{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T21:51:41Z","timestamp":1775771501469,"version":"3.50.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T00:00:00Z","timestamp":1718928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T00:00:00Z","timestamp":1718928000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004434","name":"Universit\u00e0 degli Studi di Firenze","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004434","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Urol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Current potential living kidney donor\u2019s assessment includes functional and anatomical evaluation. Scintigraphy is recommended in some cases and some centers include this test in the donor\u2019s protocol. Recent studies advocate for the avoidance of this test as CT or MRI volumetry showed to accurately assess donor\u2019s renal function.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Objective<\/jats:title>\n                <jats:p>To summarize scientific evidence on image tests for pre-donation and\/or post-nephrectomy renal function evaluation.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Evidence acquisition<\/jats:title>\n                <jats:p>This review followed the guidelines set by the European Association of Urology and adhered to PRISMA 2020 recommendations. The protocol was registered in PROSPERO on 10th December 2022 (ID: CRD42022379273).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Evidence synthesis<\/jats:title>\n                <jats:p>Twenty-one studies met the inclusion criteria after thorough screening and eligibility assessment. According to QUADAS-2, patient selection and flow\/timing domains showed a predominant low risk of bias.<\/jats:p>\n                <jats:p>The correlation between split renal function (SRF) using CT and scintigraphy varied from weak (<jats:italic>r<\/jats:italic>\u2009=\u20090.21) to remarkably strong (<jats:italic>r<\/jats:italic>\u2009=\u20090.949). Bland\u2013Altman agreement demonstrated moderate to excellent results, with mean differences ranging from -0.06% to 1.76%. The correlation between split renal volume (CT) and estimated glomerular filtration rate (eGFR) at 6\u00a0months or 1\u00a0year after nephrectomy showed a moderate correlation, with coefficients ranging from 0.708 to 0.83.<\/jats:p>\n                <jats:p>The correlation between SRF (MRI) and renal scintigraphy reported a moderate correlation, with correlation coefficients of 0.58 and 0.84. MRI and scintigraphy displayed a good agreement, with a 66% agreement observed and mean differences of\u2009\u00b1\u20090.3%.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Despite study heterogeneity, MRI or CT-based renal volumetry appears promising compared to scintigraphy, with favorable correlations and agreement.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00345-024-05024-y","type":"journal-article","created":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T09:02:27Z","timestamp":1718960547000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Can CT or MRI volumetry substitute scintigraphy in living kidney donor evaluation? A systematic review"],"prefix":"10.1007","volume":"42","author":[{"given":"Alicia","family":"L\u00f3pez-Abad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Prudhomme","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessio","family":"Pecoraro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romain","family":"Boissier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammet Irfan","family":"D\u00f6nmez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Piana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz Ba\u00f1uelos","family":"Marco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Belmonte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Serni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5237-0888","authenticated-orcid":false,"given":"Riccardo","family":"Campi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo","family":"Territo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,6,21]]},"reference":[{"issue":"8","key":"5024_CR1","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1056\/NEJMra2014530","volume":"385","author":"S Hariharan","year":"2021","unstructured":"Hariharan S, Israni AK, Danovitch G (2021) Long-term survival after kidney transplantation. N Engl J Med 385(8):729\u2013743","journal-title":"N