{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T01:44:13Z","timestamp":1778636653858,"version":"3.51.4"},"reference-count":210,"publisher":"Springer Science and Business Media LLC","issue":"7-8","license":[{"start":{"date-parts":[[2018,6,19]],"date-time":"2018-06-19T00:00:00Z","timestamp":1529366400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Canadian Institute for Advanced Research (CA)","award":["162216"],"award-info":[{"award-number":["162216"]}]},{"DOI":"10.13039\/501100000030","name":"Institute of Genetics","doi-asserted-by":"publisher","award":["FDN-148369"],"award-info":[{"award-number":["FDN-148369"]}],"id":[{"id":"10.13039\/501100000030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mamm Genome"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1007\/s00335-018-9752-9","type":"journal-article","created":{"date-parts":[[2018,6,19]],"date-time":"2018-06-19T05:48:33Z","timestamp":1529387313000},"page":"488-506","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Genetic analysis of cerebral malaria in the mouse model infected with Plasmodium berghei"],"prefix":"10.1007","volume":"29","author":[{"given":"Sabrina","family":"Torre","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Langlais","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Gros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,6,19]]},"reference":[{"key":"9752_CR1","doi-asserted-by":"publisher","first-page":"19517","DOI":"10.1074\/jbc.M116.746594","volume":"291","author":"J Alferink","year":"2016","unstructured":"Alferink J, Specht S, Arends H et al (2016) Cannabinoid receptor 2 modulates susceptibility to experimental cerebral malaria through a CCL17-dependent Mechanism. J Biol Chem 291:19517\u201319531. https:\/\/doi.org\/10.1074\/jbc.M116.746594","journal-title":"J Biol Chem"},{"key":"9752_CR2","doi-asserted-by":"publisher","first-page":"1646","DOI":"10.1002\/1521-4141(200006)30:6<1646::AID-IMMU1646>3.0.CO;2-0","volume":"30","author":"V Amani","year":"2000","unstructured":"Amani V, Vig\u00e1rio AM, Belnoue E, et al (2000) Involvement of IFN-\u03b3 receptor-mediated signaling in pathology and anti-malarial immunity induced by Plasmodium berghei infection. Eur J Immunol 30:1646\u20131655","journal-title":"Eur J Immunol"},{"key":"9752_CR3","doi-asserted-by":"publisher","first-page":"3632","DOI":"10.4049\/jimmunol.1000944","volume":"185","author":"FH Amante","year":"2010","unstructured":"Amante FH, Haque A, Stanley AC et al (2010) Immune-mediated mechanisms of parasite tissue sequestration during experimental cerebral malaria. J Immunol 185:3632\u20133642. https:\/\/doi.org\/10.4049\/jimmunol.1000944","journal-title":"J Immunol"},{"key":"9752_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1475-2875-13-354","volume":"13","author":"A Baccarella","year":"2014","unstructured":"Baccarella A, Huang BW, Fontana MF, Kim CC (2014) Loss of Toll-like receptor 7 alters cytokine production and protects against experimental cerebral malaria. Malar J 13:1\u20138. https:\/\/doi.org\/10.1186\/1475-2875-13-354","journal-title":"Malar J"},{"key":"9752_CR5","doi-asserted-by":"publisher","first-page":"9919","DOI":"10.1073\/pnas.152215199","volume":"99","author":"S Bagot","year":"2002","unstructured":"Bagot S, Campino S, Penha-Gon\u00e7alves C et al (2002) Identification of two cerebral malaria resistance loci using an inbred wild-derived mouse strain. Proc Natl Acad Sci U S A 99:9919\u20139923. https:\/\/doi.org\/10.1073\/pnas.152215199","journal-title":"Proc Natl Acad Sci U S A"},{"key":"9752_CR6","doi-asserted-by":"publisher","first-page":"2817","DOI":"10.1128\/IAI.72.5.2817","volume":"72","author":"S Bagot","year":"2004","unstructured":"Bagot S, Nogueira F, Collette A et al (2004) Comparative study of brain CD8 + T cells induced by sporozoites and those induced by blood-stage Plasmodium berghei ANKA involved in the development of cerebral malaria. Infect Immun 72:2817\u20132826. https:\/\/doi.org\/10.1128\/IAI.72.5.2817","journal-title":"Infect Immun"},{"key":"9752_CR7","doi-asserted-by":"publisher","first-page":"5118","DOI":"10.4049\/jimmunol.1300114","volume":"190","author":"EA Ball","year":"2013","unstructured":"Ball EA, Sambo MR, Martins M et al (2013) IFNAR1 controls progression to cerebral malaria in children and CD8+ T Cell brain pathology in Plasmodium berghei-infected mice. J Immunol 190:5118\u20135127. https:\/\/doi.org\/10.4049\/jimmunol.1300114","journal-title":"J Immunol"},{"key":"9752_CR8","doi-asserted-by":"publisher","first-page":"e1003509","DOI":"10.1371\/journal.pgen.1003509","volume":"9","author":"G Band","year":"2013","unstructured":"Band G, Le QS, Jostins L et al (2013) Imputation-based meta-analysis of severe malaria in three african populations. PLoS Genet 9:e1003509. https:\/\/doi.org\/10.1371\/journal.pgen.1003509","journal-title":"PLoS Genet"},{"key":"9752_CR9","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1038\/nature15390","volume":"526","author":"G Band","year":"2015","unstructured":"Band G, Rockett KA, Spencer CCA et al (2015) A novel locus of resistance to severe malaria in a region of ancient balancing selection. Nature 526:253\u2013257. https:\/\/doi.org\/10.1038\/nature15390","journal-title":"Nature"},{"key":"9752_CR10","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1038\/382262a0","volume":"382","author":"MDFS Barbosa","year":"1996","unstructured":"Barbosa MDFS., Nguyen QA, Tchernev VT et al (1996) Identification of the homologous beige and Chediak-Higashi syndrome genes. Nature 382:262\u2013265. https:\/\/doi.org\/10.1038\/382262a0","journal-title":"Nature"},{"key":"9752_CR11","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1084\/jem.20071548","volume":"205","author":"W Beghdadi","year":"2008","unstructured":"Beghdadi W, Porcherie A, Schneider BS et al (2008) Inhibition of histamine-mediated signaling confers significant protection against severe malaria in mouse models of disease. J Exp Med 205:395\u2013408. https:\/\/doi.org\/10.1084\/jem.20071548","journal-title":"J Exp Med"},{"key":"9752_CR12","doi-asserted-by":"publisher","unstructured":"Beghdadi W, Porcherie A, Schneider BS et al (2009) Histamine H3 receptor-mediated signaling protects mice from cerebral malaria. PLoS ONE 4:. https:\/\/doi.org\/10.1371\/journal.pone.0006004","DOI":"10.1371\/journal.pone.0006004"},{"key":"9752_CR13","doi-asserted-by":"publisher","first-page":"6369","DOI":"10.4049\/jimmunol.169.11.6369","volume":"169","author":"E Belnoue","year":"2002","unstructured":"Belnoue E, Kayibanda M, Vigario AM et al (2002) On the pathogenic role of brain-sequestered CD8+ T cells in experimental cerebral malaria. J Immunol 169:6369\u20136375. https:\/\/doi.org\/10.4049\/jimmunol.169.11.6369","journal-title":"J Immunol"},{"key":"9752_CR14","doi-asserted-by":"publisher","first-page":"3648","DOI":"10.1128\/IAI.71.6.3648","volume":"71","author":"E Belnoue","year":"2003","unstructured":"Belnoue E, Costa F, Vig\u00e1rio A et al (2003a) Chemokine receptor CCR2 is not essential for the development of experimental cerebral malaria. Infect Immun 71:3648. https:\/\/doi.org\/10.1128\/IAI.71.6.3648","journal-title":"Infect Immun"},{"key":"9752_CR15","doi-asserted-by":"publisher","first-page":"4253","DOI":"10.1182\/blood-2002-05-1493","volume":"101","author":"E Belnoue","year":"2003","unstructured":"Belnoue E, Kayibanda M, Deschemin JC et al (2003b) CCR5 deficiency decreases susceptibility to experimental cerebral malaria. Blood 101:4253\u20134259. https:\/\/doi.org\/10.1182\/blood-2002-05-1493","journal-title":"Blood"},{"key":"9752_CR16","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1111\/j.1365-3024.2008.01053.x","volume":"30","author":"E Belnoue","year":"2008","unstructured":"Belnoue E, Potter SM, Rosa DS et al (2008) Control of pathogenic CD8 + T cell migration to the brain by IFN-\u03b3 during experimental cerebral malaria. Parasite Immunol 30:544\u2013553. https:\/\/doi.org\/10.1111\/j.1365-3024.2008.01053.x","journal-title":"Parasite Immunol"},{"key":"9752_CR17","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1038\/gene.2009.79","volume":"11","author":"J Berghout","year":"2010","unstructured":"Berghout J, Min-Oo G, Tam M et al (2010) Identification of a novel cerebral malaria susceptibility locus (Berr5) on mouse chromosome 19. Genes Immun 11:310\u2013318. https:\/\/doi.org\/10.1038\/gene.2009.79","journal-title":"Genes Immun"},{"key":"9752_CR18","doi-asserted-by":"publisher","first-page":"e1003491","DOI":"10.1371\/journal.ppat.1003491","volume":"9","author":"J Berghout","year":"2013","unstructured":"Berghout J, Langlais D, Radovanovic I et al (2013) Irf8-regulated genomic responses drive pathological inflammation during cerebral malaria. PLoS Pathog 9:e1003491. https:\/\/doi.org\/10.1371\/journal.ppat.1003491","journal-title":"PLoS Pathog"},{"key":"9752_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/ncomms6966","volume":"6","author":"RC Betz","year":"2015","unstructured":"Betz RC, Petukhova L, Ripke S et al (2015) Genome-wide meta-analysis in alopecia areata resolves HLA associations and reveals two new susceptibility loci. Nat Commun 6:1\u20138. https:\/\/doi.org\/10.1038\/ncomms6966","journal-title":"Nat Commun"},{"key":"9752_CR20","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.pt.2009.05.012","volume":"25","author":"SE Bongfen","year":"2009","unstructured":"Bongfen SE, Laroque A, Berghout J, Gros P (2009) Genetic and genomic analyses of host-pathogen interactions in malaria. Trends Parasitol 25:417\u2013422","journal-title":"Trends Parasitol"},{"key":"9752_CR21","doi-asserted-by":"publisher","first-page":"e31012","DOI":"10.1371\/journal.pone.0031012","volume":"7","author":"SE Bongfen","year":"2012","unstructured":"Bongfen SE, Rodrigue-Gervais IG, Berghout J et al (2012) An N-ethyl-N-nitrosourea (ENU)-induced dominant negative mutation in the JAK3 kinase protects against cerebral malaria. PLoS ONE 7:e31012. https:\/\/doi.org\/10.1371\/journal.pone.0031012","journal-title":"PLoS ONE"},{"key":"9752_CR22","doi-asserted-by":"publisher","first-page":"e10903","DOI":"10.1371\/journal.pone.0010903","volume":"5","author":"SER Bopp","year":"2010","unstructured":"Bopp SER, Ramachandran V, Henson K et al (2010) Genome wide analysis of inbred mouse lines identifies a locus containing ppar-\u03b3 as contributing to enhanced malaria survival. PLoS ONE 5:e10903. https:\/\/doi.org\/10.1371\/journal.pone.0010903","journal-title":"PLoS ONE"},{"key":"9752_CR23","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1186\/1475-2875-12-316","volume":"12","author":"SE Bopp","year":"2013","unstructured":"Bopp SE, Rodrigo E, Gonz\u00e1lez-P\u00e1ez GE et al (2013) Identification of the Plasmodium berghei resistance locus 9 linked to survival on chromosome 9. Malar J 12:316. https:\/\/doi.org\/10.1186\/1475-2875-12-316","journal-title":"Malar J"},{"key":"9752_CR24","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1093\/intimm\/11.9.1553","volume":"11","author":"MI Boubou","year":"1999","unstructured":"Boubou MI, Collette A, Voegtl\u00e9 D et al (1999) T cell response in malaria pathogenesis: Selective increase in T cells carrying the TCR V(\u03b2)8 during experimental cerebral malaria. Int Immunol 11:1553\u20131562. https:\/\/doi.org\/10.1093\/intimm\/11.9.1553","journal-title":"Int Immunol"},{"key":"9752_CR25","doi-asserted-by":"publisher","first-page":"3127","DOI":"10.1128\/IAI.01733-14","volume":"82","author":"F Brant","year":"2014","unstructured":"Brant F, Miranda AS, Esper L et al (2014) Role of the aryl hydrocarbon receptor in the immune response profile and development of pathology during Plasmodium berghei Anka infection. Infect Immun 82:3127\u20133140. https:\/\/doi.org\/10.1128\/IAI.01733-14","journal-title":"Infect Immun"},{"key":"9752_CR26","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.bbi.2016.01.002","volume":"54","author":"F Brant","year":"2016","unstructured":"Brant F, Miranda AS, Esper L et al (2016) Suppressor of cytokine signaling 2 modulates the immune response profile and development of experimental cerebral malaria. Brain Behav Immun 54:73\u201385. https:\/\/doi.org\/10.1016\/j.bbi.2016.01.002","journal-title":"Brain Behav Immun"},{"key":"9752_CR27","doi-asserted-by":"publisher","first-page":"7535","DOI":"10.1074\/jbc.M110.201236","volume":"286","author":"C Brockmeyer","year":"2011","unstructured":"Brockmeyer C, Paster W, Pepper D et al (2011) T cell receptor (TCR)-induced tyrosine phosphorylation dynamics identifies THEMIS as a new TCR signalosome component. J Biol Chem 286:7535\u20137547. https:\/\/doi.org\/10.1074\/jbc.M110.201236","journal-title":"J Biol Chem"},{"key":"9752_CR28","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1046\/j.1365-3024.2003.00616.x","volume":"25","author":"DVR Bullen","year":"2003","unstructured":"Bullen DVR, Hansen DS, Siomos MAV et al (2003) The lack of suppressor of cytokine signalling-1 (SOCS1) protects mice from the development of cerebral malaria caused by Plasmodium berghei ANKA. Parasite Immunol 25:113\u2013118. https:\/\/doi.org\/10.1046\/j.1365-3024.2003.00616.x","journal-title":"Parasite Immunol"},{"key":"9752_CR29","doi-asserted-by":"publisher","first-page":"887","DOI":"10.3390\/genes5040887","volume":"5","author":"G Caignard","year":"2014","unstructured":"Caignard G, Eva MM, Van Bruggen R et al (2014) Mouse ENU mutagenesis to understand immunity to infection: methods, selected examples, and perspectives. Genes (Basel) 5:887\u2013925","journal-title":"Genes (Basel)"},{"key":"9752_CR30","doi-asserted-by":"publisher","first-page":"4814","DOI":"10.1073\/pnas.0801544105","volume":"105","author":"GSV Campanella","year":"2008","unstructured":"Campanella GSV, Tager AM, El Khoury JK et al (2008) Chemokine receptor CXCR3 and its ligands CXCL9 and CXCL10 are required for the development of murine cerebral malaria. Proc Natl Acad Sci U S A 105:4814\u20134819. https:\/\/doi.org\/10.1073\/pnas.0801544105","journal-title":"Proc Natl Acad Sci U S A"},{"key":"9752_CR31","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1038\/sj.gene.6364219","volume":"6","author":"S Campino","year":"2005","unstructured":"Campino S, Bagot S, Bergman ML et al (2005) Genetic control of parasite clearance leads to resistance to Plasmodium berghei ANKA infection and confers immunity. Genes Immun 6:416\u2013421. https:\/\/doi.org\/10.1038\/sj.gene.6364219","journal-title":"Genes Immun"},{"key":"9752_CR32","doi-asserted-by":"crossref","first-page":"3996","DOI":"10.1182\/blood.V90.10.3996","volume":"90","author":"BF Candotti","year":"1997","unstructured":"Candotti BF, Oakes SA, Johnston JA et al (1997) Structural and functional basis for JAK3-deficient severe combined immunodeficiency. Blood 90:3996\u20134003","journal-title":"Blood"},{"key":"9752_CR33","doi-asserted-by":"publisher","first-page":"1911","DOI":"10.1128\/IAI.71.4.1911-1918.2003","volume":"71","author":"WL Chang","year":"2003","unstructured":"Chang WL, Li J, Sun G et al (2003) P-selectin contributes to severe experimental malaria but is not required for leukocyte adhesion to brain microvasculature. Infect Immun 71:1911\u20131918. https:\/\/doi.org\/10.1128\/IAI.71.4.1911-1918.2003","journal-title":"Infect Immun"},{"key":"9752_CR34","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1186\/1475-2875-5-85","volume":"5","author":"IA Clark","year":"2006","unstructured":"Clark IA, Budd AC, Alleva LM, Cowden WB (2006) Human malarial disease: a consequence of inflammatory cytokine release. Malar J 5:85. https:\/\/doi.org\/10.1186\/1475-2875-5-85","journal-title":"Malar J"},{"key":"9752_CR35","doi-asserted-by":"publisher","first-page":"e18720","DOI":"10.1371\/journal.pone.0018720","volume":"6","author":"C Claser","year":"2011","unstructured":"Claser C, Malleret B, Gun SY et al (2011) CD8 + T cells and IFN-\u03b3 mediate the time-dependent accumulation of infected red blood cells in deep organs during experimental cerebral malaria. PLoS ONE 6:e18720. https:\/\/doi.org\/10.1371\/journal.pone.0018720","journal-title":"PLoS ONE"},{"key":"9752_CR36","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1093\/intimm\/dxl123","volume":"19","author":"C Coban","year":"2007","unstructured":"Coban C, Ishii KJ, Uematsu S et al (2007) Pathological role of Toll-like receptor signaling in cerebral malaria. Int Immunol 19:67\u201379. https:\/\/doi.org\/10.1093\/intimm\/dxl123","journal-title":"Int Immunol"},{"key":"9752_CR37","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1016\/S0002-9440(10)63166-5","volume":"164","author":"V Combes","year":"2004","unstructured":"Combes V, Rosenkranz AR, Redard M et al (2004) Pathogenic role of P-selectin in experimental cerebral malaria: importance of the endothelial compartment. Am J Pathol 164:781\u2013786. https:\/\/doi.org\/10.1016\/S0002-9440(10)63166-5","journal-title":"Am J Pathol"},{"key":"9752_CR38","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/S0002-9440(10)62253-5","volume":"166","author":"V Combes","year":"2005","unstructured":"Combes V, Coltel N, Alibert M et al (2005) ABCA1 Gene Deletion Protects against Cerebral Malaria. Am J Pathol 166:295\u2013302. https:\/\/doi.org\/10.1016\/S0002-9440(10)62253-5","journal-title":"Am J Pathol"},{"key":"9752_CR39","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1016\/j.cell.2006.02.006","volume":"124","author":"AF Cowman","year":"2006","unstructured":"Cowman AF, Crabb BS (2006) Invasion of red blood cells by malaria parasites. Cell 124:755\u2013766","journal-title":"Cell"},{"key":"9752_CR40","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/1756-3305-3-5","volume":"3","author":"FE Cox","year":"2010","unstructured":"Cox FE (2010) History of the discovery of the malaria parasites and their vectors. Parasites Vectors 3:5","journal-title":"Parasites Vectors"},{"key":"9752_CR41","doi-asserted-by":"publisher","first-page":"e1002401","DOI":"10.1371\/journal.ppat.1002401","volume":"8","author":"AG Craig","year":"2012","unstructured":"Craig AG, Grau GE, Janse C et al (2012) The role of animal models for research on severe malaria. PLoS Pathog 8:e1002401. https:\/\/doi.org\/10.1371\/journal.ppat.1002401","journal-title":"PLoS Pathog"},{"key":"9752_CR42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2180-6-73","volume":"6","author":"M Cunha-Rodrigues","year":"2006","unstructured":"Cunha-Rodrigues M, Portugal S, Febbraio M, Mota MM (2006) Infection by and protective immune responses against Plasmodium berghei ANKA are not affected in macrophage scavenger receptors A deficient mice. BMC Microbiol 6:1\u20135. https:\/\/doi.org\/10.1186\/1471-2180-6-73","journal-title":"BMC Microbiol"},{"key":"9752_CR43","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1111\/j.1365-3024.2012.01376.x","volume":"34","author":"MM Darley","year":"2012","unstructured":"Darley MM, Ramos TN, Wetsel RA, Barnum SR (2012) Deletion of carboxypeptidase N delays onset of experimental cerebral malaria. Parasite Immunol 34:444\u2013447. https:\/\/doi.org\/10.1111\/j.1365-3024.2012.01376.x","journal-title":"Parasite Immunol"},{"key":"9752_CR44","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/S1286-4579(02)01541-1","volume":"4","author":"J Souza De","year":"2002","unstructured":"De Souza J, Riley E (2002) Cerebral malaria: the contribution of studies in animal models to our understanding of immunopathogenesis. Microbes Infect 4:291\u2013300","journal-title":"Microbes Infect"},{"key":"9752_CR45","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1017\/S0031182009991715","volume":"137","author":"J Souza De","year":"2010","unstructured":"De Souza J, Hafalla J, Riley E, Couper K (2010) Cerebral malaria: Why experimental murine models are required to understand the pathogenesis of disease. Parasitology 137:755\u2013772","journal-title":"Parasitology"},{"key":"9752_CR46","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/S0169-4758(00)01666-5","volume":"16","author":"AM Dondorp","year":"2000","unstructured":"Dondorp AM, Kager PA, Vreeken J, White NJ (2000) Abnormal blood flow and red blood cell deformability in severe malaria. Parasitol Today 16:228\u2013232. https:\/\/doi.org\/10.1016\/S0169-4758(00)01666-5","journal-title":"Parasitol Today"},{"key":"9752_CR47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0006510","volume":"4","author":"C Dostert","year":"2009","unstructured":"Dostert C, Guarda G, Romero JF et al (2009) Malarial hemozoin is a Nalp3 inflammasome activating danger signal. PLoS One 4:1\u201310. https:\/\/doi.org\/10.1371\/journal.pone.0006510","journal-title":"PLoS One"},{"key":"9752_CR48","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1186\/1475-2875-10-271","volume":"10","author":"A Driss","year":"2011","unstructured":"Driss A, Hibbert JM, Wilson NO et al (2011) Genetic polymorphisms linked to susceptibility to malaria. Malar J 10:271. https:\/\/doi.org\/10.1186\/1475-2875-10-271","journal-title":"Malar J"},{"key":"9752_CR49","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1038\/ng.543","volume":"42","author":"PCA Dubois","year":"2010","unstructured":"Dubois PCA, Trynka G, Franke L et al (2010) Multiple common variants for celiac disease influencing immune gene expression. Nat Genet 42:295\u2013302. https:\/\/doi.org\/10.1038\/ng.543","journal-title":"Nat Genet"},{"key":"9752_CR50","doi-asserted-by":"publisher","unstructured":"Dunst J, Kamena F, Matuschewski K (2017) Cytokines and Chemokines in Cerebral Malaria Pathogenesis. Front