{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:10:41Z","timestamp":1791389441851,"version":"4.3.3"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2009,8,5]],"date-time":"2009-08-05T00:00:00Z","timestamp":1249430400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Urol"],"published-print":{"date-parts":[[2010,6]]},"DOI":"10.1007\/s00345-009-0462-5","type":"journal-article","created":{"date-parts":[[2009,8,4]],"date-time":"2009-08-04T14:02:56Z","timestamp":1249394576000},"page":"359-364","source":"Crossref","is-referenced-by-count":151,"title":["Elevated scrotal temperature, but not varicocele grade, reflects testicular oxidative stress-mediated apoptosis"],"prefix":"10.1007","volume":"28","author":[{"given":"Koji","family":"Shiraishi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Takihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideyasu","family":"Matsuyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,8,5]]},"reference":[{"key":"462_CR1","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.1365-2605.1995.tb00408.x","volume":"18","author":"LM Bujan","year":"1995","unstructured":"Bujan LM (1995) Testicular heating and its possible contributions to male infertility: a review. Int J Androl 18:169\u2013184","journal-title":"Int J Androl"},{"key":"462_CR2","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.1439-0272.2007.00794.x","volume":"39","author":"A Jung","year":"2007","unstructured":"Jung A, Schuppe HC (2007) Influence of genital heat stress on semen quality in humans. Andrologia 39:203\u2013215","journal-title":"Andrologia"},{"key":"462_CR3","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0890-6238(02)00025-4","volume":"16","author":"NHI Hjollund","year":"2002","unstructured":"Hjollund NHI, Storgaard L, Ernst E et al (2002) Impact of diurnal scrotal temperature on semen quality. Reprod Toxicol 16:215\u2013221","journal-title":"Reprod Toxicol"},{"key":"462_CR4","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0015-0282(16)60858-0","volume":"52","author":"M Yamaguchi","year":"1989","unstructured":"Yamaguchi M, Sakatoku J, Takihara H et al (1989) The application of intrascrotal deep body temperature measurement for the noninvasive diagnosis of varicocele. Fertil Steril 52:295\u2013301","journal-title":"Fertil Steril"},{"key":"462_CR5","doi-asserted-by":"crossref","first-page":"488","DOI":"10.2164\/jandrol.108.005132","volume":"29","author":"TT Turner","year":"2008","unstructured":"Turner TT, Lysiak JJ (2008) Oxidative stress: a common factor in testicular dysfunction. J Androl 29:488\u2013498","journal-title":"J Androl"},{"key":"462_CR6","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1046\/j.1464-410X.2000.00755.x","volume":"86","author":"IT K\u00f6ksal","year":"2000","unstructured":"K\u00f6ksal IT, Tefekli A, Usta M et al (2000) The role of reactive oxygen species in testicular dysfunction associated with varicocele. BJU Int 86:549\u2013552","journal-title":"BJU Int"},{"key":"462_CR7","doi-asserted-by":"crossref","first-page":"2608","DOI":"10.1093\/humrep\/dei063","volume":"20","author":"K Shiraishi","year":"2005","unstructured":"Shiraishi K, Naito K (2005) Increased expression of Leydig cell heme oxygenase-1 preserves spermatogenesis in varicocele. Hum Reprod 20:2608\u20132613","journal-title":"Hum Reprod"},{"key":"462_CR8","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.fertnstert.2005.12.022","volume":"86","author":"K Shiraishi","year":"2006","unstructured":"Shiraishi K, Naito K (2006) Generation of 4-hydroxy-2-nonenal modified proteins in testis predicts improvement in spermatogenesis after varicocelectomy. Fertil Steril 86:233\u2013235","journal-title":"Fertil Steril"},{"key":"462_CR9","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.juro.2007.05.027","volume":"178","author":"K Shiraishi","year":"2007","unstructured":"Shiraishi K, Naito K (2007) Effects of 4-hydroxy-2-nonenal, a marker of oxidative stress, on spermatogenesis and expression of p53 protein in male infertility. J Urol 178:1012\u20131017","journal-title":"J Urol"},{"key":"462_CR10","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/0167-5699(94)90018-3","volume":"15","author":"TM Buttke","year":"1994","unstructured":"Buttke TM, Sandstrom OA (1994) Oxidative stress as mediators of apoptosis. Immunol Today 15:7\u201310","journal-title":"Immunol Today"},{"key":"462_CR11","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1095\/biolreprod.108.071779","volume":"80","author":"C Paul","year":"2009","unstructured":"Paul C, Teng S, Saunders PTK (2009) A single, mild, transient scrotal heat stress causes hypoxia and oxidative stress in mouse testes, which induces germ cell death. Biol Reprod 80:913\u2013919","journal-title":"Biol Reprod"},{"key":"462_CR12","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1093\/humrep\/deh697","volume":"20","author":"A Jung","year":"2005","unstructured":"Jung A, Leonhardt F, Shill WB et al (2005) Influence of the type of undertrousers and physical activity on scrotal temperatures. Hum Reprod 20:1022\u20131027","journal-title":"Hum Reprod"},{"key":"462_CR13","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1093\/humrep\/dem133","volume":"22","author":"B Bengoudifa","year":"2007","unstructured":"Bengoudifa B, Mieusset R (2007) Thermal asymmetry of the human scrotum. Hum Reprod 22:2178\u20132182","journal-title":"Hum Reprod"},{"key":"462_CR14","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/S0015-0282(97)81525-7","volume":"68","author":"C Wang","year":"1997","unstructured":"Wang C, Berman N, McDonald V et al (1997) Effect of increased scrotal temperature on sperm production in normal men. Fertil Steril 68:334\u2013339","journal-title":"Fertil