{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T07:26:04Z","timestamp":1771658764607,"version":"3.50.1"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2005,6,2]],"date-time":"2005-06-02T00:00:00Z","timestamp":1117670400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Urol"],"published-print":{"date-parts":[[2005,7]]},"DOI":"10.1007\/s00345-004-0491-z","type":"journal-article","created":{"date-parts":[[2005,6,1]],"date-time":"2005-06-01T15:00:21Z","timestamp":1117638021000},"page":"102-108","source":"Crossref","is-referenced-by-count":46,"title":["Lifelong premature ejaculation: definition, serotonergic neurotransmission and drug treatment"],"prefix":"10.1007","volume":"23","author":[{"given":"Marcel D.","family":"Waldinger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2005,6,2]]},"reference":[{"key":"491_CR1","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/sj.ijir.3901172","volume":"16","author":"Waldinger","year":"2004","unstructured":"Waldinger MD, Zwinderman AH, Schweitzer DH, Olivier B (2004) Relevance of methodological design for the interpretation of efficacy of drug treatment of premature ejaculation: a systematic review and meta-analysis. J Impot Res 16:369\u2013381","journal-title":"J Impot Res"},{"key":"491_CR2","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/S0022-5347(17)70462-4","volume":"50","author":"Schapiro","year":"1943","unstructured":"Schapiro B (1943) Premature ejaculation, a review of 1130 cases. J Urol 50:374\u2013379","journal-title":"J Urol"},{"key":"491_CR3","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1177\/030006057300100531","volume":"1","author":"Eaton","year":"1973","unstructured":"Eaton H (1973) Clomipramine in the treatment of premature ejaculation. J Int Med Res 1:432\u2013434","journal-title":"J Int Med Res"},{"key":"491_CR4","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1080\/00224498809551414","volume":"24","author":"Assalian","year":"1988","unstructured":"Assalian P (1988) Clomipramine in the treatment of premature ejaculation. J Sex Res 24:213\u2013215","journal-title":"J Sex Res"},{"key":"491_CR5","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/S0015-0282(16)48157-4","volume":"42","author":"Shilon","year":"1984","unstructured":"Shilon M, Paz GF, Hommonai ZT (1984) The use of phenoxybenzamine treatment in premature ejaculation. Fertil Steril 42:659\u2013661","journal-title":"Fertil Steril"},{"key":"491_CR6","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1176\/ajp.151.9.1377","volume":"151","author":"Waldinger","year":"1994","unstructured":"Waldinger MD, Hengeveld MW, Zwinderman AH (1994) Paroxetine treatment of premature ejaculation: a double-blind, randomised, placebo-controlled study. Am J Psychiatry 151:1377\u20131379","journal-title":"Am J Psychiatry"},{"key":"491_CR7","first-page":"rationale","volume":"ejaculation","author":"Althof","year":"2005","unstructured":"Althof SE (2005) Psychological treatment strategies for rapid ejaculation: rationale, practical aspects, and outcome. World J Urol (this issue)","journal-title":"Psychological treatment strategies for rapid"},{"key":"491_CR8","doi-asserted-by":"crossref","unstructured":"Assalian P (2005) Guidelines for pharmacotherapy of premature ejaculation. World J Urol (this issue)","DOI":"10.1007\/s00345-004-0463-3"},{"key":"491_CR9","doi-asserted-by":"crossref","unstructured":"Hartmann U, Schedlowski M, Kruger THC (2005) Cognitive and partner-related factors in rapid ejaculation: differences between dysfunctional and functional men. World J Urol (this issue)","DOI":"10.1007\/s00345-004-0490-0"},{"key":"491_CR10","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/sj.ijir.3901023","volume":"15","author":"Waldinger","year":"2003","unstructured":"Waldinger MD (2003) Towards evidence-based drug treatment research on premature ejaculation: a critical evaluation of methodology. J Impot Res 15:309\u2013313","journal-title":"J Impot Res"},{"key":"491_CR11","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1464-410X.2004.04495.x","volume":"93","author":"Waldinger","year":"2004","unstructured":"Waldinger