{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T13:02:26Z","timestamp":1789650146184,"version":"4.0.0"},"reference-count":93,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Radiol"],"DOI":"10.1007\/s00330-026-12910-z","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:09:12Z","timestamp":1789646952000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Photon-counting CT in head and neck radiology: bridging detector physics and clinical applications"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7200-5028","authenticated-orcid":false,"given":"Teodoro","family":"Mart\u00edn-Noguerol","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Escart\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"L\u00f3pez-\u00dabeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Luna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"key":"12910_CR1","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.diii.2024.09.002","volume":"106","author":"J Greffier","year":"2025","unstructured":"Greffier J, Viry A, Robert A, Khorsi M, Si-Mohamed S (2025) Photon-counting CT systems: a technical review of current clinical possibilities. Diagn Interv Imaging 106:53\u201359. https:\/\/doi.org\/10.1016\/j.diii.2024.09.002","journal-title":"Diagn Interv Imaging"},{"key":"12910_CR2","doi-asserted-by":"publisher","unstructured":"Mart\u00edn-Noguerol T, Santos-Armentia E, Zhu D, Diehn FE, Amrhein TJ, Luna A (2025) Photon-counting CT in neuroradiology: a comprehensive SWOT analysis. Eur Radiol. https:\/\/doi.org\/10.1007\/s00330-025-12229-1","DOI":"10.1007\/s00330-025-12229-1"},{"key":"12910_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2025.112189","volume":"190","author":"J van der Bie","year":"2025","unstructured":"van der Bie J, van der Laan T, van Straten M et al (2025) Photon-counting CT: an updated review of clinical results. Eur J Radiol 190:112189. https:\/\/doi.org\/10.1016\/j.ejrad.2025.112189","journal-title":"Eur J Radiol"},{"key":"12910_CR4","doi-asserted-by":"publisher","first-page":"4383","DOI":"10.1007\/s00261-024-04414-5","volume":"49","author":"H Onishi","year":"2024","unstructured":"Onishi H, Tsuboyama T, Nakamoto A et al (2024) Photon-counting CT: technical features and clinical impact on abdominal imaging. Abdom Radiol 49:4383\u20134399. https:\/\/doi.org\/10.1007\/s00261-024-04414-5","journal-title":"Abdom Radiol"},{"key":"12910_CR5","doi-asserted-by":"publisher","first-page":"12801","DOI":"10.1117\/1.jmi.11.s1.s12801","volume":"11","author":"PJ La Riviere","year":"2024","unstructured":"La Riviere PJ, Das M (2024) Photon counting: detectors and applications. J Med Imaging 11:12801. https:\/\/doi.org\/10.1117\/1.jmi.11.s1.s12801","journal-title":"J Med Imaging"},{"key":"12910_CR6","doi-asserted-by":"publisher","first-page":"03TR01","DOI":"10.1088\/1361-6560\/abc5a5","volume":"66","author":"M Danielsson","year":"2021","unstructured":"Danielsson M, Persson M, Sj\u00f6lin M (2021) Photon-counting x-ray detectors for CT. Phys Med Biol 66:03TR01. https:\/\/doi.org\/10.1088\/1361-6560\/abc5a5","journal-title":"Phys Med Biol"},{"key":"12910_CR7","doi-asserted-by":"publisher","first-page":"e220158","DOI":"10.1148\/rg.220158","volume":"43","author":"AK Nehra","year":"2023","unstructured":"Nehra AK, Rajendran K, Baffour FI et al (2023) Seeing more with less: clinical benefits of photon-counting detector CT. Radiographics 43:e220158. https:\/\/doi.org\/10.1148\/rg.220158","journal-title":"Radiographics"},{"key":"12910_CR8","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.rxeng.2022.05.003","volume":"64","author":"E Santos Armentia","year":"2022","unstructured":"Santos Armentia E, Mart\u00edn Noguerol T, Silva Priegue N, Delgado S\u00e1nchez-Graci\u00e1n C, Trinidad L\u00f3pez C, Prada Gonz\u00e1lez R (2022) Strengths, weaknesses, opportunities, and threat analysis of dual-energy CT in head and neck imaging. Radiologia 64:333\u2013347. https:\/\/doi.org\/10.1016\/j.rxeng.2022.05.003","journal-title":"Radiologia"},{"key":"12910_CR9","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.diii.2022.11.003","volume":"104","author":"J Greffier","year":"2023","unstructured":"Greffier J, Villani N, Defez D, Dabli D, Si-Mohamed S (2023) Spectral CT imaging: technical principles of dual-energy CT and multi-energy photon-counting CT. Diagn Interv Imaging 104:167\u2013177. https:\/\/doi.org\/10.1016\/j.diii.2022.11.003","journal-title":"Diagn Interv Imaging"},{"key":"12910_CR10","doi-asserted-by":"publisher","first-page":"5309","DOI":"10.1007\/s00330-023-09596-y","volume":"33","author":"CH McCollough","year":"2023","unstructured":"McCollough CH, Rajendran K, Baffour FI et al (2023) Clinical applications of photon counting detector CT. Eur Radiol 33:5309\u20135320. https:\/\/doi.org\/10.1007\/s00330-023-09596-y","journal-title":"Eur Radiol"},{"key":"12910_CR11","doi-asserted-by":"publisher","unstructured":"Stein T, Rau A, Russe MF et al (2023) Photon-counting computed tomography\u2014basic principles, potenzial benefits, and initial clinical experience. RoFo 195:691\u2013698. https:\/\/doi.org\/10.1055\/a-2018-3396","DOI":"10.1055\/a-2018-3396"},{"key":"12910_CR12","doi-asserted-by":"publisher","first-page":"3626","DOI":"10.3390\/jcm12113626","volume":"12","author":"F