{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:42:41Z","timestamp":1787161361013,"version":"build-2736575974"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T00:00:00Z","timestamp":1616716800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T00:00:00Z","timestamp":1616716800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","award":["MRSG-18-01-CPHPS"],"award-info":[{"award-number":["MRSG-18-01-CPHPS"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Urol"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1007\/s00345-021-03674-w","type":"journal-article","created":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T13:02:56Z","timestamp":1616763776000},"page":"3415-3422","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Enhanced antibiotic prophylaxis and infection-related complications following prostate biopsy"],"prefix":"10.1007","volume":"39","author":[{"given":"Rebecca S.","family":"Steinberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Kipling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. C. Biebighauser","family":"Bens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dattatraya","family":"Patil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Henry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akanksha","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8184-7275","authenticated-orcid":false,"given":"Christopher","family":"Filson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,3,26]]},"reference":[{"key":"3674_CR1","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.urology.2016.12.011","volume":"104","author":"MJ Roberts","year":"2017","unstructured":"Roberts MJ, Bennett HY, Harris PN, Holmes M, Grummet J, Naber K, Wagenlehner FME (2017) Prostate biopsy-related infection: a systematic review of risk factors, prevention strategies, and management approaches. Urology 104:11\u201321. https:\/\/doi.org\/10.1016\/j.urology.2016.12.011","journal-title":"Urology"},{"issue":"5","key":"3674_CR2","doi-asserted-by":"publisher","first-page":"1830","DOI":"10.1016\/j.juro.2011.06.057","volume":"186","author":"S Loeb","year":"2011","unstructured":"Loeb S, Carter HB, Berndt SI, Ricker W, Schaeffer EM (2011) Complications after prostate biopsy: data from SEER-medicare. J Urol 186(5):1830\u20131834. https:\/\/doi.org\/10.1016\/j.juro.2011.06.057","journal-title":"J Urol"},{"issue":"2","key":"3674_CR3","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.juro.2018.03.078","volume":"200","author":"P Jiang","year":"2018","unstructured":"Jiang P, Liss MA, Szabo RJ (2018) Targeted antimicrobial prophylaxis does not always prevent sepsis after transrectal prostate biopsy. J Urol 200(2):361\u2013368. https:\/\/doi.org\/10.1016\/j.juro.2018.03.078","journal-title":"J Urol"},{"issue":"4","key":"3674_CR4","doi-asserted-by":"publisher","first-page":"158.e7","DOI":"10.1016\/j.urolonc.2017.12.005","volume":"36","author":"C Cheung","year":"2018","unstructured":"Cheung C, Patel HD, Landis P, Carter HB, Han M (2018) Targeted antimicrobial prophylaxis for transrectal ultrasound-guided prostate biopsy during active surveillance: effect on hospitalization. Urol Oncol 36(4):158.e7-158.e12. https:\/\/doi.org\/10.1016\/j.urolonc.2017.12.005","journal-title":"Urol Oncol"},{"key":"3674_CR5","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.urology.2019.06.011","volume":"133","author":"MD Gross","year":"2019","unstructured":"Gross MD, Alshak MN, Shoag JE, Laviana AA, Gorin MA, Sedrakyan A, Hu JC (2019) Healthcare costs of post-prostate biopsy sepsis. Urology 133:11\u201315. https:\/\/doi.org\/10.1016\/j.urology.2019.06.011","journal-title":"Urology"},{"issue":"1","key":"3674_CR6","doi-asserted-by":"publisher","first-page":"ofw265","DOI":"10.1093\/ofid\/ofw265","volume":"4","author":"R