{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:35:40Z","timestamp":1790789740700,"version":"4.1.0"},"reference-count":61,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2022,10,15]],"date-time":"2022-10-15T00:00:00Z","timestamp":1665792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,10,15]],"date-time":"2022-10-15T00:00:00Z","timestamp":1665792000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["32100783 to Hui Zhao"],"award-info":[{"award-number":["32100783 to Hui Zhao"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31830036 and 31921002 to Y.Q. Zhang"],"award-info":[{"award-number":["31830036 and 31921002 to Y.Q. Zhang"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the National Key Research and Development Program","award":["2019YFA0707100 and 2021ZD0203901 to Y.Q. Zhang"],"award-info":[{"award-number":["2019YFA0707100 and 2021ZD0203901 to Y.Q. Zhang"]}]},{"name":"the Strategic Priority Research Program B of the Chinese Academy of Sciences","award":["XDBS1020100 to Y.Q. Zhang"],"award-info":[{"award-number":["XDBS1020100 to Y.Q. Zhang"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mamm Genome"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1007\/s00335-022-09965-w","type":"journal-article","created":{"date-parts":[[2022,10,15]],"date-time":"2022-10-15T18:02:36Z","timestamp":1665856956000},"page":"262-269","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Dog models of human atherosclerotic cardiovascular diseases"],"prefix":"10.1007","volume":"34","author":[{"given":"Hui","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enqi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Q.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,10,15]]},"reference":[{"key":"9965_CR1","doi-asserted-by":"publisher","DOI":"10.1007\/s12015-021-10280-1","author":"E Afjeh-Dana","year":"2022","unstructured":"Afjeh-Dana E, Naserzadeh P, Moradi E, Hosseini N, Seifalian AM, Ashtari B (2022) Stem cell differentiation into cardiomyocytes: Current methods and emerging approaches. Stem Cell Rev Rep. https:\/\/doi.org\/10.1007\/s12015-021-10280-1","journal-title":"Stem Cell Rev Rep"},{"issue":"6410","key":"9965_CR2","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1126\/science.aau1549","volume":"362","author":"L Amoasii","year":"2018","unstructured":"Amoasii L, Hildyard JCW, Li H, Sanchez-Ortiz E, Mireault A, Caballero D, Harron R, Stathopoulou TR, Massey C, Shelton JM et al (2018) Gene editing restores dystrophin expression in a canine model of Duchenne muscular dystrophy. Science 362(6410):86\u201391","journal-title":"Science"},{"issue":"7441","key":"9965_CR3","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1038\/nature11837","volume":"495","author":"E Axelsson","year":"2013","unstructured":"Axelsson E, Ratnakumar A, Arendt ML, Maqbool K, Webster MT, Perloski M, Liberg O, Arnemo JM, Hedhammar A, Lindblad-Toh K (2013) The genomic signature of dog domestication reveals adaptation to a starch-rich diet. Nature 495(7441):360\u2013364","journal-title":"Nature"},{"issue":"5","key":"9965_CR4","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1097\/MOL.0b013e32833ded6a","volume":"21","author":"JF Bentzon","year":"2010","unstructured":"Bentzon JF, Falk E (2010) Atherosclerotic lesions in mouse and man: is it the same disease? Curr Opin Lipidol 21(5):434\u2013440","journal-title":"Curr Opin Lipidol"},{"issue":"12","key":"9965_CR5","doi-asserted-by":"publisher","first-page":"1852","DOI":"10.1161\/CIRCRESAHA.114.302721","volume":"114","author":"JF Bentzon","year":"2014","unstructured":"Bentzon JF, Otsuka F, Virmani R, Falk E (2014) Mechanisms of plaque formation and rupture. Circ Res 114(12):1852\u20131866","journal-title":"Circ Res"},{"issue":"2","key":"9965_CR6","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.jvc.2005.07.001","volume":"7","author":"BJ Brundel","year":"2005","unstructured":"Brundel BJ, Melnyk P, Rivard L, Nattel S (2005) The pathology of atrial fibrillation in dogs. J Vet Cardiol 7(2):121\u2013129","journal-title":"J Vet Cardiol"},{"issue":"4","key":"9965_CR7","doi-asserted-by":"publisher","first-page":"30","DOI":"10.3390\/jcdd3040030","volume":"3","author":"P Camacho","year":"2016","unstructured":"Camacho P, Fan H, Liu Z, He JQ (2016) Large mammalian animal models of heart disease. J Cardiovasc Dev Dis 3(4):30","journal-title":"J Cardiovasc Dev Dis"},{"issue":"Pt 3","key":"9965_CR8","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1042\/bj2930745","volume":"293","author":"S Chang","year":"1993","unstructured":"Chang S, Borensztajn J (1993) Hepatic lipase function and the accumulation of beta-very-low-density lipoproteins in the plasma of cholesterol-fed rabbits. Biochem J 293(Pt 3):745\u2013750","journal-title":"Biochem J"},{"issue":"22","key":"9965_CR9","doi-asserted-by":"publisher","first-page":"5635","DOI":"10.1016\/j.cell.2021.09.018","volume":"184","author":"PJ Chen","year":"2021","unstructured":"Chen PJ, Hussmann JA, Yan J, Knipping F, Ravisankar P, Chen PF, Chen C, Nelson JW, Newby GA, Sahin M et al (2021) Enhanced prime editing systems by manipulating cellular determinants of editing outcomes. Cell 184(22):5635\u20135652","journal-title":"Cell"},{"issue":"6","key":"9965_CR10","doi-asserted-by":"publisher","first-page":"e53","DOI":"10.1161\/RES.0000000000000169","volume":"121","author":"A Daugherty","year":"2017","unstructured":"Daugherty A, Tall AR, Daemen MJAP, Falk E, Fisher EA, Garc\u00eda-Carde\u00f1a G, Lusis AJ, Owens AP 3rd, Rosenfeld ME, Virmani R et al (2017) Recommendation on design, execution, and reporting of animal atherosclerosis studies: a scientific statement from the American Heart Association. Circ Res 121(6):e53\u2013e79","journal-title":"Circ Res"},{"key":"9965_CR11","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.ejphar.2017.05.010","volume":"816","author":"B Emini Veseli","year":"2017","unstructured":"Emini Veseli B, Perrotta P, De Meyer GRA, Roth L, Van der Donckt C, Martinet W, De Meyer GRY (2017) Animal models of atherosclerosis. Eur J Pharmacol 816:3\u201313","journal-title":"Eur J Pharmacol"},{"issue":"10","key":"9965_CR12","doi-asserted-by":"publisher","first-page":"dmm036632","DOI":"10.1242\/dmm.036632","volume":"11","author":"B Fang","year":"2018","unstructured":"Fang B, Ren X, Wang Y, Li Z, Zhao L, Zhang M, Li C, Zhang Z, Chen L, Li X et al (2018) Apolipoprotein E deficiency accelerates atherosclerosis development in miniature pigs. Dis Model Mech 11(10):dmm036632","journal-title":"Dis Model Mech"},{"issue":"1","key":"9965_CR13","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.jgg.2017.11.003","volume":"45","author":"C Feng","year":"2018","unstructured":"Feng C, Wang X, Shi H, Yan Q, Zheng M, Li J, Zhang Q, Qin Y, Zhong Y, Mi J et al (2018) Generation of ApoE deficient dogs via combination of embryo injection of CRISPR\/Cas9 with somatic cell nuclear transfer. J Genet Genomics 45(1):47\u201350","journal-title":"J Genet Genomics"},{"issue":"2","key":"9965_CR14","first-page":"241","volume":"47","author":"JC Geer","year":"1965","unstructured":"Geer JC (1965) Fine structure of canine experimental atherosclerosis. Am J Pathol 47(2):241\u2013269","journal-title":"Am J Pathol"},{"key":"9965_CR15","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.exger.2015.08.008","volume":"71","author":"KM Gilmore","year":"2015","unstructured":"Gilmore KM, Greer KA (2015) Why is the dog an ideal model for aging research? Exp Gerontol 71:14\u201320","journal-title":"Exp Gerontol"},{"issue":"9050","key":"9965_CR16","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1016\/S0140-6736(96)07591-5","volume":"349","author":"F Haverkate","year":"1997","unstructured":"Haverkate F, Thompson SG, Pyke SD, Gallimore JR, Pepys