Cademartiri","year":"2023","unstructured":"Cademartiri F, Meloni A, Pistoia L et al (2023) Dual source photon-counting computed tomography\u2014Part II: Clinical overview of neurovascular applications. J Clin Med 12:3626. https:\/\/doi.org\/10.3390\/jcm12113626","journal-title":"J Clin Med"},{"key":"12910_CR13","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.1007\/s11547-024-01889-6","volume":"129","author":"C Booz","year":"2024","unstructured":"Booz C, Bucolo GM, D\u2019Angelo T et al (2024) Carotid artery assessment in dual-source photon-counting CT: impact of low-energy virtual monoenergetic imaging on image quality, vascular contrast and diagnostic assessability. Radiol Med 129:1633\u20131643. https:\/\/doi.org\/10.1007\/s11547-024-01889-6","journal-title":"Radiol Med"},{"key":"12910_CR14","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1097\/RLI.0000000000001108","volume":"60","author":"JP Grunz","year":"2025","unstructured":"Grunz JP, Huflage H (2025) Photon-counting detector CT applications in musculoskeletal radiology. Invest Radiol 60:198\u2013204. https:\/\/doi.org\/10.1097\/RLI.0000000000001108","journal-title":"Invest Radiol"},{"key":"12910_CR15","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1097\/RLI.0000000000000418","volume":"53","author":"R Symons","year":"2018","unstructured":"Symons R, Reich DS, Bagheri M et al (2018) Photon-counting computed tomography for vascular imaging of the head and neck: first in vivo human results. Invest Radiol 53:135\u2013142. https:\/\/doi.org\/10.1097\/RLI.0000000000000418","journal-title":"Invest Radiol"},{"key":"12910_CR16","doi-asserted-by":"publisher","first-page":"3742","DOI":"10.1007\/s00330-023-10430-8","volume":"34","author":"FB Pallasch","year":"2024","unstructured":"Pallasch FB, Rau A, Reisert M et al (2024) Impact of different metal artifact reduction techniques in photon-counting computed tomography head and neck scans in patients with dental hardware. Eur Radiol 34:3742\u20133749. https:\/\/doi.org\/10.1007\/s00330-023-10430-8","journal-title":"Eur Radiol"},{"key":"12910_CR17","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1097\/RCT.0000000000001464","volume":"47","author":"JR Rajagopal","year":"2023","unstructured":"Rajagopal JR, Schwartz FR, Solomon JB, Enterline DS, Samei E (2023) High spatial-resolution skull base imaging with photon-counting computed tomography and energy-integrating computed tomography: a comparative phantom study. J Comput Assist Tomogr 47:613\u2013620. https:\/\/doi.org\/10.1097\/RCT.0000000000001464","journal-title":"J Comput Assist Tomogr"},{"key":"12910_CR18","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1186\/s13244-023-01467-w","volume":"14","author":"R Hermans","year":"2023","unstructured":"Hermans R, Boomgaert L, Cockmartin L, Binst J, De Stefanis R, Bosmans H (2023) Photon-counting CT allows better visualization of temporal bone structures in comparison with current generation multi-detector CT. Insights Imaging 14:112. https:\/\/doi.org\/10.1186\/s13244-023-01467-w","journal-title":"Insights Imaging"},{"key":"12910_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2025.104429","volume":"54","author":"M Scheer","year":"2026","unstructured":"Scheer M, Willenberg F, Surov A, Passmann B, Niehoff J, Borggrefe J (2026) Photon-counting CT in the diagnostic workup of OSCC and OPSCC: a prospective evaluation of tumour conspicuity using virtual monoenergetic imaging. J Craniomaxillofac Surg 54:104429. https:\/\/doi.org\/10.1016\/j.jcms.2025.104429","journal-title":"J Craniomaxillofac Surg"},{"key":"12910_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2023.110829","volume":"163","author":"J van der Bie","year":"2023","unstructured":"van der Bie J, van Straten M, Booij R et al (2023) Photon-counting CT: review of initial clinical results. Eur J Radiol 163:110829. https:\/\/doi.org\/10.1016\/j.ejrad.2023.110829","journal-title":"Eur J Radiol"},{"key":"12910_CR21","doi-asserted-by":"publisher","first-page":"1802","DOI":"10.1093\/bjr\/tqae226","volume":"98","author":"S Dogra","year":"2025","unstructured":"Dogra S, Shekhrajka N, Moonis G (2025) A review of applications of photon-counting computed tomography in head and neck imaging. Br J Radiol 98:1802\u20131812. https:\/\/doi.org\/10.1093\/bjr\/tqae226","journal-title":"Br J Radiol"},{"key":"12910_CR22","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.3174\/ajnr.A8265","volume":"45","author":"JC Benson","year":"2024","unstructured":"Benson JC, Campeau NG, Diehn FE, Lane JI, Leng S, Moonis G (2024) Photon-counting CT in the head and neck: current applications and future prospects. AJNR Am J Neuroradiol 45:1000\u20131005. https:\/\/doi.org\/10.3174\/ajnr.A8265","journal-title":"AJNR Am J Neuroradiol"},{"key":"12910_CR23","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.ejmp.2020.10.030","volume":"79","author":"T Flohr","year":"2020","unstructured":"Flohr T, Petersilka M, Henning A, Ulzheimer S, Ferda J, Schmidt B (2020) Photon-counting CT review. Phys Med 79:126\u2013136. https:\/\/doi.org\/10.1016\/j.ejmp.2020.10.030","journal-title":"Phys Med"},{"key":"12910_CR24","doi-asserted-by":"publisher","first-page":"2362","DOI":"10.1016\/j.acra.2023.05.029","volume":"30","author":"Y