{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T14:02:46Z","timestamp":1784383366817,"version":"3.55.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:00:00Z","timestamp":1784332800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:00:00Z","timestamp":1784332800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"the National Research Foundation of Korea (NRF) grant funded by the Korea government","award":["2022R1C1C1008107"],"award-info":[{"award-number":["2022R1C1C1008107"]}]},{"DOI":"10.13039\/501100002560","name":"Soonchunhyang University","doi-asserted-by":"publisher","award":["Soonchunhyang University Research Fund"],"award-info":[{"award-number":["Soonchunhyang University Research Fund"]}],"id":[{"id":"10.13039\/501100002560","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Radiol"],"DOI":"10.1007\/s00330-026-12776-1","type":"journal-article","created":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T13:14:08Z","timestamp":1784380448000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Imaging phenotypes of pancreatic acinar cell carcinoma: a multicenter study of morphologic subtypes and recurrence"],"prefix":"10.1007","author":[{"given":"Jeong Ah","family":"Hwang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunyoung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2434-8779","authenticated-orcid":false,"given":"Seo-Youn","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Eun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jisun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,18]]},"reference":[{"key":"12776_CR1","doi-asserted-by":"publisher","first-page":"4673","DOI":"10.1200\/JCO.2002.02.005","volume":"20","author":"KD Holen","year":"2002","unstructured":"Holen KD, Klimstra DS, Hummer A et al (2002) Clinical characteristics and outcomes from an institutional series of acinar cell carcinoma of the pancreas and related tumors. J Clin Oncol 20:4673\u20134678","journal-title":"J Clin Oncol"},{"key":"12776_CR2","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1097\/00000478-199209000-00001","volume":"16","author":"DS Klimstra","year":"1992","unstructured":"Klimstra DS, Heffess CS, Oertel JE, Rosai J (1992) Acinar cell carcinoma of the pancreas. A clinicopathologic study of 28 cases. Am J Surg Pathol 16:815\u2013837","journal-title":"Am J Surg Pathol"},{"key":"12776_CR3","doi-asserted-by":"publisher","first-page":"2078","DOI":"10.1007\/s11605-008-0705-6","volume":"12","author":"CM Schmidt","year":"2008","unstructured":"Schmidt CM, Matos JM, Bentrem DJ, Talamonti MS, Lillemoe KD, Bilimoria KY (2008) Acinar cell carcinoma of the pancreas in the United States: prognostic factors and comparison to ductal adenocarcinoma. J Gastrointest Surg 12:2078\u20132086","journal-title":"J Gastrointest Surg"},{"key":"12776_CR4","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1093\/jjco\/hyad176","volume":"54","author":"K Ikezawa","year":"2024","unstructured":"Ikezawa K, Urabe M, Kai Y et al (2024) Comprehensive review of pancreatic acinar cell carcinoma: epidemiology, diagnosis, molecular features and treatment. Jpn J Clin Oncol 54:271\u2013281","journal-title":"Jpn J Clin Oncol"},{"key":"12776_CR5","doi-asserted-by":"publisher","first-page":"5827","DOI":"10.3748\/wjg.v28.i40.5827","volume":"28","author":"LF Calimano-Ramirez","year":"2022","unstructured":"Calimano-Ramirez LF, Daoud T, Gopireddy DR et al (2022) Pancreatic acinar cell carcinoma: a comprehensive review. World J Gastroenterol 28:5827\u20135844","journal-title":"World J Gastroenterol"},{"key":"12776_CR6","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.hbpd.2023.05.004","volume":"23","author":"G Mazzarella","year":"2024","unstructured":"Mazzarella G, Muttillo EM, Coletta D et al (2024) Solid pseudopapillary tumor of the pancreas: a systematic review of clinical, surgical and oncological characteristics of 1384 patients underwent pancreatic surgery. Hepatobiliary Pancreat Dis Int 23:331\u2013338","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"12776_CR7","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1016\/j.annonc.2020.03.304","volume":"31","author":"M Pavel","year":"2020","unstructured":"Pavel