MB (1997) Production of C-reactive protein and risk of coronary events in stable and unstable angina. European Concerted Action on Thrombosis and Disabilities Angina Pectoris Study Group. Lancet 349(9050):462\u2013466","journal-title":"Lancet"},{"issue":"3","key":"9965_CR17","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1177\/0271678X19827446","volume":"39","author":"AM Herrmann","year":"2019","unstructured":"Herrmann AM, Meckel S, Gounis MJ, Kringe L, Motschall E, M\u00fclling C, Boltze J (2019) Large animals in neurointerventional research: a systematic review on models, techniques and their application in endovascular procedures for stroke, aneurysms and vascular malformations. J Cereb Blood Flow Metab 39(3):375\u2013394","journal-title":"J Cereb Blood Flow Metab"},{"key":"9965_CR18","doi-asserted-by":"publisher","first-page":"100261","DOI":"10.1016\/j.mcpro.2022.100261","volume":"21","author":"HL Hong","year":"2022","unstructured":"Hong HL, Zhao ZG, Huang XH, Guo C, Zhao H, Wang GD, Zhang YP, Zhao JP, Shi JH, Wu QF et al (2022) Comparative proteome and cis-regulatory element analysis reveals specific molecular pathways conserved in dog and human brains. Mol Cell Proteomics 21:100261","journal-title":"Mol Cell Proteomics"},{"issue":"23","key":"9965_CR19","doi-asserted-by":"publisher","first-page":"37751","DOI":"10.18632\/oncotarget.17154","volume":"8","author":"L Huang","year":"2017","unstructured":"Huang L, Hua Z, Xiao H, Cheng Y, Xu K, Gao Q, Xia Y, Liu Y, Zhang X, Zheng X et al (2017) CRISPR\/Cas9-mediated ApoE-\/- and LDLR-\/- double gene knockout in pigs elevates serum LDL-C and TC levels. Oncotarget 8(23):37751\u201337760","journal-title":"Oncotarget"},{"issue":"5","key":"9965_CR20","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1161\/CIRCRESAHA.119.315856","volume":"126","author":"CK Huang","year":"2020","unstructured":"Huang CK, Kafert-Kasting S, Thum T (2020) Preclinical and clinical development of noncoding RNA therapeutics for cardiovascular disease. Circ Res 126(5):663\u2013678","journal-title":"Circ Res"},{"issue":"3\u20134","key":"9965_CR21","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.vph.2009.09.004","volume":"52","author":"T Ichiki","year":"2010","unstructured":"Ichiki T (2010) Thyroid hormone and atherosclerosis. Vascul Pharmacol 52(3\u20134):151\u2013156","journal-title":"Vascul Pharmacol"},{"key":"9965_CR22","first-page":"154","volume":"16","author":"AC Ignatowski","year":"1908","unstructured":"Ignatowski AC (1908) Influence of animal food on the organism of rabbits. ST Petersburg Izvest Imp Voyenno-Med Akad 16:154\u2013176","journal-title":"ST Petersburg Izvest Imp Voyenno-Med Akad"},{"issue":"2","key":"9965_CR23","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1172\/JCI116663","volume":"92","author":"S Ishibashi","year":"1993","unstructured":"Ishibashi S, Brown MS, Goldstein JL, Gerard RD, Hammer RE, Herz J (1993) Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery. J Clin Investig 92(2):883\u2013893","journal-title":"J Clin Investig"},{"key":"9965_CR24","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.athplu.2021.12.001","volume":"47","author":"LY Jia","year":"2022","unstructured":"Jia LY, Li Y, Hua Y, Liu YM, Zhang N, Gao MJ, Zhang K, Li JZ, Mi JD, Zhang JQ et al (2022) Identification of the atherosclerosis phenotype in vivo by vascular duplex ultrasonography in ApoE-deficient dogs. Atheroscler plus 47:8\u201315","journal-title":"Atheroscler plus"},{"issue":"9\u201310","key":"9965_CR25","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1002\/prca.201300123","volume":"8","author":"V Kooij","year":"2014","unstructured":"Kooij V, Venkatraman V, Tra J, Kirk JA, Rowell J, Blice-Baum A, Cammarato A, Van Eyk JE (2014) Sizing up models of heart failure: proteomics from flies to humans. Proteomics Clin Appl 8(9\u201310):653\u2013664","journal-title":"Proteomics