Wu","year":"2023","unstructured":"Wu Y, Ye Z, Chen J, Deng L, Song B (2023) Photon counting CT: technical principles, clinical applications, and future prospects. Acad Radiol 30:2362\u20132382. https:\/\/doi.org\/10.1016\/j.acra.2023.05.029","journal-title":"Acad Radiol"},{"key":"12910_CR25","doi-asserted-by":"publisher","first-page":"1526","DOI":"10.1002\/mp.17591","volume":"52","author":"B Heismann","year":"2025","unstructured":"Heismann B, Kreisler B, Fasbender R (2025) Photon counting CT versus energy-integrating CT: a comparative evaluation of advances in image resolution, noise, and dose efficiency. Med Phys 52:1526\u20131535. https:\/\/doi.org\/10.1002\/mp.17591","journal-title":"Med Phys"},{"key":"12910_CR26","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.diii.2025.02.003","volume":"106","author":"F Boubaker","year":"2025","unstructured":"Boubaker F, Eliezer M, Poillon G et al (2025) Ultra-high-resolution CT of the temporal bone: technical aspects, current applications and future directions. Diagn Interv Imaging 106:205\u2013216. https:\/\/doi.org\/10.1016\/j.diii.2025.02.003","journal-title":"Diagn Interv Imaging"},{"key":"12910_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2024.104585","volume":"46","author":"JP McDonald","year":"2025","unstructured":"McDonald JP, Farnsworth PJ, Campeau NG et al (2025) Improved visualization of the inferior tympanic and mastoid canaliculi with photon counting detector CT. Am J Otolaryngol 46:104585. https:\/\/doi.org\/10.1016\/j.amjoto.2024.104585","journal-title":"Am J Otolaryngol"},{"key":"12910_CR28","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1007\/s11604-023-01485-0","volume":"42","author":"Y Takahashi","year":"2024","unstructured":"Takahashi Y, Higaki F, Sugaya A et al (2024) Evaluation of the ear ossicles with photon-counting detector CT. Jpn J Radiol 42:158\u2013164. https:\/\/doi.org\/10.1007\/s11604-023-01485-0","journal-title":"Jpn J Radiol"},{"key":"12910_CR29","doi-asserted-by":"publisher","first-page":"400","DOI":"10.3390\/tomography10030031","volume":"10","author":"A Klempka","year":"2024","unstructured":"Klempka A, Ackermann E, Clausen S, Groden C (2024) Photon counting computed tomography for accurate cribriform plate (lamina cribrosa) imaging in adult patients. Tomography 10:400\u2013414. https:\/\/doi.org\/10.3390\/tomography10030031","journal-title":"Tomography"},{"key":"12910_CR30","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1093\/dmfr\/twad010","volume":"53","author":"HL Kaatsch","year":"2024","unstructured":"Kaatsch HL, Fulisch F, Dillinger D et al (2024) Ultra-low-dose photon-counting CT of paranasal sinus: an in vivo comparison of radiation dose and image quality to cone-beam CT. Dentomaxillofac Radiol 53:103\u2013108. https:\/\/doi.org\/10.1093\/dmfr\/twad010","journal-title":"Dentomaxillofac Radiol"},{"key":"12910_CR31","doi-asserted-by":"publisher","first-page":"111785","DOI":"10.1016\/j.ejrad.2024.111785","volume":"181","author":"E Klintstr\u00f6m","year":"2024","unstructured":"Klintstr\u00f6m E, Ly A, Sandborg M, Woisetschl\u00e4ger M, Tesselaar E (2024) Image quality of photon-counting detector CT for visualization of maxillofacial anatomy in comparison with energy-integrating detector CT and intraoperative C-arm CBCT. Eur J Radiol 181:111785. https:\/\/doi.org\/10.1016\/j.ejrad.2024.111785","journal-title":"Eur J Radiol"},{"key":"12910_CR32","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1177\/15910199231175198","volume":"31","author":"PJ Farnsworth","year":"2023","unstructured":"Farnsworth PJ, Campeau NG, Diehn FE et al (2023) High-resolution computed tomography angiography of the orbit using a photon-counting computed tomography scanner. Interv Neuroradiol 31:539\u2013554. https:\/\/doi.org\/10.1177\/15910199231175198","journal-title":"Interv Neuroradiol"},{"key":"12910_CR33","doi-asserted-by":"publisher","first-page":"185015","DOI":"10.1088\/1361-6560\/ab32fe","volume":"64","author":"EC Harvey","year":"2019","unstructured":"Harvey EC, Feng M, Ji X et al (2019) Impacts of photon counting CT to maximum intensity projection (MIP) images of cerebral CT angiography: theoretical and experimental studies. Phys Med Biol 64:185015. https:\/\/doi.org\/10.1088\/1361-6560\/ab32fe","journal-title":"Phys Med Biol"},{"key":"12910_CR34","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.3390\/diagnostics14121223","volume":"14","author":"M Sta\u0144ski","year":"2024","unstructured":"Sta\u0144ski M, Micha\u0142owska I, Lemanowicz A et al (2024) Dual-energy and photon-counting computed tomography in vascular applications\u2014technical background and post-processing techniques. Diagnostics 14:1223. https:\/\/doi.org\/10.3390\/diagnostics14121223","journal-title":"Diagnostics"},{"key":"12910_CR35","doi-asserted-by":"publisher","DOI":"10.1016\/j.phro.2025.100864","volume":"36","author":"N Bertini","year":"2025","unstructured":"Bertini N, Gabry\u015b HS, Alkadhi H et al (2025) First implementation of photon-counting detector computed tomography for optimizing segmentation in head-and-neck cancer radiotherapy. Phys Imaging Radiat Oncol 36:100864. https:\/\/doi.org\/10.1016\/j.phro.2025.100864","journal-title":"Phys Imaging Radiat