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We developed a novel port placement and technique allowing to perform robot-assisted NU by a unique retroperitoneal approach.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Between February and June 2021 patients with history of UTUC were treated by robot-assisted NU completely restricted to retroperitoneal space using a singular trocar placement and a two-step docking without relocation of the surgical robot. Patient characteristics, perioperative outcomes and short-term follow-up were prospectively analyzed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The analysis included five patients [median age: 73\u00a0years; BMI: 27.2\u00a0kg\/m<jats:sup>2<\/jats:sup>; Charlson comorbidity index 5]. All five patients had UTUC with a mean tumor size of 3.02\u00a0cm (range 0.9\u20136.0). UTUC was localized to distal ureter in two and to kidney in three cases. No positive surgical margins were noted for all patients with UTUC [1 low-grade and 4 high-grade]. Retroperitoneal lymphadenectomy in three patients did not reveal positive nodes. No intraoperative adverse events exceeding EAUiaiC classification\u2009\u2265\u20092 were observed, while median EBL was 150\u00a0ml (IQR 100\u2013250). No patient experienced postoperative complications exceeding Clavien\u2013Dindo classification\u2009\u2265\u20093a. Median hospital stay was 5.4d without any 30-d readmission.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>We demonstrate safety and feasibility of the first entire robot-assisted retroperitoneal nephroureterectomy (RRNU) with bladder cuff. This surgical technique is easily reproducible, while surgical outcomes are similar to other established techniques.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00345-021-03920-1","type":"journal-article","created":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T08:25:49Z","timestamp":1642407949000},"page":"1019-1026","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["First completely robot-assisted retroperitoneal nephroureterectomy with bladder cuff: a step-by-step technique"],"prefix":"10.1007","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8469-8113","authenticated-orcid":false,"given":"P.","family":"Sparwasser","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Epple","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Dotzauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Boehm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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