Clin Appl"},{"issue":"2","key":"9965_CR26","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1073\/pnas.78.2.1194","volume":"78","author":"PT Kovanen","year":"1981","unstructured":"Kovanen PT, Bilheimer DW, Goldstein JL, Jaramillo JJ, Brown MS (1981) Regulatory role for hepatic low density lipoprotein receptors in vivo in the dog. Proc Natl Acad Sci USA 78(2):1194\u20131198","journal-title":"Proc Natl Acad Sci USA"},{"issue":"7347","key":"9965_CR27","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1038\/nature10146","volume":"473","author":"P Libby","year":"2011","unstructured":"Libby P, Ridker PM, Hansson GK (2011) Progress and challenges in translating the biology of atherosclerosis. Nature 473(7347):317\u2013325","journal-title":"Nature"},{"issue":"7069","key":"9965_CR28","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1038\/nature04338","volume":"438","author":"K Lindblad-Toh","year":"2005","unstructured":"Lindblad-Toh K, Wade CM, Mikkelsen TS, Karlsson EK, Jaffe DB, Kamal M, Clamp M, Chang JL, Kulbokas EJ 3rd, Zody MC et al (2005) Genome sequence, comparative analysis and haplotype structure of the domestic dog. Nature 438(7069):803\u2013819","journal-title":"Nature"},{"issue":"15","key":"9965_CR29","doi-asserted-by":"publisher","first-page":"323","DOI":"10.46234\/ccdcw2021.087","volume":"3","author":"J Liu","year":"2021","unstructured":"Liu J, Qi J, Yin P, Liu Y, You J, Lin L, Zhou M, Wang L (2021) Cardiovascular disease mortality\u2014China, 2019. China CDC Wkly 3(15):323\u2013326","journal-title":"China CDC Wkly"},{"issue":"5","key":"9965_CR31","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1161\/01.RES.35.5.722","volume":"35","author":"RW Mahley","year":"1974","unstructured":"Mahley RW, Weisgraber KH, Innerarity T (1974) Canine lipoproteins and atherosclerosis. II. Characterization of the plasma lipoproteins associated with atherogenic and nonatherogenic hyperlipidemia. Circ Res 35(5):722\u2013733","journal-title":"Circ Res"},{"issue":"4244","key":"9965_CR32","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1126\/science.1273587","volume":"192","author":"RW Mahley","year":"1976","unstructured":"Mahley RW, Nelson AW, Ferrans VJ, Fry DL (1976) Thrombosis in association with atherosclerosis induced by dietary perturbations in dogs. Science 192(4244):1139\u20131141","journal-title":"Science"},{"key":"9965_CR33","first-page":"413","volume":"76","author":"P Manalo-Estrella","year":"1963","unstructured":"Manalo-Estrella P, Cox GE, Taylor CB (1963) Atherosclerosis in rhesus monkeys. VII. Mechanism of hypercholesteremia: hepatic cholesterolgenesis and the hypercholesteremic threshold of dietary cholesterol. Arch Pathol 76:413\u2013423","journal-title":"Arch Pathol"},{"issue":"8","key":"9965_CR34","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1007\/s00439-012-1158-2","volume":"131","author":"KM Meurs","year":"2012","unstructured":"Meurs KM, Lahmers S, Keene BW, White SN, Oyama MA, Mauceli E, Lindblad-Toh K (2012) A splice site mutation in a gene encoding for PDK4, a mitochondrial protein, is associated with the development of dilated cardiomyopathy in the Doberman pinscher. Hum Genet 131(8):1319\u20131325","journal-title":"Hum Genet"},{"key":"9965_CR35","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.atherosclerosis.2015.12.002","volume":"245","author":"M Niimi","year":"2016","unstructured":"Niimi M, Yang D, Kitajima S, Ning B, Wang C, Li S, Liu E, Zhang J, Eugene Chen Y, Fan J (2016) ApoE knockout rabbits: a novel model for the study of human hyperlipidemia. Atherosclerosis 245:187\u2013193","journal-title":"Atherosclerosis"},{"key":"9965_CR36","doi-asserted-by":"publisher","DOI":"10.3791\/61790","author":"M Niimi","year":"2021","unstructured":"Niimi M, Yan H, Chen Y, Wang Y, Fan J (2021) Isolation and analysis of plasma lipoproteins by