Cell Infect Microbiol 7:. https:\/\/doi.org\/10.3389\/fcimb.2017.00324","DOI":"10.3389\/fcimb.2017.00324"},{"key":"9752_CR51","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1002\/eji.201444824","volume":"45","author":"CL Edwards","year":"2015","unstructured":"Edwards CL, Best SE, Gun SY et al (2015) Spatiotemporal requirements for IRF7 in mediating type I IFN-dependent susceptibility to blood-stage Plasmodium infection. Eur J Immunol 45:130\u2013141. https:\/\/doi.org\/10.1002\/eji.201444824","journal-title":"Eur J Immunol"},{"key":"9752_CR52","doi-asserted-by":"publisher","first-page":"3984","DOI":"10.1128\/IAI.00428-13","volume":"81","author":"F El-Assaad","year":"2013","unstructured":"El-Assaad F, Wheway J, Mitchell AJ et al (2013) Cytoadherence of plasmodium berghei-infected red blood cells to murine brain and lung microvascular endothelial cells in vitro. Infect Immun 81:3984\u20133991. https:\/\/doi.org\/10.1128\/IAI.00428-13","journal-title":"Infect Immun"},{"key":"9752_CR53","doi-asserted-by":"publisher","first-page":"92","DOI":"10.14440\/jbm.2015.54.A","volume":"2","author":"F El-Assaad","year":"2014","unstructured":"El-Assaad F, Combes V, Grau GE (2014) Experimental models of microvascular immunopathology: the example of cerebral malaria. J Neuroinfect Dis 2:92\u201394. https:\/\/doi.org\/10.14440\/jbm.2015.54.A","journal-title":"J Neuroinfect Dis"},{"key":"9752_CR54","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1016\/j.ajhg.2012.02.020","volume":"90","author":"D Ellinghaus","year":"2012","unstructured":"Ellinghaus D, Ellinghaus E, Nair RP et al (2012) Combined analysis of genome-wide association studies for Crohn disease and psoriasis identifies seven shared susceptibility loci. Am J Hum Genet 90:636\u2013647. https:\/\/doi.org\/10.1016\/j.ajhg.2012.02.020","journal-title":"Am J Hum Genet"},{"key":"9752_CR55","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1128\/IAI.00371-17","volume":"85","author":"RE Elphinstone","year":"2017","unstructured":"Elphinstone RE, Besla R, Shikatani EA et al (2017) S-Nitrosoglutathione reductase deficiency confers improved survival and neurological outcome in experimental cerebral malaria. Infect Immun 85:1\u201312. https:\/\/doi.org\/10.1128\/IAI.00371-17","journal-title":"Infect Immun"},{"key":"9752_CR56","doi-asserted-by":"publisher","unstructured":"Engelhardt KR, McGhee S, Winkler S et al (2009) Large deletions and point mutations involving the dedicator of cytokinesis 8 (DOCK8) in the autosomal-recessive form of hyper-IgE syndrome. J Allergy Clin Immunol 124:. https:\/\/doi.org\/10.1016\/j.jaci.2009.10.038","DOI":"10.1016\/j.jaci.2009.10.038"},{"key":"9752_CR57","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1084\/jem.20020128","volume":"195","author":"CR Engwerda","year":"2002","unstructured":"Engwerda CR, Mynott TL, Sawhney S et al (2002) Locally up-regulated lymphotoxin alpha, not systemic tumor necrosis factor alpha, is the principle mediator of murine cerebral malaria. J Exp Med 195:1371\u20131377. https:\/\/doi.org\/10.1084\/jem.20020128","journal-title":"J Exp Med"},{"key":"9752_CR58","first-page":"103","volume":"297","author":"C Engwerda","year":"2005","unstructured":"Engwerda C, Belnoue E, Gruner AC, Renia L (2005) Experimental models of cerebral malaria. Curr Top Microbiol Immunol 297:103\u2013143","journal-title":"Curr Top Microbiol Immunol"},{"key":"9752_CR59","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0080723","volume":"8","author":"AR Everitt","year":"2013","unstructured":"Everitt AR, Clare S, McDonald JU et al (2013) Defining the range of pathogens susceptible to ifitm3 restriction using a knockout mouse model. PLoS One 8:1\u201312. https:\/\/doi.org\/10.1371\/journal.pone.0080723","journal-title":"PLoS One"},{"key":"9752_CR60","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.ajpath.2010.11.008","volume":"178","author":"M Fauconnier","year":"2011","unstructured":"Fauconnier M, Bourigault M-L, Meme S et al (2011) Protein kinase C-Theta is required for development of experimental cerebral malaria. Am J Pathol 178:212\u2013221. https:\/\/doi.org\/10.1016\/j.ajpath.2010.11.008","journal-title":"Am J Pathol"},{"key":"9752_CR61","doi-asserted-by":"publisher","first-page":"1905","DOI":"10.4049\/jimmunol.1101978","volume":"188","author":"M Fauconnier","year":"2012","unstructured":"Fauconnier M, Palomo J, Bourigault M-L et al (2012) IL-12R 2 Is essential for the development of experimental cerebral malaria. J Immunol 188:1905\u20131914. https:\/\/doi.org\/10.4049\/jimmunol.1101978","journal-title":"J Immunol"},{"key":"9752_CR62","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1016\/S1286-4579(99)80513-9","volume":"1","author":"N Favre","year":"1999","unstructured":"Favre N, Da Laperousaz C, Ryffel B et al (1999a) Role of ICAM-1 (CD54) in the development of murine cerebral malaria. Microbes Infect 1:961\u2013968. https:\/\/doi.org\/10.1016\/S1286-4579(99)80513-9","journal-title":"Microbes Infect"},{"key":"9752_CR63","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1017\/S0031182098003606","volume":"118","author":"N Favre","year":"1999","unstructured":"Favre N, Ryffel B, Rudin W (1999b) The development of murine cerebral malaria does not require nitric oxide production. Parasitology 118:135\u2013138. https:\/\/doi.org\/10.1017\/S0031182098003606","journal-title":"Parasitology"},{"key":"9752_CR64","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-017-01381-y","volume":"8","author":"N Fodil","year":"2017","unstructured":"Fodil N, Moradin N, Leung V et al (2017) CCDC88B is required for pathogenesis of inflammatory bowel disease. Nat Commun 8:1\u201312. https:\/\/doi.org\/10.1038\/s41467-017-01381-y","journal-title":"Nat Commun"},{"key":"9752_CR65","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1038\/18997","volume":"398","author":"J Frank","year":"1999","unstructured":"Frank J, Pignata C, Panteleyev AA et al (1999) Exposing the human nude phenotype. Nature 398:473\u2013474. https:\/\/doi.org\/10.1038\/18997","journal-title":"Nature"},{"key":"9752_CR66","doi-asserted-by":"publisher","first-page":"11468","DOI":"10.1073\/pnas.0503386102","volume":"102","author":"B Franke-Fayard","year":"2005","unstructured":"Franke-Fayard B, Janse CJ, Cunha-Rodrigues M et al (2005) From the cover: murine malaria parasite sequestration: CD36 is the major receptor, but cerebral pathology is unlinked to sequestration. Proc Natl Acad Sci 102:11468\u201311473. https:\/\/doi.org\/10.1073\/pnas.0503386102","journal-title":"Proc Natl Acad Sci"},{"key":"9752_CR67","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1038\/nri3742","volume":"14","author":"RT Gazzinelli","year":"2014","unstructured":"Gazzinelli RT, Kalantari P, Fitzgerald KA, Golenbock DT (2014) Innate sensing of malaria parasites. Nat Rev Immunol 14:744\u2013757","journal-title":"Nat Rev Immunol"},{"key":"9752_CR68","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1172\/JCI3205","volume":"102","author":"FD Goldman","year":"1998","unstructured":"Goldman FD, Ballas ZK, Schutte BC et al (1998) Defective p56lck expression in an Infant with SCID defective expression of p56lck in an infant with severe combined immunodeficiency. J Clin Invest 102:421\u2013429. https:\/\/doi.org\/10.1172\/JCI3205","journal-title":"J Clin Invest"},{"key":"9752_CR69","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1038\/nm1499","volume":"12","author":"I Gramaglia","year":"2006","unstructured":"Gramaglia I, Sobolewski P, Meays D et al (2006) Low nitric oxide bioavailability contributes to the genesis of experimental cerebral malaria. Nat Med 12:1417\u20131422. https:\/\/doi.org\/10.1038\/nm1499","journal-title":"Nat Med"},{"key":"9752_CR70","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1086\/522865","volume":"196","author":"JW Griffith","year":"2007","unstructured":"Griffith JW, O\u2019Connor C, Bernard K et al (2007) Toll-like receptor modulation of murine cerebral malaria is dependent on the genetic background of the host. J Infect Dis 196:1553\u20131564. https:\/\/doi.org\/10.1086\/522865","journal-title":"J Infect Dis"},{"key":"9752_CR71","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.1128\/IAI.02701-14","volume":"83","author":"J Guo","year":"2015","unstructured":"Guo J, McQuillan JA, Yau B et al (2015) IRGM3 contributes to immunopathology and is required for differentiation of antigen-specific effector CD8+ T cells in experimental cerebral malaria. Infect Immun 83:1406\u20131417. https:\/\/doi.org\/10.1128\/IAI.02701-14","journal-title":"Infect Immun"},{"key":"9752_CR72","doi-asserted-by":"publisher","first-page":"3984","DOI":"10.4049\/jimmunol.1402897","volume":"194","author":"H Ham","year":"2015","unstructured":"Ham H, Huynh W, Schoon R et al (2015) HkRP3 Is a microtubule-binding protein regulating lytic granule clustering and NK cell killing. J Immunol 194:3984\u20133996. https:\/\/doi.org\/10.4049\/jimmunol.1402897","journal-title":"J Immunol"},{"key":"9752_CR73","doi-asserted-by":"publisher","first-page":"e1003045","DOI":"10.1371\/journal.ppat.1003045","volume":"8","author":"DS Hansen","year":"2012","unstructured":"Hansen DS (2012) Inflammatory responses associated with the induction of cerebral malaria: lessons from experimental murine models. PLoS Pathog 8:e1003045. https:\/\/doi.org\/10.1371\/journal.ppat.1003045","journal-title":"PLoS Pathog"},{"key":"9752_CR74","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/S1074-7613(03)00052-9","volume":"18","author":"DS Hansen","year":"2003","unstructured":"Hansen DS, Siomos MA, Buckingham L et al (2003) Regulation of murine cerebral malaria pathogenesis by CD1d-restricted NKT cells and the natural killer complex. Immunity 18:391\u2013402. https:\/\/doi.org\/10.1016\/S1074-7613(03)00052-9","journal-title":"Immunity"},{"key":"9752_CR75","doi-asserted-by":"publisher","first-page":"6148","DOI":"10.4049\/jimmunol.1003955","volume":"186","author":"A Haque","year":"2011","unstructured":"Haque A, Best SE, Unosson K et al (2011) Granzyme B Expression by CD8 + T Cells Is Required for the Development of Experimental Cerebral Malaria. J Immunol 186:6148\u20136156. https:\/\/doi.org\/10.4049\/jimmunol.1003955","journal-title":"J Immunol"},{"key":"9752_CR76","doi-asserted-by":"publisher","first-page":"5364","DOI":"10.1128\/IAI.68.9.5364-5376.2000","volume":"68","author":"J Hearn","year":"2000","unstructured":"Hearn J, Rayment N, Landon DN et al (2000) Immunopathology of cerebral malaria: Morphological evidence of parasite sequestration in murine brain microvasculature. Infect Immun 68:5364\u20135376. https:\/\/doi.org\/10.1128\/IAI.68.9.5364-5376.2000","journal-title":"Infect Immun"},{"key":"9752_CR77","doi-asserted-by":"publisher","first-page":"1939","DOI":"10.1016\/j.ajpath.2011.06.027","volume":"179","author":"C Hempel","year":"2011","unstructured":"Hempel C, Combes V, Hunt NH et al (2011) CNS hypoxia is more pronounced in murine cerebral than noncerebral malaria and is reversed by erythropoietin. Am J Pathol 179:1939\u20131950. https:\/\/doi.org\/10.1016\/j.ajpath.2011.06.027","journal-title":"Am J Pathol"},{"key":"9752_CR78","doi-asserted-by":"publisher","unstructured":"Herbas MS, Okazaki M, Terao E et al (2010) a-Tocopherol transfer protein inhibition is effective in the prevention of cerebral malaria in mice 1\u20133. 