{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:40:09Z","timestamp":1790732409469,"version":"4.1.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T00:00:00Z","timestamp":1679875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T00:00:00Z","timestamp":1679875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100011645","name":"Kaohsiung Medical University Chung-Ho Memorial Hospital","doi-asserted-by":"publisher","award":["KMUH-110-0M57"],"award-info":[{"award-number":["KMUH-110-0M57"]}],"id":[{"id":"10.13039\/501100011645","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011645","name":"Kaohsiung Medical University Chung-Ho Memorial Hospital","doi-asserted-by":"publisher","award":["KMUH105-5M07"],"award-info":[{"award-number":["KMUH105-5M07"]}],"id":[{"id":"10.13039\/501100011645","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Kaohsiung Medical University Hospital","award":["KMUH111-1M48"],"award-info":[{"award-number":["KMUH111-1M48"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Urol"],"DOI":"10.1007\/s00345-023-04376-1","type":"journal-article","created":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T10:03:44Z","timestamp":1679911424000},"page":"1373-1379","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Skin sympathetic nerve activity as a potential biomarker for overactive bladder"],"prefix":"10.1007","volume":"41","author":[{"given":"Yu-Chen","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao-Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tien-Chi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-Yin","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yung-Shun","family":"Juan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Yu","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiang-Ying","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Pin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Peng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao-Ju","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Ni","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuang-Shun","family":"Chueh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Chia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Hung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Chung","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Jeng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,3,27]]},"reference":[{"key":"4376_CR1","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.ejogrb.2022.01.022","volume":"271","author":"PA Pi\u0119tak","year":"2022","unstructured":"Pi\u0119tak PA, Rechberger T (2022) Overactive bladder as a dysfunction of the autonomic nervous system\u2014a narrative review. Eur J Obstet Gynecol Reprod Biol 271:102\u2013107","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"6","key":"4376_CR2","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1590\/s1677-5538.ibju.2021.0177","volume":"47","author":"R Gondim","year":"2021","unstructured":"Gondim R, Gorj\u00e3o J, Nacif A, Franco I, Barroso U Jr (2021) Evaluation of autonomic function in children and adolescents with overactive bladder. Int Braz J Urol 47(6):1178\u20131188","journal-title":"Int Braz J Urol"},{"issue":"8","key":"4376_CR3","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1002\/nau.21154","volume":"30","author":"K Hubeaux","year":"2011","unstructured":"Hubeaux K, Deffieux X, Raibaut P, Le Breton F, Jousse M, Amarenco G (2011) Evidence for autonomic nervous system dysfunction in females with idiopathic overactive bladder syndrome. Neurourol Urodyn 30(8):1467\u20131472","journal-title":"Neurourol Urodyn"},{"key":"4376_CR4","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1016\/j.urology.2005.01.029","volume":"65","author":"JB Choi","year":"2005","unstructured":"Choi JB, Kim YB, Kim BT et al (2005) Analysis of heart rate variability in female patients with overactive bladder. Urology 65:1109\u20131112","journal-title":"Urology"},{"key":"4376_CR5","doi-asserted-by":"publisher","first-page":"2483","DOI":"10.1016\/j.juro.2007.08.036","volume":"178","author":"K