MD (2004) Lifelong premature ejaculation: from authority-based to evidence-based medicine. BJU Int 93:201\u2013207","journal-title":"BJU Int"},{"key":"491_CR12","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1037\/h0087604","volume":"10","author":"Tanner","year":"1973","unstructured":"Tanner BA (1973) Two case reports on the modification of the ejaculatory response with the squeeze technique. Psychother Res Pract 10:297","journal-title":"Psychother Res Pract"},{"key":"491_CR13","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/0022-3999(84)90055-2","volume":"28","author":"Cooper","year":"1984","unstructured":"Cooper AJ, Magnus RV (1984) A clinical trial of the beta blocker propranolol in premature ejaculation. J Psychosom Res 28:331\u2013336","journal-title":"J Psychosom Res"},{"key":"491_CR14","first-page":"402","volume":"56","author":"Althof","year":"1995","unstructured":"Althof SE, Levine SB, Corty EW, Risen CB, Stern EB (1995) A double-blind crossover trial of clomipramine for rapid ejaculation in 15 couples. J. Clin Psychiatry 56:402\u2013407","journal-title":"Clin Psychiatry"},{"key":"491_CR15","doi-asserted-by":"crossref","first-page":"287","DOI":"10.3109\/13651509809115376","volume":"2","author":"Waldinger","year":"1998","unstructured":"Waldinger MD, Hengeveld MW, Zwinderman AH, Olivier B (1998) An empirical operationalization study of DSM-IV diagnostic criteria for premature ejaculation. Int J Psychiatry Clin Pract 2:287\u2013293","journal-title":"Int J Psychiatry Clin Pract"},{"key":"491_CR16","unstructured":"Masters WH, Johnson VE (1970) Premature ejaculation. In: Masters WH, Johnson VE (eds) Human sexual inadequacy. Little, Brown, Boston, pp 92\u2013115"},{"key":"491_CR17","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0166-4328(97)00183-6","volume":"92","author":"Waldinger","year":"1998","unstructured":"Waldinger MD, Berendsen HHG, Blok BFM, Olivier B, Holstege G (1998) Premature ejaculation and SSRI-induced delayed ejaculation: the involvement of the serotonergic system. Behav Brain Res 92:111\u2013118","journal-title":"Behav Brain Res"},{"key":"491_CR18","unstructured":"Waldinger MD, Olivier B (2000) Selective serotonin reuptake inhibitors (SSRIs) and sexual side effects: differences in delaying ejaculation. In: Sacchetti E, Spano P (eds) Advances in preclinical and clinical psychiatry, vol 1, Fluvoxamine: established and emerging roles in psychiatric disorders. Excerpta Medica, Milan, pp 117\u2013130"},{"key":"491_CR19","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1016\/S0022-5347(05)64146-8","volume":"168","author":"Waldinger","year":"2002","unstructured":"Waldinger MD (2002) The neurobiological approach to premature ejaculation.J Urol 168:2359\u20132367","journal-title":"J Urol"},{"key":"491_CR20","doi-asserted-by":"crossref","unstructured":"Waldinger MD, Quinn P, Dilleen M, Mundayat R, Schweitzer DH, Boolell M (2005) A multinational population survey of intravaginal ejaculation latency time. J Sex Med (in press)","DOI":"10.1111\/j.1743-6109.2005.00070.x"},{"key":"491_CR21","doi-asserted-by":"crossref","unstructured":"Waldinger MD, Zwinderman AH, Olivier B, Schweitzer DH (2005) Proposal for a definition of lifelong premature ejaculation based on epidemiological stopwatch data. J Sex Med (in press)","DOI":"10.1111\/j.1743-6109.2005.00069.x"},{"key":"491_CR22","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1743-6109.2005.20112.x","volume":"2","author":"Waldinger","year":"2005","unstructured":"Waldinger MD, Schweitzer DH, Olivier B (2005) On-demand SSRI treatment of premature ejaculation: pharmacodynamic limitations for relevant ejaculation delay and consequent solutions. J Sex Med 2:121\u2013131","journal-title":"J Sex Med"},{"key":"491_CR23","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1111\/j.1743-6109.2005.20353.x","volume":"2","author":"Patrick","year":"2005","unstructured":"Patrick DL, Althof SE, Pryor JL, Rosen R, Rowland DL, Ho KF, McNulty P, Rothman M, Jamieson C (2005) Premature ejaculation: an