200\u2013207. https:\/\/doi.org\/10.3945\/ajcn.2009.28260.200","DOI":"10.3945\/ajcn.2009.28260.200"},{"key":"9752_CR79","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1152\/physiolgenomics.00044.2013","volume":"46","author":"M Hernandez-Valladares","year":"2014","unstructured":"Hernandez-Valladares M, Rihet P, Iraqi FA (2014) Host susceptibility to malaria in human and mice: compatible approaches to identify potential resistant genes. Physiol Genomics 46:1\u201316. https:\/\/doi.org\/10.1152\/physiolgenomics.00044.2013","journal-title":"Physiol Genomics"},{"key":"9752_CR80","doi-asserted-by":"publisher","first-page":"1934","DOI":"10.1126\/science.1102737","volume":"306","author":"NL Hiller","year":"2004","unstructured":"Hiller NL, Bhattacharjee S, Van Ooij C et al (2004) A host-targeting signal in virulence proteins reveals a secretome in malarial infection. Science 306:1934\u20131937. https:\/\/doi.org\/10.1126\/science.1102737","journal-title":"Science"},{"key":"9752_CR81","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1007\/s11011-015-9787-5","volume":"31","author":"R Hora","year":"2016","unstructured":"Hora R, Kapoor P, Thind KK, Mishra PC (2016) Cerebral malaria \u2013 clinical manifestations and pathogenesis. Metab Brain Dis 31:225\u2013237. https:\/\/doi.org\/10.1007\/s11011-015-9787-5","journal-title":"Metab Brain Dis"},{"key":"9752_CR82","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1007\/s00281-015-0476-6","volume":"37","author":"SW Howland","year":"2015","unstructured":"Howland SW, Claser C, Poh CM et al (2015) Pathogenic CD8 + T cells in experimental cerebral malaria. Semin Immunopathol 37:221\u2013231. https:\/\/doi.org\/10.1007\/s00281-015-0476-6","journal-title":"Semin Immunopathol"},{"key":"9752_CR83","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1186\/1475-2875-10-90","volume":"10","author":"L Hulden","year":"2011","unstructured":"Hulden L, Hulden L, Hay S et al (2011) Activation of the hypnozoite: a part of Plasmodium vivax life cycle and survival. Malar J 10:90. https:\/\/doi.org\/10.1186\/1475-2875-10-90","journal-title":"Malar J"},{"key":"9752_CR84","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/S1471-4906(03)00229-1","volume":"24","author":"NH Hunt","year":"2003","unstructured":"Hunt NH, Grau GE (2003a) Cytokines: Accelerators and brakes in the pathogenesis of cerebral malaria. Trends Immunol 24:491\u2013499. https:\/\/doi.org\/10.1016\/S1471-4906(03)00229-1","journal-title":"Trends Immunol"},{"key":"9752_CR85","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/S1471-4906(03)00229-1","volume":"24","author":"NH Hunt","year":"2003","unstructured":"Hunt NH, Grau GE (2003b) Cytokines: Accelerators and brakes in the pathogenesis of cerebral malaria. Trends Immunol 24:491\u2013499","journal-title":"Trends Immunol"},{"key":"9752_CR86","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1179\/135100001101536508","volume":"6","author":"NH Hunt","year":"2001","unstructured":"Hunt NH, Driussi C, Sai-Kiang L (2001) Haptoglobin and malaria. Redox Rep 6:389\u2013392. https:\/\/doi.org\/10.1179\/135100001101536508","journal-title":"Redox Rep"},{"key":"9752_CR87","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/j.ijpara.2006.02.016","volume":"36","author":"NH Hunt","year":"2006","unstructured":"Hunt NH, Golenser J, Chan-Ling T et al (2006) Immunopathogenesis of cerebral malaria. Int J Parasitol 36:569\u2013582","journal-title":"Int J Parasitol"},{"key":"9752_CR88","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.4049\/jimmunol.1501562","volume":"196","author":"LJ Ioannidis","year":"2016","unstructured":"Ioannidis LJ, Nie CQ, Ly A et al (2016) Monocyte- and neutrophil-derived CXCL10 Impairs efficient control of blood-stage malaria infection and promotes severe disease. J Immunol 196:1227\u20131238. https:\/\/doi.org\/10.4049\/jimmunol.1501562","journal-title":"J Immunol"},{"key":"9752_CR89","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1016\/j.bbrc.2010.10.114","volume":"402","author":"H Ishida","year":"2010","unstructured":"Ishida H, Matsuzaki-Moriya C, Imai T et al (2010) Development of experimental cerebral malaria is independent of IL-23 and IL-17. Biochem Biophys Res Commun 402:790\u2013795. https:\/\/doi.org\/10.1016\/j.bbrc.2010.10.114","journal-title":"Biochem Biophys Res Commun"},{"key":"9752_CR90","doi-asserted-by":"publisher","first-page":"645","DOI":"10.4269\/ajtmh.2004.70.645","volume":"70","author":"S Ishikawa","year":"2004","unstructured":"Ishikawa S, Uozumi N, Shiibashi T et al (2004) Short report: Lethal malaria in cytosolic phospholipase A2- and phospholipase A2IIA-deficient mice. Am J Trop Med Hyg 70:645\u2013650","journal-title":"Am J Trop Med Hyg"},{"key":"9752_CR91","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1038\/ng.388","volume":"41","author":"M Jallow","year":"2009","unstructured":"Jallow M, Teo YY, Small KS et al (2009) Genome-wide and fine-resolution association analysis of malaria in West Africa. Nat Genet 41:657\u2013665. https:\/\/doi.org\/10.1038\/ng.388","journal-title":"Nat Genet"},{"key":"9752_CR92","volume-title":"Disease and Mortality in Sub-Saharan Africa","author":"DT Jamison","year":"2006","unstructured":"Jamison DT, Feachem RG, Makgoba MW et al (2006) Disease and Mortality in Sub-Saharan Africa. The International Bank for Reconstruction and Development\/The World Bank, Washington (DC)"},{"key":"9752_CR93","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1038\/nature11582","volume":"491","author":"L Jostins","year":"2012","unstructured":"Jostins L, Ripke S, Weersma RK et al (2012) Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature 491:119\u2013124. https:\/\/doi.org\/10.1038\/nature11582","journal-title":"Nature"},{"key":"9752_CR94","doi-asserted-by":"publisher","first-page":"69","DOI":"10.4269\/ajtmh.2010.09-0753","volume":"83","author":"KC Kain","year":"2010","unstructured":"Kain KC, Yeh W-C, Liles WC et al (2010) Divergent Roles of IRAK4-Mediated Innate Immune Responses in Two Experimental Models of Severe Malaria. Am J Trop Med Hyg 83:69\u201374. https:\/\/doi.org\/10.4269\/ajtmh.2010.09-0753","journal-title":"Am J Trop Med Hyg"},{"key":"9752_CR95","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/srep33615","volume":"6","author":"FA Kassa","year":"2016","unstructured":"Kassa FA, Van Den Ham K, Rainone A et al (2016) Absence of apolipoprotein e protects mice from cerebral malaria. Sci Rep 6:1\u201313. https:\/\/doi.org\/10.1038\/srep33615","journal-title":"Sci Rep"},{"key":"9752_CR96","doi-asserted-by":"publisher","first-page":"2519","DOI":"10.1084\/jem.20140455","volume":"211","author":"JM Kennedy","year":"2014","unstructured":"Kennedy JM, Fodil N, Torre S et al (2014) CCDC88B is a novel regulator of maturation and effector functions of T cells during pathological inflammation. J Exp Med 211:2519\u20132535. https:\/\/doi.org\/10.1084\/jem.20140455","journal-title":"J Exp Med"},{"key":"9752_CR97","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1128\/IAI.01246-13","volume":"82","author":"H Kim","year":"2014","unstructured":"Kim H, Erdman LK, Lu Z et al (2014) Functional roles for C5a and C5aR but not C5L2 in the pathogenesis of human and experimental cerebral malaria. Infect Immun 82:371\u2013379. https:\/\/doi.org\/10.1128\/IAI.01246-13","journal-title":"Infect Immun"},{"key":"9752_CR98","doi-asserted-by":"publisher","first-page":"3633","DOI":"10.1128\/IAI.05459-11","volume":"79","author":"M Kordes","year":"2011","unstructured":"Kordes M, Matuschewski K, Hafalla JCR (2011) Caspase-1 activation of interleukin-1\u03b2 (IL-1\u03b2) And IL-18 Is Dispensable for Induction of Experimental Cerebral Malaria. Infect Immun 79:3633\u20133641. https:\/\/doi.org\/10.1128\/IAI.05459-11","journal-title":"Infect Immun"},{"key":"9752_CR99","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1086\/432519","volume":"77","author":"DP Kwiatkowski","year":"2005","unstructured":"Kwiatkowski DP (2005) How malaria has affected the human genome and what human genetics can teach us about malaria. Am J Hum Genet 77:171\u2013192. https:\/\/doi.org\/10.1086\/432519","journal-title":"Am J Hum Genet"},{"key":"9752_CR100","doi-asserted-by":"publisher","first-page":"5495","DOI":"10.4049\/jimmunol.1002517","volume":"185","author":"K Labbe","year":"2010","unstructured":"Labbe K, Miu J, Yeretssian G et al (2010) Caspase-12 dampens the immune response to malaria independently of the inflammasome by targeting NF- B signaling. J Immunol 185:5495\u20135502. https:\/\/doi.org\/10.4049\/jimmunol.1002517","journal-title":"J Immunol"},{"key":"9752_CR101","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.ajpath.2011.09.038","volume":"180","author":"N Lacerda-Queiroz","year":"2012","unstructured":"Lacerda-Queiroz N, Rodrigues DH, Vilela MC et al (2012) Platelet-activating factor receptor is essential for the development of experimental cerebral malaria. Ajpa 180:246\u2013255. https:\/\/doi.org\/10.1016\/j.ajpath.2011.09.038","journal-title":"Ajpa"},{"key":"9752_CR102","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0119633","volume":"10","author":"N Lacerda-Queiroz","year":"2015","unstructured":"Lacerda-Queiroz N, Brant F, Rodrigues DH et al (2015) Phosphatidylinositol 3-kinase ? is required for the development of experimental cerebral malaria. PLoS ONE 10:1\u201313. https:\/\/doi.org\/10.1371\/journal.pone.0119633","journal-title":"PLoS ONE"},{"key":"9752_CR103","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.1038\/ng.2802","volume":"45","author":"JC Lambert","year":"2013","unstructured":"Lambert JC, Ibrahim-Verbaas C, Harold D et al (2013) Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer\u2019s disease. Nat Genet 45:1452\u20131458. https:\/\/doi.org\/10.1038\/ng.2802","journal-title":"Nat Genet"},{"key":"9752_CR104","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/1475-2875-10-23","volume":"10","author":"J Langhorne","year":"2011","unstructured":"Langhorne J, Buffet P, Galinski M et al (2011) The relevance of non-human primate and rodent malaria models for humans. Malar J 