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Experimental rodent models play a central role in cardiovascular disease research by effectively simulating human cardiovascular diseases. Using mice, the International Mouse Phenotyping Consortium (IMPC) aims to target each protein-coding gene and phenotype multiple organ systems in single-gene knockout models by a global network of mouse clinics. In this review, we summarize the current advances of the IMPC in cardiac research and describe in detail the diagnostic requirements of high-throughput electrocardiography and transthoracic echocardiography capable of detecting cardiac arrhythmias and cardiomyopathies in mice. Beyond that, we are linking metabolism to the heart and describing phenotypes that emerge in a set of known genes, when knocked out in mice, such as the <jats:italic>leptin receptor<\/jats:italic> (<jats:italic>Lepr<\/jats:italic>), <jats:italic>leptin<\/jats:italic> (<jats:italic>Lep<\/jats:italic>), and <jats:italic>Bardet\u2013Biedl syndrome 5<\/jats:italic> (<jats:italic>Bbs5<\/jats:italic>). Furthermore, we are presenting not yet associated loss-of-function genes affecting both, metabolism and the cardiovascular system, such as\u00a0the <jats:italic>RING finger protein 10<\/jats:italic> (<jats:italic>Rfn10<\/jats:italic>), <jats:italic>F-box protein 38<\/jats:italic> (<jats:italic>Fbxo38<\/jats:italic>), and <jats:italic>Dipeptidyl peptidase 8<\/jats:italic> (<jats:italic>Dpp8<\/jats:italic>). These extensive high-throughput data from IMPC mice provide a promising opportunity to explore genetics causing metabolic heart disease with an important translational approach.<\/jats:p>","DOI":"10.1007\/s00335-023-09997-w","type":"journal-article","created":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T12:02:05Z","timestamp":1686916925000},"page":"107-122","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A review of standardized high-throughput cardiovascular phenotyping with a link to metabolism in mice"],"prefix":"10.1007","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0443-0388","authenticated-orcid":false,"given":"Jiri","family":"Lindovsky","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7358-3268","authenticated-orcid":false,"given":"Zuzana","family":"Nichtova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6856-5468","authenticated-orcid":false,"given":"Nathalia R. 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