M, Oberg K, Falconi M et al (2020) Gastroenteropancreatic neuroendocrine neoplasms: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol 31:844\u2013860","journal-title":"Ann Oncol"},{"key":"12776_CR8","doi-asserted-by":"publisher","first-page":"511","DOI":"10.2214\/ajr.184.2.01840511","volume":"184","author":"S Tatli","year":"2005","unstructured":"Tatli S, Mortele KJ, Levy AD et al (2005) CT and MRI features of pure acinar cell carcinoma of the pancreas in adults. AJR Am J Roentgenol 184:511\u2013519","journal-title":"AJR Am J Roentgenol"},{"key":"12776_CR9","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/j.diii.2019.02.003","volume":"100","author":"D Jornet","year":"2019","unstructured":"Jornet D, Soyer P, Terris B et al (2019) MR imaging features of pancreatic acinar cell carcinoma. Diagn Interv Imaging 100:427\u2013435","journal-title":"Diagn Interv Imaging"},{"key":"12776_CR10","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/j.diii.2020.02.007","volume":"101","author":"M Barat","year":"2020","unstructured":"Barat M, Dohan A, Gaujoux S et al (2020) Computed tomography features of acinar cell carcinoma of the pancreas. Diagn Interv Imaging 101:565\u2013575","journal-title":"Diagn Interv Imaging"},{"key":"12776_CR11","doi-asserted-by":"publisher","DOI":"10.1186\/s40644-025-00859-z","volume":"25","author":"M Cheng","year":"2025","unstructured":"Cheng M, Consul N, Chung R, Del Castillo CF, Hernandez-Barco Y, Kambadakone A (2025) Acinar cell carcinoma of the pancreas: Can CT and MR features predict survival? Cancer Imaging 25:38","journal-title":"Cancer Imaging"},{"key":"12776_CR12","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.crad.2009.11.010","volume":"65","author":"MY Hsu","year":"2010","unstructured":"Hsu MY, Pan KT, Chu SY, Hung CF, Wu RC, Tseng JH (2010) CT and MRI features of acinar cell carcinoma of the pancreas with pathological correlations. Clin Radiol 65:223\u2013229","journal-title":"Clin Radiol"},{"key":"12776_CR13","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.2214\/AJR.17.17963","volume":"209","author":"SW Kim","year":"2017","unstructured":"Kim SW, Kim SH, Lee DH et al (2017) Isolated main pancreatic duct dilatation: CT differentiation between benign and malignant causes. AJR Am J Roentgenol 209:1046\u20131055","journal-title":"AJR Am J Roentgenol"},{"key":"12776_CR14","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1111\/j.1440-1746.2004.03219.x","volume":"19","author":"JE Kim","year":"2004","unstructured":"Kim JE, Lee KT, Lee JK, Paik SW, Rhee JC, Choi KW (2004) Clinical usefulness of carbohydrate antigen 19-9 as a screening test for pancreatic cancer in an asymptomatic population. J Gastroenterol Hepatol 19:182\u2013186","journal-title":"J Gastroenterol Hepatol"},{"key":"12776_CR15","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1007\/s00261-012-9970-7","volume":"38","author":"P Bhosale","year":"2013","unstructured":"Bhosale P, Balachandran A, Wang H et al (2013) CT imaging features of acinar cell carcinoma and its hepatic metastases. Abdom Imaging 38:1383\u20131390","journal-title":"Abdom Imaging"},{"key":"12776_CR16","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1097\/00004728-200403000-00005","volume":"28","author":"YY Chiou","year":"2004","unstructured":"Chiou YY, Chiang JH, Hwang JI, Yen CH, Tsay SH, Chang CY (2004) Acinar cell carcinoma of the pancreas: clinical and computed tomography manifestations. J Comput Assist Tomogr 28:180\u2013186","journal-title":"J Comput Assist Tomogr"},{"key":"12776_CR17","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1007\/s00261-013-0015-7","volume":"38","author":"DM Ganeshan","year":"2013","unstructured":"Ganeshan DM, Paulson E, Tamm EP, Taggart MW, Balachandran A, Bhosale P (2013) Solid pseudo-papillary tumors of the pancreas: current update. Abdom Imaging 38:1373\u20131382","journal-title":"Abdom Imaging"},{"key":"12776_CR18","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1007\/s00261-014-0169-y","volume":"39","author":"A Ventriglia","year":"2014","unstructured":"Ventriglia A, Manfredi R, Mehrabi S et al (2014) MRI features of solid pseudopapillary neoplasm of the