Evans","year":"2017","unstructured":"Evans R, Loeb A, Kaye KS, Cher ML, Martin ET (2017) Infection-related hospital admissions after prostate biopsy in United States men. Open Forum Infect Dis 4(1):ofw265. https:\/\/doi.org\/10.1093\/ofid\/ofw265","journal-title":"Open Forum Infect Dis"},{"issue":"2","key":"3674_CR7","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1097\/JU.0000000000000509","volume":"203","author":"DJ Lightner","year":"2020","unstructured":"Lightner DJ, Wymer K, Sanchez J, Kavoussi L (2020) Best practice statement on urologic procedures and antimicrobial prophylaxis. J Urol 203(2):351\u2013356. https:\/\/doi.org\/10.1097\/JU.0000000000000509","journal-title":"J Urol"},{"issue":"3","key":"3674_CR8","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.eururo.2019.06.011","volume":"76","author":"G Bonkat","year":"2019","unstructured":"Bonkat G, Pilatz A, Wagenlehner F (2019) Time to adapt our practice? The European Commission has restricted the use of fluoroquinolones since March 2019. Eur Urol 76(3):273\u2013275. https:\/\/doi.org\/10.1016\/j.eururo.2019.06.011","journal-title":"Eur Urol"},{"key":"3674_CR9","unstructured":"European Medicines Agency (2019) Quinolone- and fluoroquinolone-containing medicinal products. Published November 3, 2019. Available at: https:\/\/www.ema.europa.eu\/en\/medicines\/human\/referrals\/quinolone-fluoroquinolone-containing-medicinal-products"},{"key":"3674_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2020.09.042","author":"N Mottet","year":"2020","unstructured":"Mottet N, van den Bergh RCN, Briers E, Van den Broeck T, Cumberbatch MG, De Santis M, Fanti S, Fossati N, Gandaglia G, Gillessen S, Grivas N, Grummet J, Henry AM, van der Kwast TH, Lam TB, Lardas M, Liew M, Mason MD, Moris L, Oprea-Lager DE, van der Poel HG, Rouviere O, Schoots IG, Tilki D, Wiegel T, Willemse PM, Cornford P (2020) EAU-EANM-ESTRO-ESUR-SIOG guidelines on prostate cancer-2020 update. Part 1: screening, diagnosis, and local treatment with curative intent. Eur Urol. https:\/\/doi.org\/10.1016\/j.eururo.2020.09.042","journal-title":"Eur Urol"},{"issue":"2","key":"3674_CR11","doi-asserted-by":"publisher","first-page":"94","DOI":"10.4111\/icu.2016.57.2.94","volume":"57","author":"L Toner","year":"2016","unstructured":"Toner L, Bolton DM, Lawrentschuk N (2016) Prevention of sepsis prior to prostate biopsy. Investig Clin Urol 57(2):94\u201399. https:\/\/doi.org\/10.4111\/icu.2016.57.2.94","journal-title":"Investig Clin Urol"},{"issue":"3","key":"3674_CR12","doi-asserted-by":"crossref","first-page":"212","DOI":"10.47102\/annals-acadmedsg.V38N3p212","volume":"38","author":"HS Ho","year":"2009","unstructured":"Ho HS, Ng LG, Tan YH, Yeo M, Cheng CW (2009) Intramuscular gentamicin improves the efficacy of ciprofloxacin as an antibiotic prophylaxis for transrectal prostate biopsy. Ann Acad Med Singap 38(3):212\u2013216","journal-title":"Ann Acad Med Singap"},{"issue":"6","key":"3674_CR13","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.1016\/j.juro.2013.12.026","volume":"191","author":"PR Womble","year":"2014","unstructured":"Womble PR, Dixon MW, Linsell SM, Ye Z, Montie JE, Lane BR, Miller DC, Burks FN, Michigan Urological Surgery Improvement Collaborative (2014) Infection related hospitalizations after prostate biopsy in a statewide quality improvement collaborative. J Urol 191(6):1787\u20131792. https:\/\/doi.org\/10.1016\/j.juro.2013.12.026","journal-title":"J Urol"},{"issue":"2","key":"3674_CR14","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.juro.2012.08.194","volume":"189","author":"M Adibi","year":"2013","unstructured":"Adibi M, Hornberger B, Bhat D, Raj G, Roehrborn CG, Lotan Y (2013) Reduction in hospital admission rates due to post-prostate biopsy infections after augmenting standard antibiotic prophylaxis. J Urol 189(2):535\u2013540. https:\/\/doi.org\/10.1016\/j.juro.2012.08.194","journal-title":"J Urol"},{"key":"3674_CR15","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1016\/j.ypmed.2015.09.016","volume":"81","author":"MA Bittoni","year":"2015","unstructured":"Bittoni MA, Wexler R, Spees CK, Clinton SK, Taylor CA (2015) Lack of private health insurance is associated with higher mortality from cancer and other chronic diseases, poor diet quality, and inflammatory biomarkers in the United States. Prev Med 81:420\u2013426. https:\/\/doi.org\/10.1016\/j.ypmed.2015.09.016","journal-title":"Prev Med"},{"issue":"4","key":"3674_CR16","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1016\/j.juro.2011.11.115","volume":"187","author":"AK Taylor","year":"2012","unstructured":"Taylor AK, Zembower TR, Nadler RB, Scheetz MH, Cashy JP, Bowen D, Murphy AB, Dielubanza E, Schaeffer AJ (2012) Targeted antimicrobial prophylaxis using rectal swab cultures in men undergoing transrectal ultrasound guided prostate biopsy is associated with reduced incidence of postoperative infectious complications and cost of care. J Urol 187(4):1275\u20131279. https:\/\/doi.org\/10.1016\/j.juro.2011.11.115","journal-title":"J Urol"},{"issue":"1","key":"3674_CR17","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.euf.2018.06.016","volume":"6","author":"M Hadjipavlou","year":"2020","unstructured":"Hadjipavlou M, Eragat M, Kenny C, Pantelidou M, Mulhem W, Wood C, Dall\u2019Antonia M, Hammadeh MY (2020) Effect of augmented antimicrobial prophylaxis and rectal swab culture-guided targeted prophylaxis on the risk of sepsis following transrectal prostate biopsy. Eur Urol Focus 6(1):95\u2013101. https:\/\/doi.org\/10.1016\/j.euf.2018.06.016","journal-title":"Eur Urol Focus"},{"issue":"4","key":"3674_CR18","first-page":"9366","volume":"25","author":"LG Gomella","year":"2018","unstructured":"Gomella LG (2018) Should urology reconsider the routine use of fluoroquinolones? Can J Urol 25(4):9366","journal-title":"Can J Urol"},{"key":"3674_CR19","unstructured":"United States Food and Drug Administration (2016) FDA drug safety communication: FDA updates warnings for oral and injectable fluoroquinolone antibiotics due to disabling side effects. Published July 26, 2016. Available at: https:\/\/www.fda.gov\/drugs\/drug-safety-and-availability\/fda-drug-safety-communication-fda-updates-warnings-oral-and-injectable-fluoroquinolone-antibiotics"},{"issue":"1","key":"3674_CR20","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.eururo.2020.10.019","volume":"79","author":"A Pilatz","year":"2021","unstructured":"Pilatz A, Veeratterapillay R, Dimitropoulos K, Omar MI, Pradere B, Yuan Y, Cai T, Mezei T, Devlies W, Bruyere F, Bartoletti R, Koves B, Geerlings S, Schubert S, Grummet J, Mottet N, Wagenlehner F, Bonkat G (2021) European Association of Urology position paper on the prevention of infectious complications following prostate biopsy. Eur Urol 79(1):11\u201315. https:\/\/doi.org\/10.1016\/j.eururo.2020.10.019","journal-title":"Eur Urol"},{"issue":"2","key":"3674_CR21","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1097\/JU.0000000000000814","volume":"204","author":"A Pilatz","year":"2020","unstructured":"Pilatz A, Dimitropoulos K, Veeratterapillay R, Yuan Y, Omar MI, MacLennan S, Cai T, Bruyere F, Bartoletti R, Koves B, Wagenlehner F, Bonkat G, Pradere B (2020) Antibiotic prophylaxis for the prevention of infectious complications following prostate biopsy: a systematic review and meta-analysis. J Urol 204(2):224\u2013230. https:\/\/doi.org\/10.1097\/JU.0000000000000814","journal-title":"J