Engl J Med"},{"key":"5024_CR2","volume-title":"Guidelines for living donor kidney transplantation","author":"British Transplantation Society","year":"2018","unstructured":"British Transplantation Society (2018) Guidelines for living donor kidney transplantation. United Kingdom Guidelines, London"},{"key":"5024_CR3","doi-asserted-by":"publisher","first-page":"109864","DOI":"10.1016\/j.ejrad.2021.109864","volume":"142","author":"P Krumm","year":"2021","unstructured":"Krumm P, Hupka T, Hau\u00dfmann F, Dittmann H, M\u00fchlbacher T, Nadalin S et al (2021) Contrast-enhanced MRI for simultaneous evaluation of renal morphology and split renal function in living kidney donor candidates. Eur J Radiol 142:109864","journal-title":"Eur J Radiol"},{"issue":"3","key":"5024_CR4","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1007\/s40620-015-0223-z","volume":"29","author":"S Weinberger","year":"2016","unstructured":"Weinberger S, Baeder M, Scheurig-Muenkler C, Steffen IG, Magheli A, Miller K et al (2016) Optimizing scintigraphic evaluation of split renal function in living kidney donors using the geometric mean method: a preliminary retrospective study. J Nephrol 29(3):435\u2013441","journal-title":"J Nephrol"},{"issue":"5","key":"5024_CR5","doi-asserted-by":"publisher","first-page":"1314","DOI":"10.1016\/j.transproceed.2019.01.130","volume":"51","author":"N Nakamura","year":"2019","unstructured":"Nakamura N, Aoyagi C, Matsuzaki H, Furuya R, Irie S, Matsuoka H et al (2019) Role of computed tomography volumetry in preoperative donor renal function evaluation of living related kidney transplantation. Transplant Proc 51(5):1314\u20131316","journal-title":"Transplant Proc"},{"issue":"6","key":"5024_CR6","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1111\/ctr.12365","volume":"28","author":"A Diez","year":"2014","unstructured":"Diez A, Powelson J, Sundaram CP, Taber TE, Mujtaba MA, Yaqub MS et al (2014) Correlation between CT-based measured renal volumes and nuclear-renography-based split renal function in living kidney donors. Clinical diagnostic utility and practice patterns. Clin Transplant 28(6):675\u2013682","journal-title":"Clin Transplant"},{"issue":"2","key":"5024_CR7","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/j.eururo.2017.08.016","volume":"73","author":"T Knoll","year":"2018","unstructured":"Knoll T, Omar MI, Maclennan S, Hern\u00e1ndez V, Canfield S, Yuan Y et al (2018) Key steps in conducting systematic reviews for underpinning clinical practice guidelines: methodology of the european association of urology. Eur Urol 73(2):290\u2013300","journal-title":"Eur Urol"},{"key":"5024_CR8","doi-asserted-by":"publisher","first-page":"n71","DOI":"10.1136\/bmj.n71","volume":"29","author":"MJ Page","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 29:n71","journal-title":"BMJ"},{"issue":"8","key":"5024_CR9","doi-asserted-by":"publisher","first-page":"529","DOI":"10.7326\/0003-4819-155-8-201110180-00009","volume":"155","author":"PF Whiting","year":"2011","unstructured":"Whiting PF (2011) QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies. Ann Intern Med 155(8):529","journal-title":"Ann Intern Med"},{"issue":"6","key":"5024_CR10","doi-asserted-by":"publisher","first-page":"1986","DOI":"10.1093\/ndt\/gfp772","volume":"25","author":"F Artunc","year":"2010","unstructured":"Artunc F, Yildiz S, Rossi C, Boss A, Dittmann H, Schlemmer HP et al (2010) Simultaneous evaluation of renal morphology and function in live kidney donors using dynamic magnetic resonance imaging. Nephrol Dial Transplant 25(6):1986\u20131991","journal-title":"Nephrol Dial Transplant"},{"key":"5024_CR11","first-page":"1","volume":"25","author":"H Lal","year":"2021","unstructured":"Lal H, Singh A, Prasad R, Yadav P, Akhtar J, Barai S et al (2021) Determination of split renal function in voluntary renal donors by multidetector computed tomography and nuclear renography How well do they correlate? South Afr J Radiol 25:1","journal-title":"South Afr J Radiol"},{"issue":"6","key":"5024_CR12","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1177\/0284185113504195","volume":"55","author":"K Patankar","year":"2014","unstructured":"Patankar K, Low RST, Blakeway D, Ferrari P (2014) Comparison of computer tomographic volumetry versus nuclear split renal function to determine residual renal function after living kidney donation. Acta Radiol 55(6):753\u2013760","journal-title":"Acta