ultracentrifugation. J vis Exp. https:\/\/doi.org\/10.3791\/61790","journal-title":"J vis Exp"},{"issue":"5","key":"9965_CR37","doi-asserted-by":"publisher","first-page":"2898","DOI":"10.3390\/ijms23052898","volume":"23","author":"HJ Oh","year":"2022","unstructured":"Oh HJ, Chung E, Kim J, Kim MJ, Kim GA, Lee SH, Ra K, Eom K, Park S, Chae JH et al (2022) Generation of a Dystrophin mutant in dog by nuclear transfer using CRISPR\/Cas9-mediated somatic cells: a preliminary study. Int J Mol Sci 23(5):2898","journal-title":"Int J Mol Sci"},{"issue":"12","key":"9965_CR39","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1038\/nrg.2017.67","volume":"18","author":"EA Ostrander","year":"2017","unstructured":"Ostrander EA, Wayne RK, Freedman AH, Davis BW (2017) Demographic history, selection and functional diversity of the canine genome. Nat Rev Genet 18(12):705\u2013720","journal-title":"Nat Rev Genet"},{"issue":"2","key":"9965_CR40","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/0092-8674(92)90362-G","volume":"71","author":"AS Plump","year":"1992","unstructured":"Plump AS, Smith JD, Hayek T, Aalto-Set\u00e4l\u00e4 K, Walsh A, Verstuyft JG, Rubin EM, Breslow JL (1992) Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. Cell 71(2):343\u2013353","journal-title":"Cell"},{"issue":"5","key":"9965_CR41","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1161\/01.CIR.56.5.786","volume":"56","author":"KA Reimer","year":"1977","unstructured":"Reimer KA, Lowe JE, Rasmussen MM, Jennings RB (1977) The wavefront phenomenon of ischemic cell death. 1. Myocardial infarct size vs duration of coronary occlusion in dogs. Circulation 56(5):786\u2013794","journal-title":"Circulation"},{"key":"9965_CR42","doi-asserted-by":"publisher","first-page":"104747","DOI":"10.1016\/j.isci.2022.104747","volume":"25","author":"W Ren","year":"2022","unstructured":"Ren W, Wei PF, Yu S, Zhang YQ (2022) Left-right asymmetry and attractor-like dynamics of dog\u2019s tail wagging during dog-human interactions. iScience 25:104747","journal-title":"iScience"},{"issue":"25","key":"9965_CR43","doi-asserted-by":"publisher","first-page":"2982","DOI":"10.1016\/j.jacc.2020.11.010","volume":"76","author":"GA Roth","year":"2020","unstructured":"Roth GA, Mensah GA, Johnson CO, Addolorato G, Ammirati E, Baddour LM, Barengo NC, Beaton AZ, Benjamin EJ, Benziger CP (2020) Global burden of cardiovascular diseases and risk factors, 1990\u20132019: update from the GBD 2019 study. J Am Coll Cardiol 76(25):2982\u20133021","journal-title":"J Am Coll Cardiol"},{"key":"9965_CR44","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1146\/annurev-animal-051021-080937","volume":"10","author":"A Ruple","year":"2022","unstructured":"Ruple A, MacLean E, Snyder-Mackler N, Creevy KE, Promislow D (2022) Dog models of aging. Annu Rev Anim Biosci 10:419\u2013439","journal-title":"Annu Rev Anim Biosci"},{"issue":"Suppl C","key":"9965_CR45","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1093\/eurheartj\/16.suppl_C.66","volume":"16","author":"W Schaper","year":"1995","unstructured":"Schaper W (1995) Control of coronary angiogenesis. Eur Heart J 16(Suppl C):66\u201368","journal-title":"Eur Heart J"},{"key":"9965_CR46","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2022.0313","author":"XF Shi","year":"2022","unstructured":"Shi XF, Zhu SM, Liu MJ, Stone SS, Rong Y, Mao K, Xu XP, Ma C, Jiang ZY, Zha Y et al (2022) Single-cell RNA-seq reveals a population of smooth muscle cells responsible for atherogenesis. Aging Dis. https:\/\/doi.org\/10.14336\/AD.2022.0313","journal-title":"Aging Dis"},{"issue":"5","key":"9965_CR47","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1161\/01.CIR.92.5.1355","volume":"92","author":"HC Stary","year":"1995","unstructured":"Stary HC, Chandler AB, Dinsmore RE, Fuster V, Glagov S, Insull W Jr, Rosenfeld ME, Schwartz CJ, Wagner WD, Wissler RW (1995) A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Circulation 92(5):1355\u20131374","journal-title":"Circulation"},{"issue":"1","key":"9965_CR48","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.repbio.2013.12.007","volume":"14","author":"M Switonski","year":"2014","unstructured":"Switonski M (2014) Dog as a model in studies on human hereditary diseases and their gene therapy. Reprod Biol 14(1):44\u201350","journal-title":"Reprod Biol"},{"issue":"5\u20136","key":"9965_CR49","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1177\/0261192919899853","volume":"47","author":"K Taylor","year":"2019","unstructured":"Taylor K, Alvarez LR (2019) An estimate of the number of animals used for scientific purposes worldwide in 2015. Altern Lab Anim 47(5\u20136):196\u2013213","journal-title":"Altern Lab Anim"},{"issue":"6","key":"9965_CR50","doi-asserted-by":"publisher","first-page":"995","DOI":"10.2310\/JIM.0b013e31829a7c1b","volume":"61","author":"Z Tian","year":"2013","unstructured":"Tian Z, Shen Y, Liao H, Yang T, Wang X, Han X, Dong Y, You T (2013) Carotid proliferative plaque formation in a canine model of chronic hypertension. J Investig Med 61(6):995\u20131003","journal-title":"J Investig Med"},{"issue":"6\u20137","key":"9965_CR51","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1007\/s00335-007-9037-1","volume":"18","author":"KL Tsai","year":"2007","unstructured":"Tsai KL, Clark LA, Murphy KE (2007) Understanding hereditary diseases using the dog and human as companion model systems. Mamm Genome 18(6\u20137):444\u2013451","journal-title":"Mamm Genome"},{"issue":"5","key":"9965_CR52","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1248\/bpb.24.579","volume":"24","author":"K Tsutsumi","year":"2001","unstructured":"Tsutsumi K, Hagi A, Inoue Y (2001) The relationship between plasma high density lipoprotein cholesterol levels and cholesteryl ester transfer protein activity in six species of healthy experimental animals. Biol Pharm Bull 24(5):579\u2013581","journal-title":"Biol Pharm Bull"},{"key":"9965_CR53","doi-asserted-by":"publisher","first-page":"1860","DOI":"10.1038\/ncomms2814","volume":"4","author":"GD Wang","year":"2013","unstructured":"Wang GD, Zhai W, Yang HC, Fan RX, Cao X, Zhong L, Wang L, Liu F, Wu H, Cheng LG et al (2013) The genomics of selection in dogs and the parallel evolution between dogs and humans. Nat Commun 4:1860","journal-title":"Nat Commun"},{"issue":"1","key":"9965_CR54","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1038\/s41421-021-00304-y","volume":"7","author":"X Wang","year":"2021","unstructured":"Wang X, Liang Y, Zhao J, Li Y, Gou S, Zheng M, Zhou J, Zhang Q, Mi J, Lai L (2021) Generation of permanent neonatal diabetes mellitus dogs with glucokinase point mutations through base editing. Cell Discov 7(1):92","journal-title":"Cell Discov"},{"issue":"8","key":"9965_CR55","doi-asserted-by":"publisher","first-page":"e254","DOI":"10.1161\/CIR.0000000000000950","volume":"143","author":"SS Virani","year":"2021","unstructured":"Virani SS, Alonso A, Aparicio HJ, Benjamin EJ, Bittencourt MS, Callaway CW, Carson AP, Chamberlain AM, Cheng S, Delling FN et al (2021) Heart disease and stroke statistics-2021 update: a report from the American heart association. Circulation 143(8):e254\u2013e743","journal-title":"Circulation"},{"issue":"7290","key":"9965_CR56","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1038\/nature08837","volume":"464","author":"BM Vonholdt","year":"2010","unstructured":"Vonholdt BM, Pollinger JP, Lohmueller KE, Han E, Parker HG, Quignon P, Degenhardt JD, Boyko AR, Earl DA, Auton A et al (2010) Genome-wide SNP and haplotype analyses reveal a rich history underlying dog domestication. Nature 464(7290):898\u2013902","journal-title":"Nature"},{"issue":"1","key":"9965_CR57","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1194\/jlr.M019927","volume":"53","author":"W