Oncol"},{"key":"12910_CR36","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1007\/s11604-025-01894-3","volume":"44","author":"H Kuno","year":"2025","unstructured":"Kuno H, Hiyama T, Sasaki T et al (2025) Imaging-detected extranodal extension in head and neck cancer: clinical implications, diagnostic criteria, and the potential of photon-counting detector CT. Jpn J Radiol 44:221\u2013241. https:\/\/doi.org\/10.1007\/s11604-025-01894-3","journal-title":"Jpn J Radiol"},{"key":"12910_CR37","doi-asserted-by":"publisher","first-page":"112","DOI":"10.3390\/jimaging8040112","volume":"8","author":"M Tortora","year":"2022","unstructured":"Tortora M, Gemini L, D\u2019iglio I, Ugga L, Spadarella G, Cuocolo R (2022) Spectral photon-counting computed tomography: a review on technical principles and clinical applications. J Imaging 8:112. https:\/\/doi.org\/10.3390\/jimaging8040112","journal-title":"J Imaging"},{"key":"12910_CR38","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1097\/RLI.0000000000000614","volume":"55","author":"K Rajendran","year":"2020","unstructured":"Rajendran K, Voss BA, Zhou W et al (2020) Dose reduction for sinus and temporal bone imaging using photon-counting detector CT with an additional tin filter. Invest Radiol 55:91\u2013100. https:\/\/doi.org\/10.1097\/RLI.0000000000000614","journal-title":"Invest Radiol"},{"key":"12910_CR39","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1097\/RLI.0000000000000901","volume":"57","author":"J-P Grunz","year":"2022","unstructured":"Grunz J-P, Heidenreich JF, Lennartz S et al (2022) Spectral shaping via tin prefiltration in ultra-high-resolution photon-counting and energy-integrating detector CT of the temporal bone. Invest Radiol 57:819\u2013825. https:\/\/doi.org\/10.1097\/RLI.0000000000000901","journal-title":"Invest Radiol"},{"key":"12910_CR40","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.3174\/ajnr.A5768","volume":"39","author":"W Zhou","year":"2018","unstructured":"Zhou W, Lane JI, Carlson ML et al (2018) Comparison of a photon-counting-detector CT with an energy-integrating-detector CT for temporal bone imaging: a cadaveric study. AJNR Am J Neuroradiol 39:1733\u20131738. https:\/\/doi.org\/10.3174\/ajnr.A5768","journal-title":"AJNR Am J Neuroradiol"},{"key":"12910_CR41","doi-asserted-by":"publisher","first-page":"7818","DOI":"10.1007\/s00330-023-09790-y","volume":"33","author":"TS Patzer","year":"2023","unstructured":"Patzer TS, Kunz AS, Huflage H et al (2023) Combining virtual monoenergetic imaging and iterative metal artifact reduction in first-generation photon-counting computed tomography of patients with dental implants. Eur Radiol 33:7818\u20137829. https:\/\/doi.org\/10.1007\/s00330-023-09790-y","journal-title":"Eur Radiol"},{"key":"12910_CR42","doi-asserted-by":"publisher","first-page":"8579","DOI":"10.1007\/s00330-022-08933-x","volume":"32","author":"LP Liu","year":"2022","unstructured":"Liu LP, Shapira N, Chen AA et al (2022) First-generation clinical dual-source photon-counting CT: ultra-low-dose quantitative spectral imaging. Eur Radiol 32:8579\u20138587. https:\/\/doi.org\/10.1007\/s00330-022-08933-x","journal-title":"Eur Radiol"},{"key":"12910_CR43","doi-asserted-by":"publisher","unstructured":"Lustermans D, Fonseca GP, Jeukens C et al (2025) Assessing quantitative material characteristics with low dose imaging in photon-counting and dual-energy computed tomography for radiotherapy. Phys Med Biol. https:\/\/doi.org\/10.1088\/1361-6560\/ae128c","DOI":"10.1088\/1361-6560\/ae128c"},{"key":"12910_CR44","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1007\/s00330-025-11818-4","volume":"36","author":"J Hirvonen","year":"2025","unstructured":"Hirvonen J, Lingam RK, Connor S (2025) ESR Essentials: acute infections of the head and neck\u2014practice recommendations by the European Society of Head and Neck Radiology. Eur Radiol 36:334\u2013343. https:\/\/doi.org\/10.1007\/s00330-025-11818-4","journal-title":"Eur Radiol"},{"key":"12910_CR45","doi-asserted-by":"publisher","first-page":"579","DOI":"10.3174\/ajnr.A7452","volume":"43","author":"JC Benson","year":"2022","unstructured":"Benson JC, Rajendran K, Lane JI et al (2022) A new frontier in temporal bone imaging: photon-counting detector CT demonstrates superior visualization of critical anatomic structures at reduced radiation dose. AJNR Am J Neuroradiol 43:579\u2013584. https:\/\/doi.org\/10.3174\/ajnr.A7452","journal-title":"AJNR Am J Neuroradiol"},{"key":"12910_CR46","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.radphyschem.2018.08.019","volume":"155","author":"M Alkhorayef","year":"2019","unstructured":"Alkhorayef M, Sulieman A, Alonazi B, Alnaaimi M, Alduaij M, Bradley D (2019) Estimation of radiation-induced cataract and cancer risks during routine CT head procedures. Radiat Phys Chem 155:65\u201368. https:\/\/doi.org\/10.1016\/j.radphyschem.2018.08.019","journal-title":"Radiat Phys Chem"},{"key":"12910_CR47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1210\/endrev\/bnad022","volume":"45","author":"V Saenko","year":"2024","unstructured":"Saenko V, Mitsutake N (2024) Radiation-related thyroid cancer. Endocr Rev 45:1\u201329. https:\/\/doi.org\/10.1210\/endrev\/bnad022","journal-title":"Endocr