Hubeaux","year":"2007","unstructured":"Hubeaux K, Deffieux X, Ismael SS et al (2007) Autonomic nervous system activity during bladder filling assessed by heart rate variability analysis in women with idiopathic overactive bladder syndrome or stress urinary incontinence. J Urol 178:2483\u20132487","journal-title":"J Urol"},{"key":"4376_CR6","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.ijgo.2010.03.007","volume":"110","author":"WC Liao","year":"2010","unstructured":"Liao WC, Jaw FS (2010) A noninvasive evaluation of autonomic nervous system dysfunction in women with an overactive bladder. Int J Gynaecol Obstet 110:12\u201317","journal-title":"Int J Gynaecol Obstet"},{"key":"4376_CR7","doi-asserted-by":"publisher","first-page":"232","DOI":"10.5213\/inj.2010.14.4.232","volume":"14","author":"JC Kim","year":"2010","unstructured":"Kim JC, Joo KJ, Kim JT et al (2010) Alteration of autonomic function in female urinary incontinence. Int Neurourol J 14:232\u2013237","journal-title":"Int Neurourol J"},{"issue":"3","key":"4376_CR8","doi-asserted-by":"publisher","first-page":"183","DOI":"10.4111\/kju.2010.51.3.183","volume":"51","author":"HW Im","year":"2010","unstructured":"Im HW, Kim MD, Kim JC, Choi JB (2010) Autonomous nervous system activity in women with detrusor overactivity. Korean J Urol 51(3):183\u2013186","journal-title":"Korean J Urol"},{"issue":"8","key":"4376_CR9","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1007\/s00192-012-1738-7","volume":"23","author":"I Ben-Dror","year":"2012","unstructured":"Ben-Dror I, Weissman A, Leurer MK, Eldor-Itskovitz J, Lowenstein L (2012) Alterations of heart rate variability in women with overactive bladder syndrome. Int Urogynecol J 23(8):1081\u20131086","journal-title":"Int Urogynecol J"},{"key":"4376_CR10","doi-asserted-by":"publisher","first-page":"26","DOI":"10.3389\/fphys.2013.00026","volume":"4","author":"GE Billman","year":"2013","unstructured":"Billman GE (2013) The LF\/HF ratio does not accurately measure cardiac sympatho-vagal balance. Front Physiol 4:26","journal-title":"Front Physiol"},{"issue":"1","key":"4376_CR11","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1002\/nau.22652","volume":"35","author":"E Ates","year":"2016","unstructured":"Ates E, Ipekci T, Akin Y, Kizilay F, Kukul E, Guntekin E (2016) Impact of sympathetic dysfunction in the etiology of overactive bladder in women: a preliminary study. Neurourol Urodyn 35(1):26\u201328","journal-title":"Neurourol Urodyn"},{"issue":"5","key":"4376_CR12","doi-asserted-by":"publisher","first-page":"1853","DOI":"10.1038\/s41596-020-0316-6","volume":"15","author":"T Kusayama","year":"2020","unstructured":"Kusayama T, Wong J, Liu X, He W, Doytchinova A, Robinson EA, Adams DE, Chen LS, Lin SF, Davoren K, Victor RG, Cai C, Dai MY, Tian Y, Zhang P, Ernst D, Rho RH, Chen M, Cha YM, Walega DR, Everett TH 4th, Chen PS (2020) Simultaneous noninvasive recording of electrocardiogram and skin sympathetic nerve activity (neuECG). Nat Protoc 15(5):1853\u20131877","journal-title":"Nat Protoc"},{"issue":"11","key":"4376_CR13","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.3390\/jpm11111053","volume":"11","author":"TC Huang","year":"2021","unstructured":"Huang TC, Chi NY, Lan CS, Chen CJ, Jhuo SJ, Lin TH, Liu YH, Chou LF, Chang CW, Liao WS, Kao PH, Hsu PC, Lee CS, Lin YH, Lee HC, Lu YH, Yen HW, Lin TH, Su HM, Lai WT, Tsai WC, Lin SF, Lee CH (2021) High skin sympathetic nerve activity in patients with recurrent syncope. J Pers Med. 11(11):1053","journal-title":"J Pers Med."