10:23","journal-title":"Malar J"},{"key":"9752_CR105","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1146\/annurev-immunol-051116-052442","volume":"35","author":"D Langlais","year":"2017","unstructured":"Langlais D, Fodil N, Gros P (2017) Genetics of infectious and inflammatory diseases: overlapping discoveries from association and exome-sequencing studies. Annu Rev Immunol 35:1\u201330. https:\/\/doi.org\/10.1146\/annurev-immunol-051116-052442","journal-title":"Annu Rev Immunol"},{"key":"9752_CR106","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1186\/1475-2875-9-145","volume":"9","author":"WW Leitner","year":"2010","unstructured":"Leitner WW, Bergmann-Leitner ES, Angov E (2010) Comparison of Plasmodium berghei challenge models for the evaluation of pre-erythrocytic malaria vaccines and their effect on perceived vaccine efficacy. Malar J 9:145. https:\/\/doi.org\/10.1186\/1475-2875-9-145","journal-title":"Malar J"},{"key":"9752_CR107","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1186\/s12936-015-0809-x","volume":"14","author":"PM Lelliott","year":"2015","unstructured":"Lelliott PM, McMorran BJ, Foote SJ, Burgio G (2015) The influence of host genetics on erythrocytes and malaria infection: Is there therapeutic potential? Malar J 14:289","journal-title":"Malar J"},{"key":"9752_CR108","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1136\/jim-51-03-15","volume":"51","author":"J Li","year":"2003","unstructured":"Li J, Chang W-L, Sun G et al (2003) Intercellular adhesion molecule 1 is important for the development of severe experimental malaria but is not required for leukocyte adhesion in the brain. J Investig Med 51:128\u2013140. https:\/\/doi.org\/10.1136\/jim-51-03-15","journal-title":"J Investig Med"},{"key":"9752_CR109","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/nm.3424","volume":"20","author":"P Liehl","year":"2014","unstructured":"Liehl P, Zuzarte-Lu\u00eds V, Chan J et al (2014) Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection. Nat Med 20:47\u201353. https:\/\/doi.org\/10.1038\/nm.3424","journal-title":"Nat Med"},{"key":"9752_CR110","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1586\/eri.13.45","volume":"11","author":"KA Lindblade","year":"2013","unstructured":"Lindblade KA, Steinhardt L, Samuels A et al (2013) The silent threat: asymptomatic parasitemia and malaria transmission. Expert Rev Anti Infect Ther 11:623\u2013639. https:\/\/doi.org\/10.1586\/eri.13.45","journal-title":"Expert Rev Anti Infect Ther"},{"key":"9752_CR111","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1007\/s00335-010-9302-6","volume":"22","author":"R Longley","year":"2011","unstructured":"Longley R, Smith C, Fortin A et al (2011) Host resistance to malaria: using mouse models to explore the host response. Mamm Genome 22:32\u201342. https:\/\/doi.org\/10.1007\/s00335-010-9302-6","journal-title":"Mamm Genome"},{"key":"9752_CR112","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1128\/CMR.14.4.810-820.2001","volume":"14","author":"J Lou","year":"2001","unstructured":"Lou J, Lucas R, Grau GE (2001) Pathogenesis of cerebral malaria: Recent experimental data and possible applications for humans. Clin Microbiol Rev 14:810\u2013820","journal-title":"Clin Microbiol Rev"},{"key":"9752_CR113","doi-asserted-by":"publisher","first-page":"6344","DOI":"10.4049\/jimmunol.177.9.6344","volume":"177","author":"Z Lu","year":"2006","unstructured":"Lu Z, Serghides L, Patel SN et al (2006) Disruption of JNK2 decreases the cytokine response to Plasmodium falciparum glycosylphosphatidylinositol in vitro and confers protection in a cerebral malaria model. J Immunol 177:6344\u20136352. https:\/\/doi.org\/10.4049\/jimmunol.177.9.6344","journal-title":"J Immunol"},{"key":"9752_CR114","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.1002\/eji.1830270719","volume":"27","author":"R Lucas","year":"1997","unstructured":"Lucas R, Juillard P, Decoster E et al (1997) Crucial role of tumor necrosis factor (TNF) receptor 2 and membrane-bound TNF in experimental cerebral malaria. Eur J Immunol 27:1719\u20131725. https:\/\/doi.org\/10.1002\/eji.1830270719","journal-title":"Eur J Immunol"},{"key":"9752_CR115","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1016\/j.pt.2004.09.006","volume":"20","author":"CL MacKintosh","year":"2004","unstructured":"MacKintosh CL, Beeson JG, Marsh K (2004) Clinical features and pathogenesis of severe malaria. Trends Parasitol 20:597\u2013603","journal-title":"Trends Parasitol"},{"key":"9752_CR116","doi-asserted-by":"publisher","first-page":"2551","DOI":"10.4049\/jimmunol.1203451","volume":"191","author":"M Maglinao","year":"2013","unstructured":"Maglinao M, Klopfleisch R, Seeberger PH, Lepenies B (2013) The C-type lectin receptor DCIR is crucial for the development of experimental cerebral malaria. J Immunol 191:2551\u20132559. https:\/\/doi.org\/10.4049\/jimmunol.1203451","journal-title":"J Immunol"},{"key":"9752_CR117","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/j.pt.2006.07.006","volume":"22","author":"K Maitland","year":"2006","unstructured":"Maitland K (2006) Severe malaria: lessons learned from the management of critical illness in children. Trends Parasitol 22:457\u2013462. https:\/\/doi.org\/10.1016\/j.pt.2006.07.006","journal-title":"Trends Parasitol"},{"key":"9752_CR118","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.pt.2004.10.010","volume":"21","author":"K Maitland","year":"2005","unstructured":"Maitland K, Newton CRJC. (2005) Acidosis of severe falciparum malaria: Heading for a shock? Trends Parasitol 21:11\u201316","journal-title":"Trends Parasitol"},{"key":"9752_CR119","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1038\/ng.3107","volume":"46","author":"Malaria Genomic Epidemiology Network","year":"2014","unstructured":"Malaria Genomic Epidemiology Network (2014) Reappraisal of known malaria resistance loci in a large multicenter study. Nat Genet 46:1197\u20131204. https:\/\/doi.org\/10.1038\/ng.3107","journal-title":"Nat Genet"},{"key":"9752_CR120","volume-title":"Two monographs on malaria and the parasites of malarial fevers (translated from the first Italian edition by JH Thompson)","author":"E Marchiafava","year":"1894","unstructured":"Porcherie A, Mathieu C, Peronet R, et al (1894) Two monographs on malaria and the parasites of malarial fevers (translated from the first Italian edition by JH Thompson). New Sydenham Soc, London"},{"key":"9752_CR122","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1126\/science.1166296","volume":"323","author":"BJ Mcmorran","year":"2009","unstructured":"Mcmorran BJ, Marshall VM, Graaf C, De et al (2009) Platelets Kill Intraerythrocytic malarial parasites and mediate survival to infection. Science 323:797\u2013800. https:\/\/doi.org\/10.1126\/science.1166296","journal-title":"Science"},{"key":"9752_CR123","first-page":"101","volume":"79","author":"IM Medana","year":"2001","unstructured":"Medana IM, Chaudhri G, Chan-Ling T, Hunt NH (2001) Central nervous system in cerebral malaria: \u201cInnocent bystander\u201d or active participant in the induction of immunopathology? Immunol. Cell Biol 79:101\u2013120","journal-title":"Cell Biol"},{"key":"9752_CR124","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1038\/ng1111-1164b","volume":"43","author":"GF Mells","year":"2011","unstructured":"Mells GF, Floyd JAB, Morley KI et al (2011) Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis. Nat Genet 43:1164\u20131164. https:\/\/doi.org\/10.1038\/ng1111-1164b","journal-title":"Nat Genet"},{"key":"9752_CR125","doi-asserted-by":"publisher","first-page":"2731","DOI":"10.4049\/jimmunol.172.5.2731","volume":"172","author":"J Mestas","year":"2004","unstructured":"Mestas J, Hughes CCW (2004) Of Mice and Not Men: Differences between Mouse and Human Immunology. J Immunol 172:2731\u20132738. https:\/\/doi.org\/10.4049\/jimmunol.172.5.2731","journal-title":"J Immunol"},{"key":"9752_CR126","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1038\/415673a","volume":"415","author":"LH Miller","year":"2002","unstructured":"Miller LH, Baruch DI, Marsh K, Doumbo OK (2002) The pathogenic basis of malaria. Nature 415:673\u2013679","journal-title":"Nature"},{"key":"9752_CR127","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1038\/nm.3073","volume":"19","author":"LH Miller","year":"2013","unstructured":"Miller LH, Ackerman HC, Su XZ, Wellems TE (2013) Malaria biology and disease pathogenesis: insights for new treatments. Nat Med 19:156\u2013167. https:\/\/doi.org\/10.1038\/nm.3073","journal-title":"Nat Med"},{"key":"9752_CR128","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/j.celrep.2014.03.018","volume":"7","author":"JL Miller","year":"2014","unstructured":"Miller JL, Sack BK, Baldwin M et al (2014) Interferon-mediated innate immune responses against malaria parasite liver stages. Cell Rep 7:436\u2013447. https:\/\/doi.org\/10.1016\/j.celrep.2014.03.018","journal-title":"Cell Rep"},{"key":"9752_CR129","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1038\/nrneurol.2009.23","volume":"5","author":"SK Mishra","year":"2009","unstructured":"Mishra SK, Newton CRJC. (2009) Diagnosis and management of the neurological complications of falciparum malaria. Nat Rev Neurol 5:189\u2013198. https:\/\/doi.org\/10.1038\/nrneurol.2009.23","journal-title":"Nat Rev Neurol"},{"key":"9752_CR130","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.4049\/jimmunol.180.2.1217","volume":"180","author":"J Miu","year":"2008","unstructured":"Miu J, Muller MaJ M, et al (2008) Chemokine gene expression during fatal murine cerebral Malaria and protection due to CXCR3 deficiency. J Immunol 180:1217\u20131230. https:\/\/doi.org\/10.4049\/jimmunol.180.2.1217","journal-title":"J Immunol"},{"key":"9752_CR131","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.ijpara.2008.10.005","volume":"39","author":"J Miu","year":"2009","unstructured":"Miu J, Ball HJ, Mellor AL, Hunt NH (2009) Effect of indoleamine dioxygenase-1 deficiency and kynurenine pathway inhibition on murine cerebral malaria. Int J Parasitol 39:363\u2013370. https:\/\/doi.org\/10.1016\/j.ijpara.2008.10.005","journal-title":"Int J Parasitol"},{"key":"9752_CR132","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.4049\/jimmunol.181.2.1420","volume":"181","author":"M Miyakoda","year":"2008","unstructured":"Miyakoda M, Kimura D, Yuda M et al (2008) Malaria-specific and nonspecific activation of CD8 + T cells during blood stage of Plasmodium berghei infection. J Immunol 181:1420\u20131428. doi: 181\/2\/1420 [pii]","journal-title":"J Immunol"},{"key":"9752_CR133","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1186\/1475-2875-13-271","volume":"13","author":"V