observational study of men and their partners. J Sex Med 2:358\u2013367","journal-title":"J Sex Med"},{"key":"491_CR24","doi-asserted-by":"crossref","unstructured":"Rowland DL (2005) Psychophysiology of ejaculatory function and dysfunction. World J Urol (this issue)","DOI":"10.1007\/s00345-004-0488-7"},{"key":"491_CR25","first-page":"an","volume":"men","author":"Waldinger","year":"2005","unstructured":"Waldinger MD, Schweitzer DH (2005) Retarded ejaculation in men: an overview of psychological and neurobiological insights. World J Urol (this issue)","journal-title":"Retarded ejaculation in"},{"key":"491_CR26","unstructured":"Pattij T, De Jong T, Uitterdijk A, Waldinger MD, Veening JG, Van der Graaf PH, Olivier B (2003) Searching for models to study ejaculation disorders. Behav Pharmacol 14 [Suppl 1]:S80\u201381"},{"key":"491_CR27","first-page":"modeling","volume":"behavior","author":"Olivier","year":"2005","unstructured":"Olivier B, Chan J, Pattij T, de Jong T, Oosting R, Veening J, Waldinger MD (2005) Psychopharmacology of male rat sexual behavior: modeling human sexual dysfunctions? Int J Impot Res (in press)","journal-title":"Psychopharmacology of male rat sexual"},{"key":"491_CR28","doi-asserted-by":"crossref","unstructured":"Waldinger MD, Olivier B (2005) Animal models of premature and delayed ejaculation. World J Urol (this issue)","DOI":"10.1007\/s00345-004-0493-x"},{"key":"491_CR29","doi-asserted-by":"crossref","unstructured":"Olivier B, Van Oorschot R, Waldinger MD (1998) Serotonin, serotonergic receptors, selective serotonin reuptake inhibitors and sexual behaviour. Int Clin Psychopharmacol 13 [Ssuppl 6]:S9\u2013S14","DOI":"10.1097\/00004850-199807006-00003"},{"key":"491_CR30","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/0091-3057(81)90023-X","volume":"15","author":"Ahlenius","year":"1981","unstructured":"Ahlenius S, Larsson K, Svensson L, Hjorth S, Carlsson A, Linberg P et al. (1981) Effects of a new type of 5-HT receptor agonist on male rat sexual behaviour. Pharmacol Biochem Behav 15:785\u2013792","journal-title":"Pharmacol Biochem Behav"},{"key":"491_CR31","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/0024-3205(89)90128-8","volume":"45","author":"Foreman","year":"1998","unstructured":"Foreman MM, Hall JL, Love RL (1998) The role of the 5-HT2 receptor in the regulation of sexual performance of male rats. Life Sci 45:1263\u20131270","journal-title":"Life Sci"},{"key":"491_CR32","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1016\/S0022-5347(01)65467-3","volume":"156","author":"Kara","year":"1996","unstructured":"Kara H, Aydin S, Agargun Y, Odabas O, Yilmiz Y (1996) The efficacy of fluoxetine in the treatment of premature ejaculation: a double-blind, placebo controlled study. J Urol 156:1631\u20131632","journal-title":"J Urol"},{"key":"491_CR33","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1097\/00004714-199808000-00004","volume":"18","author":"Waldinger","year":"1998","unstructured":"Waldinger MD, Hengeveld MW, Zwinderman AH, Olivier B (1998) Effect of SSRI antidepressants on ejaculation: a double-blind, randomized, placebo-controlled study with fluoxetine, fluvoxamine, paroxetine and sertraline. J Clin Psychopharmacol 18:274\u2013281","journal-title":"J Clin Psychopharmacol"},{"key":"491_CR34","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1097\/00004714-200106000-00007","volume":"21","author":"Waldinger","year":"2001","unstructured":"Waldinger MD, Zwinderman AH, Olivier B (2001) Antidepressants and ejaculation: a double-blind, randomized, placebo-controlled, fixed-dose study with paroxetine, sertraline, and nefazodone. J Clin Psychopharmacol 21:293\u2013297","journal-title":"J Clin Psychopharmacol"},{"key":"491_CR35","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1097\/00004714-200112000-00003","volume":"21","author":"Waldinger","year":"2001","unstructured":"Waldinger MD, Zwinderman AH, Olivier B (2001) SSRIs and ejaculation: a double-blind, randomised, fixed-dose study with paroxetine and citalopram. J Clin Psychopharmacol 21:556\u2013560","journal-title":"J