{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T23:35:32Z","timestamp":1790379332470,"version":"4.1.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"3-4","license":[{"start":{"date-parts":[[2011,2,24]],"date-time":"2011-02-24T00:00:00Z","timestamp":1298505600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mamm Genome"],"published-print":{"date-parts":[[2011,4]]},"DOI":"10.1007\/s00335-011-9317-7","type":"journal-article","created":{"date-parts":[[2011,2,23]],"date-time":"2011-02-23T08:02:13Z","timestamp":1298448133000},"page":"235-248","source":"Crossref","is-referenced-by-count":21,"title":["A missense mutation in the transcription factor Foxo3a causes teratomas and oocyte abnormalities in mice"],"prefix":"10.1007","volume":"22","author":[{"given":"N. A.","family":"Youngson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Vickaryous","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"van der Horst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Epp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Harten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. S.","family":"Fleming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. K.","family":"Khanna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. M.","family":"de Kretser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Whitelaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,2,24]]},"reference":[{"key":"9317_CR1","doi-asserted-by":"crossref","first-page":"R182","DOI":"10.1186\/gb-2008-9-12-r182","volume":"9","author":"A Ashe","year":"2008","unstructured":"Ashe A, Morgan DK, Whitelaw NC, Bruxner TJ, Vickaryous NK, Cox LL, Butterfield NC, Wicking C, Blewitt ME, Wilkins SJ, Anderson GJ, Cox TC, Whitelaw E (2008) A genome-wide screen for modifiers of transgene variegation identifies genes with critical roles in development. Genome Biol 9:R182","journal-title":"Genome Biol"},{"key":"9317_CR2","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1083\/jcb.200307056","volume":"164","author":"WJ Bakker","year":"2004","unstructured":"Bakker WJ, Blazquez-Domingo M, Kolbus A, Besooyen J, Steinlein P, Beug H, Coffer PJ, Lowenberg B, von Lindern M, van Dijk TB (2004) FoxO3a regulates erythroid differentiation and induces BTG1, an activator of protein arginine methyl transferase 1. J Cell Biol 164:175\u2013184","journal-title":"J Cell Biol"},{"key":"9317_CR3","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1002\/prot.10621","volume":"54","author":"S Banerjee-Basu","year":"2004","unstructured":"Banerjee-Basu S, Baxevanis AD (2004) Structural analysis of disease-causing mutations in the P-subfamily of forkhead transcription factors. Proteins 54:639\u2013647","journal-title":"Proteins"},{"key":"9317_CR4","doi-asserted-by":"crossref","first-page":"7629","DOI":"10.1073\/pnas.0409375102","volume":"102","author":"ME Blewitt","year":"2005","unstructured":"Blewitt ME, Vickaryous NK, Hemley SJ, Ashe A, Bruxner TJ, Preis JI, Arkell R, Whitelaw E (2005) An N-ethyl-N-nitrosourea screen for genes involved in variegation in the mouse. Proc Natl Acad Sci USA 102:7629\u20137634","journal-title":"Proc Natl Acad Sci USA"},{"key":"9317_CR5","doi-asserted-by":"crossref","first-page":"e49","DOI":"10.1371\/journal.pgen.0020049","volume":"2","author":"ME Blewitt","year":"2006","unstructured":"Blewitt ME, Vickaryous NK, Paldi A, Koseki H, Whitelaw E (2006) Dynamic reprogramming of DNA methylation at an epigenetically sensitive allele in mice. PLoS Genet 2:e49","journal-title":"PLoS Genet"},{"key":"9317_CR6","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/S0092-8674(00)80595-4","volume":"96","author":"A Brunet","year":"1999","unstructured":"Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, Anderson MJ, Arden KC, Blenis J, Greenberg ME (1999) Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96:857\u2013868","journal-title":"Cell"},{"key":"9317_CR7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/dbio.2002.0780","volume":"250","author":"P Carlsson","year":"2002","unstructured":"Carlsson P, Mahlapuu M (2002) Forkhead transcription factors: key players in development and metabolism. Dev Biol 250:1\u201323","journal-title":"Dev Biol"},{"key":"9317_CR8","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1126\/science.1086336","volume":"301","author":"DH