Moya-Alvarez","year":"2014","unstructured":"Moya-Alvarez V, Abellana R, Cot M (2014) Pregnancy-associated malaria and malaria in infants: An old problem with present consequences. Malar J 13:271","journal-title":"Malar J"},{"key":"9752_CR134","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1128\/IAI.70.2.512-516.2002","volume":"70","author":"E Nagayasu","year":"2002","unstructured":"Nagayasu E, Nagakura K, Akaki M et al (2002) Association of a determinant on mouse chromosome 18 with experimental severe Plasmodium berghei malaria. Infect Immun 70:512\u2013516. https:\/\/doi.org\/10.1128\/IAI.70.2.512-516.2002","journal-title":"Infect Immun"},{"key":"9752_CR135","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1038\/ng1196-307","volume":"14","author":"DL Nagle","year":"1996","unstructured":"Nagle DL, Karim MA, Woolf EA et al (1996) Identification and mutation analysis of the complete gene for Chediak-Higashi syndrome. Nat Genet 14:307\u2013311. https:\/\/doi.org\/10.1038\/ng1196-307","journal-title":"Nat Genet"},{"key":"9752_CR136","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1038\/372103a0","volume":"372","author":"M Nehls","year":"1994","unstructured":"Nehls M, Pfeifer D, Schorpp M et al (1994) New member of the winged-helix protein family disrupted in mouse and rat nude mutations. Nature 372:103\u2013107. https:\/\/doi.org\/10.1038\/372103a0","journal-title":"Nature"},{"key":"9752_CR137","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1038\/nm1297-1315","volume":"57","author":"C Newbold","year":"1997","unstructured":"Newbold C, Warn P, Black G et al (1997) Receptor-specific adhesion and clinical disease in Plasmodium falciparum. Am J Trop Med Hyg 57:389\u2013398. https:\/\/doi.org\/10.1038\/nm1297-1315","journal-title":"Am J Trop Med Hyg"},{"key":"9752_CR138","doi-asserted-by":"publisher","first-page":"e1000369","DOI":"10.1371\/journal.ppat.1000369","volume":"5","author":"CQ Nie","year":"2009","unstructured":"Nie CQ, Bernard NJ, Norman MU et al (2009) IP-10-mediated T cell homing promotes cerebral inflammation over splenic immunity to malaria infection. PLoS Pathog 5:e1000369. https:\/\/doi.org\/10.1371\/journal.ppat.1000369","journal-title":"PLoS Pathog"},{"key":"9752_CR139","doi-asserted-by":"publisher","first-page":"2221","DOI":"10.4049\/jimmunol.170.4.2221","volume":"170","author":"J Nitcheu","year":"2003","unstructured":"Nitcheu J, Bonduelle O, Combadiere C et al (2003) Perforin-dependent brain-infiltrating cytotoxic CD8+ T lymphocytes mediate experimental cerebral malaria pathogenesis. J Immunol 170:2221\u20132228. https:\/\/doi.org\/10.4049\/jimmunol.170.4.2221","journal-title":"J Immunol"},{"key":"9752_CR140","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1182\/blood-2015-07-654921","volume":"127","author":"NO O\u2019regan","year":"2016","unstructured":"O\u2019regan NO, Gegenbauer K, Sullivan JMO et al (2016) A novel role for von Willebrand factor in the pathogenesis of experimental cerebral malaria. Blood 127:1192\u20131202. https:\/\/doi.org\/10.1182\/blood-2015-07-654921","journal-title":"Blood"},{"key":"9752_CR141","doi-asserted-by":"publisher","first-page":"4518","DOI":"10.1128\/IAI.00525-08","volume":"76","author":"MS Oakley","year":"2008","unstructured":"Oakley MS, McCutchan TF, Anantharaman V et al (2008) Host biomarkers and biological pathways that are associated with the expression of experimental cerebral malaria in mice. Infect Immun 76:4518\u20134529. https:\/\/doi.org\/10.1128\/IAI.00525-08","journal-title":"Infect Immun"},{"key":"9752_CR142","doi-asserted-by":"publisher","unstructured":"Oakley MS, Majam V, Mahajan B et al (2009) Pathogenic roles of CD14, galectin-3, and OX40 during experimental cerebral malaria in mice. PLoS One 4:. https:\/\/doi.org\/10.1371\/journal.pone.0006793","DOI":"10.1371\/journal.pone.0006793"},{"key":"9752_CR143","doi-asserted-by":"publisher","first-page":"4699","DOI":"10.4049\/jimmunol.1300396","volume":"191","author":"MS Oakley","year":"2013","unstructured":"Oakley MS, Sahu BR, Lotspeich-Cole L et al (2013) The transcription factor T-bet regulates parasitemia and promotes pathogenesis during Plasmodium berghei ANKA murine malaria. J Immunol 191:4699\u20134708. https:\/\/doi.org\/10.4049\/jimmunol.1300396","journal-title":"J Immunol"},{"key":"9752_CR144","doi-asserted-by":"publisher","first-page":"4195","DOI":"10.1128\/IAI.00465-10","volume":"78","author":"A Ohayon","year":"2010","unstructured":"Ohayon A, Golenser J, Sinay R et al (2010) Protein kinase C \u03b8 deficiency increases resistance of C57BL\/6J mice to Plasmodium berghei infection-induced cerebral malaria. Infect Immun 78:4195\u20134205. https:\/\/doi.org\/10.1128\/IAI.00465-10","journal-title":"Infect Immun"},{"key":"9752_CR145","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1007\/s00251-004-0739-1","volume":"56","author":"T Ohno","year":"2004","unstructured":"Ohno T, Nishimura M (2004) Detection of a new cerebral malaria susceptibility locus, using CBA mice. Immunogenetics 56:675\u2013678. https:\/\/doi.org\/10.1007\/s00251-004-0739-1","journal-title":"Immunogenetics"},{"key":"9752_CR146","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1007\/s00251-005-0791-5","volume":"57","author":"T Ohno","year":"2005","unstructured":"Ohno T, Kobayashi F, Nishimura M (2005) Fas has a role in cerebral malaria, but not in proliferation or exclusion of the murine parasite in mice. Immunogenetics 57:293\u2013296. https:\/\/doi.org\/10.1007\/s00251-005-0791-5","journal-title":"Immunogenetics"},{"key":"9752_CR147","doi-asserted-by":"publisher","first-page":"2683","DOI":"10.1002\/eji.201343327","volume":"43","author":"J Palomo","year":"2013","unstructured":"Palomo J, Fauconnier M, Coquard L et al (2013) Type I interferons contribute to experimental cerebral malaria development in response to sporozoite or blood-stage Plasmodium berghei ANKA. Eur J Immunol 43:2683\u20132695. https:\/\/doi.org\/10.1002\/eji.201343327","journal-title":"Eur J Immunol"},{"key":"9752_CR148","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1002\/eji.201445206","volume":"45","author":"J Palomo","year":"2015","unstructured":"Palomo J, Reverchon F, Piotet J et al (2015) Critical role of IL-33 receptor ST2 in experimental cerebral malaria development. Eur J Immunol 45:1354\u20131365. https:\/\/doi.org\/10.1002\/eji.201445206","journal-title":"Eur J Immunol"},{"key":"9752_CR149","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1038\/nm1586","volume":"13","author":"A Pamplona","year":"2007","unstructured":"Pamplona A, Ferreira A, Balla J et al (2007) Heme oxygenase-1 and carbon monoxide suppress the pathogenesis of experimental cerebral malaria. Nat Med 13:703\u2013710. https:\/\/doi.org\/10.1038\/nm1586","journal-title":"Nat Med"},{"key":"9752_CR150","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1084\/jem.20072248","volume":"205","author":"SN Patel","year":"2008","unstructured":"Patel SN, Berghout J, Lovegrove FE et al (2008) C5 deficiency and C5a or C5aR blockade protects against cerebral malaria. J Exp Med 205:1133\u20131143. https:\/\/doi.org\/10.1084\/jem.20072248","journal-title":"J Exp Med"},{"key":"9752_CR151","doi-asserted-by":"publisher","first-page":"ra3","DOI":"10.1126\/scisignal.2004577","volume":"7","author":"EK Pauli","year":"2014","unstructured":"Pauli EK, Chan YK, Davis ME et al (2014) The ubiquitin-specific protease USP15 promotes RIG-I-mediated antiviral signaling by deubiquitylating TRIM25. Sci Signal 7:ra3. https:\/\/doi.org\/10.1126\/scisignal.2004577","journal-title":"Sci Signal"},{"key":"9752_CR152","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1002\/(SICI)1096-8628(19961016)65:2<167::AID-AJMG17>3.0.CO;2-O","volume":"65","author":"C Pignata","year":"1996","unstructured":"Pignata C, Fiore M, Guzzetta V, et al (1996) Congenital alopecia and nail dystrophy associated with severe functional T-cell immunodeficiency in two sibs. Am J Med Genet 65:167\u2013170","journal-title":"Am J Med Genet"},{"key":"9752_CR153","doi-asserted-by":"publisher","first-page":"3822","DOI":"10.1128\/IAI.68.7.3822-3829.2000.Updated","volume":"68","author":"PF Piguet","year":"2000","unstructured":"Piguet PF, Laperrousaz CDA, Tacchini-cottier F et al (2000) Delayed mortality and attenuated thrombocytopenia associated with severe malaria in Urokinase- and Urokinase receptor-deficient mice delayed mortality and attenuated thrombocytopenia associated with severe malaria in Urokinase- and Urokinase receptor-defi. Infect Immun 68:3822\u20133829. https:\/\/doi.org\/10.1128\/IAI.68.7.3822-3829.2000.Updated","journal-title":"Infect Immun"},{"key":"9752_CR154","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1016\/S0002-9440(10)61744-0","volume":"159","author":"PF Piguet","year":"2001","unstructured":"Piguet PF, Kan CD, Vesin C et al (2001) Role of CD40-CVD40L in mouse severe malaria. Am J Pathol 159:733\u2013742. https:\/\/doi.org\/10.1016\/S0002-9440(10)61744-0","journal-title":"Am J Pathol"},{"key":"9752_CR155","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1097\/01.LAB.0000028822.94883.8A","volume":"82","author":"PF Piguet","year":"2002","unstructured":"Piguet PF, Da Kan C, Vesin C (2002) Role of the tumor necrosis factor receptor 2 (TNFR2) in cerebral malaria in mice. Lab Investig 82:1155\u20131166. https:\/\/doi.org\/10.1097\/01.LAB.0000028822.94883.8A","journal-title":"Lab Investig"},{"key":"9752_CR121","doi-asserted-by":"publisher","first-page":"2225","DOI":"10.1084\/jem.20110845","volume":"208","author":"A Porcherie","year":"2011","unstructured":"Porcherie A, Mathieu C, Peronet R, et al (2011) Critical role of the neutrophil-associated high-affinity receptor for IgE in the pathogenesis of experimental cerebral malaria. J Exp Med 208:2225\u20132236. https:\/\/doi.org\/10.1084\/jem.20110845","journal-title":"J Exp Med"},{"key":"9752_CR156","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1179\/135100099101535070","volume":"4","author":"S Potter","year":"1999","unstructured":"Potter S, Chaudhri G, Hansen A, Hunt NH (1999) Fas and perforin contribute to the pathogenesis of murine cerebral malaria. Redox Rep 4:333\u2013335. https:\/\/doi.org\/10.1179\/135100099101535070","journal-title":"Redox Rep"},{"key":"9752_CR157","doi-asserted-by":"publisher","first-page":"4941","DOI":"10.1128\/IAI.73.8.4941","volume":"73","author":"SM Potter","year":"2005","unstructured":"Potter SM, Mitchell AJ, Cowden WB et al (2005) Phagocyte-derived reactive oxygen species do not influence the progression of murine blood-stage malaria infections. Infect Immun 73:4941\u20134947. https:\/\/doi.org\/10.1128\/IAI.73.8.4941","journal-title":"Infect