Yin","year":"2012","unstructured":"Yin W, Carballo-Jane E, McLaren DG, Mendoza VH, Gagen K, Geoghagen NS, McNamara LA, Gorski JN, Eiermann GJ, Petrov A et al (2012) Plasma lipid profiling across species for the identification of optimal animal models of human dyslipidemia. J Lipid Res 53(1):51\u201365","journal-title":"J Lipid Res"},{"issue":"5081","key":"9965_CR58","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1126\/science.1411543","volume":"258","author":"SH Zhang","year":"1992","unstructured":"Zhang SH, Reddick RL, Piedrahita JA, Maeda N (1992) Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science 258(5081):468\u2013471","journal-title":"Science"},{"issue":"6","key":"9965_CR59","doi-asserted-by":"publisher","first-page":"871","DOI":"10.3892\/mmr.2021.12511","volume":"24","author":"Y Zhang","year":"2021","unstructured":"Zhang Y, Fatima M, Hou S, Bai L, Zhao S, Liu E (2021) Research methods for animal models of atherosclerosis (Review). Mol Med Rep 24(6):871","journal-title":"Mol Med Rep"},{"issue":"3","key":"9965_CR60","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1093\/nsr\/nwz013","volume":"6","author":"J Zhao","year":"2019","unstructured":"Zhao J, Lai L, Ji W, Zhou Q (2019) Genome editing in large animals: current status and future prospects. Natl Sci Rev 6(3):402\u2013420","journal-title":"Natl Sci Rev"},{"issue":"7","key":"9965_CR61","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.1007\/s11427-021-2006-y","volume":"65","author":"H Zhao","year":"2022","unstructured":"Zhao H, Zhao J, Wu D, Sun Z, Hua Y, Zheng M, Liu Y, Yang Q, Huang X, Li Y et al (2022) Dogs lacking Apolipoprotein E show advanced atherosclerosis leading to apparent clinical complications. Sci China Life Sci 65(7):1342\u20131356","journal-title":"Sci China Life Sci"},{"issue":"6","key":"9965_CR62","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1093\/jmcb\/mjv061","volume":"7","author":"Q Zou","year":"2015","unstructured":"Zou Q, Wang X, Liu Y, Ouyang Z, Long H, Wei S, Xin J, Zhao B, Lai S, Shen J et al (2015) Generation of gene-target dogs using CRISPR\/Cas9 system. J Mol Cell Biol 7(6):580\u2013583","journal-title":"J Mol Cell Biol"},{"issue":"7","key":"9965_CR63","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1038\/labinvest.2013.65","volume":"93","author":"QQ Zu","year":"2013","unstructured":"Zu QQ, Liu S, Xu XQ, Lu SS, Sun L, Shi HB (2013) An endovascular canine stroke model: middle cerebral artery occlusion with autologous clots followed by ipsilateral internal carotid artery blockade. Lab Investig 93(7):760\u2013767","journal-title":"Lab Investig"}],"container-title":["Mammalian Genome"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00335-022-09965-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00335-022-09965-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00335-022-09965-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,24]],"date-time":"2023-06-24T13:02:59Z","timestamp":1687611779000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00335-022-09965-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,15]]},"references-count":61,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["9965"],"URL":"https:\/\/doi.org\/10.1007\/s00335-022-09965-w","relation":{},"ISSN":["0938-8990","1432-1777"],"issn-type":[{"value":"0938-8990","type":"print"},{"value":"1432-1777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,15]]},"assertion":[{"value":"30 June 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 October 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 October 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no competing interests as defined by Springer, or other interests that might be perceived to influence the results and\/or discussion reported in this paper.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}