Castrillon","year":"2003","unstructured":"Castrillon DH, Miao L, Kollipara R, Horner JW, DePinho RA (2003) Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a. Science 301:215\u2013218","journal-title":"Science"},{"key":"9317_CR9","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1038\/ng2031","volume":"39","author":"S Chong","year":"2007","unstructured":"Chong S, Vickaryous N, Ashe A, Zamudio N, Youngson N, Hemley S, Stopka T, Skoultchi A, Matthews J, Scott HS, de Kretser D, O\u2019Bryan M, Blewitt M, Whitelaw E (2007) Modifiers of epigenetic reprogramming show paternal effects in the mouse. Nat Genet 39:614\u2013622","journal-title":"Nat Genet"},{"key":"9317_CR10","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1080\/15287398709531039","volume":"21","author":"JJ Collins","year":"1987","unstructured":"Collins JJ, Montali RJ, Manus AG (1987) Toxicological evaluation of 4-vinylcyclohexene. II. Induction of ovarian tumors in female B6C3F1 mice by chronic oral administration of 4-vinylcyclohexene. J Toxicol Environ Health 21:507\u2013524","journal-title":"J Toxicol Environ Health"},{"key":"9317_CR11","first-page":"5047","volume":"56","author":"JJ Eppig","year":"1996","unstructured":"Eppig JJ, Wigglesworth K, Varnum DS, Nadeau JH (1996) Genetic regulation of traits essential for spontaneous ovarian teratocarcinogenesis in strain LT\/Sv mice: aberrant meiotic cell cycle, oocyte activation, and parthenogenetic development. Cancer Res 56:5047\u20135054","journal-title":"Cancer Res"},{"key":"9317_CR12","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1007\/s003359900052","volume":"7","author":"MK Fafalios","year":"1996","unstructured":"Fafalios MK, Olander EA, Melhem MF, Chaillet JR (1996) Ovarian teratomas associated with the insertion of an imprinted transgene. Mamm Genome 7:188\u2013193","journal-title":"Mamm Genome"},{"key":"9317_CR13","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1080\/07357900802146204","volume":"27","author":"M Fei","year":"2009","unstructured":"Fei M, Zhao Y, Wang Y, Lu M, Cheng C, Huang X, Zhang D, Lu J, He S, Shen A (2009) Low expression of Foxo3a is associated with poor prognosis in ovarian cancer patients. Cancer Invest 27:52\u201359","journal-title":"Cancer Invest"},{"key":"9317_CR15","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1042\/0264-6021:3490629","volume":"349","author":"T Furuyama","year":"2000","unstructured":"Furuyama T, Nakazawa T, Nakano I, Mori N (2000) Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues. Biochem J 349:629\u2013634","journal-title":"Biochem J"},{"key":"9317_CR14","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1016\/j.cub.2004.09.060","volume":"14","author":"T Furuyama","year":"2004","unstructured":"Furuyama T, Banerjee R, Breen TR, Harte PJ (2004) SIR2 is required for polycomb silencing and is associated with an E(Z) histone methyltransferase complex. Curr Biol 14:1812\u20131821","journal-title":"Curr Biol"},{"key":"9317_CR16","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1101\/gad.14.9.1021","volume":"14","author":"L Guarente","year":"2000","unstructured":"Guarente L (2000) Sir2 links chromatin silencing, metabolism, and aging. Genes Dev 14:1021\u20131026","journal-title":"Genes Dev"},{"key":"9317_CR17","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/370068a0","volume":"370","author":"N Hashimoto","year":"1994","unstructured":"Hashimoto N, Watanabe N, Furuta Y, Tamemoto H, Sagata N, Yokoyama M, Okazaki K, Nagayoshi M, Takeda N, Ikawa Y et al (1994) Parthenogenetic activation of oocytes in c-mos-deficient mice. Nature 370:68\u201371","journal-title":"Nature"},{"key":"9317_CR18","unstructured":"Hogan B, Beddington R, Costantini F, Lacy E (1994) Manipulating the mouse embryo, a laboratory manual. Cold Spring Laboratory Press, Cold Spring Harbor, NY"},{"key":"9317_CR19","doi-asserted-by":"crossref","first-page":"4837","DOI":"10.1210\/en.137.11.4837","volume":"137","author":"SY Hsu","year":"1996","unstructured":"Hsu SY, Lai RJ, Finegold M, Hsueh AJ (1996) Targeted overexpression of Bcl-2 in ovaries of transgenic mice leads to decreased follicle apoptosis, enhanced folliculogenesis, and increased germ cell tumorigenesis. Endocrinology 137:4837\u20134843","journal-title":"Endocrinology"},{"key":"9317_CR20","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1101\/gad.14.2.142","volume":"14","author":"KH