{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T15:26:51Z","timestamp":1785338811190,"version":"3.55.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T00:00:00Z","timestamp":1519171200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Urol"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1007\/s00345-018-2235-5","type":"journal-article","created":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T01:48:25Z","timestamp":1519177705000},"page":"1019-1029","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Is neutrophil-to-lymphocytes ratio a clinical relevant preoperative biomarker in upper tract urothelial carcinoma? A meta-analysis of 4385 patients"],"prefix":"10.1007","volume":"36","author":[{"given":"Mihai Dorin","family":"Vartolomei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoji","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Ferro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana","family":"Vartolomei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beat","family":"Foerster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Abufaraj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahrokh F.","family":"Shariat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,2,21]]},"reference":[{"key":"2235_CR1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21387","volume":"67","author":"RL Siegel","year":"2017","unstructured":"Siegel RL, Miller KD, Jemal A (2017) Cancer statistics, 2017. CA Cancer J Clin 67:7\u201330. \n                    https:\/\/doi.org\/10.3322\/caac.21387","journal-title":"CA Cancer J Clin"},{"key":"2235_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2017.07.036","author":"M Roupr\u00eat","year":"2017","unstructured":"Roupr\u00eat M, Babjuk M, Comp\u00e9rat E et al (2017) European Association of Urology Guidelines on Upper Urinary Tract Urothelial Carcinoma: 2017 Update. Eur Urol. \n                    https:\/\/doi.org\/10.1016\/j.eururo.2017.07.036","journal-title":"Eur Urol"},{"key":"2235_CR3","doi-asserted-by":"publisher","first-page":"E107","DOI":"10.1111\/bju.12025","volume":"112","author":"MF Eylert","year":"2013","unstructured":"Eylert MF, Hounsome L, Verne J et al (2013) Prognosis is deteriorating for upper tract urothelial cancer: data for England 1985\u20132010. BJU Int 112:E107\u2013E113. \n                    https:\/\/doi.org\/10.1111\/bju.12025","journal-title":"BJU Int"},{"key":"2235_CR4","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1111\/j.1464-410X.2010.09675.x","volume":"107","author":"JD Raman","year":"2011","unstructured":"Raman JD, Messer J, Sielatycki JA, Hollenbeak CS (2011) Incidence and survival of patients with carcinoma of the ureter and renal pelvis in the USA, 1973\u20132005. BJU Int 107:1059\u20131064. \n                    https:\/\/doi.org\/10.1111\/j.1464-410X.2010.09675.x","journal-title":"BJU Int"},{"key":"2235_CR5","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1016\/j.eururo.2012.01.021","volume":"61","author":"EK Cha","year":"2012","unstructured":"Cha EK, Shariat SF, Kormaksson M et al (2012) Predicting clinical outcomes after radical nephroureterectomy for upper tract urothelial carcinoma. Eur Urol 61:818\u2013825. \n                    https:\/\/doi.org\/10.1016\/j.eururo.2012.01.021","journal-title":"Eur Urol"},{"key":"2235_CR6","doi-asserted-by":"publisher","first-page":"4337","DOI":"10.1245\/s10434-012-2499-8","volume":"19","author":"M Rink","year":"2012","unstructured":"Rink M, Sjoberg D, Comploj E et al (2012) Risk of cancer-specific mortality following recurrence after radical nephroureterectomy. Ann Surg Oncol 19:4337\u20134344. \n                    https:\/\/doi.org\/10.1245\/s10434-012-2499-8","journal-title":"Ann Surg Oncol"},{"key":"2235_CR7","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1111\/bju.12014","volume":"112","author":"M Rink","year":"2013","unstructured":"Rink M, Xylinas E, Trinh Q-D et al (2013) Gender-specific effect of smoking on upper tract urothelial carcinoma outcomes. BJU Int 112:623\u2013637. \n                    https:\/\/doi.org\/10.1111\/bju.12014","journal-title":"BJU Int"},{"key":"2235_CR8","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1016\/j.eururo.2014.08.003","volume":"67","author":"G