{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T21:21:23Z","timestamp":1765228883492,"version":"3.46.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mamm Genome"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s00335-025-10181-5","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T18:58:35Z","timestamp":1765220315000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cross-tissue enrichment patterns reveal functional clustering in normal human tissues from GTEx"],"prefix":"10.1007","volume":"37","author":[{"given":"Arunima","family":"P. S.","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajesh","family":"Raju","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debodipta","family":"Das","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,12,8]]},"reference":[{"key":"10181_CR1","doi-asserted-by":"publisher","first-page":"416","DOI":"10.4183\/aeb.2019.416","volume":"15","author":"C Badiu","year":"2019","unstructured":"Badiu C (2019) Williams textbook of endocrinology - 14th revised edition. Acta Endocrinologica (Bucharest) 15:416\u2013416. https:\/\/doi.org\/10.4183\/aeb.2019.416","journal-title":"Acta Endocrinologica (Bucharest)"},{"key":"10181_CR2","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1186\/s13059-020-02252-4","volume":"22","author":"AN Barbeira","year":"2021","unstructured":"Barbeira AN, Bonazzola R, Gamazon ER et al (2021) Exploiting the GTEx resources to decipher the mechanisms at GWAS loci. Genome Biol 22:49. https:\/\/doi.org\/10.1186\/s13059-020-02252-4","journal-title":"Genome Biol"},{"key":"10181_CR3","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1038\/415198a","volume":"415","author":"DM Bers","year":"2002","unstructured":"Bers DM (2002) Cardiac excitation-contraction coupling. Nature 415:198\u2013205. https:\/\/doi.org\/10.1038\/415198a","journal-title":"Nature"},{"key":"10181_CR4","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1038\/s41467-020-14561-0","volume":"11","author":"MKR Donovan","year":"2020","unstructured":"Donovan MKR, D\u2019Antonio-Chronowska A, D\u2019Antonio M, Frazer KA (2020) Cellular deconvolution of GTEx tissues powers discovery of disease and cell-type associated regulatory variants. Nat Commun 11:955. https:\/\/doi.org\/10.1038\/s41467-020-14561-0","journal-title":"Nat Commun"},{"key":"10181_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1152\/physrev.00013.2015","volume":"96","author":"MD Griswold","year":"2016","unstructured":"Griswold MD (2016) Spermatogenesis: the commitment to meiosis. Physiol Rev 96:1\u201317. https:\/\/doi.org\/10.1152\/physrev.00013.2015","journal-title":"Physiol Rev"},{"key":"10181_CR6","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1126\/science.1262110","volume":"348","author":"GTEx Consortium","year":"2015","unstructured":"GTEx Consortium (2015) Human genomics. The genotype-tissue expression (GTEx) pilot analysis: multitissue gene regulation in humans. Science 348:648\u2013660. https:\/\/doi.org\/10.1126\/science.1262110","journal-title":"Science"},{"key":"10181_CR7","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1038\/nature24489","volume":"551","author":"AL Haber","year":"2017","unstructured":"Haber AL, Biton M, Rogel N et al (2017) A single-cell survey of the small intestinal epithelium. Nature 551:333\u2013339. https:\/\/doi.org\/10.1038\/nature24489","journal-title":"Nature"},{"issue":"5","key":"10181_CR8","doi-asserted-by":"publisher","first-page":"S2","DOI":"10.1186\/1471-2105-9-S5-S2","volume":"9","author":"DP Hill","year":"2008","unstructured":"Hill DP, Smith B, McAndrews-Hill MS, Blake JA (2008) Gene ontology annotations: what they mean and where they come from. BMC Bioinform 9(5):S2. https:\/\/doi.org\/10.1186\/1471-2105-9-S5-S2","journal-title":"BMC Bioinform"},{"key":"10181_CR9","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1038\/nri3581","volume":"14","author":"LB Ivashkiv","year":"2014","unstructured":"Ivashkiv LB, Donlin LT (2014) Regulation of type I interferon responses. Nat Rev Immunol 14:36\u201349. https:\/\/doi.org\/10.1038\/nri3581","journal-title":"Nat Rev Immunol"},{"key":"10181_CR10","doi-asserted-by":"publisher","first-page":"D353","DOI":"10.1093\/nar\/gkw1092","volume":"45","author":"M Kanehisa","year":"2017","unstructured":"Kanehisa M, Furumichi M, Tanabe M et