Rev"},{"key":"12910_CR48","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.251496","volume":"319","author":"P Sahbaee","year":"2026","unstructured":"Sahbaee P, Dunning C, Primak A et al (2026) Toward broader clinical adoption of photon-counting CT: where we stand according to high-impact literature. Radiology 319:e251496. https:\/\/doi.org\/10.1148\/radiol.251496","journal-title":"Radiology"},{"key":"12910_CR49","doi-asserted-by":"publisher","first-page":"5421","DOI":"10.1002\/mp.16583","volume":"50","author":"S Vrbaski","year":"2023","unstructured":"Vrbaski S, Bache S, Rajagopal J, Samei E (2023) Quantitative performance of photon-counting CT at low dose: virtual monochromatic imaging and iodine quantification. Med Phys 50:5421\u20135433. https:\/\/doi.org\/10.1002\/mp.16583","journal-title":"Med Phys"},{"key":"12910_CR50","doi-asserted-by":"publisher","first-page":"580","DOI":"10.2214\/AJR.22.28391","volume":"220","author":"J Cao","year":"2023","unstructured":"Cao J, Bache S, Schwartz FR, Frush D (2023) Pediatric applications of photon-counting detector CT. AJR Am J Roentgenol 220:580\u2013589. https:\/\/doi.org\/10.2214\/AJR.22.28391","journal-title":"AJR Am J Roentgenol"},{"key":"12910_CR51","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1016\/j.acra.2020.07.033","volume":"28","author":"JR Rajagopal","year":"2021","unstructured":"Rajagopal JR, Farhadi F, Solomon J et al (2021) Comparison of low dose performance of photon-counting and energy integrating CT. Acad Radiol 28:1754\u20131760. https:\/\/doi.org\/10.1016\/j.acra.2020.07.033","journal-title":"Acad Radiol"},{"key":"12910_CR52","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1097\/RLI.0000000000000251","volume":"51","author":"R Gutjahr","year":"2016","unstructured":"Gutjahr R, Halaweish AF, Yu Z et al (2016) Human imaging with photon counting-based computed tomography at clinical dose levels: contrast-to-noise ratio and cadaver studies. Invest Radiol 51:421\u2013429. https:\/\/doi.org\/10.1097\/RLI.0000000000000251","journal-title":"Invest Radiol"},{"key":"12910_CR53","doi-asserted-by":"publisher","first-page":"e28142","DOI":"10.1016\/j.heliyon.2024.e28142","volume":"10","author":"YC Layer","year":"2024","unstructured":"Layer YC, Isaak A, Mesropyan N et al (2024) Image quality of abdominal photon-counting CT with reduced contrast media dose: evaluation of reduced contrast media protocols during the COVID19 pandemic supply shortage. Heliyon 10:e28142. https:\/\/doi.org\/10.1016\/j.heliyon.2024.e28142","journal-title":"Heliyon"},{"key":"12910_CR54","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1007\/s00247-018-4306-6","volume":"49","author":"E Maloney","year":"2019","unstructured":"Maloney E, Iyer RS, Phillips GS, Menon S, Lee JJ, Callahan MJ (2019) Practical administration of intravenous contrast media in children: screening, prophylaxis, administration and treatment of adverse reactions. Pediatr Radiol 49:433\u2013447. https:\/\/doi.org\/10.1007\/s00247-018-4306-6","journal-title":"Pediatr Radiol"},{"key":"12910_CR55","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1007\/s00330-023-09962-w","volume":"34","author":"U Nyman","year":"2024","unstructured":"Nyman U, Leander P, Liss P, Sterner G, Brismar T (2024) Absolute and relative GFR and contrast medium dose\/GFR ratio: cornerstones when predicting the risk of acute kidney injury. Eur Radiol 34:612\u2013621. https:\/\/doi.org\/10.1007\/s00330-023-09962-w","journal-title":"Eur Radiol"},{"key":"12910_CR56","doi-asserted-by":"publisher","first-page":"1729","DOI":"10.1007\/s11604-025-01823-4","volume":"43","author":"Y Nagayama","year":"2025","unstructured":"Nagayama Y, Nakaura T, Awai K et al (2025) Contrast medium dose optimization in the era of multi-energy CT. Jpn J Radiol 43:1729\u20131745. https:\/\/doi.org\/10.1007\/s11604-025-01823-4","journal-title":"Jpn J Radiol"},{"key":"12910_CR57","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2024.111680","volume":"179","author":"EJI Hoeijmakers","year":"2024","unstructured":"Hoeijmakers EJI, Stammen L, Wildberger JE et al (2024) PCD-CT enables contrast media reduction in abdominal imaging compared to an individualized kV-adapted contrast media injection protocol on EID-CT. Eur J Radiol 179:111680. https:\/\/doi.org\/10.1016\/j.ejrad.2024.111680","journal-title":"Eur J Radiol"},{"key":"12910_CR58","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/s41747-025-00573-2","volume":"9","author":"D Dabli","year":"2025","unstructured":"Dabli D, Pastor M, Faby S et al (2025) Photon-counting versus energy-integrating CT of abdomen-pelvis: a phantom study on the potential for reducing iodine contrast media. Eur Radiol Exp 9:36. https:\/\/doi.org\/10.1186\/s41747-025-00573-2","journal-title":"Eur Radiol Exp"},{"key":"12910_CR59","doi-asserted-by":"publisher","first-page":"4635","DOI":"10.1007\/s00330-025-11409-3","volume":"35","author":"D Popp","year":"2025","unstructured":"Popp D, Siedlecki M, Friedrich L et al (2025) Potential of photon-counting detector CT technology for contrast medium reduction in portal venous phase thoracoabdominal CT. Eur Radiol 35:4635\u20134648. https:\/\/doi.org\/10.1007\/s00330-025-11409-3","journal-title":"Eur