Steril"},{"key":"462_CR15","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/S0015-0282(16)59600-9","volume":"48","author":"R Mieusset","year":"1987","unstructured":"Mieusset R, Bujan L, Mondinat C et al (1987) Association of scrotal hyperthermia with impaired spermatogenesis in infertile men. Fertil Steril 48:1006\u20131011","journal-title":"Fertil Steril"},{"key":"462_CR16","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1530\/jrf.0.0820563","volume":"82","author":"AW Zorgniotti","year":"1998","unstructured":"Zorgniotti AW, Sealfon AI (1998) Measurement of intrascrotal temperature in normal and subfertile men. J Reprod Fertil 82:563\u2013566","journal-title":"J Reprod Fertil"},{"key":"462_CR17","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1095\/biolreprod46.6.1114","volume":"46","author":"M Ahotupa","year":"1992","unstructured":"Ahotupa M, Huhtaniemi I (1992) Impaired detoxification of reactive oxygen and consequent oxidative stress in experimentally cryptorchid rat testis. Biol Reprod 46:1114\u20131118","journal-title":"Biol Reprod"},{"key":"462_CR18","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1095\/biolreprod61.2.393","volume":"61","author":"M Ikeda","year":"1999","unstructured":"Ikeda M, Kodama H, Fukuda J et al (1999) Role of radical oxygen species in rat testicular germ cell apoptosis induced by heat stress. Biol Reprod 61:393\u2013399","journal-title":"Biol Reprod"},{"key":"462_CR19","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1093\/humrep\/deh139","volume":"19","author":"SH Benoff","year":"2004","unstructured":"Benoff SH, Millan C, Hurley IR et al (2004) Bilateral increased apoptosis and bilateral accumulation of cadmium in infertile men with left varicocele. Hum Reprod 19:616\u2013627","journal-title":"Hum Reprod"},{"key":"462_CR20","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/j.1365-2605.2004.00476.x","volume":"27","author":"K Cam","year":"2004","unstructured":"Cam K, Simsek F, Yuksel M et al (2004) The role of reactive oxygen species and apoptosis in the pathogenesis of varicocele in a rat model and efficiency of vitamin E treatment. Int J Androl 27:228\u2013233","journal-title":"Int J Androl"},{"key":"462_CR21","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1530\/jrf.0.1140179","volume":"114","author":"BP Setchell","year":"1998","unstructured":"Setchell BP (1998) The Parkes lecture. Heat and the testis. J Reprod Fertil 114:179\u2013194","journal-title":"J Reprod Fertil"},{"key":"462_CR22","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1095\/biolreprod.103.020065","volume":"70","author":"H Izu","year":"2004","unstructured":"Izu H, Inouye S, Fujimoto M et al (2004) Heat shock transcription factor 1 is involved in quality-control mechanisms in male germ cells. Biol Reprod 70:18\u201324","journal-title":"Biol Reprod"},{"key":"462_CR23","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1210\/endo.140.4.6629","volume":"140","author":"YH Lue","year":"1999","unstructured":"Lue YH, Hikim AP, Swerdloff RS et al (1999) Single exposure to heat induces stage-specific germ cell apoptosis in rats: role of intratesticular testosterone on stage specificity. Endocrinology 140:1709\u20131717","journal-title":"Endocrinology"},{"key":"462_CR24","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1439-0272.2008.00894.x","volume":"41","author":"A Hassan","year":"2009","unstructured":"Hassan A, El-Nashar EM, Mostafa T (2009) Programmed cell death in varicocele-bearing testes. Andrologia 41:39\u201345","journal-title":"Andrologia"},{"key":"462_CR25","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1095\/biolreprod58.2.492","volume":"58","author":"Y Yin","year":"1998","unstructured":"Yin Y, DeWolf WC, Morgentaler A (1998) Experimental cryptorchidism induces testicular germ cell apoptosis by p53-dependent and -independent pathways in mice. Biol Reprod 58:492\u2013496","journal-title":"Biol Reprod"},{"key":"462_CR26","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/j.1939-4640.1999.tb02509.x","volume":"20","author":"A Morgentaler","year":"1999","unstructured":"Morgentaler A, Stahl BC, Yin Y (1999) Testis and temperature: an historical, clinical, and research perspective. J Androl 20:189\u2013195","journal-title":"J Androl"},{"key":"462_CR27","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1093\/oxfordjournals.humrep.a137909","volume":"8","author":"A Lenzi","year":"1993","unstructured":"Lenzi A, Culasso F, Gandini L et al (1993) Placebo-controlled, double-blind, cross-over trial of glutathione therapy in male infertility. Hum Reprod 8:1657\u20131662","journal-title":"Hum Reprod"},{"key":"462_CR28","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/S0015-0282(16)57861-3","volume":"64","author":"E Kessopoulou","year":"1995","unstructured":"Kessopoulou E, Powers HJ, Sharma KK et al (1995) A double-blind randomized placebo cross-over controlled trial using the antioxidant vitamin E to treat reactive oxygen species associated male infertility. Fertil Steril 64:825\u2013831","journal-title":"Fertil Steril"}],"container-title":["World Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00345-009-0462-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00345-009-0462-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00345-009-0462-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T17:29:08Z","timestamp":1710523748000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00345-009-0462-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8,5]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["462"],"URL":"https:\/\/doi.org\/10.1007\/s00345-009-0462-5","relation":{},"ISSN":["0724-4983","1433-8726"],"issn-type":[{"value":"0724-4983","type":"print"},{"value":"1433-8726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,8,5]]}}}