{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T12:14:50Z","timestamp":1783685690370,"version":"3.55.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,4,16]],"date-time":"2019-04-16T00:00:00Z","timestamp":1555372800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Urol"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1007\/s00345-019-02754-2","type":"journal-article","created":{"date-parts":[[2019,4,16]],"date-time":"2019-04-16T12:03:38Z","timestamp":1555416218000},"page":"143-150","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Absolute basophil count is associated with time to recurrence in patients with high-grade T1 bladder cancer receiving bacillus Calmette\u2013Gu\u00e9rin after transurethral resection of the bladder tumor"],"prefix":"10.1007","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9250-7858","authenticated-orcid":false,"given":"M.","family":"Ferro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Di Lorenzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. D.","family":"Vartolomei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Bruzzese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Cantiello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Lucarelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Musi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Di Stasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Hurle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Guazzoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. M.","family":"Busetto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Gabriele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Del Giudice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Damiano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Perri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Perdona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Verze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Borghesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Schiavina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. L.","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Bove","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Autorino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Crisan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. R. Abu","family":"Farhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Battaglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. I.","family":"Russo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Ieluzzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Morgia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"De Placido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Terracciano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Cimmino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Scafuri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Mirone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"De Cobelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Shariat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guru","family":"Sonpavde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Buonerba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,4,16]]},"reference":[{"issue":"1","key":"2754_CR1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s00345-018-2436-y","volume":"37","author":"Fern\u00e1ndezMI","year":"2018","unstructured":"Fern\u00e1ndezMI et al (2018) Epidemiology, prevention, screening, diagnosis, and evaluation: update of the ICUD\u2013SIU joint consultation on bladder cancer. World J Urol 37(1):3\u201313. \nhttps:\/\/doi.org\/10.1007\/s00345-018-2436-y","journal-title":"World J Urol"},{"issue":"1","key":"2754_CR2","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.eururo.2013.10.001","volume":"66","author":"S Chavan","year":"2014","unstructured":"Chavan S, Bray F, Lortet-Tieulent J, Goodman M, Jemal A (2014) International variations in bladder cancer incidence and mortality. Eur Urol 66(1):59\u201373","journal-title":"Eur Urol"},{"issue":"3","key":"2754_CR3","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1016\/j.critrevonc.2015.07.004","volume":"96","author":"G Lorenzo Di","year":"2015","unstructured":"Di Lorenzo G, Federico P, De Placido S, Buonerba C (2015) Increased risk of bladder cancer in critical areas at high pressure of pollution of the Campania region in Italy: a systematic review. Crit Rev Oncol Hematol 96(3):534\u2013541","journal-title":"Crit Rev Oncol Hematol"},{"issue":"1","key":"2754_CR4","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.eururo.2015.06.045","volume":"69","author":"S Cambier","year":"2016","unstructured":"Cambier S et al (2016) EORTC nomograms and risk groups for predicting recurrence, progression, and disease-specific and overall survival in non-muscle-invasive stage Ta-T1 urothelial bladder cancer patients treated with 1\u20133 years of maintenance bacillus Calmette\u2013Gu\u00e9rin. Eur Urol 69(1):60\u201369","journal-title":"Eur