Radiol"},{"key":"12910_CR60","doi-asserted-by":"publisher","first-page":"2779","DOI":"10.1007\/s00247-025-06394-0","volume":"55","author":"AA Daniels","year":"2025","unstructured":"Daniels AA, Pinkney LP, Strubel NA, Druhan SM, El-Ali AM (2025) Pediatric photon-counting chest CT enables iodinated contrast dose reduction with preserved image quality. Pediatr Radiol 55:2779\u20132791. https:\/\/doi.org\/10.1007\/s00247-025-06394-0","journal-title":"Pediatr Radiol"},{"key":"12910_CR61","doi-asserted-by":"publisher","first-page":"195","DOI":"10.3390\/jcdd12050195","volume":"12","author":"G Fahrni","year":"2025","unstructured":"Fahrni G, Saliba T, Racine D et al (2025) Trading off iodine and radiation dose in coronary computed tomography. J Cardiovasc Dev Dis 12:195. https:\/\/doi.org\/10.3390\/jcdd12050195","journal-title":"J Cardiovasc Dev Dis"},{"key":"12910_CR62","doi-asserted-by":"publisher","unstructured":"Woolen SA, Martin M, Foster CA, MacEachern MP, Maturen KE (2025) Green imaging: scoping review of radiology\u2019s environmental impact. J Am Coll Radiol. https:\/\/doi.org\/10.1016\/j.jacr.2025.09.013","DOI":"10.1016\/j.jacr.2025.09.013"},{"key":"12910_CR63","first-page":"276","volume":"95","author":"KL Wininger","year":"2024","unstructured":"Wininger KL (2024) Photon-counting CT binning and electronic noise reduction. Radiol Technol 95:276\u2013279","journal-title":"Radiol Technol"},{"key":"12910_CR64","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.radi.2022.09.010","volume":"29","author":"H Huflage","year":"2023","unstructured":"Huflage H, Grunz JP, Kunz AS et al (2023) Potential of employing a quantum iterative reconstruction algorithm for ultra-high-resolution photon-counting detector CT of the hip. Radiography 29:44\u201349. https:\/\/doi.org\/10.1016\/j.radi.2022.09.010","journal-title":"Radiography"},{"key":"12910_CR65","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1007\/s00256-024-04820-2","volume":"54","author":"RP Marcus","year":"2025","unstructured":"Marcus RP, Feuerriegel GC, Marth AA et al (2025) Reducing metal artifacts in clinical photon counting detector computed tomography\u2014a phantom study of an exemplary total hip arthroplasty. Skelet Radiol 54:1233\u20131246. https:\/\/doi.org\/10.1007\/s00256-024-04820-2","journal-title":"Skelet Radiol"},{"key":"12910_CR66","first-page":"251","volume":"58","author":"A Jahangiri","year":"2014","unstructured":"Jahangiri A, Coucher J, Pratap J (2014) Metal artefact reduction in head and neck imaging using dual-energy computed tomography and metal artifact reduction software. Scientific Exhibits. J Med Imaging Radiat Oncol 58:251","journal-title":"J Med Imaging Radiat Oncol"},{"key":"12910_CR67","doi-asserted-by":"publisher","first-page":"e0247355","DOI":"10.1371\/journal.pone.0247355","volume":"16","author":"CL Lee","year":"2021","unstructured":"Lee CL, Park J, Nam S et al (2021) Metal artifact reduction and tumor detection using photon-counting multi-energy computed tomography. PLoS One 16:e0247355. https:\/\/doi.org\/10.1371\/journal.pone.0247355","journal-title":"PLoS One"},{"key":"12910_CR68","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1038\/s41405-021-00060-x","volume":"7","author":"L Vanden Broeke","year":"2021","unstructured":"Vanden Broeke L, Grillon M, Yeung AWK, Wu W, Tanaka R, Vardhanabhuti V (2021) Feasibility of photon-counting spectral CT in dental applications\u2014a comparative qualitative analysis. BDJ Open 7:4. https:\/\/doi.org\/10.1038\/s41405-021-00060-x","journal-title":"BDJ Open"},{"key":"12910_CR69","doi-asserted-by":"publisher","first-page":"1642","DOI":"10.3390\/tomography8040136","volume":"8","author":"S Waldeck","year":"2022","unstructured":"Waldeck S, Overhoff D, Alizadeh L et al (2022) Photon-counting detector CT virtual monoengergetic images for cochlear implant visualization\u2014a head to head comparison to energy-integrating detector CT. Tomography 8:1642\u20131648. https:\/\/doi.org\/10.3390\/tomography8040136","journal-title":"Tomography"},{"key":"12910_CR70","doi-asserted-by":"publisher","first-page":"104859","DOI":"10.1016\/j.jdent.2024.104859","volume":"142","author":"S Sawall","year":"2024","unstructured":"Sawall S, Maier J, Sen S et al (2024) Dental imaging in clinical photon-counting CT at a quarter of DVT dose. J Dent 142:104859. https:\/\/doi.org\/10.1016\/j.jdent.2024.104859","journal-title":"J Dent"},{"key":"12910_CR71","doi-asserted-by":"publisher","first-page":"2436","DOI":"10.3390\/jcm13082436","volume":"13","author":"C Zanon","year":"2024","unstructured":"Zanon C, Pepe A, Cademartiri F et al (2024) Potential benefits of photon-counting CT in dental imaging: a narrative review. J Clin Med 13:2436. https:\/\/doi.org\/10.3390\/jcm13082436","journal-title":"J Clin Med"},{"key":"12910_CR72","doi-asserted-by":"publisher","first-page":"215","DOI":"10.3390\/jimaging11070215","volume":"11","author":"M Ruetters","year":"2025","unstructured":"Ruetters M, Gehrig H, Mertens C et al (2025) Opportunistic diagnostics of dental implants in routine clinical photon-counting CT acquisitions. J Imaging 11:215. https:\/\/doi.org\/10.3390\/jimaging11070215","journal-title":"J Imaging"},{"key":"12910_CR73","doi-asserted-by":"publisher","first-page":"S12804","DOI":"10.1117\/1.jmi.11.s1.s12804","volume":"11","author":"S