{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:23:48Z","timestamp":1790742228476,"version":"4.1.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T00:00:00Z","timestamp":1595289600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T00:00:00Z","timestamp":1595289600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Urol"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1007\/s00345-020-03373-y","type":"journal-article","created":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T07:05:38Z","timestamp":1595315138000},"page":"2217-2222","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Penile low intensity shock wave treatment for PDE5I refractory erectile dysfunction: a randomized double-blind sham-controlled clinical trial"],"prefix":"10.1007","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7883-1782","authenticated-orcid":false,"given":"Jose","family":"Vinay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osvaldo","family":"Rajmil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduard","family":"Ruiz-Casta\u00f1e","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josvany","family":"Sanchez-Curbelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,7,21]]},"reference":[{"key":"3373_CR1","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1038\/nrurol.2017.119","volume":"14","author":"M Fode","year":"2017","unstructured":"Fode M, Hatzichristodoulou G, Serefoglu EC et al (2017) Low-intensity shockwave therapy for erectile dysfunction: Is the evidence strong enough? Nat Rev Urol 14:593\u2013606. https:\/\/doi.org\/10.1038\/nrurol.2017.119","journal-title":"Nat Rev Urol"},{"key":"3373_CR2","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1016\/j.eururo.2010.02.020","volume":"57","author":"K Hatzimouratidis","year":"2010","unstructured":"Hatzimouratidis K, Amar E, Eardley I et al (2010) Guidelines on male sexual dysfunction: erectile dysfunction and premature ejaculation. Eur Urol 57:804\u2013814. https:\/\/doi.org\/10.1016\/j.eururo.2010.02.020","journal-title":"Eur Urol"},{"key":"3373_CR3","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1038\/s41443-019-0132-0","volume":"31","author":"E Schoofs","year":"2019","unstructured":"Schoofs E, Fode M, Capogrosso P, Albersen M (2019) Current guideline recommendations and analysis of evidence quality on low-intensity shockwave therapy for erectile dysfunction. Int J Impot Res 31:209\u2013217. https:\/\/doi.org\/10.1038\/s41443-019-0132-0","journal-title":"Int J Impot Res"},{"key":"3373_CR4","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1111\/jsm.12885","volume":"12","author":"H Besiroglu","year":"2015","unstructured":"Besiroglu H, Otunctemur A, Ozbek E (2015) The relationship between metabolic syndrome, its components, and erectile dysfunction: a systematic review and a meta-analysis of observational studies. J Sex Med 12:1309\u20131318. https:\/\/doi.org\/10.1111\/jsm.12885","journal-title":"J Sex Med"},{"key":"3373_CR5","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.eururo.2010.04.004","volume":"58","author":"Y Vardi","year":"2010","unstructured":"Vardi Y, Appel B, Jacob G et al (2010) Can low-intensity extracorporeal shockwave therapy improve erectile function? A 6-month follow-up pilot study in patients with organic erectile dysfunction. Eur Urol 58:243\u2013248. https:\/\/doi.org\/10.1016\/j.eururo.2010.04.004","journal-title":"Eur Urol"},{"key":"3373_CR6","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1002\/smrj.9","volume":"1","author":"I Gruenwald","year":"2013","unstructured":"Gruenwald I, Kitrey ND, Appel B, Vardi Y (2013) Low-intensity extracorporeal shock wave therapy in vascular disease and erectile dysfunction: theory and outcomes. Sex Med Rev 1:83\u201390. https:\/\/doi.org\/10.1002\/smrj.9","journal-title":"Sex Med Rev"},{"key":"3373_CR7","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1111\/j.1743-6109.2011.02498.x","volume":"9","author":"I Gruenwald","year":"2012","unstructured":"Gruenwald I, Appel B, Vardi Y (2012) Low-intensity extracorporeal shock wave therapy-a novel effective treatment for erectile dysfunction in severe ED patients who respond poorly to PDE5 inhibitor therapy. J Sex Med 9:259\u2013264. https:\/\/doi.org\/10.1111\/j.1743-6109.2011.02498.x","journal-title":"J Sex Med"},{"key":"3373_CR8","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/sj.ijir.3901227","volume":"16","author":"C Carson","year":"2004","unstructured":"Carson C, Giuliano F, Goldstein I et al (2004) The \u201ceffectiveness\u201d scale\u2014Therapeutic outcome of pharmacologic therapies for ED: an international consensus