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J.K.F. reports receiving grants\/contracts from NIH (USA), EU Horizon, CRUK, Elypta, and Alchemab, consulting fees from Elypta, Qure.ai, iDNA, and AstraZeneca, and support for meeting attendance from IASLC. M.S. reports receiving support for a lecture at ESTI Congress from Coreline Ltd. M.O. and C.M.v.d.A. report receiving support from the EU Horizon grant as part of the ongoing 4ITLR screening implementation trial. J.Y. is an employee of Coreline Soft, the developer of the AI software (AVIEW LCS) evaluated in this study. All other authors declare that they have no competing interests.","order":2,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"No complex statistical methods were necessary for this paper.","order":3,"name":"Ethics","label":"Statistics and biometry","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Written informed consent was waived by the Institutional Review Board for this retrospective analysis.","order":4,"name":"Ethics","label":"Informed consent","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Institutional Review Board approval was obtained for the original UK Lung Screening (UKLS) Trial. This retrospective analysis of the curated dataset was performed in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments.","order":5,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The study cohort is a subset of the UKLS trial cohort, which has been previously reported in recent evaluations of this AI system. To ensure full transparency, the distinct focuses of the related publications are: (1) Lancaster et al [\n                      \n                      ] evaluated the AI\u2019s baseline detection performance, (2) Jiang et al [\n                      \n                      ] quantified the baseline morphological impact of perifissural nodules, and (3) Jiang et al [\n                      \n                      ] validated the clinical outcomes of automated volume doubling time assessment.","order":6,"name":"Ethics","label":"Study subjects or cohorts overlap","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"order":7,"name":"Ethics","label":"Methodology","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}}]}}