{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T12:01:21Z","timestamp":1791460881630,"version":"4.3.4"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Radiol"],"DOI":"10.1007\/s00330-026-12930-9","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T11:40:43Z","timestamp":1791459643000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Enabling unenhanced endolymphatic hydrops MRI: a subtraction method using 3D-FLAIR sequences with different inversion time"],"prefix":"10.1007","author":[{"given":"Menglong","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaili","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Sha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xixi","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinsheng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2172-9218","authenticated-orcid":false,"given":"Mengsu","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,8]]},"reference":[{"key":"12930_CR1","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.crad.2020.07.021","volume":"76","author":"S Connor","year":"2021","unstructured":"Connor S, Pai I (2021) Endolymphatic hydrops magnetic resonance imaging in M\u00e9ni\u00e8re\u2019s disease. Clin Radiol 76:71\u201376","journal-title":"Clin Radiol"},{"key":"12930_CR2","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1007\/s00234-022-02913-0","volume":"64","author":"A Bernaerts","year":"2022","unstructured":"Bernaerts A, Janssen N, Wuyts FL et al (2022) Comparison between 3D SPACE FLAIR and 3D TSE FLAIR in Meni\u00e8re\u2019s disease. Neuroradiology 64:1011\u20131020","journal-title":"Neuroradiology"},{"key":"12930_CR3","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1080\/00016489.2020.1792550","volume":"140","author":"VV Su\u00e1rez","year":"2020","unstructured":"Su\u00e1rez VV, Dominguez P, Caballeros LF, Leal JI, Perez-Fernandez N (2020) Comparison between high-resolution 3D-IR with real reconstruction and 3D-flair sequences in the assessment of endolymphatic hydrops in 3 Tesla. Acta Otolaryngol 140:883\u2013888","journal-title":"Acta Otolaryngol"},{"key":"12930_CR4","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1097\/MLG.0b013e31802c300c","volume":"117","author":"T Nakashima","year":"2007","unstructured":"Nakashima T, Naganawa S, Sugiura M et al (2007) Visualization of endolymphatic hydrops in patients with Meniere\u2019s disease. Laryngoscope 117:415\u2013420","journal-title":"Laryngoscope"},{"key":"12930_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2022.110614","volume":"158","author":"M Zhao","year":"2023","unstructured":"Zhao M, Jiang H, Zhang S et al (2023) Comparison of an optimized 3D-real IR and a 3D-FLAIR with a constant flip angle in the evaluation of endolymphatic hydrops. Eur J Radiol 158:110614","journal-title":"Eur J Radiol"},{"key":"12930_CR6","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/0378-5955(92)90071-T","volume":"63","author":"I Thalmann","year":"1992","unstructured":"Thalmann I, Comegys TH, Liu SZ, Ito Z, Thalmann R (1992) Protein profiles of perilymph and endolymph of the guinea pig. Hear Res 63:37\u201342","journal-title":"Hear Res"},{"key":"12930_CR7","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1089\/scd.2018.0016","volume":"27","author":"J Gao","year":"2018","unstructured":"Gao J, Wang S, Tang Q et al (2018) In vitro survival of human mesenchymal stem cells is enhanced in artificial endolymph with moderately high concentrations of potassium. Stem Cells Dev 27:658\u2013670","journal-title":"Stem Cells Dev"},{"key":"12930_CR8","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.heares.2006.02.010","volume":"215","author":"B Mazurek","year":"2006","unstructured":"Mazurek B, Amarjargal N, Haupt H, Gross J (2006) High potassium concentrations protect inner and outer hair cells in the newborn rat culture from ischemia-induced damage. Hear Res 215:31\u201338","journal-title":"Hear Res"},{"key":"12930_CR9","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/s00330-024-10906-1","volume":"35","author":"M Zhao","year":"2025","unstructured":"Zhao M, Jiang H, Zhang S et al (2025) An unenhanced 3D-FLAIR sequence using long repetition time and constant flip angle to image endolymphatic hydrops. Eur Radiol 35:29\u201337","journal-title":"Eur Radiol"},{"key":"12930_CR10","doi-asserted-by":"publisher","first-page":"93","DOI":"10.2463\/mrms.2014-0132","volume":"14","author":"S Naganawa","year":"2015","unstructured":"Naganawa S (2015) The technical and clinical features of 3D-FLAIR in neuroimaging. Magn