panel report. Int J Impot Res 16:207\u2013213. https:\/\/doi.org\/10.1038\/sj.ijir.3901227","journal-title":"Int J Impot Res"},{"key":"3373_CR9","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1016\/j.juro.2015.12.049","volume":"195","author":"ND Kitrey","year":"2016","unstructured":"Kitrey ND, Gruenwald I, Appel B et al (2016) Penile low intensity shock wave treatment is able to shift PDE5i nonresponders to responders: a double-blind, sham controlled study. J Urol 195:1550\u20131555. https:\/\/doi.org\/10.1016\/j.juro.2015.12.049","journal-title":"J Urol"},{"key":"3373_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.esxm.2017.09.002","volume":"6","author":"GL Fojecki","year":"2018","unstructured":"Fojecki GL, Tiessen S, Osther PJS (2018) Effect of linear low-intensity extracorporeal shockwave therapy for erectile dysfunction\u201412-month follow-up of a randomized, double-blinded, sham-controlled study. Sex Med 6:1\u20137. https:\/\/doi.org\/10.1016\/j.esxm.2017.09.002","journal-title":"Sex Med"},{"key":"3373_CR11","doi-asserted-by":"publisher","first-page":"1490","DOI":"10.1016\/j.jsxm.2019.07.016","volume":"16","author":"P Capogrosso","year":"2019","unstructured":"Capogrosso P, Frey A, Jensen CFS et al (2019) Low-intensity shock wave therapy in sexual medicine\u2014clinical recommendations from the European Society of Sexual Medicine (ESSM). J Sex Med 16:1490\u20131505. https:\/\/doi.org\/10.1016\/j.jsxm.2019.07.016","journal-title":"J Sex Med"},{"key":"3373_CR12","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1038\/s41443-019-0115-1","volume":"31","author":"P Patel","year":"2019","unstructured":"Patel P, Huang C, Molina M, Ramasamy R (2019) Clinical trial update on shockwave therapy and future of erectile function restoration. Int J Impot Res 31:206\u2013208. https:\/\/doi.org\/10.1038\/s41443-019-0115-1","journal-title":"Int J Impot Res"},{"key":"3373_CR13","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/j.juro.2018.05.004","volume":"200","author":"AL Burnett","year":"2018","unstructured":"Burnett AL, Nehra A, Breau RH et al (2018) Erectile dysfunction: AUA guideline. J Urol 200:633\u2013641. https:\/\/doi.org\/10.1016\/j.juro.2018.05.004","journal-title":"J Urol"},{"key":"3373_CR14","unstructured":"Salonia A, Bettocchi C, Carvalho J CG, Jones TH, Kadioglu A M-SJ, Minhas S, Serefoglu EC (2020) VP EAU guidelines on sexual and reproductive health. Eur Assoc Urol"},{"key":"3373_CR15","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1111\/jsm.12024","volume":"10","author":"X Qiu","year":"2013","unstructured":"Qiu X, Lin G, Xin Z et al (2013) Effects of low-energy shockwave therapy on the erectile function and tissue of a diabetic rat model. J Sex Med 10:738\u2013746. https:\/\/doi.org\/10.1111\/jsm.12024","journal-title":"J Sex Med"},{"key":"3373_CR16","doi-asserted-by":"publisher","first-page":"6839","DOI":"10.1016\/j.febslet.2005.11.023","volume":"579","author":"AR Ciampa","year":"2005","unstructured":"Ciampa AR, De Prati AC, Amelio E et al (2005) Nitric oxide mediates anti-inflammatory action of extracorporeal shock waves. FEBS Lett 579:6839\u20136845. https:\/\/doi.org\/10.1016\/j.febslet.2005.11.023","journal-title":"FEBS Lett"},{"key":"3373_CR17","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.expneurol.2012.04.019","volume":"236","author":"T Hausner","year":"2012","unstructured":"Hausner T, Pajer K, Halat G et al (2012) Improved rate of peripheral nerve regeneration induced by extracorporeal shock wave treatment in the rat. Exp Neurol 236:363\u2013370. https:\/\/doi.org\/10.1016\/j.expneurol.2012.04.019","journal-title":"Exp Neurol"},{"key":"3373_CR18","doi-asserted-by":"publisher","first-page":"138","DOI":"10.4103\/2394-8108.192520","volume":"2","author":"C Schuh","year":"2016","unstructured":"Schuh C, Hausner T, Redl H (2016) A therapeutic shock propels Schwann cells to proliferate in peripheral nerve injury. Brain Circ 2:138. https:\/\/doi.org\/10.4103\/2394-8108.192520","journal-title":"Brain Circ"},{"key":"3373_CR19","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1016\/j.jtcvs.2013.01.017","volume":"146","author":"C Tepek\u00f6yl\u00fc","year":"2013","unstructured":"Tepek\u00f6yl\u00fc C, Wang FS, Kozaryn R et al (2013) Shock wave treatment induces angiogenesis and mobilizes endogenous CD31\/CD34-positive endothelial cells in a hindlimb ischemia model: implications for angiogenesis and vasculogenesis. J Thorac Cardiovasc Surg 146:971\u2013978. https:\/\/doi.org\/10.1016\/j.jtcvs.2013.01.017","journal-title":"J Thorac Cardiovasc