741_CR5","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1111\/his.15179","volume":"85","author":"Y Tsushima","year":"2024","unstructured":"Tsushima Y, Okoshi EN, Ishijima S et al (2024) Presence of focal usual interstitial pneumonia is a key prognostic factor in progressive pulmonary fibrosis. Histopathology 85:104\u2013115","journal-title":"Histopathology"},{"key":"12741_CR6","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1111\/j.1365-2559.2008.03183.x","volume":"53","author":"Y Kawabata","year":"2008","unstructured":"Kawabata Y, Hoshi E, Murai K et al (2008) Smoking-related changes in the background lung of specimens resected for lung cancer: a semiquantitative study with correlation to postoperative course. Histopathology 53:707\u2013714","journal-title":"Histopathology"},{"key":"12741_CR7","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/j.humpath.2009.09.003","volume":"41","author":"AL Katzenstein","year":"2010","unstructured":"Katzenstein AL, Mukhopadhyay S, Zanardi C, Dexter E (2010) Clinically occult interstitial fibrosis in smokers: classification and significance of a surprisingly common finding in lobectomy specimens. Hum Pathol 41:316\u2013325","journal-title":"Hum Pathol"},{"key":"12741_CR8","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1148\/radiol.2511080917","volume":"251","author":"M Akira","year":"2009","unstructured":"Akira M, Inoue Y, Kitaichi M, Yamamoto S, Arai T, Toyokawa K (2009) Usual interstitial pneumonia and nonspecific interstitial pneumonia with and without concurrent emphysema: thin-section CT findings. Radiology 251:271\u2013279","journal-title":"Radiology"},{"key":"12741_CR9","doi-asserted-by":"publisher","first-page":"W458","DOI":"10.2214\/AJR.12.9437","volume":"200","author":"JF Gruden","year":"2013","unstructured":"Gruden JF, Panse PM, Leslie KO, Tazelaar HD, Colby TV (2013) UIP diagnosed at surgical lung biopsy, 2000-2009: HRCT patterns and proposed classification system. AJR Am J Roentgenol 200:W458\u2013W467","journal-title":"AJR Am J Roentgenol"},{"key":"12741_CR10","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1378\/chest.124.4.1215","volume":"124","author":"GW Hunninghake","year":"2003","unstructured":"Hunninghake GW, Lynch DA, Galvin JR et al (2003) Radiologic findings are strongly associated with a pathologic diagnosis of usual interstitial pneumonia. Chest 124:1215\u20131223","journal-title":"Chest"},{"key":"12741_CR11","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1148\/rg.285075223","volume":"28","author":"AK Attili","year":"2008","unstructured":"Attili AK, Kazerooni EA, Gross BH, Flaherty KR, Myers JL, Martinez FJ (2008) Smoking-related interstitial lung disease: radiologic-clinical-pathologic correlation. Radiographics 28:1383\u20131396. discussion 1396-1388","journal-title":"Radiographics"},{"key":"12741_CR12","doi-asserted-by":"publisher","first-page":"2463","DOI":"10.1007\/s00330-006-0340-0","volume":"16","author":"A Hidalgo","year":"2006","unstructured":"Hidalgo A, Franquet T, Gimenez A, Bordes R, Pineda R, Madrid M (2006) Smoking-related interstitial lung diseases: radiologic-pathologic correlation. Eur Radiol 16:2463\u20132470","journal-title":"Eur Radiol"},{"key":"12741_CR13","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.241001","volume":"314","author":"DC Marinescu","year":"2025","unstructured":"Marinescu DC, Hague CJ, Muller NL et al (2025) CT Honeycombing and traction bronchiectasis extent independently predict survival across fibrotic interstitial lung disease subtypes. Radiology 314:.e241001","journal-title":"Radiology"},{"key":"12741_CR14","doi-asserted-by":"crossref","unstructured":"Fujisawa T, Mori K, Mikamo M et al (2019) Nationwide cloud-based integrated database of idiopathic interstitial pneumonias for multidisciplinary discussion. Eur Respir J 53:1802243","DOI":"10.1183\/13993003.02243-2018"},{"key":"12741_CR15","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1148\/radiology.182.2.1732946","volume":"182","author":"K Nishimura","year":"1992","unstructured":"Nishimura K, Kitaichi M, Izumi T, Nagai S, Kanaoka M, Itoh H (1992) Usual interstitial pneumonia: histologic correlation with high-resolution CT. Radiology 182:337\u2013342","journal-title":"Radiology"},{"key":"12741_CR16","doi-asserted-by":"publisher","first-page":"e44","DOI":"10.1164\/rccm.201807-1255ST","volume":"198","author":"G Raghu","year":"2018","unstructured":"Raghu G, Remy-Jardin M, Myers JL et al (2018) Diagnosis of idiopathic pulmonary fibrosis. An official ATS\/ERS\/JRS\/ALAT Clinical Practice Guideline. Am J Respir Crit Care Med 198:e44\u2013e68","journal-title":"Am J Respir Crit Care Med"},{"key":"12741_CR17","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1164\/rccm.2009-040GL","volume":"183","author":"G Raghu","year":"2011","unstructured":"Raghu G, Collard HR, Egan JJ et al (2011) An official ATS\/ERS\/JRS\/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management. Am J Respir Crit Care Med 183:788\u2013824","journal-title":"Am J Respir Crit Care Med"},{"key":"12741_CR18","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1183\/13993003.01680-2015","volume":"47","author":"K Yagihashi","year":"2016","unstructured":"Yagihashi K, Huckleberry J, Colby TV et al (2016) Radiologic-pathologic discordance in biopsy-proven usual interstitial pneumonia. Eur Respir J 47:1189\u20131197","journal-title":"Eur Respir J"},{"key":"12741_CR19","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1016\/j.chest.2018.12.011","volume":"155","author":"A Adegunsoye","year":"2019","unstructured":"Adegunsoye A, Vij R, Noth I (2019) Integrating genomics into management of fibrotic interstitial lung disease. Chest 155:1026\u20131040","journal-title":"Chest"},{"key":"12741_CR20","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.ejrad.2017.02.037","volume":"90","author":"T