Reson Med Sci 14:93\u2013106","journal-title":"Magn Reson Med Sci"},{"key":"12930_CR11","doi-asserted-by":"crossref","unstructured":"Nakashima T, Naganawa S, Katayama N et al (2009) Clinical significance of endolymphatic imaging after intratympanic gadolinium injection. Acta Otolaryngol Suppl 129:9\u201314","DOI":"10.1080\/00016480902729801"},{"key":"12930_CR12","doi-asserted-by":"publisher","first-page":"338","DOI":"10.3109\/00016480903143986","volume":"130","author":"T Nakashima","year":"2010","unstructured":"Nakashima T, Naganawa S, Teranishi M et al (2010) Endolymphatic hydrops revealed by intravenous gadolinium injection in patients with M\u00e9ni\u00e8re\u2019s disease. Acta Otolaryngol 130:338\u2013343","journal-title":"Acta Otolaryngol"},{"key":"12930_CR13","doi-asserted-by":"publisher","first-page":"706","DOI":"10.3174\/ajnr.A6483","volume":"41","author":"S Nahmani","year":"2020","unstructured":"Nahmani S, Vaussy A, Hautefort C et al (2020) Comparison of enhancement of the vestibular perilymph between variable and constant flip angle-delayed 3D-FLAIR sequences in Meni\u00e8re disease. AJNR Am J Neuroradiol 41:706\u2013711","journal-title":"AJNR Am J Neuroradiol"},{"key":"12930_CR14","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1007\/s00330-008-0854-8","volume":"18","author":"S Naganawa","year":"2008","unstructured":"Naganawa S, Satake H, Kawamura M, Fukatsu H, Sone M, Nakashima T (2008) Separate visualization of endolymphatic space, perilymphatic space and bone by a single pulse sequence; 3D-inversion recovery imaging utilizing real reconstruction after intratympanic Gd-DTPA administration at 3 Tesla. Eur Radiol 18:920\u2013924","journal-title":"Eur Radiol"},{"key":"12930_CR15","doi-asserted-by":"publisher","first-page":"213","DOI":"10.2463\/mrms.11.213","volume":"11","author":"S Naganawa","year":"2012","unstructured":"Naganawa S, Yamazaki M, Kawai H, Bokura K, Sone M, Nakashima T (2012) Imaging of M\u00e9ni\u00e8re\u2019s disease after intravenous administration of single-dose gadodiamide: utility of subtraction images with different inversion time. Magn Reson Med Sci 11:213\u2013219","journal-title":"Magn Reson Med Sci"},{"key":"12930_CR16","doi-asserted-by":"publisher","first-page":"272","DOI":"10.2463\/mrms.mp.2020-0082","volume":"20","author":"S Naganawa","year":"2021","unstructured":"Naganawa S, Nakamichi R, Ichikawa K et al (2021) MR imaging of endolymphatic hydrops: utility of iHYDROPS-Mi2 combined with deep learning reconstruction denoising. Magn Reson Med Sci 20:272\u2013279","journal-title":"Magn Reson Med Sci"},{"key":"12930_CR17","doi-asserted-by":"publisher","first-page":"357","DOI":"10.2463\/mrms.tn.2016-0126","volume":"16","author":"S Naganawa","year":"2017","unstructured":"Naganawa S, Kawai H, Taoka T, Sone M (2017) Improved HYDROPS: imaging of endolymphatic hydrops after intravenous administration of gadolinium. Magn Reson Med Sci 16:357\u2013361","journal-title":"Magn Reson Med Sci"},{"key":"12930_CR18","doi-asserted-by":"publisher","first-page":"119","DOI":"10.2463\/mrms.mp.2019-0013","volume":"19","author":"T Ohashi","year":"2020","unstructured":"Ohashi T, Naganawa S, Takeuchi A, Katagiri T, Kuno K (2020) Quantification of endolymphatic space volume after intravenous administration of a single dose of gadolinium-based contrast agent: 3D-real inversion recovery versus HYDROPS-Mi2. Magn Reson Med Sci 19:119\u2013124","journal-title":"Magn Reson Med Sci"},{"key":"12930_CR19","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.3174\/ajnr.A1036","volume":"29","author":"JI Lane","year":"2008","unstructured":"Lane JI, Witte RJ, Bolster B, Bernstein MA, Johnson K, Morris J (2008) State of the art: 3T imaging of the membranous labyrinth. AJNR Am J Neuroradiol 29:1436\u20131440","journal-title":"AJNR Am J Neuroradiol"},{"key":"12930_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3233\/VES-150549","volume":"25","author":"JA Lopez-Escamez","year":"2015","unstructured":"Lopez-Escamez JA, Carey J, Chung WH et al (2015) Diagnostic criteria for Meni\u00e8re\u2019s disease. J Vestib Res 25:1\u20137","journal-title":"J Vestib Res"},{"key":"12930_CR21","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.3174\/ajnr.A3856","volume":"35","author":"K Bar\u00e1th","year":"2014","unstructured":"Bar\u00e1th K, Schuknecht B, Naldi AM, Schrepfer T, Bockisch CJ, Hegemann SC (2014) Detection and grading of endolymphatic hydrops in Meni\u00e8re disease using MR imaging. AJNR Am J Neuroradiol 35:1387\u20131392","journal-title":"AJNR Am J