Surg"},{"key":"3373_CR20","doi-asserted-by":"publisher","first-page":"1241.e11","DOI":"10.1016\/j.urology.2015.07.026","volume":"86","author":"H Lei","year":"2015","unstructured":"Lei H, Xin H, Guan R et al (2015) Low-intensity Pulsed ultrasound improves erectile function in streptozotocin-induced type i diabetic rats. Urology 86:1241.e11\u20131241.e18. https:\/\/doi.org\/10.1016\/j.urology.2015.07.026","journal-title":"Urology"},{"key":"3373_CR21","first-page":"7614","volume":"22","author":"VS Srini","year":"2015","unstructured":"Srini VS, Reddy RK, Shultz T, Denes B (2015) Low intensity extracorporeal shockwave therapy for erectile dysfunction: a study in an Indian population. Can J Urol 22:7614\u20137622","journal-title":"Can J Urol"},{"key":"3373_CR22","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1038\/s41443-019-0124-0","volume":"31","author":"H Yang","year":"2019","unstructured":"Yang H, Seftel AD (2019) Controversies in low intensity extracorporeal shockwave therapy for erectile dysfunction. Int J Impot Res 31:239\u2013242","journal-title":"Int J Impot Res"},{"key":"3373_CR23","doi-asserted-by":"publisher","first-page":"1769","DOI":"10.1016\/j.juro.2011.12.117","volume":"187","author":"Y Vardi","year":"2012","unstructured":"Vardi Y, Appel B, Kilchevsky A, Gruenwald I (2012) Does low intensity extracorporeal shock wave therapy have a physiological effect on erectile function? Short-term results of a randomized, double-blind, sham controlled study. J Urol 187:1769\u20131775. https:\/\/doi.org\/10.1016\/j.juro.2011.12.117","journal-title":"J Urol"},{"key":"3373_CR24","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.jsxm.2016.11.307","volume":"14","author":"GL Fojecki","year":"2017","unstructured":"Fojecki GL, Tiessen S, Osther PJS (2017) Effect of Low-energy linear shockwave therapy on erectile dysfunction\u2014a double-blinded, sham-controlled, randomized clinical trial. J Sex Med 14:106\u2013112. https:\/\/doi.org\/10.1016\/j.jsxm.2016.11.307","journal-title":"J Sex Med"},{"key":"3373_CR25","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1111\/iju.12506","volume":"21","author":"CH Yee","year":"2014","unstructured":"Yee CH, Chan ESY, Hou SSM, Ng CF (2014) Extracorporeal shockwave therapy in the treatment of erectile dysfunction: a prospective, randomized, double-blinded, placebo controlled study. Int J Urol 21:1041\u20131045. https:\/\/doi.org\/10.1111\/iju.12506","journal-title":"Int J Urol"},{"key":"3373_CR26","doi-asserted-by":"publisher","first-page":"329","DOI":"10.3109\/21681805.2014.984326","volume":"49","author":"AB Olsen","year":"2015","unstructured":"Olsen AB, Persiani M, Boie S et al (2015) Can low-intensity extracorporeal shockwave therapy improve erectile dysfunction? A prospective, randomized, double-blind, placebo-controlled study. Scand J Urol 49:329\u2013333. https:\/\/doi.org\/10.3109\/21681805.2014.984326","journal-title":"Scand J Urol"},{"key":"3373_CR27","doi-asserted-by":"publisher","first-page":"15","DOI":"10.4236\/asm.2016.62002","volume":"06","author":"I Motil","year":"2016","unstructured":"Motil I, Kubis I, Sramkova T (2016) Treatment of vasculogenic erectile dysfunction with piezowave2 device. application of low intensity shockwaves using novel linear shockwave tissue coverage (LSTC-ED&reg;) technique. A prospective, multicentric placebo-controlled study. Adv Sex Med 06:15\u201318. https:\/\/doi.org\/10.4236\/asm.2016.62002","journal-title":"Adv Sex Med"},{"key":"3373_CR28","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1038\/s41443-018-0062-2","volume":"31","author":"KGR Yama\u00e7ake","year":"2019","unstructured":"Yama\u00e7ake KGR, Carneiro F, Cury J et al (2019) Low-intensity shockwave therapy for erectile dysfunction in kidney transplant recipients. A prospective, randomized, double blinded, sham-controlled study with evaluation by penile Doppler ultrasonography. Int J Impot Res 31:195\u2013203. https:\/\/doi.org\/10.1038\/s41443-018-0062-2","journal-title":"Int J Impot Res"},{"key":"3373_CR29","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1016\/j.jsxm.2017.05.012","volume":"14","author":"D Kalyvianakis","year":"2017","unstructured":"Kalyvianakis D, Hatzichristou D (2017) Low-intensity shockwave therapy improves hemodynamic parameters in patients with vasculogenic erectile dysfunction: a triplex ultrasonography-based sham-controlled trial. J Sex Med 14:891\u2013897. https:\/\/doi.org\/10.1016\/j.jsxm.2017.05.012","journal-title":"J Sex Med"},{"key":"3373_CR30","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1016\/j.jsxm.2019.12.024","volume":"17","author":"W Baccaglini","year":"2020","unstructured":"Baccaglini W, Pazeto