Iwasawa","year":"2017","unstructured":"Iwasawa T, Takemura T, Okudera K et al (2017) The importance of subpleural fibrosis in the prognosis of patients with idiopathic interstitial pneumonias. Eur J Radiol 90:106\u2013113","journal-title":"Eur J Radiol"},{"key":"12741_CR21","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1186\/s12931-025-03136-6","volume":"26","author":"AC Swaminathan","year":"2025","unstructured":"Swaminathan AC, Weber JM, Todd JL et al (2025) Extent of lung fibrosis is of greater prognostic importance than HRCT pattern in patients with progressive pulmonary fibrosis: data from the ILD-PRO registry. Respir Res 26:73","journal-title":"Respir Res"},{"key":"12741_CR22","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1513\/AnnalsATS.202301-084OC","volume":"21","author":"AS Oh","year":"2024","unstructured":"Oh AS, Lynch DA, Swigris JJ et al (2024) Deep learning-based fibrosis extent on computed tomography predicts outcome of fibrosing interstitial lung disease independent of visually assessed computed tomography pattern. Ann Am Thorac Soc 21:218\u2013227","journal-title":"Ann Am Thorac Soc"},{"key":"12741_CR23","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1164\/rccm.201308-1483ST","volume":"188","author":"WD Travis","year":"2013","unstructured":"Travis WD, Costabel U, Hansell DM et al (2013) An official American Thoracic Society\/European Respiratory Society statement: Update of the international multidisciplinary classification of the idiopathic interstitial pneumonias. Am J Respir Crit Care Med 188:733\u2013748","journal-title":"Am J Respir Crit Care Med"}],"container-title":["European Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-026-12741-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00330-026-12741-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-026-12741-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:02:30Z","timestamp":1791936150000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00330-026-12741-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,18]]},"references-count":23,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2026,11]]}},"alternative-id":["12741"],"URL":"https:\/\/doi.org\/10.1007\/s00330-026-12741-y","relation":{},"ISSN":["1432-1084"],"issn-type":[{"value":"1432-1084","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,18]]},"assertion":[{"value":"22 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 June 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 June 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 July 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The scientific guarantor of this publication is Osamu Togao, Department of Radiology, Faculty of Medicine, Saga University, Japan. Email: togao@cc.saga-u.ac.jp","order":1,"name":"Ethics","label":"Guarantor","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors of this manuscript declare relationships with the following companies outside the submitted work: R.E., K.K., and M.K. report lecture fees from Boehringer Ingelheim. K.F. received lecture fees from Boehringer Ingelheim, AstraZeneca, Kyorin, and Bayer Pharma Japan. Y.K. reports consulting fees from Asahi Kasei Pharma Corp, Boehringer Ingelheim, Bristol Myers Squibb, Chugai Pharmaceutical Co., Ltd., GlaxoSmithKline plc, Healios K.K., Insmed Inc., Janssen Pharmaceutical KK, Mochida Pharmaceutical Co., Ltd, Shionogi Co, Ltd., TAIHO PHARMACEUTICAL CO., LTD., lecture fees from Asahi Kasei Pharma Corp, Bristol Myers Squibb, Boehringer Ingelheim, Eisai Co, Ltd, Janssen Pharmaceutical K.K., GlaxoSmithKline plc, KYORIN Pharmaceutical Co, Ltd, Mitsubishi Tanabe Pharma, Mochida Pharmaceutical Co., Ltd., Nippon Shinyaku Co, Ltd., Novartis Pharma KK, Shionogi Co, Ltd., Teijin Pharma Ltd. and research funding from MICIN Inc. J.F. reports stock or stock options in N Lab and Pathology Institute, lecture fees and research funding from Boehringer Ingelheim. T.J. reports lecture fees from AstraZeneca K.K., Boehringer Ingelheim, KYORIN Pharmaceutical Co, Ltd. The remaining authors have no relevant disclosures. T.S. reports lecture fees and consulting fees from Nippon Boehringer Ingelheim, lecture fees from Shionogi & Co., Ltd., consulting fees from Bristol Myers Squibb and consulting fees from Mochida Pharmaceutical Co., Ltd. J.F. reports lecture fees from Nippon Boehringer Ingelheim and Mochida Pharmaceutical Co., Ltd. The other authors of this manuscript declare no relationship with any companies whose products or services may be related to the subject matter of the article.","order":2,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"One of the authors has significant statistical expertise, Atsushi Kawaguchi.","order":3,"name":"Ethics","label":"Statistics and biometry","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Informed consent was obtained through opt-out processes in this study; written informed consent from each patient was waived.","order":4,"name":"Ethics","label":"Informed consent","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Institutional Review Board approval was obtained at Saga University.","order":5,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The cohorts used in this study originated from a Japanese registry (nonpublic) and a single-centre database. While many publications have partially or fully overlapped with these cohorts in the past, none have pursued the identical research objective. Due to the anonymisation process and differences in inclusion criteria, it was difficult to determine how many individuals overlapped between studies.","order":6,"name":"Ethics","label":"Study subjects or cohorts overlap","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"order":7,"name":"Ethics","label":"Methodology","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}}]}}