Chang","year":"2024","unstructured":"Chang S, Marsh JF, Koons EK, Gong H, McCollough CH, Leng S (2024) Improved noise reduction in photon-counting detector CT using prior knowledge-aware iterative denoising neural network. J Med Imaging 11:S12804. https:\/\/doi.org\/10.1117\/1.jmi.11.s1.s12804","journal-title":"J Med Imaging"},{"key":"12910_CR74","doi-asserted-by":"publisher","first-page":"175014","DOI":"10.1088\/1361-6560\/ac8866","volume":"67","author":"NR Huber","year":"2022","unstructured":"Huber NR, Ferrero A, Rajendran K et al (2022) Dedicated convolutional neural network for noise reduction in ultra-high-resolution photon-counting detector computed tomography. Phys Med Biol 67:175014. https:\/\/doi.org\/10.1088\/1361-6560\/ac8866","journal-title":"Phys Med Biol"},{"key":"12910_CR75","doi-asserted-by":"publisher","first-page":"276","DOI":"10.6109\/jicce.2021.19.4.276","volume":"19","author":"J Lee","year":"2021","unstructured":"Lee J, Kurosaki M, Cho M, Lee MC (2021) Noise reduction for photon counting imaging using discrete wavelet transform. J Inf Commun Converg Eng 19:276\u2013283. https:\/\/doi.org\/10.6109\/jicce.2021.19.4.276","journal-title":"J Inf Commun Converg Eng"},{"key":"12910_CR76","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1109\/TRPMS.2020.3020212","volume":"5","author":"SS Hsieh","year":"2021","unstructured":"Hsieh SS, Leng S, Rajendran K, Tao S, McCollough CH (2021) Photon counting CT: clinical applications and future developments. IEEE Trans Radiat Plasma Med Sci 5:441\u2013452. https:\/\/doi.org\/10.1109\/TRPMS.2020.3020212","journal-title":"IEEE Trans Radiat Plasma Med Sci"},{"key":"12910_CR77","doi-asserted-by":"publisher","unstructured":"Farhadi F, Sahbaee P, Rajagopal JR et al (2023) Virtual monoenergetic imaging in photon-counting CT of the head and neck. Clin Imaging. https:\/\/doi.org\/10.1016\/j.clinimag.2023.08.004.Virtual","DOI":"10.1016\/j.clinimag.2023.08.004.Virtual"},{"key":"12910_CR78","doi-asserted-by":"publisher","first-page":"811","DOI":"10.3233\/XST-230054","volume":"31","author":"X Zhang","year":"2023","unstructured":"Zhang X, Wang Z, Yun X et al (2023) Research on accuracy of material identification based on photon counting spectral CT. J Xray Sci Technol 31:811\u2013824. https:\/\/doi.org\/10.3233\/XST-230054","journal-title":"J Xray Sci Technol"},{"key":"12910_CR79","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1117\/1.jmi.6.1.013501","volume":"6","author":"TE Curtis","year":"2019","unstructured":"Curtis TE, Roeder RK (2019) Quantification of multiple mixed contrast and tissue compositions using photon-counting spectral computed tomography. J Med Imaging 6:1. https:\/\/doi.org\/10.1117\/1.jmi.6.1.013501","journal-title":"J Med Imaging"},{"key":"12910_CR80","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.3390\/diagnostics14121262","volume":"14","author":"J Neumann","year":"2024","unstructured":"Neumann J, Nowak T, Schmidt B, von Zanthier J (2024) An image-based prior knowledge-free approach for a multi-material decomposition in photon-counting computed tomography. Diagnostics 14:1262. https:\/\/doi.org\/10.3390\/diagnostics14121262","journal-title":"Diagnostics"},{"key":"12910_CR81","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1007\/s00117-023-01166-z","volume":"63","author":"YC Layer","year":"2023","unstructured":"Layer YC, Kravchenko D, Dell T, K\u00fctting D (2023) CT technology: photon-counting detector computed tomography. Radiologie 63:497\u2013506. https:\/\/doi.org\/10.1007\/s00117-023-01166-z","journal-title":"Radiologie"},{"key":"12910_CR82","doi-asserted-by":"publisher","first-page":"e231878","DOI":"10.1148\/radiol.231878","volume":"310","author":"A Surov","year":"2024","unstructured":"Surov A, Niehoff JH (2024) Bone marrow edema at photon-counting CT. Radiology 310:e231878. https:\/\/doi.org\/10.1148\/radiol.231878","journal-title":"Radiology"},{"key":"12910_CR83","doi-asserted-by":"publisher","first-page":"111964","DOI":"10.1016\/j.ejrad.2025.111964","volume":"184","author":"M Nakashima","year":"2025","unstructured":"Nakashima M, Kawai T, Matsumoto K et al (2025) Delineation of the brachial plexus by contrast-enhanced photon-counting detector CT and virtual monoenergetic images. Eur J Radiol 184:111964. https:\/\/doi.org\/10.1016\/j.ejrad.2025.111964","journal-title":"Eur J Radiol"},{"key":"12910_CR84","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1007\/s11547-019-00997-y","volume":"124","author":"G Foti","year":"2019","unstructured":"Foti G, Beltramello A, Minerva G et al (2019) Identification of residual\u2013recurrent cholesteatoma in operated ears: diagnostic accuracy of dual-energy CT and MRI. Radiol Med 124:478\u2013486. https:\/\/doi.org\/10.1007\/s11547-019-00997-y","journal-title":"Radiol Med"},{"key":"12910_CR85","doi-asserted-by":"publisher","first-page":"1678","DOI":"10.1109\/TMI.2011.2142188","volume":"30","author":"E Roessl","year":"2011","unstructured":"Roessl E, Brendel B, Engel KJ, Schlomka JP, Thran A, Proksa R (2011) Sensitivity of photon-counting based K-edge imaging in X-ray computed tomography. IEEE Trans Med Imaging 30:1678\u20131690. https:\/\/doi.org\/10.1109\/TMI.2011.2142188","journal-title":"IEEE Trans