Immun"},{"key":"9752_CR158","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.jneuroim.2005.12.004","volume":"173","author":"SM Potter","year":"2006","unstructured":"Potter SM, Chan-Ling T, Rosinova E et al (2006a) A role for Fas-Fas ligand interactions during the late-stage neuropathological processes of experimental cerebral malaria. J Neuroimmunol 173:96\u2013107. https:\/\/doi.org\/10.1016\/j.jneuroim.2005.12.004","journal-title":"J Neuroimmunol"},{"key":"9752_CR159","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/j.ijpara.2005.12.005","volume":"36","author":"S Potter","year":"2006","unstructured":"Potter S, Chan-Ling T, Ball HJ et al (2006b) Perforin mediated apoptosis of cerebral microvascular endothelial cells during experimental cerebral malaria. Int J Parasitol 36:485\u2013496. https:\/\/doi.org\/10.1016\/j.ijpara.2005.12.005","journal-title":"Int J Parasitol"},{"key":"9752_CR160","volume-title":"Encyclopedia of Life Sciences","author":"HJ Power","year":"2001","unstructured":"Power HJ (2001) History of Malaria. In: Encyclopedia of Life Sciences. Wiley, Chichester"},{"key":"9752_CR161","doi-asserted-by":"publisher","first-page":"614","DOI":"10.4269\/ajtmh.2001.65.614","volume":"65","author":"RN Price","year":"2001","unstructured":"Price RN, Simpson JA, Nosten F et al (2001) Factors contributing to anemia after uncomplicated falciparum malaria. Am J Trop Med Hyg 65:614\u2013622","journal-title":"Am J Trop Med Hyg"},{"key":"9752_CR162","doi-asserted-by":"publisher","first-page":"6657","DOI":"10.4049\/jimmunol.1100603","volume":"186","author":"TN Ramos","year":"2011","unstructured":"Ramos TN, Darley MM, Hu X et al (2011) Cutting edge: the membrane attack complex of complement is required for the development of murine experimental cerebral malaria. J Immunol 186:6657\u20136660. https:\/\/doi.org\/10.4049\/jimmunol.1100603","journal-title":"J Immunol"},{"key":"9752_CR163","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1111\/pim.12002","volume":"34","author":"TN Ramos","year":"2012","unstructured":"Ramos TN, Bullard DC, Barnum SR (2012a) Deletion of the complement phagocytic receptors CR3 and CR4 does not alter susceptibility to experimental cerebral malaria. Parasite Immunol 34:547\u2013550. https:\/\/doi.org\/10.1111\/pim.12002","journal-title":"Parasite Immunol"},{"key":"9752_CR164","doi-asserted-by":"publisher","first-page":"24734","DOI":"10.1074\/jbc.C112.378364","volume":"287","author":"TN Ramos","year":"2012","unstructured":"Ramos TN, Darley MM, Weckbach S et al (2012b) The C5 convertase is not required for activation of the terminal complement pathway in murine experimental cerebral malaria. J Biol Chem 287:24734\u201324738. https:\/\/doi.org\/10.1074\/jbc.C112.378364","journal-title":"J Biol Chem"},{"key":"9752_CR165","doi-asserted-by":"publisher","first-page":"10962","DOI":"10.1074\/jbc.C113.457028","volume":"288","author":"TN Ramos","year":"2013","unstructured":"Ramos TN, Bullard DC, Darley MM et al (2013) Experimental cerebral malaria develops independently of endothelial expression of intercellular adhesion molecule-1 (ICAM-1). J Biol Chem 288:10962\u201310966. https:\/\/doi.org\/10.1074\/jbc.C113.457028","journal-title":"J Biol Chem"},{"key":"9752_CR166","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1002\/eji.200939996","volume":"40","author":"T Reimer","year":"2010","unstructured":"Reimer T, Shaw MH, Franchi L et al (2010) Experimental cerebral malaria progresses independently of the Nlrp3 inflammasome. Eur J Immunol 40:764\u2013769. https:\/\/doi.org\/10.1002\/eji.200939996","journal-title":"Eur J Immunol"},{"key":"9752_CR167","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1016\/0035-9203(82)90203-6","volume":"76","author":"JR Rest","year":"1982","unstructured":"Rest JR (1982) Cerebral malaria in inbred mice. I. A new model and its pathology. Trans R Soc Trop Med Hyg 76:410\u2013415","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"9752_CR168","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.ppat.1006322","volume":"13","author":"F Reverchon","year":"2017","unstructured":"Reverchon F, Mortaud S, Sivoyon M et al (2017) IL-33 receptor ST2 regulates the cognitive impairments associated with experimental cerebral malaria. PLoS Pathog 13:1\u201325. https:\/\/doi.org\/10.1371\/journal.ppat.1006322","journal-title":"PLoS Pathog"},{"key":"9752_CR169","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.pt.2010.03.002","volume":"26","author":"EM Riley","year":"2010","unstructured":"Riley EM, Couper KN, Helmby H et al (2010) Neuropathogenesis of human and murine malaria. Trends Parasitol 26:277\u2013278","journal-title":"Trends Parasitol"},{"key":"9752_CR170","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1126\/science.270.5237.797","volume":"270","author":"SM Russell","year":"1995","unstructured":"Russell SM, Tayebi N, Nakajima H et al (1995) Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development. Science 270:797\u2013800. https:\/\/doi.org\/10.1126\/science.270.5237.797","journal-title":"Science"},{"key":"9752_CR171","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1128\/IAI.72.1.322-331.2004","volume":"72","author":"M Saeftel","year":"2004","unstructured":"Saeftel M, Krueger A, Arriens S et al (2004) Mice Deficient in Interleukin-4 (IL-4) or IL-4 Receptor \u03b1 Have Higher Resistance to Sporozoite Infection with Plasmodium berghei (ANKA) than Do Naive Wild-Type Mice. Infect Immun 72:322\u2013331. https:\/\/doi.org\/10.1128\/IAI.72.1.322-331.2004","journal-title":"Infect Immun"},{"key":"9752_CR172","first-page":"611","volume":"152","author":"LA Sanni","year":"1998","unstructured":"Sanni LA, Thomas SR, Tattam BN et al (1998) Dramatic changes in oxidative tryptophan metabolism along the kynurenine pathway in experimental cerebral and noncerebral malaria. Am J Pathol 152:611\u2013619","journal-title":"Am J Pathol"},{"key":"9752_CR173","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1086\/314552","volume":"179","author":"LA Sanni","year":"1999","unstructured":"Sanni LA, Fu S, Dean RT et al (1999) Are reactive oxygen species involved in the pathogenesis of murine cerebral malaria? J Infect Dis 179:217\u2013222. https:\/\/doi.org\/10.1086\/314552","journal-title":"J Infect Dis"},{"key":"9752_CR174","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1038\/nature10251","volume":"476","author":"S Sawcer","year":"2011","unstructured":"Sawcer S, Hellenthal G, Pirinen M et al (2011) Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature 476:214\u2013219. https:\/\/doi.org\/10.1038\/nature10251","journal-title":"Nature"},{"key":"9752_CR175","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fimmu.2017.00027","volume":"8","author":"U Schmid","year":"2017","unstructured":"Schmid U, Stenzel W, Koschel J et al (2017) The deubiquitinating enzyme cylindromatosis dampens CD8 + T cell responses and is a critical factor for experimental cerebral malaria and blood-brain barrier damage. Front Immunol 8:1\u201317. https:\/\/doi.org\/10.3389\/fimmu.2017.00027","journal-title":"Front Immunol"},{"key":"9752_CR176","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1038\/nri1686","volume":"5","author":"L Schofield","year":"2005","unstructured":"Schofield L, Grau GE (2005) Immunological processes in malaria pathogenesis. Nat Rev Immunol 5:722\u2013735. https:\/\/doi.org\/10.1038\/nri1686","journal-title":"Nat Rev Immunol"},{"key":"9752_CR177","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/srep28058","volume":"6","author":"J Sellau","year":"2016","unstructured":"Sellau J, Alvarado CF, Hoenow S et al (2016) IL-22 dampens the T cell response in experimental malaria. Sci Rep 6:1\u201311. https:\/\/doi.org\/10.1038\/srep28058","journal-title":"Sci Rep"},{"key":"9752_CR178","doi-asserted-by":"crossref","first-page":"6820","DOI":"10.4049\/jimmunol.163.12.6820","volume":"163","author":"G Senaldi","year":"1999","unstructured":"Senaldi G, Shaklee CL, Guo J et al (1999) Protection against the mortality associated with disease models mediated by TNF and IFN-\u03b3 in mice lacking IFN regulatory factor-1. J Immunol 163:6820\u20136826","journal-title":"J Immunol"},{"key":"9752_CR179","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.immuni.2011.05.016","volume":"35","author":"S Sharma","year":"2011","unstructured":"Sharma S, DeOliveira RB, Kalantari P et al (2011) Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome. Immunity 35:194\u2013207. https:\/\/doi.org\/10.1016\/j.immuni.2011.05.016","journal-title":"Immunity"},{"key":"9752_CR180","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.bbrep.2015.12.007","volume":"5","author":"A Shibui","year":"2016","unstructured":"Shibui A, Takamori A, Tolba MEM et al (2016) IL-25, IL-33 and TSLP receptor are not critical for development of experimental murine malaria. Biochem Biophys Reports 5:191\u2013195. https:\/\/doi.org\/10.1016\/j.bbrep.2015.12.007","journal-title":"Biochem Biophys Reports"},{"key":"9752_CR181","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1371\/journal.pone.0061882","volume":"8","author":"N Shryock","year":"2013","unstructured":"Shryock N, McBerry C, Salazar Gonzalez RM et al (2013) Lipoxin A4 and 15-Epi-Lipoxin A4 protect against experimental cerebral malaria by inhibiting IL-12\/IFN-\u03b3 in the brain. PLoS ONE 8:2\u201310. https:\/\/doi.org\/10.1371\/journal.pone.0061882","journal-title":"PLoS ONE"},{"key":"9752_CR182","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.chom.2008.07.003","volume":"4","author":"K Srivastava","year":"2008","unstructured":"Srivastava K, Cockburn IA, Swaim A et al (2008) Platelet factor 4 mediates inflammation in experimental cerebral malaria. Cell Host Microbe 4:179\u2013187. https:\/\/doi.org\/10.1016\/j.chom.2008.07.003","journal-title":"Cell Host Microbe"},{"key":"9752_CR183","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.pt.2010.03.008","volume":"26","author":"MM Stevenson","year":"2010","unstructured":"Stevenson MM, Gros P, Olivier M et al (2010) Cerebral malaria: human versus mouse studies. Trends Parasitol 26:274\u2013275","journal-title":"Trends Parasitol"},{"key":"9752_CR184","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1038\/nrg2126","volume":"8","author":"X Su","year":"2007","unstructured":"Su X, Hayton K, Wellems TE (2007) Genetic linkage and association analyses for trait mapping in Plasmodium falciparum. Nat Rev Genet 8:497\u2013506","journal-title":"Nat Rev Genet"},{"key":"9752_CR185","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1093\/trstmh\/tru098","volume":"108","author":"AJ Szalai","year":"2014","unstructured":"Szalai AJ, Barnum SR, Ramos TN (2014) Deletion of C-reactive protein ameliorates experimental cerebral malaria? Trans R Soc Trop Med Hyg 