{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T13:37:52Z","timestamp":1787665072566,"version":"build-2736575974"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mamm Genome"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s00335-025-10190-4","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T16:22:09Z","timestamp":1768234929000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["MiR-324-5p mitigates experimental acute pancreatitis by suppressing Rock2 expression"],"prefix":"10.1007","volume":"37","author":[{"given":"Qian","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingmei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yehong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunhui","family":"Fei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caixia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,12]]},"reference":[{"key":"10190_CR1","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-025-03916-4","author":"A Amodio","year":"2025","unstructured":"Amodio A, de Pretis N, De Marchi G, Campagnola P, Crucill\u00e0 S, Caldart F, Frulloni L (2025) Management of acute pancreatitis in the \u201cno man\u2019s land.\u201d Intern Emerg Med. https:\/\/doi.org\/10.1007\/s11739-025-03916-4","journal-title":"Intern Emerg Med"},{"key":"10190_CR2","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1186\/s11658-019-0196-3","volume":"24","author":"R Bartoszewski","year":"2019","unstructured":"Bartoszewski R, Sikorski AF (2019) Editorial focus: understanding off-target effects as the key to successful RNAi therapy. Cell Mol Biol Lett 24:69","journal-title":"Cell Mol Biol Lett"},{"issue":"10252","key":"10190_CR3","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1016\/S0140-6736(20)31310-6","volume":"396","author":"L Boxhoorn","year":"2020","unstructured":"Boxhoorn L, Voermans RP, Bouwense SA, Bruno MJ, Verdonk RC, Boermeester MA, van Santvoort HC, Besselink MG (2020) Acute pancreatitis. Lancet 396(10252):726\u2013734","journal-title":"Lancet"},{"issue":"12","key":"10190_CR4","doi-asserted-by":"publisher","first-page":"22082","DOI":"10.1002\/jcp.28771","volume":"234","author":"P Chen","year":"2019","unstructured":"Chen P, Zhong J, Ye J, He Y, Liang Z, Cheng Y, Zheng J, Chen H, Chen C (2019) miR-324-5p protects against oxidative stress-induced endothelial progenitor cell injury by targeting Mtfr1. J Cell Physiol 234(12):22082\u201322092","journal-title":"J Cell Physiol"},{"issue":"4","key":"10190_CR5","doi-asserted-by":"publisher","DOI":"10.1002\/iid3.819","volume":"11","author":"H Chen","year":"2023","unstructured":"Chen H, Tu J, He L, Gao N, Yang W (2023) Mmu_circ_0000037 inhibits the progression of acute pancreatitis by miR-92a-3p\/Pias1 axis. Immun Inflamm Dis 11(4):e819","journal-title":"Immun Inflamm Dis"},{"issue":"4","key":"10190_CR6","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1016\/j.ymthe.2022.01.033","volume":"30","author":"W Du","year":"2022","unstructured":"Du W, Liu G, Shi N, Tang D, Ferdek PE, Jakubowska MA, Liu S, Zhu X, Zhang J, Yao L, Sang X, Zou S, Liu T, Mukherjee R, Criddle DN, Zheng X, Xia Q, Berggren P-O, Huang W, Sutton R, Tian Y, Huang W, Fu X (2022) A microRNA checkpoint for Ca\u2009<\u2009sup\u2009>\u20092+\u2009signaling and overload in acute pancreatitis. Mol Ther 30(4):1754\u20131774","journal-title":"Mol Ther"},{"issue":"27","key":"10190_CR7","first-page":"2126","volume":"100","author":"YY Han","year":"2020","unstructured":"Han YY, Wang CY, Yang L, Zhao GY, Liu HL, Li JZ, Chen PL, Cui K (2020) [Significance of microRNA 216a, 324-5p and 29a expression in peripheral blood in patients with acute pancreatitis and their correlation with liver injury]. Zhonghua Yi Xue Za Zhi 100(27):2126\u20132131","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"10190_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.109847","volume":"124","author":"YD