Radiol"},{"issue":"1","key":"5024_CR13","doi-asserted-by":"publisher","first-page":"5144","DOI":"10.1038\/s41598-022-09187-9","volume":"12","author":"SH Eum","year":"2022","unstructured":"Eum SH, Lee H, Ko EJ, Cho HJ, Yang CW, Chung BH (2022) Comparison of CT volumetry versus nuclear renography for predicting remaining kidney function after uninephrectomy in living kidney donors. Sci Rep 12(1):5144","journal-title":"Sci Rep"},{"issue":"4","key":"5024_CR14","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1080\/02841850410005282","volume":"45","author":"H Nilsson","year":"2004","unstructured":"Nilsson H, Wadstr\u00f6m J, Andersson L-G, Raland H, Magnusson A (2004) Measuring split renal function in renal donors: can computed tomography replace renography? Acta Radiol 45(4):474\u2013480","journal-title":"Acta Radiol"},{"issue":"7","key":"5024_CR15","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1111\/tri.13150","volume":"31","author":"D Lange","year":"2018","unstructured":"Lange D, Helck A, Rominger A, Crispin A, Meiser B, Werner J et al (2018) Renal volume assessed by magnetic resonance imaging volumetry correlates with renal function in living kidney donors pre- and postdonation: a retrospective cohort study. Transpl Int 31(7):773\u2013780","journal-title":"Transpl Int"},{"issue":"2","key":"5024_CR16","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1007\/s10157-017-1454-1","volume":"22","author":"Y Mitsui","year":"2018","unstructured":"Mitsui Y, Sadahira T, Araki M, Wada K, Tanimoto R, Ariyoshi Y et al (2018) The assessment of renal cortex and parenchymal volume using automated CT volumetry for predicting renal function after donor nephrectomy. Clin Exp Nephrol 22(2):453\u2013458","journal-title":"Clin Exp Nephrol"},{"issue":"5","key":"5024_CR17","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1016\/j.transproceed.2017.03.056","volume":"49","author":"HH Lee","year":"2017","unstructured":"Lee HH, Han WK, Kang SK, Huh KH, Kim MS, Kim SI et al (2017) Usefulness of multi-detector computed tomography scanning as a replacement for diethylenetriamine pentaacetic acid. Transplant Proc 49(5):1023\u20131026","journal-title":"Transplant Proc"},{"issue":"3","key":"5024_CR18","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1007\/s11255-022-03441-9","volume":"55","author":"M Almeida","year":"2022","unstructured":"Almeida M, Pereira PR, Ramos M, Carneiro D, Mandaleno M, Silva F et al (2022) CT volumetry performs better than nuclear renography in predicting estimated renal function one year after living donation. Int Urol Nephrol 55(3):553\u2013562","journal-title":"Int Urol Nephrol"},{"issue":"9","key":"5024_CR19","doi-asserted-by":"publisher","first-page":"2700","DOI":"10.1016\/j.transproceed.2015.07.037","volume":"47","author":"M Yanishi","year":"2015","unstructured":"Yanishi M, Kinoshita H, Yoshida T, Takayasu K, Yoshida K, Kawa G et al (2015) Comparison of renal scintigraphy and computed tomographic renal volumetry for determining split renal function and estimating post-transplant renal function. Transplant Proc 47(9):2700\u20132702","journal-title":"Transplant Proc"},{"issue":"6","key":"5024_CR20","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.1097\/TP.0000000000000889","volume":"100","author":"R Wahba","year":"2016","unstructured":"Wahba R, Franke M, Hellmich M, Kleinert R, Cing\u00f6z T, Schmidt MC et al (2016) Computed tomography volumetry in preoperative living kidney donor assessment for prediction of split renal function. Transplantation 100(6):1270\u20131277","journal-title":"Transplantation"},{"issue":"12","key":"5024_CR21","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1111\/tri.12195","volume":"26","author":"F Halleck","year":"2013","unstructured":"Halleck F, Diederichs G, Koehlitz T, Slowinski T, Engelken F, Liefeldt L et al (2013) Volume matters: CT-based renal cortex volume measurement in the evaluation of living kidney donors. Transpl Int 26(12):1208\u20131216","journal-title":"Transpl Int"},{"issue":"3","key":"5024_CR22","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1016\/j.transproceed.2014.11.044","volume":"47","author":"N Yokoyama","year":"2015","unstructured":"Yokoyama N, Ishimura T (2015) Usefulness of three-dimensional computerized tomographic volumetry for determining split renal function in donors for living-related kidney transplantation. Transplant Proc 47(3):588\u2013590","journal-title":"Transplant