Urol"},{"issue":"10","key":"2754_CR5","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1038\/s41585-018-0055-4","volume":"15","author":"C Pettenati","year":"2018","unstructured":"Pettenati C, Ingersoll MA (2018) Mechanisms of BCG immunotherapy and its outlook for bladder cancer. Nat Rev Urol 15(10):615\u2013625. \nhttps:\/\/doi.org\/10.1038\/s41585-018-0055-4","journal-title":"Nat Rev Urol"},{"issue":"6","key":"2754_CR6","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.clgc.2018.07.003","volume":"16","author":"MD Vartolomei","year":"2018","unstructured":"Vartolomei MD et al (2018) Validation of neutrophil-to-lymphocyte ratio in a multi-institutional cohort of patients with T1G3 non-muscle-invasive bladder cancer. Clin Genitourin Cancer 16(6):445\u2013452. \nhttps:\/\/doi.org\/10.1016\/j.clgc.2018.07.003","journal-title":"Clin Genitourinary Cancer."},{"issue":"2","key":"2754_CR7","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1016\/j.juro.2013.01.089","volume":"190","author":"LA Kluth","year":"2013","unstructured":"Kluth LA et al (2013) Obesity is associated with worse outcomes in patients with T1 high grade urothelial carcinoma of the bladder. J Urol 190(2):480\u2013486","journal-title":"J Urol"},{"issue":"4","key":"2754_CR8","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1111\/j.1464-410X.2009.09166.x","volume":"106","author":"C Bolenz","year":"2010","unstructured":"Bolenz C et al (2010) Lymphovascular invasion is an independent predictor of oncological outcomes in patients with lymph node-negative urothelial bladder cancer treated by radical cystectomy: a multicentre validation trial. BJU Int 106(4):493\u2013499","journal-title":"BJU Int"},{"issue":"9","key":"2754_CR9","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.urolonc.2018.05.014","volume":"36","author":"MD Vartolomei","year":"2018","unstructured":"Vartolomei MD et al (2018) Prognostic role of pretreatment neutrophil-to-lymphocyte ratio (NLR) in patients with non-muscle-invasive bladder cancer (NMIBC): a systematic review and meta-analysis. Urol Oncol Semin Orig Investig 36(9):389\u2013399","journal-title":"Urol Oncol Semin Orig Investig"},{"issue":"19","key":"2754_CR10","doi-asserted-by":"publisher","first-page":"2473","DOI":"10.1002\/sim.3623","volume":"28","author":"M Schemper","year":"2009","unstructured":"Schemper M, Wakounig S, Heinze G (2009) The estimation of average hazard ratios by weighted Cox regression. Stat Med 28(19):2473\u20132489","journal-title":"Stat Med"},{"issue":"4","key":"2754_CR11","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1128\/CMR.9.4.532","volume":"9","author":"DR Lucey","year":"1996","unstructured":"Lucey DR, Clerici M, Shearer GM (1996) Type 1, and type 2 cytokine dysregulation in human infectious, neoplastic, and inflammatory diseases. Clin Microbiol Rev 9(4):532\u2013562","journal-title":"Clin Microbiol Rev"},{"issue":"2","key":"2754_CR12","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1007\/BF01520291","volume":"40","author":"A Thanh\u00e4user","year":"1995","unstructured":"Thanh\u00e4user A et al (1995) The induction of bacillus-Calmette\u2013Gu\u00e9rin-activated killer cells requires the presence of monocytes and T-helper type-1 cells. Cancer Immunol Immunother 40(2):103\u2013108","journal-title":"Cancer Immunol Immunother"},{"key":"2754_CR13","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/S0022-5347(05)65469-9","volume":"167","author":"F Saint","year":"2002","unstructured":"Saint F et al (2002) Prognostic value of a T helper 1 urinary cytokine response after intravesical bacillus Calmette\u2013Guerin treatment for superficial bladder cancer. J Urol 167(1):364\u2013367","journal-title":"J. Urol"},{"issue":"1","key":"2754_CR14","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/S1043-4666(02)00490-8","volume":"21","author":"Y Luo","year":"2003","unstructured":"Luo Y, Chen X, O\u2019Donnell MA (2003) Role of Th1 and Th2 cytokines in BCG-induced IFN-\u03b3 production: cytokine promotion and simulation of BCG effect. Cytokine 21(1):17\u201326","journal-title":"Cytokine"},{"issue":"1","key":"2754_CR15","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1046\/j.1365-2249.2002.01734.x","volume":"127","author":"J Riemensberger","year":"2002","unstructured":"Riemensberger J, B\u00f6hle A, Brandau S (2002) IFN-gamma and IL-12 but not IL-10 are required for local tumour surveillance in a syngeneic model of orthotopic bladder cancer. Clin Exp Immunol 127(1):20\u201326","journal-title":"Clin Exp Immunol"},{"issue":"3","key":"2754_CR16","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1002\/ijc.11352","volume":"107","author":"F Saint","year":"2003","unstructured":"Saint F et al (2003) Urinary IL-2 assay for monitoring intravesical bacillus Calmette\u2013Gu\u00e9rin response of superficial bladder cancer during induction course and maintenance therapy. Int J Cancer 107(3):434\u2013440","journal-title":"Int J Cancer"},{"key":"2754_CR17","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.12688\/f1000research.11697.1","volume":"6","author":"D Voehringer","year":"2017","unstructured":"Voehringer D (2017) Recent advances in understanding basophil functions in vivo. F1000Research 6:1464","journal-title":"F1000Research"},{"key":"2754_CR18","doi-asserted-by":"publisher","first-page":"393","DOI":"10.3389\/fimmu.2015.00393","volume":"6","author":"A Otsuka","year":"2015","unstructured":"Otsuka A, Kabashima K (2015) Contribution of basophils to cutaneous immune reactions and Th2-mediated allergic responses. Front Immunol 6:393. \nhttps:\/\/doi.org\/10.3389\/fimmu.2015.00393","journal-title":"Front. Immunol."