Jeon","year":"2020","unstructured":"Jeon YD, Lee JH, Lee YM, Kim DK (2020) Puerarin inhibits inflammation and oxidative stress in dextran sulfate sodium-induced colitis mice model. Biomed Pharmacother 124:109847","journal-title":"Biomed Pharmacother"},{"issue":"3","key":"10190_CR9","doi-asserted-by":"publisher","first-page":"298","DOI":"10.15283\/ijsc21025","volume":"14","author":"Z Ji","year":"2021","unstructured":"Ji Z, Wang C, Tong Q (2021) Role of miRNA-324-5p-modified adipose-derived stem cells in post-myocardial infarction repair. Int J Stem Cells 14(3):298\u2013309","journal-title":"Int J Stem Cells"},{"issue":"9","key":"10190_CR10","doi-asserted-by":"publisher","first-page":"4471","DOI":"10.1007\/s10620-021-07322-6","volume":"67","author":"A Jia","year":"2022","unstructured":"Jia A, Yang ZW, Shi JY, Liu JM, Zhang K, Cui YF (2022) MiR-325-3p alleviates acute pancreatitis via targeting RIPK3. Dig Dis Sci 67(9):4471\u20134483","journal-title":"Dig Dis Sci"},{"key":"10190_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2022.108740","volume":"108","author":"A Jin","year":"2022","unstructured":"Jin A, Zhang Q, Cheng H, Yang C, Wang X (2022) Circ_0050908 up-regulates TRAF3 by sponging miR-324-5p to aggravate myocardial ischemia-reperfusion injury. Int Immunopharmacol 108:108740","journal-title":"Int Immunopharmacol"},{"issue":"8","key":"10190_CR12","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1038\/s41575-019-0158-2","volume":"16","author":"PJ Lee","year":"2019","unstructured":"Lee PJ, Papachristou GI (2019) New insights into acute pancreatitis. Nat Rev Gastroenterol Hepatol 16(8):479\u2013496","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"12","key":"10190_CR13","doi-asserted-by":"publisher","first-page":"2184","DOI":"10.2174\/1386207326666230202141348","volume":"26","author":"B Luo","year":"2023","unstructured":"Luo B, Wang C, Wang Z, Chen C, Peng X, Xu Q (2023) Evaluation of serum miR-216a, miR-216b, miR-217, miR-92b, miR-375 and miR-148a as potential biomarkers for acute pancreatitis and the role of miR-92b in attenuating caerulein-induced injury and inflammatory responses in AR42J cells. Comb Chem High Throughput Screen 26(12):2184\u20132193","journal-title":"Comb Chem High Throughput Screen"},{"key":"10190_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2019.151414","volume":"44","author":"C Magro","year":"2020","unstructured":"Magro C, Schwartz Z, Saab J, Hedayat A (2020) Enhanced cutaneous Rock2 expression as a marker of Rho Kinase pathway activation in autoimmune disease and Kohlemeier-Degos disease. Ann Diagn Pathol 44:151414","journal-title":"Ann Diagn Pathol"},{"issue":"7","key":"10190_CR15","doi-asserted-by":"publisher","first-page":"1951","DOI":"10.1053\/j.gastro.2018.11.081","volume":"156","author":"J Mayerle","year":"2019","unstructured":"Mayerle J, Sendler M, Hegyi E, Beyer G, Lerch MM, Sahin-T\u00f3th M (2019) Genetics, cell biology, and pathophysiology of pancreatitis. Gastroenterology 156(7):1951-1968.e1951","journal-title":"Gastroenterology"},{"issue":"3","key":"10190_CR16","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1038\/s41575-018-0087-5","volume":"16","author":"MS Petrov","year":"2019","unstructured":"Petrov MS, Yadav D (2019) Global epidemiology and holistic prevention of pancreatitis. Nat Rev Gastroenterol Hepatol 16(3):175\u2013184","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"5","key":"10190_CR17","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1007\/s00018-017-2656-0","volume":"75","author":"H Seok","year":"2018","unstructured":"Seok H, Lee H, Jang ES, Chi SW (2018) Evaluation and control of miRNA-like off-target repression for RNA interference. Cell Mol Life Sci 75(5):797\u2013814","journal-title":"Cell Mol Life