108:591\u2013593. https:\/\/doi.org\/10.1093\/trstmh\/tru098","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"9752_CR186","first-page":"99","volume":"86","author":"TE Taylor","year":"1993","unstructured":"Taylor TE, Borgstein A, Molyneux ME (1993) Acid-base status in paediatric Plasmodium falciparum malaria. Q J Med 86:99\u2013109","journal-title":"Q J Med"},{"key":"9752_CR187","doi-asserted-by":"publisher","first-page":"45","DOI":"10.4303\/jnp\/N100601","volume":"1","author":"AW Taylor-Robinson","year":"2010","unstructured":"Taylor-Robinson AW (2010) Validity of modelling cerebral malaria in mice: argument and counter argument. J Neuroparasitol 1:45\u201349. https:\/\/doi.org\/10.4303\/jnp\/N100601","journal-title":"J Neuroparasitol"},{"key":"9752_CR188","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1038\/nature11334","volume":"489","author":"C Timmann","year":"2012","unstructured":"Timmann C, Thye T, Vens M et al (2012) Genome-wide association study indicates two novel resistance loci for severe malaria. Nature 489:443\u2013446. https:\/\/doi.org\/10.1038\/nature11334","journal-title":"Nature"},{"key":"9752_CR189","doi-asserted-by":"publisher","first-page":"1640","DOI":"10.2353\/ajpath.2007.060889","volume":"170","author":"D Togbe","year":"2007","unstructured":"Togbe D, Schofield L, Grau GE et al (2007) Murine cerebral malaria development is independent of toll-like receptor signaling. Am J Pathol 170:1640\u20131648. https:\/\/doi.org\/10.2353\/ajpath.2007.060889","journal-title":"Am J Pathol"},{"key":"9752_CR190","doi-asserted-by":"publisher","unstructured":"Togbe D, de Sousa PL, Fauconnier M et al (2008) Both functional LT\u03b2 receptor and TNF receptor 2 are required for the development of experimental cerebral malaria. PLoS ONE 3:. https:\/\/doi.org\/10.1371\/journal.pone.0002608","DOI":"10.1371\/journal.pone.0002608"},{"key":"9752_CR191","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1038\/gene.2013.16","volume":"14","author":"S Torre","year":"2013","unstructured":"Torre S, Van Bruggen R, Kennedy JM et al (2013) Susceptibility to lethal cerebral malaria is regulated by epistatic interaction between chromosome 4 (Berr6) and chromosome 1 (Berr7) loci in mice. Genes Immun 14:249\u2013257. https:\/\/doi.org\/10.1038\/gene.2013.16","journal-title":"Genes Immun"},{"key":"9752_CR192","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1128\/IAI.02586-14","volume":"83","author":"S Torre","year":"2015","unstructured":"Torre S, Faucher SP, Fodil N et al (2015) THEMIS Is required for pathogenesis of cerebral malaria and protection against pulmonary tuberculosis. Infect Immun 83:759\u2013768. https:\/\/doi.org\/10.1128\/IAI.02586-14","journal-title":"Infect Immun"},{"key":"9752_CR193","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1038\/ni.3581","volume":"18","author":"S Torre","year":"2017","unstructured":"Torre S, Polyak MJ, Langlais D et al (2017) USP15 regulates type I interferon response and is required for pathogenesis of neuroinflammation. Nat Immunol 18:54\u201363. https:\/\/doi.org\/10.1038\/ni.3581","journal-title":"Nat Immunol"},{"key":"9752_CR194","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1186\/cc2183","volume":"7","author":"A Trampuz","year":"2003","unstructured":"Trampuz A, Jereb M, Muzlovic I, Prabhu RM (2003) Clinical review: Severe malaria. Crit Care 7:315\u2013323","journal-title":"Crit Care"},{"key":"9752_CR195","doi-asserted-by":"publisher","first-page":"e0144555","DOI":"10.1371\/journal.pone.0144555","volume":"10","author":"R Bruggen Van","year":"2015","unstructured":"Van Bruggen R, Gualtieri C, Iliescu A et al (2015) Modulation of malaria phenotypes by pyruvate kinase (pklr) variants in a Thai population. PLoS ONE 10:e0144555. https:\/\/doi.org\/10.1371\/journal.pone.0144555","journal-title":"PLoS ONE"},{"key":"9752_CR196","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1038\/labinvest.3700454","volume":"86","author":"PE Steen Van Den","year":"2006","unstructured":"Van Den Steen PE, Van Aelst I, Starckx S et al (2006) Matrix metalloproteinases, tissue inhibitors of MMPs and TACE in experimental cerebral malaria. Lab Investig 86:873\u2013888. https:\/\/doi.org\/10.1038\/labinvest.3700454","journal-title":"Lab Investig"},{"key":"9752_CR197","doi-asserted-by":"publisher","first-page":"3460","DOI":"10.1128\/IAI.69.5.3460-3465.2001","volume":"69","author":"HC Heyde Van Der","year":"2001","unstructured":"Van Der Heyde HC, Bauer P, Sun G et al (2001) Assessing vascular permeability during experimental cerebral malaria by a radiolabeled monoclonal antibody technique. Infect Immun 69:3460\u20133465. https:\/\/doi.org\/10.1128\/IAI.69.5.3460-3465.2001","journal-title":"Infect Immun"},{"key":"9752_CR198","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/j.pt.2006.09.002","volume":"22","author":"HC Heyde van der","year":"2006","unstructured":"van der Heyde HC, Nolan J, Combes V et al (2006) A unified hypothesis for the genesis of cerebral malaria: sequestration, inflammation and hemostasis leading to microcirculatory dysfunction. Trends Parasitol 22:503\u2013508. https:\/\/doi.org\/10.1016\/j.pt.2006.09.002","journal-title":"Trends Parasitol"},{"key":"9752_CR199","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1111\/j.1365-3024.2009.01106.x","volume":"31","author":"F Verra","year":"2009","unstructured":"Verra F, Mangano VD, Modiano D (2009) Genetics of susceptibility to Plasmodium falciparum: from classical malaria resistance genes towards genome-wide association studies. Parasite Immunol 31:234\u2013253","journal-title":"Parasite Immunol"},{"key":"9752_CR200","doi-asserted-by":"publisher","first-page":"968","DOI":"10.4049\/jimmunol.1200688","volume":"189","author":"A Villegas-Mendez","year":"2012","unstructured":"Villegas-Mendez A, Greig R, Shaw TN et al (2012) IFN-\u03b3-producing CD4+ T Cells promote experimental cerebral malaria by modulating CD8+ T cell accumulation within the brain. J Immunol 189:968\u2013979. https:\/\/doi.org\/10.4049\/jimmunol.1200688","journal-title":"J Immunol"},{"key":"9752_CR201","doi-asserted-by":"publisher","first-page":"2401","DOI":"10.1186\/s41182-016-0033-6","volume":"44","author":"ST Wah","year":"2016","unstructured":"Wah ST, Hananantachai H, Kerdpin U et al (2016) Molecular basis of human cerebral malaria development. Trop Med Health 44:2401\u20132407","journal-title":"Trop Med Health"},{"key":"9752_CR202","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1073\/pnas.1017996108","volume":"108","author":"M Waisberg","year":"2011","unstructured":"Waisberg M, Tarasenko T, Vickers BK et al (2011) Genetic susceptibility to systemic lupus erythematosus protects against cerebral malaria in mice. Proc Natl Acad Sci 108:1122\u20131127. https:\/\/doi.org\/10.1073\/pnas.1017996108","journal-title":"Proc Natl Acad Sci"},{"key":"9752_CR203","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1080\/17474086.2016.1179571","volume":"9","author":"SC Wassmer","year":"2016","unstructured":"Wassmer SC, Grau GER (2016) Platelets as pathogenetic effectors and killer cells in cerebral malaria. Expert Rev Hematol 9:515\u2013517. https:\/\/doi.org\/10.1080\/17474086.2016.1179571","journal-title":"Expert Rev Hematol"},{"key":"9752_CR204","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.pt.2009.10.007","volume":"26","author":"NJ White","year":"2010","unstructured":"White NJ, Turner GDH, Medana IM et al (2010) The murine cerebral malaria phenomenon. Trends Parasitol 26:11\u201315. https:\/\/doi.org\/10.1016\/j.pt.2009.10.007","journal-title":"Trends Parasitol"},{"key":"9752_CR205","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1093\/infdis\/jit116","volume":"208","author":"NJ White","year":"2013","unstructured":"White NJ, Turner GDH, Day NPJ, Dondorp AM (2013) Lethal malaria: marchiafava and bignami were right. J Infect Dis 208:192\u2013198","journal-title":"J Infect Dis"},{"key":"9752_CR206","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1016\/S0140-6736(13)60024-0","volume":"383","author":"NJ White","year":"2014","unstructured":"White NJ, Pukrittayakamee S, Hien TT et al (2014) Malaria Lancet 383:723\u2013735. https:\/\/doi.org\/10.1016\/S0140-6736(13)60024-0","journal-title":"Malaria Lancet"},{"key":"9752_CR207","doi-asserted-by":"publisher","DOI":"10.30875\/4348b814-en","volume-title":"World Malaria Report 2016","author":"World Health Organization","year":"2016","unstructured":"World Health Organization (2016) World Malaria Report 2016. World Health Organization, Geneva"},{"key":"9752_CR208","doi-asserted-by":"publisher","DOI":"10.30875\/50d27d62-en","volume-title":"World Malaria Report 2017","author":"World Health Organization","year":"2017","unstructured":"World Health Organization (2017) World Malaria Report 2017. World Health Organization, Geneva"},{"key":"9752_CR209","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.4049\/jimmunol.157.4.1620","volume":"157","author":"DM Yanez","year":"1996","unstructured":"Yanez DM, Manning DD, Cooley AJ et al (1996) Participation of lymphocyte subpopulations in the pathogenesis of experimental murine cerebral malaria. J Immunol 157:1620\u20131624","journal-title":"J Immunol"},{"key":"9752_CR210","doi-asserted-by":"publisher","first-page":"2046","DOI":"10.1056\/NEJMoa0905506","volume":"361","author":"Q Zhang","year":"2009","unstructured":"Zhang Q, Davis JC, Lamborn IT et al (2009) Combined immunodeficiency associated with DOCK8 Mutations. N Engl J Med 361:2046\u20132055. https:\/\/doi.org\/10.1056\/NEJMoa0905506","journal-title":"N Engl J Med"}],"container-title":["Mammalian Genome"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00335-018-9752-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00335-018-9752-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00335-018-9752-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T07:14:53Z","timestamp":1693725293000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00335-018-9752-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,19]]},"references-count":210,"journal-issue":{"issue":"7-8","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["9752"],"URL":"https:\/\/doi.org\/10.1007\/s00335-018-9752-9","relation":{},"ISSN":["0938-8990","1432-1777"],"issn-type":[{"value":"0938-8990","type":"print"},{"value":"1432-1777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,19]]},"assertion":[{"value":"28 January 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 June 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 June 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"On behalf of all authors, the corresponding author states that there is no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Confilct of interest"}}]}}