{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T02:17:38Z","timestamp":1785291458705,"version":"3.55.0"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T00:00:00Z","timestamp":1696204800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T00:00:00Z","timestamp":1696204800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Urol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>The removal of ureteral stent can be performed with disposable or reusable flexible cystoscopes, but limited comparative data are available on functionality, risk of infections, and costs.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We performed a multicentric, prospective, observational study on patients undergoing in-office ureteral stent removal with Isiris-\u03b1<jats:sup>\u00ae<\/jats:sup> or a reusable Storz\u2122 flexible cystoscope. Study endpoints were the functionality and effectiveness of the devices, the rate of postoperative bacteriuria and UTIs, and the costs of the procedure.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A total of 135 patients were included, 80 (59.2%) treated with reusable cystoscopes and 55 (40.8%) with Isiris-\u03b1<jats:sup>\u00ae<\/jats:sup>. No significant baseline differences between groups were detected. Isiris-\u03b1<jats:sup>\u00ae<\/jats:sup> outperformed the reusable device in terms of quality of vision (<jats:italic>p<\/jats:italic> 0.001), manoeuvrability (<jats:italic>p<\/jats:italic> 0.001), grasper functionality (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and quality of the procedure (<jats:italic>p<\/jats:italic> 0.01). Mean procedure time was shorter with Isiris-\u03b1<jats:sup>\u00ae<\/jats:sup> (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) due to a shorter instrument preparation time (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). No differences were found in terms of perceived patient pain (<jats:italic>p<\/jats:italic> 0.34), nor postoperative bacteriuria or symptomatic UTIs. According to our cost analysis, the in-office procedure performed with Isiris-\u03b1<jats:sup>\u00ae<\/jats:sup> was more expensive (+\u2009137.8\u20ac) but was independent from instrument turnover or disinfection. Among limitations of study we acknowledge the lack of randomization, the use of antibiotic prophylaxis in several patients, and the high rate of missing preoperative urine cultures.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Isiris-\u03b1<jats:sup>\u00ae<\/jats:sup> outperforms reusable cystoscopes for in-office ureteral stent removal in terms of total operative time and quality of the procedure, at the cost of being more expensive. No significant differences in postoperative bacteriuria or symptomatic UTIs were found.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00345-023-04636-0","type":"journal-article","created":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T19:01:25Z","timestamp":1696273285000},"page":"3175-3180","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Single-use digital flexible cystoscope for double J removal versus reusable instruments: a prospective, comparative study of functionality, risk of infection, and costs"],"prefix":"10.1007","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4681-888X","authenticated-orcid":false,"given":"Marco","family":"Oderda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasios","family":"Asimakopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerio","family":"Batetta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Bosio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ettore","family":"Dalmasso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivano","family":"Morra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenia","family":"Vercelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Gontero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,10,2]]},"reference":[{"key":"4636_CR1","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1007\/s00345-016-1986-0","volume":"35","author":"S Doizi","year":"2017","unstructured":"Doizi S, Kamphuis G, Giusti G et al (2017) First clinical evaluation of a new single-use flexible cystoscope dedicated to double-J stent removal (Isiris\u2122): a European prospective multicenter study. 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The authors have no competing interests to declare that are relevant to the content of this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by the \u201cA.O.U. Citt\u00e0 della Salute e della Scienza\u201d ethics committee as coordinator centre (N. 00515\/2020).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Research involving human participants and\/or animals"}},{"value":"All enrolled patients signed an informed consent before participating in this study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}