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Using MRT, the size of the area was determined in which the thermal dose as measured by the Cumulative Equivalent Minutes (CEM<jats:sub>43<\/jats:sub>) method exceeded a value of 120\u00a0min.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In the calyx, CEM<jats:sub>43<\/jats:sub> never exceeded 120\u00a0min for flow rates\u2009\u2265\u200970\u00a0ml\/min at 14\u00a0W, and longer <jats:italic>t<\/jats:italic><jats:sub><jats:italic>L<\/jats:italic><\/jats:sub> (10\u00a0s vs. 5\u00a0s) lead to exponentially lower thermal affection of tissue (3.6 vs. 21.9 mm<jats:sup>2<\/jats:sup>). Similarly at 30\u00a0W and\u2009\u2265\u200970\u00a0ml\/min CEM<jats:sub>43<\/jats:sub> was below 120\u00a0min. Interestingly, at irrigation rates of 10\u00a0ml\/min, <jats:italic>t<\/jats:italic><jats:sub><jats:italic>L<\/jats:italic><\/jats:sub>\u2009=\u200910\u00a0s and <jats:italic>t<\/jats:italic><jats:sub><jats:italic>D<\/jats:italic><\/jats:sub>\u2009=\u200910\u00a0s CEM<jats:sub>43<\/jats:sub> were observed\u2009&gt;\u2009120\u00a0min in an area of 84.4 mm<jats:sup>2<\/jats:sup> and 49.1 mm<jats:sup>2<\/jats:sup> at <jats:italic>t<\/jats:italic><jats:sub><jats:italic>D<\/jats:italic><\/jats:sub>\u2009=\u20095\u00a0s. Here, <jats:italic>t<\/jats:italic><jats:sub><jats:italic>L<\/jats:italic><\/jats:sub>\u2009=\u20095\u00a0s revealed relevant thermal affection of 29.1 mm<jats:sup>2<\/jats:sup> at 10\u00a0ml\/min.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>We demonstrate that critical temperature dose areas in the kidney parenchyma were associated with high laser power and application times, a low irrigation rate, and anatomical volume of the targeted calyx.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00345-022-04255-1","type":"journal-article","created":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T19:11:36Z","timestamp":1671649896000},"page":"543-549","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Assessing critical temperature dose areas in the kidney by magnetic resonance imaging thermometry in an ex vivo Holmium:YAG laser lithotripsy model"],"prefix":"10.1007","volume":"41","author":[{"given":"Robert","family":"Wriedt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Yilmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Lottner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Reichert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konrad","family":"Wilhelm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe-Fabian","family":"Pohlmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Gratzke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Bock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5894-9647","authenticated-orcid":false,"given":"Arkadiusz","family":"Miernik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,12,21]]},"reference":[{"key":"4255_CR1","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1097\/MOU.0000000000000573","volume":"29","author":"B Becker","year":"2019","unstructured":"Becker B, Gross AJ, Netsch C (2019) Ho: YaG laser lithotripsy: recent innovations. 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Miernik receives research funds from the German Federal Ministry of Education and Research, Berlin (D). He receives support for his travel activities from the European Society of Urology, Arnhem (NL), and the German Society of Urology, D\u00fcsseldorf (D). Furthermore, A. Miernik is consulted for: KLS Martin, Tuttlingen (D), Avateramedical, Jena (D), LISA LaserProducts GmbH, Katlenburg-Lindau (D), Schoellyfiberoptics GmbH, Denzlingen (D), Dornier MedTech Laser GmbH (D), Medi-Tate Ltd. (IL, USA) and B. Braun Newventures GmbH, Freiburg (D). A. Miernik is the speaker for the companies Richard Wolf GmbH (D) and Boston Scientific (USA). In addition, he performed expert activities for the Ludwig Boltzmann Gesellschaft, Wien (A). A. Miernik is involved in numerous patents and inventions in the field of medical technology. C. Gratzke is advisor for Astellas Pharma GmbH, Munich (D), Ipsen Pharma GmbH, Munich (D), Steba Biotech S.A., Luxembourg (LUX), Bayer Pharma, Leverkusen (D), Olympus Winter &Ibe GmbH, Hamburg (D), Medi-Tate Ltd., Or Akiva (IL), MSD, Haar (D), Astra-Zeneca, Cambridge (UK) and Roche, Basel (CH). C. Gratzke receives speaker fees from Amgen, California (USA), Astellas Pharma GmbH, Munich (D), Ipsen Pharma GmbH, Munich (D), Janssen-Cilag GmbH, Neuss (D), Bayer Pharma, Leverkusen (D), Takeda Pharmaceuticals, Tokyo (JPN) and medac GmbH, Wedel (D). R. Wriedt, M. Yilmaz, T. Lottner, A. Reichert, K. Wilhelm, P-F. Pohlmann and M. Bock have no conflicts of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable for this section. The manuscript does not contain clinical studies or patient data. This article does not contain any studies with human subjects performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable for this section.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable for this section.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}