Ploussard","year":"2015","unstructured":"Ploussard G, Xylinas E, Lotan Y et al (2015) Conditional survival after radical nephroureterectomy for upper tract carcinoma. Eur Urol 67:803\u2013812. \n                    https:\/\/doi.org\/10.1016\/j.eururo.2014.08.003","journal-title":"Eur Urol"},{"key":"2235_CR9","doi-asserted-by":"publisher","first-page":"261","DOI":"10.3978\/j.issn.2223-4683.2015.05.01","volume":"4","author":"R Mathieu","year":"2015","unstructured":"Mathieu R, Bensalah K, Lucca I et al (2015) Upper urinary tract disease: what we know today and unmet needs. Transl Androl Urol 4:261\u2013272. \n                    https:\/\/doi.org\/10.3978\/j.issn.2223-4683.2015.05.01","journal-title":"Transl Androl Urol"},{"key":"2235_CR10","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.eururo.2011.09.017","volume":"61","author":"TF Chromecki","year":"2012","unstructured":"Chromecki TF, Cha EK, Fajkovic H et al (2012) The impact of tumor multifocality on outcomes in patients treated with radical nephroureterectomy. Eur Urol 61:245\u2013253. \n                    https:\/\/doi.org\/10.1016\/j.eururo.2011.09.017","journal-title":"Eur Urol"},{"key":"2235_CR11","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1016\/j.eururo.2010.07.003","volume":"58","author":"RL Favaretto","year":"2010","unstructured":"Favaretto RL, Shariat SF, Chade DC et al (2010) The effect of tumor location on prognosis in patients treated with radical nephroureterectomy at Memorial Sloan-Kettering Cancer Center. Eur Urol 58:574\u2013580. \n                    https:\/\/doi.org\/10.1016\/j.eururo.2010.07.003","journal-title":"Eur Urol"},{"key":"2235_CR12","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1016\/j.eururo.2009.07.002","volume":"57","author":"JD Raman","year":"2010","unstructured":"Raman JD, Ng CK, Scherr DS et al (2010) Impact of tumor location on prognosis for patients with upper tract urothelial carcinoma managed by radical nephroureterectomy. Eur Urol 57:1072\u20131079. \n                    https:\/\/doi.org\/10.1016\/j.eururo.2009.07.002","journal-title":"Eur Urol"},{"key":"2235_CR13","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1016\/j.eururo.2009.06.004","volume":"56","author":"M Roscigno","year":"2009","unstructured":"Roscigno M, Shariat SF, Margulis V et al (2009) The extent of lymphadenectomy seems to be associated with better survival in patients with nonmetastatic upper-tract urothelial carcinoma: how many lymph nodes should be removed? Eur Urol 56:512\u2013518. \n                    https:\/\/doi.org\/10.1016\/j.eururo.2009.06.004","journal-title":"Eur Urol"},{"key":"2235_CR14","doi-asserted-by":"publisher","first-page":"2482","DOI":"10.1016\/j.juro.2009.02.021","volume":"181","author":"M Roscigno","year":"2009","unstructured":"Roscigno M, Shariat SF, Margulis V et al (2009) Impact of lymph node dissection on cancer specific survival in patients with upper tract urothelial carcinoma treated with radical nephroureterectomy. J Urol 181:2482\u20132489. \n                    https:\/\/doi.org\/10.1016\/j.juro.2009.02.021","journal-title":"J Urol"},{"key":"2235_CR15","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1111\/j.1464-410X.2008.08003.x","volume":"103","author":"M Remzi","year":"2009","unstructured":"Remzi M, Haitel A, Margulis V et al (2009) Tumour architecture is an independent predictor of outcomes after nephroureterectomy: a multi-institutional analysis of 1363 patients. BJU Int 103:307\u2013311. \n                    https:\/\/doi.org\/10.1111\/j.1464-410X.2008.08003.x","journal-title":"BJU Int"},{"key":"2235_CR16","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/j.eururo.2009.11.035","volume":"57","author":"R Zigeuner","year":"2010","unstructured":"Zigeuner R, Shariat SF, Margulis V et al (2010) Tumour necrosis is an indicator of aggressive biology in patients with urothelial carcinoma of the upper urinary tract. Eur Urol 57:575\u2013581. \n                    https:\/\/doi.org\/10.1016\/j.eururo.2009.11.035","journal-title":"Eur Urol"},{"key":"2235_CR17","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1016\/j.eururo.2009.12.029","volume":"57","author":"G