al (2017) KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res 45:D353\u2013D361. https:\/\/doi.org\/10.1093\/nar\/gkw1092","journal-title":"Nucleic Acids Res"},{"key":"10181_CR11","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaz8528","author":"S Kim-Hellmuth","year":"2020","unstructured":"Kim-Hellmuth S, Aguet F, Oliva M et al (2020) Cell type-specific genetic regulation of gene expression across human tissues. Science. https:\/\/doi.org\/10.1126\/science.aaz8528","journal-title":"Science"},{"key":"10181_CR12","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21165760","author":"C Kothari","year":"2020","unstructured":"Kothari C, Diorio C, Durocher F (2020) The importance of breast adipose tissue in breast cancer. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms21165760","journal-title":"Int J Mol Sci"},{"key":"10181_CR13","doi-asserted-by":"publisher","first-page":"W90","DOI":"10.1093\/nar\/gkw377","volume":"44","author":"MV Kuleshov","year":"2016","unstructured":"Kuleshov MV, Jones MR, Rouillard AD et al (2016) Enrichr: a comprehensive gene set enrichment analysis web server 2016 update. Nucleic Acids Res 44:W90\u2013W97. https:\/\/doi.org\/10.1093\/nar\/gkw377","journal-title":"Nucleic Acids Res"},{"key":"10181_CR14","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.cels.2015.12.004","volume":"1","author":"A Liberzon","year":"2015","unstructured":"Liberzon A, Birger C, Thorvaldsd\u00f3ttir H et al (2015) The molecular signatures database (MSigDB) hallmark gene set collection. Cell Syst 1:417\u2013425. https:\/\/doi.org\/10.1016\/j.cels.2015.12.004","journal-title":"Cell Syst"},{"key":"10181_CR15","doi-asserted-by":"publisher","DOI":"10.1186\/s13040-022-00315-9","volume":"15","author":"HB L\u00fcleci","year":"2022","unstructured":"L\u00fcleci HB, Y\u0131lmaz A (2022) Robust and rigorous identification of tissue-specific genes by statistically extending tau score. BioData Min 15:31. https:\/\/doi.org\/10.1186\/s13040-022-00315-9","journal-title":"BioData Min"},{"key":"10181_CR16","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1038\/nrm3434","volume":"13","author":"J Massagu\u00e9","year":"2012","unstructured":"Massagu\u00e9 J (2012) TGF\u03b2 signalling in context. Nat Rev Mol Cell Biol 13:616\u2013630. https:\/\/doi.org\/10.1038\/nrm3434","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10181_CR17","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1126\/science.aaa0355","volume":"348","author":"M Mel\u00e9","year":"2015","unstructured":"Mel\u00e9 M, Ferreira PG, Reverter F et al (2015) Human genomics. The human transcriptome across tissues and individuals. Science 348:660\u2013665. https:\/\/doi.org\/10.1126\/science.aaa0355","journal-title":"Science"},{"key":"10181_CR18","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1056\/NEJMra1810772","volume":"382","author":"S Melmed","year":"2020","unstructured":"Melmed S (2020) Pituitary-tumor endocrinopathies. N Engl J Med 382:937\u2013950. https:\/\/doi.org\/10.1056\/NEJMra1810772","journal-title":"N Engl J Med"},{"key":"10181_CR19","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1016\/j.bbamem.2007.12.015","volume":"1778","author":"CM Niessen","year":"2008","unstructured":"Niessen CM, Gottardi CJ (2008) Molecular components of the adherens junction. Biochim Biophys Acta 1778:562\u2013571. https:\/\/doi.org\/10.1016\/j.bbamem.2007.12.015","journal-title":"Biochim Biophys Acta"},{"key":"10181_CR20","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/j.cell.2008.01.025","volume":"132","author":"SH Orkin","year":"2008","unstructured":"Orkin SH, Zon LI (2008) Hematopoiesis: an evolving paradigm for stem cell biology. Cell 132:631\u2013644. https:\/\/doi.org\/10.1016\/j.cell.2008.01.025","journal-title":"Cell"},{"key":"10181_CR21","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1016\/j.bpg.2010.08.008","volume":"24","author":"RC Orlando","year":"2010","unstructured":"Orlando RC (2010) The integrity of the esophageal mucosa. Balance between offensive and defensive mechanisms. Best Pract Res Clin Gastroenterol 24:873\u2013882. https:\/\/doi.org\/10.1016\/j.bpg.2010.08.008","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"10181_CR22","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1002\/cphy.c130024","volume":"4","author":"L