Med Imaging"},{"key":"12910_CR86","doi-asserted-by":"publisher","first-page":"2167","DOI":"10.1002\/mp.17604","volume":"52","author":"S Sawall","year":"2025","unstructured":"Sawall S, Baader E, Trapp P, Kachelrie\u00df M (2025) CT material decomposition with contrast agents: single or multiple spectral photon-counting CT scans? A simulation study. Med Phys 52:2167\u20132190. https:\/\/doi.org\/10.1002\/mp.17604","journal-title":"Med Phys"},{"key":"12910_CR87","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1586\/14737140.2015.1108193","volume":"15","author":"R Forghani","year":"2015","unstructured":"Forghani R (2015) Advanced dual-energy CT for head and neck cancer imaging. Expert Rev Anticancer Ther 15:1489\u20131501. https:\/\/doi.org\/10.1586\/14737140.2015.1108193","journal-title":"Expert Rev Anticancer Ther"},{"key":"12910_CR88","doi-asserted-by":"publisher","first-page":"1780","DOI":"10.3390\/tomography10110131","volume":"10","author":"E Bicci","year":"2024","unstructured":"Bicci E, Di Finizio A, Calamandrei L et al (2024) Head and neck squamous cell carcinoma: insights from dual-energy computed tomography (DECT). Tomography 10:1780\u20131797. https:\/\/doi.org\/10.3390\/tomography10110131","journal-title":"Tomography"},{"key":"12910_CR89","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.nic.2017.04.001","volume":"27","author":"R Forghani","year":"2017","unstructured":"Forghani R, Kelly HR, Curtin HD (2017) Applications of dual-energy computed tomography for the evaluation of head and neck squamous cell carcinoma. Neuroimaging Clin N Am 27:445\u2013459. https:\/\/doi.org\/10.1016\/j.nic.2017.04.001","journal-title":"Neuroimaging Clin N Am"},{"key":"12910_CR90","doi-asserted-by":"publisher","first-page":"5321","DOI":"10.1007\/s00330-023-09545-9","volume":"33","author":"CH McCollough","year":"2023","unstructured":"McCollough CH, Rajendran K, Leng S et al (2023) The technical development of photon-counting detector CT. Eur Radiol 33:5321\u20135330. https:\/\/doi.org\/10.1007\/s00330-023-09545-9","journal-title":"Eur Radiol"},{"key":"12910_CR91","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1117\/1.jmi.6.1.011004","volume":"6","author":"M Holbrook","year":"2018","unstructured":"Holbrook M (2018) Overcoming detector limitations of x-ray photon counting for preclinical microcomputed tomography. J Med Imaging 6:1. https:\/\/doi.org\/10.1117\/1.jmi.6.1.011004","journal-title":"J Med Imaging"},{"key":"12910_CR92","doi-asserted-by":"publisher","first-page":"522","DOI":"10.3390\/diagnostics12020522","volume":"12","author":"T Sartoretti","year":"2022","unstructured":"Sartoretti T, Racine D, Mergen V et al (2022) Quantum iterative reconstruction for low-dose ultra-high-resolution photon-counting detector CT of the lung. Diagnostics 12:522. https:\/\/doi.org\/10.3390\/diagnostics12020522","journal-title":"Diagnostics"},{"key":"12910_CR93","doi-asserted-by":"publisher","unstructured":"Scarfato E, Stile S, Maiello V, De Feo G (2024) The revolution of photon-counting CT towards new horizons of diagnostic imaging. J Adv Health Care. https:\/\/doi.org\/10.36017\/jahc202462333","DOI":"10.36017\/jahc202462333"}],"container-title":["European Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-026-12910-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00330-026-12910-z","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-026-12910-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:09:14Z","timestamp":1789646954000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00330-026-12910-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,17]]},"references-count":93,"alternative-id":["12910"],"URL":"https:\/\/doi.org\/10.1007\/s00330-026-12910-z","relation":{},"ISSN":["1432-1084"],"issn-type":[{"value":"1432-1084","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,17]]},"assertion":[{"value":"20 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 July 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 September 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 September 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The scientific guarantor of this publication is Dr. Antonio Luna.","order":1,"name":"Ethics","label":"Guarantor","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors of this manuscript declare relationships with the following companies: Antonio Luna, MD, PhD, is an occasional lecturer for Philips, Siemens Healthineers, Bracco, and Canon, and receives royalties as book editor from Springer-Verlag. The rest of the authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article.","order":2,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Not applicable.","order":3,"name":"Ethics","label":"Statistics and biometry","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Not applicable.","order":4,"name":"Ethics","label":"Informed consent","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Not applicable.","order":5,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Not applicable.","order":6,"name":"Ethics","label":"Study subjects or cohorts overlap","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"order":7,"name":"Ethics","label":"Methodology","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}}]}}