Novara","year":"2010","unstructured":"Novara G, Matsumoto K, Kassouf W et al (2010) Prognostic role of lymphovascular invasion in patients with urothelial carcinoma of the upper urinary tract: an international validation study. Eur Urol 57:1064\u20131071. \n                    https:\/\/doi.org\/10.1016\/j.eururo.2009.12.029","journal-title":"Eur Urol"},{"key":"2235_CR18","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s00345-012-0947-5","volume":"31","author":"E Xylinas","year":"2013","unstructured":"Xylinas E, Kluth L, Mangal S et al (2013) Predictive tools for clinical decision-making and counseling of patients with upper tract urothelial carcinoma. World J Urol 31:31\u201336. \n                    https:\/\/doi.org\/10.1007\/s00345-012-0947-5","journal-title":"World J Urol"},{"key":"2235_CR19","doi-asserted-by":"publisher","first-page":"483-e17","DOI":"10.1016\/j.urolonc.2016.05.013","volume":"34","author":"A Mbeutcha","year":"2016","unstructured":"Mbeutcha A, Shariat SF, Rieken M et al (2016) Prognostic significance of markers of systemic inflammatory response in patients with non-muscle-invasive bladder cancer. Urol Oncol 34:483-e17\u2013483-e24. \n                    https:\/\/doi.org\/10.1016\/j.urolonc.2016.05.013","journal-title":"Urol Oncol"},{"key":"2235_CR20","doi-asserted-by":"publisher","first-page":"e493","DOI":"10.1016\/S1470-2045(14)70263-3","volume":"15","author":"CI Diakos","year":"2014","unstructured":"Diakos CI, Charles KA, McMillan DC, Clarke SJ (2014) Cancer-related inflammation and treatment effectiveness. Lancet Oncol 15:e493\u2013e503. \n                    https:\/\/doi.org\/10.1016\/S1470-2045(14)70263-3","journal-title":"Lancet Oncol"},{"key":"2235_CR21","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1007\/s00345-016-1826-2","volume":"35","author":"A Mbeutcha","year":"2017","unstructured":"Mbeutcha A, Roupr\u00eat M, Kamat AM et al (2017) Prognostic factors and predictive tools for upper tract urothelial carcinoma: a systematic review. World J Urol 35:337\u2013353. \n                    https:\/\/doi.org\/10.1007\/s00345-016-1826-2","journal-title":"World J Urol"},{"key":"2235_CR22","first-page":"381","volume":"68","author":"R Mathieu","year":"2016","unstructured":"Mathieu R, Vartolomei MD, Mbeutcha A et al (2016) Urothelial cancer of the upper urinary tract: emerging biomarkers and integrative models for risk stratification. Minerva Urol E Nefrol Ital J Urol Nephrol 68:381\u2013395","journal-title":"Minerva Urol E Nefrol Ital J Urol Nephrol"},{"key":"2235_CR23","doi-asserted-by":"publisher","first-page":"e2544","DOI":"10.1097\/MD.0000000000002544","volume":"95","author":"X Yin","year":"2016","unstructured":"Yin X, Xiao Y, Li F et al (2016) Prognostic role of neutrophil-to-lymphocyte ratio in prostate cancer: a systematic review and meta-analysis. Medicine (Baltimore) 95:e2544. \n                    https:\/\/doi.org\/10.1097\/MD.0000000000002544","journal-title":"Medicine (Baltimore)"},{"issue":"343\u2013349","key":"2235_CR24","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1016\/j.clgc.2016.12.027","volume":"15","author":"M Marchioni","year":"2017","unstructured":"Marchioni M, Cindolo L, Autorino R et al (2017) High neutrophil-to-lymphocyte ratio as prognostic factor in patients affected by upper tract urothelial cancer: a systematic review and meta-analysis. Clin Genitourin Cancer 15(343\u2013349):e1. \n                    https:\/\/doi.org\/10.1016\/j.clgc.2016.12.027","journal-title":"Clin Genitourin Cancer"},{"key":"2235_CR25","doi-asserted-by":"publisher","first-page":"E304","DOI":"10.1111\/j.1464-410X.2011.10188.x","volume":"108","author":"K Matsumoto","year":"2011","unstructured":"Matsumoto K, Novara G, Gupta A et al (2011) Racial differences in the outcome of patients with urothelial carcinoma of the upper urinary tract: an international study. BJU Int 108:E304\u2013E309. \n                    https:\/\/doi.org\/10.1111\/j.1464-410X.2011.10188.x","journal-title":"BJU Int"},{"key":"2235_CR26","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/j.ijsu.2010.02.007","volume":"8","author":"D Moher","year":"2010","unstructured":"Moher D, Liberati A, Tetzlaff J et al (2010) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Int J Surg Lond Engl 8:336\u2013341. \n                    https:\/\/doi.org\/10.1016\/j.ijsu.2010.02.007","journal-title":"Int J Surg Lond Engl"},{"key":"2235_CR27","unstructured":"Wells GA, Shea B, O\u2019Connell D, Peterson J, Welch V, Losos M, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality if nonrandomized studies in meta-analyses. \n                    http:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.htm\n                    \n                  , Accessed 3 Oct 2017"},{"key":"2235_CR28","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1111\/bju.12846","volume":"115","author":"HH Sung","year":"2015","unstructured":"Sung HH, Jeon HG, Jeong BC et al (2015) Clinical significance of prognosis using the neutrophil-lymphocyte ratio and erythrocyte sedimentation rate in patients undergoing radical nephroureterectomy for upper urinary tract urothelial carcinoma. Bju Int 115:587\u2013594. \n                    https:\/\/doi.org\/10.1111\/bju.12846","journal-title":"Bju Int"},{"key":"2235_CR29","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.clgc.2013.04.003","volume":"11","author":"T Azuma","year":"2013","unstructured":"Azuma T, Matayoshi Y, Odani K et al (2013) Preoperative neutrophil-lymphocyte ratio as an independent prognostic marker for patients with upper urinary tract urothelial carcinoma. Clin Genitourin Cancer 11:337\u2013341. \n                    https:\/\/doi.org\/10.1016\/j.clgc.2013.04.003","journal-title":"Clin Genitourin Cancer"},{"key":"2235_CR30","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1111\/bju.12441","volume":"114","author":"O Dalpiaz","year":"2014","unstructured":"Dalpiaz O, Ehrlich GC, Mannweiler S et al (2014) Validation of pretreatment neutrophil\u2013lymphocyte ratio as a prognostic factor in a European cohort of patients with upper tract urothelial carcinoma. BJU Int 114:334\u2013339. \n                    https:\/\/doi.org\/10.1111\/bju.12441","journal-title":"BJU Int"},{"key":"2235_CR31","doi-asserted-by":"publisher","first-page":"E144","DOI":"10.1111\/bju.12582","volume":"113","author":"H-L Luo","year":"2014","unstructured":"Luo H-L, Chen Y-T, Chuang Y-C et al (2014) Subclassification of upper urinary tract urothelial carcinoma by the neutrophil-to-lymphocyte ratio (NLR) improves prediction of oncological outcome. BJU Int 113:E144\u2013E149. \n                    https:\/\/doi.org\/10.1111\/bju.12582","journal-title":"BJU Int"},{"key":"2235_CR32","doi-asserted-by":"publisher","first-page":"4041","DOI":"10.1245\/s10434-014-3830-3","volume":"21","author":"N Tanaka","year":"2014","unstructured":"Tanaka N, Kikuchi E, Kanao K et al (2014) A multi-institutional validation of the prognostic value of the neutrophil-to-lymphocyte ratio for upper tract urothelial carcinoma treated with radical nephroureterectomy. Ann Surg Oncol 21:4041\u20134048. \n                    https:\/\/doi.org\/10.1245\/s10434-014-3830-3","journal-title":"Ann Surg Oncol"},{"key":"2235_CR33","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1245\/s10434-015-4781-z","volume":"23","author":"Y-C Cheng","year":"2016","unstructured":"Cheng Y-C, Huang C-N, Wu W-J et al (2016) The prognostic significance of inflammation-associated blood cell markers in patients with upper tract urothelial carcinoma. Ann Surg Oncol 23:343\u2013351. \n                    https:\/\/doi.org\/10.1245\/s10434-015-4781-z","journal-title":"Ann Surg Oncol"},{"key":"2235_CR34","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.2147\/OTT.S97520","volume":"9","author":"X Song","year":"2016","unstructured":"Song X, Zhang G-M, Ma X-C et al (2016) Comparison of preoperative neutrophil\u2013lymphocyte, lymphocyte\u2013monocyte, and platelet\u2013lymphocyte ratios in patients with upper urinary tract urothelial carcinoma undergoing radical nephroureterectomy. OncoTargets Ther 9:1399\u20131407. \n                    https:\/\/doi.org\/10.2147\/OTT.S97520","journal-title":"OncoTargets Ther"},{"key":"2235_CR35","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/s00345-016-1848-9","volume":"35","author":"MD Vartolomei","year":"2017","unstructured":"Vartolomei MD, Mathieu