Rui","year":"2014","unstructured":"Rui L (2014) Energy metabolism in the liver. Compr Physiol 4:177\u2013197. https:\/\/doi.org\/10.1002\/cphy.c130024","journal-title":"Compr Physiol"},{"key":"10181_CR23","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1146\/annurev.biochem.72.121801.161712","volume":"72","author":"DW Russell","year":"2003","unstructured":"Russell DW (2003) The enzymes, regulation, and genetics of bile acid synthesis. Annu Rev Biochem 72:137\u2013174. https:\/\/doi.org\/10.1146\/annurev.biochem.72.121801.161712","journal-title":"Annu Rev Biochem"},{"key":"10181_CR24","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1189\/jlb.0603252","volume":"75","author":"K Schroder","year":"2004","unstructured":"Schroder K, Hertzog PJ, Ravasi T, Hume DA (2004) Interferon-gamma: an overview of signals, mechanisms and functions. J Leukoc Biol 75:163\u2013189. https:\/\/doi.org\/10.1189\/jlb.0603252","journal-title":"J Leukoc Biol"},{"key":"10181_CR25","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"A Subramanian","year":"2005","unstructured":"Subramanian A, Tamayo P, Mootha VK et al (2005) Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA 102:15545\u201315550. https:\/\/doi.org\/10.1073\/pnas.0506580102","journal-title":"Proc Natl Acad Sci USA"},{"key":"10181_CR26","doi-asserted-by":"publisher","first-page":"1260419","DOI":"10.1126\/science.1260419","volume":"347","author":"M Uhl\u00e9n","year":"2015","unstructured":"Uhl\u00e9n M, Fagerberg L, Hallstr\u00f6m BM et al (2015) Tissue-based map of the human proteome. Science 347:1260419. https:\/\/doi.org\/10.1126\/science.1260419","journal-title":"Science"},{"key":"10181_CR27","doi-asserted-by":"publisher","first-page":"862","DOI":"10.15252\/msb.20155865","volume":"12","author":"M Uhl\u00e9n","year":"2016","unstructured":"Uhl\u00e9n M, Hallstr\u00f6m BM, Lindskog C et al (2016) Transcriptomics resources of human tissues and organs. Mol Syst Biol 12:862. https:\/\/doi.org\/10.15252\/msb.20155865","journal-title":"Mol Syst Biol"},{"key":"10181_CR28","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1038\/nbt.3772","volume":"35","author":"J Vivian","year":"2017","unstructured":"Vivian J, Rao AA, Nothaft FA et al (2017) Toil enables reproducible, open source, big biomedical data analyses. Nat Biotechnol 35:314\u2013316. https:\/\/doi.org\/10.1038\/nbt.3772","journal-title":"Nat Biotechnol"},{"key":"10181_CR29","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1530\/rep.1.00358","volume":"130","author":"WH Walker","year":"2005","unstructured":"Walker WH, Cheng J (2005) FSH and testosterone signaling in Sertoli cells. Reproduction 130:15\u201328. https:\/\/doi.org\/10.1530\/rep.1.00358","journal-title":"Reproduction"},{"key":"10181_CR30","doi-asserted-by":"publisher","first-page":"100141","DOI":"10.1016\/j.xinn.2021.100141","volume":"2","author":"T Wu","year":"2021","unstructured":"Wu T, Hu E, Xu S et al (2021) ClusterProfiler 4.0: a universal enrichment tool for interpreting omics data. Innovation 2:100141. https:\/\/doi.org\/10.1016\/j.xinn.2021.100141","journal-title":"Innovation"},{"key":"10181_CR31","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1089\/omi.2011.0118","volume":"16","author":"G Yu","year":"2012","unstructured":"Yu G, Wang L-G, Han Y, He Q-Y (2012) clusterProfiler: an R package for comparing biological themes among gene clusters. OMICS 16:284\u2013287. https:\/\/doi.org\/10.1089\/omi.2011.0118","journal-title":"OMICS"}],"container-title":["Mammalian Genome"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00335-025-10181-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00335-025-10181-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00335-025-10181-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T18:58:35Z","timestamp":1765220315000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00335-025-10181-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,8]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["10181"],"URL":"https:\/\/doi.org\/10.1007\/s00335-025-10181-5","relation":{},"ISSN":["0938-8990","1432-1777"],"issn-type":[{"value":"0938-8990","type":"print"},{"value":"1432-1777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,8]]},"assertion":[{"value":"27 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"9"}}