Proc"},{"issue":"9","key":"5024_CR23","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1111\/ctr.12784","volume":"30","author":"AS Barbas","year":"2016","unstructured":"Barbas AS, Li Y, Zair M, Van JA, Famure O, Dib MJ et al (2016) CT volumetry is superior to nuclear renography for prediction of residual kidney function in living donors. Clin Transplant 30(9):1028\u20131035","journal-title":"Clin Transplant"},{"issue":"5","key":"5024_CR24","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.2214\/AJR.07.4023","volume":"191","author":"AL Summerlin","year":"2008","unstructured":"Summerlin AL, Lockhart ME, Strang AM, Kolettis PN, Fineberg NS, Smith JK (2008) Determination of split renal function by 3D reconstruction of CT angiograms: a comparison with gamma camera renography. Am J Roentgenol 191(5):1552\u20131558","journal-title":"Am J Roentgenol"},{"issue":"7","key":"5024_CR25","doi-asserted-by":"publisher","first-page":"e0253609","DOI":"10.1371\/journal.pone.0253609","volume":"16","author":"KC Harper","year":"2021","unstructured":"Harper KC, Salameh JP, Akhlaq N, McInnes MDF, Ivankovic V, Beydoun MH et al (2021) The impact of measuring split kidney function on post-donation kidney function: a retrospective cohort study. PLoS ONE 16(7):e0253609","journal-title":"PLoS ONE"},{"issue":"3","key":"5024_CR26","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1097\/RCT.0b013e318251db15","volume":"36","author":"S Soga","year":"2012","unstructured":"Soga S, Britz-Cunningham S, Kumamaru KK, Malek SK, Tullius SG, Rybicki FJ (2012) Comprehensive comparative study of computed tomography-based estimates of split renal function for potential renal donors: modified ellipsoid method and other CT-based methods. J Comput Assist Tomogr 36(3):323\u2013329","journal-title":"J Comput Assist Tomogr"},{"issue":"6","key":"5024_CR27","doi-asserted-by":"publisher","first-page":"1786","DOI":"10.1016\/j.transproceed.2012.06.006","volume":"44","author":"M Giessing","year":"2012","unstructured":"Giessing M (2012) Living donor nephrectomy\u2014quantifying the risk for the donor. Transplant Proc 44(6):1786\u20131789","journal-title":"Transplant Proc"},{"issue":"1","key":"5024_CR28","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.ejrad.2009.11.013","volume":"79","author":"F Kato","year":"2011","unstructured":"Kato F, Kamishima T, Morita K, Muto NS, Okamoto S, Omatsu T et al (2011) Rapid estimation of split renal function in kidney donors using software developed for computed tomographic renal volumetry. Eur J Radiol 79(1):15\u201320","journal-title":"Eur J Radiol"},{"issue":"2","key":"5024_CR29","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1097\/RCT.0000000000000988","volume":"44","author":"C Houbois","year":"2020","unstructured":"Houbois C, Haneder S, Merkt M, Holz JA, Morelli J, Kiel A et al (2020) Semiautomated renal cortex volumetry in multislice computed tomography: effect of slice thickness and iterative reconstruction algorithms. J Comput Assist Tomogr 44(2):236\u2013241","journal-title":"J Comput Assist Tomogr"},{"key":"5024_CR30","volume-title":"Nuclear renal scan. StatPearls","author":"H Banker","year":"2023","unstructured":"Banker H, Sheffield EG, Cohen HL (2023) Nuclear renal scan. StatPearls. StatPearls Publishing, Treasure Island, FL"}],"container-title":["World Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00345-024-05024-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00345-024-05024-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00345-024-05024-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T21:33:13Z","timestamp":1735853593000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00345-024-05024-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,21]]},"references-count":30,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["5024"],"URL":"https:\/\/doi.org\/10.1007\/s00345-024-05024-y","relation":{},"ISSN":["1433-8726"],"issn-type":[{"value":"1433-8726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,21]]},"assertion":[{"value":"20 November 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 April 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 June 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"The authors certify that this document complies with the current ethical standards and that no individual data have been used.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical statement"}}],"article-number":"382"}}