pancreas. Abdom Imaging 39:1213\u20131220","journal-title":"Abdom Imaging"},{"key":"12776_CR19","doi-asserted-by":"publisher","first-page":"395","DOI":"10.2214\/ajr.181.2.1810395","volume":"181","author":"V Cantisani","year":"2003","unstructured":"Cantisani V, Mortele KJ, Levy A et al (2003) MR imaging features of solid pseudopapillary tumor of the pancreas in adult and pediatric patients. AJR Am J Roentgenol 181:395\u2013401","journal-title":"AJR Am J Roentgenol"},{"key":"12776_CR20","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1148\/rg.314105731","volume":"31","author":"G Low","year":"2011","unstructured":"Low G, Panu A, Millo N, Leen E (2011) Multimodality imaging of neoplastic and nonneoplastic solid lesions of the pancreas. Radiographics 31:993\u20131015","journal-title":"Radiographics"},{"key":"12776_CR21","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1097\/01.rct.0000445639.26581.65","volume":"38","author":"SH Chae","year":"2014","unstructured":"Chae SH, Lee JM, Baek JH et al (2014) Magnetic resonance imaging spectrum of solid pseudopapillary neoplasm of the pancreas. J Comput Assist Tomogr 38:249\u2013257","journal-title":"J Comput Assist Tomogr"},{"key":"12776_CR22","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1148\/rg.2020200025","volume":"40","author":"L Khanna","year":"2020","unstructured":"Khanna L, Prasad SR, Sunnapwar A et al (2020) Pancreatic neuroendocrine neoplasms: 2020 update on pathologic and imaging findings and classification. Radiographics 40:1240\u20131262","journal-title":"Radiographics"},{"key":"12776_CR23","doi-asserted-by":"publisher","first-page":"942","DOI":"10.5009\/gnl220378","volume":"17","author":"HK Chon","year":"2023","unstructured":"Chon HK, Song TJ, Yoo KH et al (2023) Enhancing mural nodules in the main pancreatic duct of main and mixed types of intraductal papillary mucinous neoplasms: Does size matter in malignancy risk? Gut Liver 17:942\u2013948","journal-title":"Gut Liver"},{"key":"12776_CR24","doi-asserted-by":"publisher","DOI":"10.1148\/rg.230054","volume":"43","author":"FH Miller","year":"2023","unstructured":"Miller FH, Lopes Vendrami C, Hammond NA, Mittal PK, Nikolaidis P, Jawahar A (2023) Pancreatic cancer and its mimics. Radiographics 43:e230054","journal-title":"Radiographics"}],"container-title":["European Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-026-12776-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00330-026-12776-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-026-12776-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T13:14:09Z","timestamp":1784380449000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00330-026-12776-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,18]]},"references-count":24,"alternative-id":["12776"],"URL":"https:\/\/doi.org\/10.1007\/s00330-026-12776-1","relation":{},"ISSN":["1432-1084"],"issn-type":[{"value":"1432-1084","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,18]]},"assertion":[{"value":"27 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 May 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 July 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 July 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The scientific guarantor of this publication is Seo-Youn Choi.","order":1,"name":"Ethics","label":"Guarantor","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article.","order":2,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"No complex statistical methods were necessary for this paper.","order":3,"name":"Ethics","label":"Statistics and biometry","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Written informed consent was waived by the Institutional Review Board (SMC 2026-03-065).","order":4,"name":"Ethics","label":"Informed consent","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Institutional Review Board approval was obtained.","order":5,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"None.","order":6,"name":"Ethics","label":"Study subjects or cohorts overlap","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"order":7,"name":"Ethics","label":"Methodology","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}}]}}