Urol"},{"issue":"8","key":"3674_CR22","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1007\/s11255-016-1299-7","volume":"48","author":"L Yang","year":"2016","unstructured":"Yang L, Tang Z, Gao L, Li T, Chen Y, Liu L, Han P, Li X, Dong Q, Wei Q (2016) The augmented prophylactic antibiotic could be more efficacious in patients undergoing transrectal prostate biopsy: a systematic review and meta-analysis. Int Urol Nephrol 48(8):1197\u20131207. https:\/\/doi.org\/10.1007\/s11255-016-1299-7","journal-title":"Int Urol Nephrol"},{"issue":"6","key":"3674_CR23","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1089\/sur.2015.040","volume":"16","author":"L Yang","year":"2015","unstructured":"Yang L, Gao L, Chen Y, Tang Z, Liu L, Han P, Zeng H, Li X, Wei Q (2015) Prophylactic antibiotics in prostate biopsy: a meta-analysis based on randomized controlled trials. Surg Infect (Larchmt) 16(6):733\u2013747. https:\/\/doi.org\/10.1089\/sur.2015.040","journal-title":"Surg Infect (Larchmt)"},{"issue":"5","key":"3674_CR24","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1097\/MOU.0000000000000310","volume":"26","author":"TA Jones","year":"2016","unstructured":"Jones TA, Radtke JP, Hadaschik B, Marks LS (2016) Optimizing safety and accuracy of prostate biopsy. Curr Opin Urol 26(5):472\u2013480. https:\/\/doi.org\/10.1097\/MOU.0000000000000310","journal-title":"Curr Opin Urol"},{"issue":"8","key":"3674_CR25","doi-asserted-by":"publisher","first-page":"1784","DOI":"10.1017\/S0950268815002885","volume":"144","author":"HY Bennett","year":"2016","unstructured":"Bennett HY, Roberts MJ, Doi SA, Gardiner RA (2016) The global burden of major infectious complications following prostate biopsy. Epidemiol Infect 144(8):1784\u20131791. https:\/\/doi.org\/10.1017\/S0950268815002885","journal-title":"Epidemiol Infect"},{"issue":"2","key":"3674_CR26","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1097\/UPJ.0000000000000073","volume":"7","author":"AK Leung","year":"2020","unstructured":"Leung AK, Patil D, Howard DH, Filson CP (2020) Payments and patient cost sharing for prostate biopsies according to image guidance practice site and use of anesthesia. Urol Pract 7(2):138\u2013144. https:\/\/doi.org\/10.1097\/UPJ.0000000000000073","journal-title":"Urol Pract"},{"issue":"1","key":"3674_CR27","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.ucl.2020.09.010","volume":"48","author":"Y Bhanji","year":"2021","unstructured":"Bhanji Y, Allaway MJ, Gorin MA (2021) Recent advances and current role of transperineal prostate biopsy. Urol Clin North Am 48(1):25\u201333. https:\/\/doi.org\/10.1016\/j.ucl.2020.09.010","journal-title":"Urol Clin North Am"},{"key":"3674_CR28","doi-asserted-by":"publisher","DOI":"10.1089\/end.2020.1093","author":"RJ Szabo","year":"2020","unstructured":"Szabo RJ (2020) \u201cFree-Hand\u201d transperineal prostate biopsy under local anesthesia: review of the literature. J Endourol. https:\/\/doi.org\/10.1089\/end.2020.1093","journal-title":"J Endourol"},{"issue":"6","key":"3674_CR29","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1097\/JU.0000000000000156","volume":"201","author":"V Stefanova","year":"2019","unstructured":"Stefanova V, Buckley R, Flax S, Spevack L, Hajek D, Tunis A, Lai E, Loblaw A (2019) Transperineal prostate biopsies using local anesthesia: experience with 1287 patients. Prostate cancer detection rate, complications and patient tolerability. J Urol 201(6):1121\u20131126. https:\/\/doi.org\/10.1097\/JU.0000000000000156","journal-title":"J Urol"},{"issue":"2","key":"3674_CR30","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.euo.2019.06.005","volume":"3","author":"L Exterkate","year":"2020","unstructured":"Exterkate L, Wegelin O, Barentsz