Kaestner","year":"2000","unstructured":"Kaestner KH, Knochel W, Martinez DE (2000) Unified nomenclature for the winged helix\/forkhead transcription factors. Genes Dev 14:142\u2013146","journal-title":"Genes Dev"},{"key":"9317_CR21","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1093\/molehr\/gaq007","volume":"16","author":"N Kimura","year":"2010","unstructured":"Kimura N, Tsunoda S, Iuchi Y, Abe H, Totsukawa K, Fujii J (2010) Intrinsic oxidative stress causes either 2-cell arrest or cell death depending on developmental stage of the embryos from SOD1-deficient mice. Mol Hum Reprod 16:441\u2013451","journal-title":"Mol Hum Reprod"},{"key":"9317_CR22","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/nature01036","volume":"419","author":"GJ Kops","year":"2002","unstructured":"Kops GJ, Dansen TB, Polderman PE, Saarloos I, Wirtz KW, Coffer PJ, Huang TT, Bos JL, Medema RH, Burgering BM (2002) Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress. Nature 419:316\u2013321","journal-title":"Nature"},{"key":"9317_CR23","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/35097076","volume":"413","author":"CS Lai","year":"2001","unstructured":"Lai CS, Fisher SE, Hurst JA, Vargha-Khadem F, Monaco AP (2001) A forkhead-domain gene is mutated in a severe speech and language disorder. Nature 413:519\u2013523","journal-title":"Nature"},{"key":"9317_CR24","doi-asserted-by":"crossref","first-page":"40429","DOI":"10.1074\/jbc.M606596200","volume":"281","author":"M Li","year":"2006","unstructured":"Li M, Chiu JF, Mossman BT, Fukagawa NK (2006) Down-regulation of manganese-superoxide dismutase through phosphorylation of FOXO3a by Akt in explanted vascular smooth muscle cells from old rats. J Biol Chem 281:40429\u201340439","journal-title":"J Biol Chem"},{"key":"9317_CR25","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.bbrc.2009.02.138","volume":"381","author":"H Liu","year":"2009","unstructured":"Liu H, Luo LL, Qian YS, Fu YC, Sui XX, Geng YJ, Huang DN, Gao ST, Zhang RL (2009) FOXO3a is involved in the apoptosis of naked oocytes and oocytes of primordial follicles from neonatal rat ovaries. Biochem Biophys Res Commun 381:722\u2013727","journal-title":"Biochem Biophys Res Commun"},{"key":"9317_CR26","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1242\/dev.02667","volume":"134","author":"L Liu","year":"2007","unstructured":"Liu L, Rajareddy S, Reddy P, Du C, Jagarlamudi K, Shen Y, Gunnarsson D, Selstam G, Boman K, Liu K (2007) Infertility caused by retardation of follicular development in mice with oocyte-specific expression of Foxo3a. Development 134:199\u2013209","journal-title":"Development"},{"key":"9317_CR27","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/IGC.0b013e3181c8ca12","volume":"20","author":"A Matrone","year":"2010","unstructured":"Matrone A, Grossi V, Chiacchiera F, Fina E, Cappellari M, Caringella AM, Di Naro E, Loverro G, Simone C (2010) p38alpha is required for ovarian cancer cell metabolism and survival. Int J Gynecol Cancer 20:203\u2013211","journal-title":"Int J Gynecol Cancer"},{"key":"9317_CR28","doi-asserted-by":"crossref","first-page":"4485","DOI":"10.1182\/blood-2008-05-159848","volume":"112","author":"K Miyamoto","year":"2008","unstructured":"Miyamoto K, Miyamoto T, Kato R, Yoshimura A, Motoyama N, Suda T (2008) FoxO3a regulates hematopoietic homeostasis through a negative feedback pathway in conditions of stress or aging. Blood 112:4485\u20134493","journal-title":"Blood"},{"key":"9317_CR29","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1530\/rep.1.00095","volume":"127","author":"M Myers","year":"2004","unstructured":"Myers M, Britt KL, Wreford NGM, Ebling FJP, Kerr JB (2004) Methods for quantifying follicular numbers within the mouse ovary. Reproduction 127:569\u2013580","journal-title":"Reproduction"},{"key":"9317_CR30","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1126\/science.1101731","volume":"306","author":"S Nemoto","year":"2004","unstructured":"Nemoto S, Fergusson MM, Finkel T (2004) Nutrient availability regulates SIRT1 through a forkhead-dependent pathway. Science 306:2105\u20132108","journal-title":"Science"},{"key":"9317_CR31","first-page":"1350","volume":"43","author":"M Ormestad","year":"2002","unstructured":"Ormestad M, Blixt A, Churchill A, Martinsson