R, Margulis V et al (2017) Promising role of preoperative neutrophil-to-lymphocyte ratio in patients treated with radical nephroureterectomy. World J Urol 35:121\u2013130. \n                    https:\/\/doi.org\/10.1007\/s00345-016-1848-9","journal-title":"World J Urol"},{"key":"2235_CR36","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2017.07.028","author":"J Huang","year":"2017","unstructured":"Huang J, Yuan Y, Wang Y et al (2017) Preoperative prognostic nutritional index is a significant predictor of survival in patients with localized upper tract urothelial carcinoma after radical nephroureterectomy. Urol Oncol. \n                    https:\/\/doi.org\/10.1016\/j.urolonc.2017.07.028","journal-title":"Urol Oncol"},{"key":"2235_CR37","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-017-1150-x","author":"M Altan","year":"2017","unstructured":"Altan M, Haberal HB, Akdogan B, Ozen H (2017) A critical prognostic analysis of neutrophil\u2013lymphocyte ratio for patients undergoing nephroureterectomy due to upper urinary tract urothelial carcinoma. Int J Clin Oncol. \n                    https:\/\/doi.org\/10.1007\/s10147-017-1150-x","journal-title":"Int J Clin Oncol"},{"key":"2235_CR38","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1111\/j.1464-410X.2011.10288.x","volume":"109","author":"RL Favaretto","year":"2012","unstructured":"Favaretto RL, Shariat SF, Savage C et al (2012) Combining imaging and ureteroscopy variables in a preoperative multivariable model for prediction of muscle-invasive and non-organ confined disease in patients with upper tract urothelial carcinoma. BJU Int 109:77\u201382. \n                    https:\/\/doi.org\/10.1111\/j.1464-410X.2011.10288.x","journal-title":"BJU Int"},{"key":"2235_CR39","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-016-1040-7","author":"N Kishimoto","year":"2016","unstructured":"Kishimoto N, Takao T, Kuribayashi S et al (2016) The neutrophil-to-lymphocyte ratio as a predictor of intravesical recurrence in patients with upper urinary tract urothelial carcinoma treated with radical nephroureterectomy. Int J Clin Oncol. \n                    https:\/\/doi.org\/10.1007\/s10147-016-1040-7","journal-title":"Int J Clin Oncol"},{"key":"2235_CR40","doi-asserted-by":"publisher","first-page":"E633","DOI":"10.1016\/j.clgc.2017.01.003","volume":"15","author":"M Kang","year":"2017","unstructured":"Kang M, Jeong CW, Kwak C et al (2017) Prognostic role of neutrophil-to-lymphocyte ratio-based markers during pre- and postadjuvant chemotherapy in patients with advanced urothelial carcinoma of upper urinary tract. Clin Genitourin Cancer 15:E633\u2013E643. \n                    https:\/\/doi.org\/10.1016\/j.clgc.2017.01.003","journal-title":"Clin Genitourin Cancer"},{"key":"2235_CR41","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1007\/s10147-017-1171-5","volume":"22","author":"X Tang","year":"2017","unstructured":"Tang X, Du P, Yang Y (2017) The clinical use of neutrophil-to-lymphocyte ratio in bladder cancer patients: a systematic review and meta-analysis. Int J Clin Oncol 22:817\u2013825. \n                    https:\/\/doi.org\/10.1007\/s10147-017-1171-5","journal-title":"Int J Clin Oncol"},{"key":"2235_CR42","doi-asserted-by":"publisher","DOI":"10.1016\/j.clgc.2016.04.008","author":"M Marchioni","year":"2016","unstructured":"Marchioni M, Primiceri G, Ingrosso M et al (2016) The clinical use of the neutrophil to lymphocyte ratio (NLR) in urothelial cancer: a systematic review. Clin Genitourin Cancer. \n                    https:\/\/doi.org\/10.1016\/j.clgc.2016.04.008","journal-title":"Clin Genitourin Cancer"},{"key":"2235_CR43","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1016\/j.eururo.2014.02.042","volume":"66","author":"BR Viers","year":"2014","unstructured":"Viers BR, Boorjian SA, Frank I et al (2014) Pretreatment neutrophil-to-lymphocyte ratio is associated with advanced pathologic tumor stage and increased cancer-specific mortality among patients with urothelial carcinoma of the bladder undergoing radical cystectomy. Eur Urol 66:1157\u20131164. \n                    https:\/\/doi.org\/10.1016\/j.eururo.2014.02.042","journal-title":"Eur