JO, van der Leest MG, Kummer JA, Vreuls W, de Bruin PC, Bosch J, van Melick HHE, Somford DM (2020) Is there still a need for repeated systematic biopsies in patients with previous negative biopsies in the era of magnetic resonance imaging-targeted biopsies of the prostate? Eur Urol Oncol 3(2):216\u2013223. https:\/\/doi.org\/10.1016\/j.euo.2019.06.005","journal-title":"Eur Urol Oncol"},{"issue":"1","key":"3674_CR31","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1111\/bju.15062","volume":"126","author":"AS Tamhankar","year":"2020","unstructured":"Tamhankar AS, El-Taji O, Vasdev N, Foley C, Popert R, Adshead J (2020) The clinical and financial implications of a decade of prostate biopsies in the NHS: analysis of hospital episode statistics data 2008\u20132019. BJU Int 126(1):133\u2013141. https:\/\/doi.org\/10.1111\/bju.15062","journal-title":"BJU Int"},{"key":"3674_CR32","unstructured":"Patient Centered Outcomes Research Institute (2020) Randomized trial comparing transperineal vs. transrectal MRI-targeted prostate biopsy. Published April 16, 2020. Available at: https:\/\/www.pcori.org\/research-results\/2020\/randomized-trial-comparing-transperineal-vs-transrectal-mri-targeted-prostate"},{"issue":"4","key":"3674_CR33","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1016\/j.eururo.2018.11.023","volume":"75","author":"M van der Leest","year":"2019","unstructured":"van der Leest M, Cornel E, Israel B, Hendriks R, Padhani AR, Hoogenboom M, Zamecnik P, Bakker D, Setiasti AY, Veltman J, van den Hout H, van der Lelij H, van Oort I, Klaver S, Debruyne F, Sedelaar M, Hannink G, Rovers M, Hulsbergen-van de Kaa C, Barentsz JO (2019) Head-to-head comparison of transrectal ultrasound-guided prostate biopsy versus multiparametric prostate resonance imaging with subsequent magnetic resonance-guided biopsy in biopsy-naive men with elevated prostate-specific antigen: a large prospective multicenter clinical study. Eur Urol 75(4):570\u2013578. https:\/\/doi.org\/10.1016\/j.eururo.2018.11.023","journal-title":"Eur Urol"},{"issue":"1","key":"3674_CR34","doi-asserted-by":"publisher","first-page":"107327481983718","DOI":"10.1177\/1073274819837184","volume":"26","author":"S Awasthi","year":"2019","unstructured":"Awasthi S, Gerke T, Williams VL, Asamoah F, Fink AK, Balkrishnan R, Park JY, Yamoah K (2019) Interrelationship between health insurance status and prostate cancer grade can have critical impact on prostate cancer disease control: a retrospective cohort study. Cancer Control 26(1):1073274819837184. https:\/\/doi.org\/10.1177\/1073274819837184","journal-title":"Cancer Control"}],"container-title":["World Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00345-021-03674-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00345-021-03674-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00345-021-03674-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T10:33:15Z","timestamp":1671705195000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00345-021-03674-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,26]]},"references-count":34,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["3674"],"URL":"https:\/\/doi.org\/10.1007\/s00345-021-03674-w","relation":{},"ISSN":["0724-4983","1433-8726"],"issn-type":[{"value":"0724-4983","type":"print"},{"value":"1433-8726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,26]]},"assertion":[{"value":"24 November 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 March 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 March 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This analysis was deemed exempt from IRB oversight with its use of de-identifed data.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}]}}