},{"key":"4376_CR14","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.hrthm.2016.09.019","volume":"14","author":"A Doytchinova","year":"2017","unstructured":"Doytchinova A, Hassel JL, Yuan Y, Lin H, Yin D, Adams D, Straka S, Wright K, Smith K, Wagner D et al (2017) Simultaneous noninvasive recording of skin sympathetic nerve activity and electrocardiogram. Heart Rhythm 14:25\u201333","journal-title":"Heart Rhythm"},{"key":"4376_CR15","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1016\/j.hrthm.2015.02.012","volume":"12","author":"Z Jiang","year":"2015","unstructured":"Jiang Z, Zhao Y, Doytchinova A, Kamp NJ, Tsai WC, Yuan Y, Adams D, Wagner D, Shen C, Chen LS et al (2015) Using skin sympathetic nerve activity to estimate stellate ganglion nerve activity in dogs. Heart Rhythm 12:1324\u20131332","journal-title":"Heart Rhythm"},{"issue":"1","key":"4376_CR16","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s00192-009-0976-9","volume":"21","author":"BT Haylen","year":"2010","unstructured":"Haylen BT, de Ridder D, Freeman RM, Swift SE, Berghmans B, Lee J, Monga A, Petri E, Rizk DE, Sand PK, Schaer GN (2010) An International Urogynecological Association (IUGA)\/International Continence Society (ICS) joint report on the terminology for female pelvic floor dysfunction. Int Urogynecol J 21(1):5\u201326. https:\/\/doi.org\/10.1007\/s00192-009-0976-9","journal-title":"Int Urogynecol J"},{"issue":"5","key":"4376_CR17","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.jfma.2011.09.020","volume":"112","author":"MJ Hung","year":"2013","unstructured":"Hung MJ, Chou CL, Yen TW, Chuang YC, Meng E, Huang ST, Kuo HC (2013) Development and validation of the Chinese Overactive Bladder Symptom Score for assessing overactive bladder syndrome in a RESORT study. J Formos Med Assoc 112(5):276\u2013282. https:\/\/doi.org\/10.1016\/j.jfma.2011.09.020","journal-title":"J Formos Med Assoc"},{"key":"4376_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1477-7525-12-1","volume":"12","author":"EP Choi","year":"2014","unstructured":"Choi EP, Lam CL, Chin WY (2014) Validation of the International Prostate Symptom Score in Chinese males and females with lower urinary tract symptoms. Health Qual Life Outcomes 12:1","journal-title":"Health Qual Life Outcomes"},{"issue":"3","key":"4376_CR19","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1002\/nau.21005","volume":"30","author":"KS Coyne","year":"2011","unstructured":"Coyne KS, Margolis MK, Hsieh R, Vats V, Chapple CR (2011) Validation of the urinary sensation scale (USS). Neurourol Urodyn 30(3):360\u2013365","journal-title":"Neurourol Urodyn"},{"issue":"15","key":"4376_CR20","doi-asserted-by":"publisher","first-page":"1864","DOI":"10.1161\/01.CIR.0000124726.72615.60","volume":"109","author":"WJ Kop","year":"2004","unstructured":"Kop WJ, Krantz DS, Nearing BD, Gottdiener JS, Quigley JF, O\u2019Callahan M, DelNegro AA, Friehling TD, Karasik P, Suchday S, Levine J, Verrier RL (2004) Effects of acute mental stress and exercise on T-wave alternans in patients with implantable cardioverter defibrillators and controls. Circulation 109(15):1864\u20131869. https:\/\/doi.org\/10.1161\/01.CIR.0000124726.72615.60","journal-title":"Circulation"},{"key":"4376_CR21","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.1093\/eurheartj\/ehn193","volume":"29","author":"G Gratze","year":"2008","unstructured":"Gratze G, Mayer H, Skrabal F (2008) Sympathetic reserve, serum potassium, and orthostatic intolerance after endurance exercise and implications for neurocardiogenic syncope. Eur Heart J 29:1531\u20131541","journal-title":"Eur Heart J"},{"key":"4376_CR22","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1109\/TBME.1985.325532","volume":"32","author":"J Pan","year":"1985","unstructured":"Pan J, Tompkins WJ (1985) A real-time QRS detection algorithm. IEEE Trans Biomed Eng 32:230\u2013236","journal-title":"IEEE Trans Biomed Eng"},{"issue":"6","key":"4376_CR23","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1097\/MOU.0b013e3283657460","volume":"23","author":"JQ Clemens","year":"2013","unstructured":"Clemens JQ (2013) Afferent neurourology and urologic pain syndromes: current state of the art. Curr Opin Urol 23(6):552\u2013553","journal-title":"Curr Opin Urol"},{"key":"4376_CR24","first-page":"2503","volume-title":"Campbell Walsh Wein urology","author":"AW Partin","year":"2020","unstructured":"Partin AW, Dmochowski RR, Kavoussi LR, Peters CA, Wein A (2020) Campbell Walsh Wein urology, 12th edn. Elsevier, pp 2503\u20132504","edition":"12"},{"issue":"1","key":"4376_CR25","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1111\/j.1469-445X.1999.tb00079.x","volume":"84","author":"WD