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It is a consequence of an elevated caloric intake, a sedentary lifestyle and a genetic as well as an epigenetic predisposition. This review summarizes changes in DNA methylation and microRNAs identified in blood cells and different tissues in obese human and rodent models. It includes information on epigenetic alterations which occur in response to fat-enriched diets, exercise and metabolic surgery and discusses the potential of interventions to reverse epigenetic modifications.<\/jats:p>","DOI":"10.1007\/s00335-020-09835-3","type":"journal-article","created":{"date-parts":[[2020,4,11]],"date-time":"2020-04-11T17:02:37Z","timestamp":1586624557000},"page":"134-145","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Epigenetic contribution to obesity"],"prefix":"10.1007","volume":"31","author":[{"given":"Meriem","family":"Ouni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4113-4377","authenticated-orcid":false,"given":"Annette","family":"Sch\u00fcrmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,4,11]]},"reference":[{"key":"9835_CR1","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.cmet.2013.07.004","volume":"18","author":"M Ahrens","year":"2013","unstructured":"Ahrens M et al (2013) DNA methylation analysis in nonalcoholic fatty liver disease suggests distinct disease-specific and remodeling signatures after bariatric surgery. 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