T, Enerback S, Carlsson P (2002) Foxe3 haploinsufficiency in mice: a model for Peters\u2019 anomaly. Invest Ophthalmol Vis Sci 43:1350\u20131357","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"9317_CR32","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/S0960-9822(03)00335-X","volume":"13","author":"JI Preis","year":"2003","unstructured":"Preis JI, Downes M, Oates NA, Rasko JE, Whitelaw E (2003) Sensitive flow cytometric analysis reveals a novel type of parent-of-origin effect in the mouse genome. Curr Biol 13:955\u2013959","journal-title":"Curr Biol"},{"key":"9317_CR33","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1086\/318792","volume":"68","author":"RA Saleem","year":"2001","unstructured":"Saleem RA, Banerjee-Basu S, Berry FB, Baxevanis AD, Walter MA (2001) Analyses of the effects that disease-causing missense mutations have on the structure and function of the winged-helix protein FOXC1. Am J Hum Genet 68:627\u2013641","journal-title":"Am J Hum Genet"},{"key":"9317_CR34","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.1093\/hmg\/ddg324","volume":"12","author":"RA Saleem","year":"2003","unstructured":"Saleem RA, Banerjee-Basu S, Berry FB, Baxevanis AD, Walter MA (2003) Structural and functional analyses of disease-causing missense mutations in the forkhead domain of FOXC1. Hum Mol Genet 12:2993\u20133005","journal-title":"Hum Mol Genet"},{"key":"9317_CR35","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/0012-1606(74)90155-9","volume":"37","author":"LC Stevens","year":"1974","unstructured":"Stevens LC, Varnum DS (1974) The development of teratomas from parthenogenetically activated ovarian mouse eggs. Dev Biol 37:369\u2013380","journal-title":"Dev Biol"},{"key":"9317_CR36","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0925-4773(00)00371-3","volume":"96","author":"M Strodicke","year":"2000","unstructured":"Strodicke M, Karberg S, Korge G (2000) Domina (Dom), a new Drosophila member of the FKH\/WH gene family, affects morphogenesis and is a suppressor of position-effect variegation. Mech Dev 96:67\u201378","journal-title":"Mech Dev"},{"key":"9317_CR37","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1139\/O10-001","volume":"88","author":"XX Sui","year":"2010","unstructured":"Sui XX, Luo LL, Xu JJ, Fu YC (2010) Evidence that FOXO3a is involved in oocyte apoptosis in the neonatal rat ovary. Biochem Cell Biol 88:621\u2013628","journal-title":"Biochem Cell Biol"},{"key":"9317_CR38","doi-asserted-by":"crossref","first-page":"29730","DOI":"10.1074\/jbc.M805514200","volume":"283","author":"WQ Tan","year":"2008","unstructured":"Tan WQ, Wang K, Lv DY, Li PF (2008) Foxo3a inhibits cardiomyocyte hypertrophy through transactivating catalase. J Biol Chem 283:29730\u201329739","journal-title":"J Biol Chem"},{"key":"9317_CR39","doi-asserted-by":"crossref","first-page":"28873","DOI":"10.1074\/jbc.M401138200","volume":"279","author":"A Horst van der","year":"2004","unstructured":"van der Horst A, Tertoolen LG, de Vries-Smits LM, Frye RA, Medema RH, Burgering BM (2004) FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1). J Biol Chem 279:28873\u201328879","journal-title":"J Biol Chem"},{"key":"9317_CR40","doi-asserted-by":"crossref","first-page":"5861","DOI":"10.1021\/bi001663w","volume":"40","author":"J Weigelt","year":"2001","unstructured":"Weigelt J, Climent I, Dahlman-Wright K, Wikstrom M (2001) Solution structure of the DNA binding domain of the human forkhead transcription factor AFX (FOXO4). Biochemistry 40:5861\u20135869","journal-title":"Biochemistry"}],"container-title":["Mammalian Genome"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00335-011-9317-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00335-011-9317-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00335-011-9317-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T10:11:57Z","timestamp":1637316717000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00335-011-9317-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2,24]]},"references-count":40,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["9317"],"URL":"https:\/\/doi.org\/10.1007\/s00335-011-9317-7","relation":{},"ISSN":["0938-8990","1432-1777"],"issn-type":[{"value":"0938-8990","type":"print"},{"value":"1432-1777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2,24]]}}}