Sci"},{"issue":"22","key":"10190_CR18","doi-asserted-by":"publisher","first-page":"16541","DOI":"10.1021\/acs.jmedchem.1c01110","volume":"64","author":"M Song","year":"2021","unstructured":"Song M, Wang Y, Zhou P, Wang J, Xu H, Zheng J (2021) MicroRNA-361-5p aggravates acute pancreatitis by promoting Interleukin-17A secretion via impairment of nuclear factor IA-dependent Hes1 downregulation. J Med Chem 64(22):16541\u201316552","journal-title":"J Med Chem"},{"issue":"8","key":"10190_CR19","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics12081974","volume":"12","author":"J Walkowska","year":"2022","unstructured":"Walkowska J, Zielinska N, Tubbs RS, Podg\u00f3rski M, D\u0142ubek-Ruxer J, Olewnik \u0141 (2022) Diagnosis and treatment of acute pancreatitis. Diagnostics 12(8):1974","journal-title":"Diagnostics"},{"issue":"3","key":"10190_CR20","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1038\/s41401-023-01186-4","volume":"45","author":"LJ Wang","year":"2024","unstructured":"Wang LJ, Jin YL, Pei WL, Li JC, Zhang RL, Wang JJ, Lin W (2024) Amuc_1100 pretreatment alleviates acute pancreatitis in a mouse model through regulating gut microbiota and inhibiting inflammatory infiltration. Acta Pharmacol Sin 45(3):570\u2013580","journal-title":"Acta Pharmacol Sin"},{"issue":"24","key":"10190_CR21","first-page":"12836","volume":"24","author":"G Wu","year":"2020","unstructured":"Wu G, Zhang J, Fan GG, Zou ZY, Yin YL, Li GX (2020) MiRNA-324-5p inhibits inflammatory response of diabetic vessels by targeting CPT1A. Eur Rev Med Pharmacol Sci 24(24):12836\u201312843","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"10190_CR22","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.jaut.2017.12.009","volume":"89","author":"W Yang","year":"2018","unstructured":"Yang W, Zhou G, Yu T, Chen L, Yu L, Guo Y, Cong Y, Liu Z (2018) Critical role of ROCK2 activity in facilitating mucosal CD4\u2009+\u2009T cell activation in inflammatory bowel disease. J Autoimmun 89:125\u2013138","journal-title":"J Autoimmun"},{"issue":"26","key":"10190_CR23","doi-asserted-by":"publisher","first-page":"12072","DOI":"10.7150\/thno.51231","volume":"10","author":"J Ye","year":"2020","unstructured":"Ye J, Wang Z, Chen X, Jiang X, Dong Z, Hu S, Li W, Liu Y, Liao B, Han W, Shen J, Xiao M (2020) YTHDF1-enhanced iron metabolism depends on TFRC m(6)A methylation. Theranostics 10(26):12072\u201312089","journal-title":"Theranostics"},{"issue":"18","key":"10190_CR24","doi-asserted-by":"publisher","first-page":"2747","DOI":"10.3748\/wjg.v29.i18.2747","volume":"29","author":"E Zerem","year":"2023","unstructured":"Zerem E, Kurtcehajic A, Kunosi\u0107 S, Zerem Malko\u010devi\u0107 D, Zerem O (2023) Current trends in acute pancreatitis: diagnostic and therapeutic challenges. World J Gastroenterol 29(18):2747\u20132763","journal-title":"World J Gastroenterol"}],"container-title":["Mammalian Genome"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00335-025-10190-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00335-025-10190-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00335-025-10190-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T16:22:10Z","timestamp":1768234930000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00335-025-10190-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,12]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["10190"],"URL":"https:\/\/doi.org\/10.1007\/s00335-025-10190-4","relation":{},"ISSN":["0938-8990","1432-1777"],"issn-type":[{"value":"0938-8990","type":"print"},{"value":"1432-1777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,12]]},"assertion":[{"value":"26 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The Ethics Committee of Huai\u2019an People\u2019s Hospital endorsed human study approval #AH2025_PHN278 and animal protocol #AH2025-045\u00a0C.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"21"}}