CL, Corr\u00eaa Barros EA et al (2020) The role of the low-intensity extracorporeal shockwave therapy on penile rehabilitation after radical prostatectomy: a randomized clinical trial. J Sex Med 17:688\u2013694. https:\/\/doi.org\/10.1016\/j.jsxm.2019.12.024","journal-title":"J Sex Med"},{"key":"3373_CR31","doi-asserted-by":"publisher","DOI":"10.1159\/000504788","author":"T Sramkova","year":"2019","unstructured":"Sramkova T, Motil I, Jarkovsky J, Sramkova K (2019) Erectile dysfunction treatment using focused linear low-intensity extracorporeal shockwaves: single-blind, sham-controlled, randomized clinical trial. Urol Int. https:\/\/doi.org\/10.1159\/000504788","journal-title":"Urol Int"},{"key":"3373_CR32","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.eururo.2016.05.050","volume":"71","author":"Z Lu","year":"2017","unstructured":"Lu Z, Lin G, Reed-Maldonado A et al (2017) Low-intensity extracorporeal shock wave treatment improves erectile function: a systematic review and meta-analysis. Eur Urol 71:223\u2013233","journal-title":"Eur Urol"},{"key":"3373_CR33","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.urology.2017.09.011","volume":"119","author":"L Man","year":"2018","unstructured":"Man L, Li G (2018) Low-intensity extracorporeal shock wave therapy for erectile dysfunction: a systematic review and meta-analysis. Urology 119:97\u2013103. https:\/\/doi.org\/10.1016\/j.urology.2017.09.011","journal-title":"Urology"},{"key":"3373_CR34","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.jsxm.2016.11.001","volume":"14","author":"RI Clavijo","year":"2017","unstructured":"Clavijo RI, Kohn TP, Kohn JR, Ramasamy R (2017) Effects of Low-intensity extracorporeal shockwave therapy on erectile dysfunction: a systematic review and meta-analysis. J Sex Med 14:27\u201335","journal-title":"J Sex Med"},{"key":"3373_CR35","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/j.acuroe.2017.07.001","volume":"41","author":"JC Angulo","year":"2017","unstructured":"Angulo JC, Arance I, de Heras MM et al (2017) Efficacy of low-intensity shock wave therapy for erectile dysfunction: a systematic review and meta-analysis. Actas Urol Esp 41:479\u2013490. https:\/\/doi.org\/10.1016\/j.acuroe.2017.07.001","journal-title":"Actas Urol Esp"},{"key":"3373_CR36","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1590\/s1677-5538.ibju.2016.0245","volume":"43","author":"ZJ Zou","year":"2017","unstructured":"Zou ZJ, Tang LY, Liu ZH et al (2017) Short-term efficacy and safety of low-intensity extracorporeal shock wave therapy in erectile dysfunction: a systematic review and meta-analysis. Int Braz J Urol 43:805\u2013821","journal-title":"Int Braz J Urol"},{"key":"3373_CR37","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1111\/j.1745-7262.2006.00138.x","volume":"8","author":"V Poulakis","year":"2006","unstructured":"Poulakis V, Skriapas K, de Vries R et al (2006) Extracorporeal shockwave therapy for Peyronie\u2019s disease: an alternative treatment? Asian J Androl 8:361\u2013366. https:\/\/doi.org\/10.1111\/j.1745-7262.2006.00138.x","journal-title":"Asian J Androl"}],"container-title":["World Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00345-020-03373-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00345-020-03373-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00345-020-03373-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T23:31:54Z","timestamp":1626823914000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00345-020-03373-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,21]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["3373"],"URL":"https:\/\/doi.org\/10.1007\/s00345-020-03373-y","relation":{},"ISSN":["0724-4983","1433-8726"],"issn-type":[{"value":"0724-4983","type":"print"},{"value":"1433-8726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,21]]},"assertion":[{"value":"12 June 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 July 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 July 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The researchers received materials for the LI-EWST device from the manufacturer (Direx Group, Wiesbaden, Germany) to carry out the clinical trial. No special funding was received.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"This study was reviewed and approved by Fundaci\u00f3 Puigvert Ethics Review Board: (FP-ANDRO-2016\/01).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Research involving human participants and\/or animals"}},{"value":"Participants provided written informed consent before enrolling in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}