Neuroradiol"},{"key":"12930_CR22","doi-asserted-by":"publisher","first-page":"3532","DOI":"10.1007\/s00330-021-08403-w","volume":"32","author":"H Fukutomi","year":"2022","unstructured":"Fukutomi H, Hamitouche L, Yamamoto T et al (2022) Visualization of the saccule and utricle with non-contrast-enhanced FLAIR sequences. Eur Radiol 32:3532\u20133540","journal-title":"Eur Radiol"},{"key":"12930_CR23","doi-asserted-by":"crossref","unstructured":"Naganawa S, Ito R, Kawamura M, Taoka T, Yoshida T, Sone M (2025) Preliminary findings on non-contrast enhanced positive endolymph images: limited delineation of endolymphatic space. Magn Reson Med Sci 24:2025-0005","DOI":"10.2463\/mrms.bc.2025-0005"},{"key":"12930_CR24","doi-asserted-by":"publisher","DOI":"10.1002\/lio2.1314","volume":"9","author":"M Ishii","year":"2024","unstructured":"Ishii M, Tanaka H, Asai R et al (2024) New non-contrast MRI of endolymphatic hydrops in M\u00e9ni\u00e8re\u2019s disease considering inversion time. Laryngoscope Investig Otolaryngol 9:e1314","journal-title":"Laryngoscope Investig Otolaryngol"},{"key":"12930_CR25","first-page":"299","volume":"85","author":"T Ohashi","year":"2023","unstructured":"Ohashi T, Naganawa S, Nasu Y, Kuno K, Kato K (2023) Magnetic resonance imaging of endolymphatic hydrops: a comparison of methods with and without gadolinium-based contrast agent administration. Nagoya J Med Sci 85:299\u2013309","journal-title":"Nagoya J Med Sci"},{"key":"12930_CR26","doi-asserted-by":"publisher","first-page":"105","DOI":"10.2463\/mrms.bc.2017-0158","volume":"18","author":"S Naganawa","year":"2019","unstructured":"Naganawa S, Kawai H, Taoka T, Sone M (2019) Improved 3D-real inversion recovery: a robust imaging technique for endolymphatic hydrops after intravenous administration of gadolinium. Magn Reson Med Sci 18:105\u2013108","journal-title":"Magn Reson Med Sci"},{"key":"12930_CR27","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.diii.2021.10.003","volume":"103","author":"S Osman","year":"2022","unstructured":"Osman S, Hautefort C, Atty\u00e9 A, Vaussy A, Houdart E, Eliezer M (2022) Increased signal intensity with delayed post contrast 3D-FLAIR MRI sequence using constant flip angle and long repetition time for inner ear evaluation. Diagn Interv Imaging 103:225\u2013229","journal-title":"Diagn Interv Imaging"}],"container-title":["European Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-026-12930-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00330-026-12930-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-026-12930-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T11:40:46Z","timestamp":1791459646000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00330-026-12930-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,8]]},"references-count":27,"alternative-id":["12930"],"URL":"https:\/\/doi.org\/10.1007\/s00330-026-12930-9","relation":{},"ISSN":["1432-1084"],"issn-type":[{"value":"1432-1084","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,8]]},"assertion":[{"value":"22 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 July 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 September 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 October 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The scientific guarantor of this publication is Mengsu Zeng.","order":1,"name":"Ethics","label":"Guarantor","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Xixi Wen is an employee of United Imaging Healthcare, Shanghai. He contributed to the acquisition of the images, but was not involved in the analysis and interpretation of data. Other authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article.","order":2,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"No complex statistical methods were necessary for this paper.","order":3,"name":"Ethics","label":"Statistics and biometry","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Written informed consent was obtained from all subjects (patients) in this study.","order":4,"name":"Ethics","label":"Informed consent","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Institutional Review Board approval was obtained (Approval Number: B2022-255R).","order":5,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"No study subjects or cohorts have been previously reported.","order":6,"name":"Ethics","label":"Study subjects or cohorts overlap","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"order":7,"name":"Ethics","label":"Methodology","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}}]}}