},{"issue":"7","key":"2754_CR19","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1038\/ni.1883","volume":"11","author":"H Tang","year":"2010","unstructured":"Tang H et al (2010) The T helper type 2 response to cysteine proteases requires dendritic cell-basophil cooperation via ROS-mediated signaling. Nat Immunol 11(7):608\u2013617","journal-title":"Nat Immunol"},{"issue":"1","key":"2754_CR20","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1146\/annurev-immunol-031210-101257","volume":"29","author":"H Karasuyama","year":"2011","unstructured":"Karasuyama H, Mukai K, Obata K, Tsujimura Y, Wada T (2011) Nonredundant roles of basophils in immunity. Annu Rev Immunol 29(1):45\u201369","journal-title":"Annu Rev Immunol"},{"issue":"7","key":"2754_CR21","doi-asserted-by":"publisher","first-page":"1792","DOI":"10.1158\/0008-5472.CAN-15-1801-T","volume":"76","author":"L Monte De","year":"2016","unstructured":"De Monte L et al (2016) Basophil recruitment into tumor-draining lymph nodes correlates with Th2 inflammation and reduced survival in pancreatic cancer patients. Cancer Res 76(7):1792\u20131803","journal-title":"Cancer Res"},{"issue":"3","key":"2754_CR22","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1084\/jem.20101876","volume":"208","author":"L Monte De","year":"2011","unstructured":"De Monte L et al (2011) Intratumor T helper type 2 cell infiltrate correlates with cancer-associated fibroblast thymic stromal lymphopoietin production and reduced survival in pancreatic cancer. J Exp Med 208(3):469\u2013478","journal-title":"J Exp Med"},{"key":"2754_CR23","first-page":"141","volume":"90","author":"E Mitre","year":"2006","unstructured":"Mitre E, Nutman TB (2006) Basophils, basophilia and helminth infections. Chem Immunol Allergy 90:141\u2013156","journal-title":"Chem Immunol Allergy"},{"issue":"1","key":"2754_CR24","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1046\/j.1365-2249.2002.01973.x","volume":"130","author":"TK Hart","year":"2002","unstructured":"Hart TK et al (2002) Preclinical efficacy and safety of pascolizumab (SB 240683): a humanized anti-interleukin-4 antibody with therapeutic potential in asthma. Clin Exp Immunol 130(1):93\u2013100","journal-title":"Clin Exp Immunol"},{"issue":"6","key":"2754_CR25","doi-asserted-by":"publisher","first-page":"1816","DOI":"10.1164\/ajrccm.160.6.9808146","volume":"160","author":"LC Borish","year":"1999","unstructured":"Borish LC et al (1999) Interleukin-4 receptor in moderate atopic asthma: a phase I\/II randomized, placebo-controlled trial. Am J Respir Crit Care Med 160(6):1816\u20131823","journal-title":"Am J Respir Crit Care Med"},{"issue":"9596","key":"2754_CR26","doi-asserted-by":"publisher","first-page":"1422","DOI":"10.1016\/S0140-6736(07)61600-6","volume":"370","author":"S Wenzel","year":"2007","unstructured":"Wenzel S, Wilbraham D, Fuller R, Getz EB, Longphre M (2007) Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies. Lancet 370(9596):1422\u20131431","journal-title":"Lancet"}],"container-title":["World Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00345-019-02754-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00345-019-02754-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00345-019-02754-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,14]],"date-time":"2020-04-14T23:06:21Z","timestamp":1586905581000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00345-019-02754-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,16]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["2754"],"URL":"https:\/\/doi.org\/10.1007\/s00345-019-02754-2","relation":{},"ISSN":["0724-4983","1433-8726"],"issn-type":[{"value":"0724-4983","type":"print"},{"value":"1433-8726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,16]]},"assertion":[{"value":"9 January 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 April 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Compliance with ethical standards","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics"}},{"value":"The authors declare they have no potential conflicts of interest to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This was a retrospective study involving Human Participants treated according to standard clinical practice. All permissions granted by competent Ethics Committees and other authorities were obtained and all informed consents required by the existing law and regulations were collected.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}