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MB Christensen: None. JM Hotaling: Dr. Hotaling receives research and fellowship support from Boston Scientific and Endo Pharmaceuticals. He holds leadership roles\/equity interest in Nanonc, StreamDx, and Andro360 which are all early stage startup companies. AW Pastuszak: Dr. Pastuszak is an advisor to Endo Pharmaceuticals, Boston Scientific, and Antares Pharmaceuticals, and a speaker for Endo Pharmaceuticals and Bayer AG. He is a consultant and receives research and fellowship support from Endo Pharmaceuticals. He holds a leadership position with Woven Health, of which he is also a founder. As this is a review article, no research involving human participants and\/or animals was carried out and no informed consent was needed.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}