Steers","year":"1999","unstructured":"Steers WD, Clemow DB, Persson K, Sherer TB, Andersson KE, Tuttle JB (1999) The spontaneously hypertensive rat: insight into the pathogenesis of irritative symptoms in benign prostatic hyperplasia and young anxious males. Exp Physiol 84(1):137\u2013147","journal-title":"Exp Physiol"},{"issue":"1","key":"4376_CR26","doi-asserted-by":"publisher","first-page":"2495","DOI":"10.4238\/2015.March.30.7","volume":"14","author":"HC Qu","year":"2015","unstructured":"Qu HC, Zhang W, Liu YL, Wang P (2015) Association between polymorphism of \u03b23-adrenoceptor gene and overactive bladder: a meta-analysis. Genet Mol Res 14(1):2495\u20132501. https:\/\/doi.org\/10.4238\/2015.March.30.7","journal-title":"Genet Mol Res"},{"issue":"1","key":"4376_CR27","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.jphs.2021.10.003","volume":"148","author":"S Yamada","year":"2022","unstructured":"Yamada S, Niiya R, Ito Y, Kato Y, Onoue S (2022) Comparative characterization of \u03b2-adrenoceptors in the bladder, heart, and lungs of rats: alterations in spontaneously hypertensive rats. J Pharmacol Sci 148(1):51\u201355","journal-title":"J Pharmacol Sci"},{"key":"4376_CR28","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1007\/s00210-006-0077-y","volume":"373","author":"EP Frazier","year":"2006","unstructured":"Frazier EP, Schneider T, Michel MC (2006) Effects of gender, age and hypertension on beta-adrenergic receptor function in rat urinary bladder. Naunyn-Schmiedeberg\u2019s Arch Pharmacol 373:300\u2013309","journal-title":"Naunyn-Schmiedeberg\u2019s Arch Pharmacol"},{"issue":"12","key":"4376_CR29","doi-asserted-by":"publisher","first-page":"1668","DOI":"10.1111\/j.1464-410X.2009.08380.x","volume":"103","author":"HT Liu","year":"2009","unstructured":"Liu HT, Chancellor MB, Kuo HC (2009) Decrease of urinary nerve growth factor levels after antimuscarinic therapy in patients with overactive bladder. BJU Int 103(12):1668\u20131672","journal-title":"BJU Int"},{"key":"4376_CR30","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1097\/01.ju.0000169481.42259.54","volume":"174","author":"A Apostolidis","year":"2005","unstructured":"Apostolidis A, Popat R, Yiangou Y, Cockayne D, Ford AP, Davis JB (2005) Decreased sensory receptors P2X3 and TRPV1 in suburothelial nerve fibers following intradetrusor injections of botulinum toxin for human detrusor overactivity. J Urol 174:977\u2013983","journal-title":"J Urol"}],"container-title":["World Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00345-023-04376-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00345-023-04376-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00345-023-04376-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T11:06:05Z","timestamp":1684235165000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00345-023-04376-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,27]]},"references-count":30,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,5]]}},"alternative-id":["4376"],"URL":"https:\/\/doi.org\/10.1007\/s00345-023-04376-1","relation":{},"ISSN":["1433-8726"],"issn-type":[{"value":"1433-8726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,27]]},"assertion":[{"value":"13 December 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 February 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 March 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interest for this research.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by the Institutional Review Board of Kaohsiung Medical University Hospital (KMUHIRB-E(II)-20180010) and was registered at ClinicalTrials.gov (identifier: NCT03243448).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All participants provided written informed consent.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The manuscript does not contain any individual personal data in any form. All authors reviewed and approved the final version of the manuscript.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}