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For over 15\u00a0years, the Diversity Outbred (DO) mice have existed as a powerful tool for mapping complex traits. With eight founder strains contributing to high levels of genetic diversity, heterozygosity, and large numbers of recombination events, DO mice allow for high-resolution genetic mapping. DO mice have been used to dissect the genetic architecture of physiological traits like blood lipids, behavioral traits such as cocaine self-administration, and molecular phenotypes such as gene expression across various tissues. Here we aim to exhaustively catalog DO mouse studies over the last 15\u00a0years, including both mapping and non-mapping studies, as well as to provide an overview of software tools and online resources related to the model.<\/jats:p>","DOI":"10.1007\/s00335-026-10196-6","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T18:34:08Z","timestamp":1769625248000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Fifteen years of the Diversity Outbred mouse model: a review"],"prefix":"10.1007","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1115-0314","authenticated-orcid":false,"given":"Zachary","family":"Tatom","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1532-584X","authenticated-orcid":false,"given":"Michael F.","family":"Miles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3634-0747","authenticated-orcid":false,"given":"Abraham A.","family":"Palmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,28]]},"reference":[{"key":"10196_CR1","doi-asserted-by":"publisher","first-page":"3408","DOI":"10.1038\/s41467-021-23649-0","volume":"12","author":"BM Al-Barghouthi","year":"2021","unstructured":"Al-Barghouthi BM et al (2021) Systems genetics in diversity outbred mice inform BMD gwas and identify determinants of bone strength. 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