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Because PRs lack enzymatic machinery to generate critical PUFA intermediates from dietary precursors, they rely on the RPE to coordinate multiple steps of PUFA uptake, metabolism and export. Consequently, disruption in any of these steps perturbs PR homeostasis and compromises overall retinal health. In this review, we summarize current evidence about the genes, proteins, molecular pathways, and pathological alterations that govern the regulation of PUFA metabolism in the RPE. Data from human genetic disorders, mouse models and in vitro studies is discussed to illustrate how disruption of PUFA pathways in the RPE leads to lipid imbalance and retinal degeneration, and to highlight how these findings illuminate molecular mechanisms underlying PUFA biology. We also identify critical gaps in knowledge and unresolved questions surrounding RPE-PR PUFA metabolism and propose that addressing these gaps will be essential for advancing therapeutic strategies for retinal disease.<\/jats:p>","DOI":"10.1007\/s00335-026-10239-y","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T14:34:44Z","timestamp":1779460484000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Polyunsaturated fatty acid metabolism in the retinal pigment epithelium and its association with outer retinal disease"],"prefix":"10.1007","volume":"37","author":[{"given":"Naga Pradeep","family":"Rayana","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navdeep","family":"Gogna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark P.","family":"Krebs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gayle B.","family":"Collin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen K.","family":"Naggert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patsy M.","family":"Nishina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,22]]},"reference":[{"key":"10239_CR1","doi-asserted-by":"publisher","first-page":"20570","DOI":"10.1074\/jbc.M114.565457","volume":"289","author":"J Adijanto","year":"2014","unstructured":"Adijanto J, Du J, Moffat C, Seifert EL, Hurle JB, Philp NJ (2014) The retinal pigment epithelium utilizes fatty acids for ketogenesis. 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