Urol"},{"key":"2235_CR44","doi-asserted-by":"publisher","first-page":"1402","DOI":"10.1016\/j.imbio.2013.06.003","volume":"218","author":"MR Galdiero","year":"2013","unstructured":"Galdiero MR, Bonavita E, Barajon I et al (2013) Tumor associated macrophages and neutrophils in cancer. Immunobiology 218:1402\u20131410. \n                    https:\/\/doi.org\/10.1016\/j.imbio.2013.06.003","journal-title":"Immunobiology"},{"key":"2235_CR45","doi-asserted-by":"publisher","first-page":"e1004651","DOI":"10.1371\/journal.ppat.1004651","volume":"11","author":"P Kruger","year":"2015","unstructured":"Kruger P, Saffarzadeh M, Weber ANR et al (2015) Neutrophils: between host defence, immune modulation, and tissue injury. PLoS Pathog 11:e1004651. \n                    https:\/\/doi.org\/10.1371\/journal.ppat.1004651","journal-title":"PLoS Pathog"},{"key":"2235_CR46","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1038\/nri3024","volume":"11","author":"A Mantovani","year":"2011","unstructured":"Mantovani A, Cassatella MA, Costantini C, Jaillon S (2011) Neutrophils in the activation and regulation of innate and adaptive immunity. Nat Rev Immunol 11:519\u2013531. \n                    https:\/\/doi.org\/10.1038\/nri3024","journal-title":"Nat Rev Immunol"},{"key":"2235_CR47","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.ccr.2009.06.017","volume":"16","author":"ZG Fridlender","year":"2009","unstructured":"Fridlender ZG, Sun J, Kim S et al (2009) Polarization of tumor-associated neutrophil phenotype by TGF-beta: \u201cN1\u201d versus \u201cN2\u201d TAN. Cancer Cell 16:183\u2013194. \n                    https:\/\/doi.org\/10.1016\/j.ccr.2009.06.017","journal-title":"Cancer Cell"},{"key":"2235_CR48","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1038\/nrc3611","volume":"13","author":"E Elinav","year":"2013","unstructured":"Elinav E, Nowarski R, Thaiss CA et al (2013) Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms. Nat Rev Cancer 13:759\u2013771. \n                    https:\/\/doi.org\/10.1038\/nrc3611","journal-title":"Nat Rev Cancer"},{"key":"2235_CR49","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1515\/rrlm-2017-0016","volume":"25","author":"O Martha","year":"2017","unstructured":"Martha O, Porav-Hodade D, B\u0103lan D et al (2017) Easily available blood test neutrophil-to-lymphocyte ratio predicts progression in high-risk non-muscle invasive bladder cancer. Rev Romana Med Lab 25:181\u2013189. \n                    https:\/\/doi.org\/10.1515\/rrlm-2017-0016","journal-title":"Rev Romana Med Lab"},{"key":"2235_CR50","doi-asserted-by":"publisher","first-page":"1518","DOI":"10.1097\/01.ju.0000154696.48217.75","volume":"173","author":"SF Shariat","year":"2005","unstructured":"Shariat SF, Zippe C, L\u00fcdecke G et al (2005) Nomograms including nuclear matrix protein 22 for prediction of disease recurrence and progression in patients with Ta, T1 or CIS transitional cell carcinoma of the bladder. J Urol 173:1518\u20131525. \n                    https:\/\/doi.org\/10.1097\/01.ju.0000154696.48217.75","journal-title":"J Urol"}],"container-title":["World Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00345-018-2235-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00345-018-2235-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00345-018-2235-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,20]],"date-time":"2019-02-20T20:17:19Z","timestamp":1550693839000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00345-018-2235-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,21]]},"references-count":50,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["2235"],"URL":"https:\/\/doi.org\/10.1007\/s00345-018-2235-5","relation":{},"ISSN":["0724-4983","1433-8726"],"issn-type":[{"value":"0724-4983","type":"print"},{"value":"1433-8726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,21]]},"assertion":[{"value":"9 December 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 February 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 February 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"For this type of study formal consent is not required.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and animal rights"}}]}}