Clin Psychopharmacol"},{"key":"491_CR36","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1097\/01.jcp.0000088904.24613.e4","volume":"23","author":"Waldinger","year":"2003","unstructured":"Waldinger MD, Zwinderman AH, Olivier B (2003) Antidepressants and ejaculation: a double-blind, randomized, fixed-dose study with mirtazapine and paroxetine. J Clin Psychopharmacol 23:467\u2013470","journal-title":"J Clin Psychopharmacol"},{"key":"491_CR37","first-page":"116","volume":"28","author":"Novaretti","year":"2002","unstructured":"Novaretti JPT, Pompeo ACL, Arap S (2002) Selective serotonin uptake inhibitor in the treatment of premature ejaculation. Brazil J Urol 28:116\u2013122","journal-title":"Brazil J Urol"},{"key":"491_CR38","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/sj.ijir.3900918","volume":"14","author":"Atmaca","year":"2002","unstructured":"Atmaca M, Kuloglu M, Tezcan E, Semercioz A (2002) The efficacy of citalopram in the treatment of premature ejaculation: a placebo-controlled study. Int J Impot Res 14:502\u2013505","journal-title":"Int J Impot Res"},{"key":"491_CR39","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0924-977X(98)00015-7","volume":"9","author":"Mos","year":"1999","unstructured":"Mos J, Mollet I, Tolboom JTBM, Waldinger MD, Olivier B (1999) A comparison of the effects of different serotonin reuptake blockers on sexual behaviour of the male rat. Eur Neuropsychopharmacol 9:123\u2013135","journal-title":"Eur Neuropsychopharmacol"},{"key":"491_CR40","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.eururo.2004.05.005","volume":"46","author":"Waldinger","year":"2004","unstructured":"Waldinger MD, Zwinderman AH, Olivier B (2004) On-demand treatment of premature ejaculation with clomipramine and paroxetine: a randomized, double-blind fixed-dose study with stopwatch assessment. Eur Urol 46:510\u2013516","journal-title":"Eur Urol"},{"key":"491_CR41","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1080\/00926239308404904","volume":"19","author":"Segraves","year":"1993","unstructured":"Segraves RT, Saran A, Segraves K, Maguire E (1993) Clomipramine vs placebo in the treatment of premature ejaculation: a pilot study. J Sex Marital Ther 19:198\u2013200","journal-title":"J Sex Marital Ther"},{"key":"491_CR42","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1016\/S0022-5347(01)65576-9","volume":"156","author":"Haensel","year":"1996","unstructured":"Haensel SM, Rowland DL, Kallan KTHK, Slob AK (1996) Clomipramine and sexual function in men with premature ejaculation and controls. J Urol 156:1310\u20131315","journal-title":"J Urol"},{"key":"491_CR43","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/sj.ijir.3900630","volume":"13","author":"Abdel-Hamid","year":"2001","unstructured":"Abdel-Hamid IA, El Naggar EA, El Gilany AH (2001) Assessment of as needed use of pharmacotherapy and the pause-squeeze technique in premature ejaculation. Int J Impot Res 13:41\u201345","journal-title":"Int J Impot Res"},{"key":"491_CR44","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/sj.ijir.3900415","volume":"11","author":"McMahon","year":"1999","unstructured":"McMahon CG, Touma K (1999) Treatment of premature ejaculation with paroxetine hydrochloride. Int J Impot Res 11:241\u2013245","journal-title":"Int J Impot Res"}],"container-title":["World Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00345-004-0491-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00345-004-0491-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00345-004-0491-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T13:35:33Z","timestamp":1559050533000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00345-004-0491-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6,2]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,7]]}},"alternative-id":["491"],"URL":"https:\/\/doi.org\/10.1007\/s00345-004-0491-z","relation":{},"ISSN":["0724-4983","1433-8726"],"issn-type":[{"value":"0724-4983","type":"print"},{"value":"1433-8726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,6,2]]}}}