{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T22:42:37Z","timestamp":1789771357731,"version":"4.0.1"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T00:00:00Z","timestamp":1722556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T00:00:00Z","timestamp":1722556800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum Freiburg"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Urol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The solid-state Thulium laser (Tm: YAG) is a novel alternative to the widely used Holmium laser for endoscopic enucleation of the prostate (EEP) due to its relatively high peak power. The aim of this study was to examine the efficacy and safety of a new pulsed Tm: YAG laser in its first application in humans.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Data were retrospectively collected for the first 103 patients who underwent EEP with a new pulsed solid-state Tm: YAG laser (Thulio\n                      <jats:sup>\u00ae<\/jats:sup>\n                      , Dornier MedTech Systems GmbH, We\u00dfling, Germany). Peri- and postoperative data were assessed. Procedure-specific complications were graded using Clavien-Dindo Classifications (CDC). Patients were interviewed 15 months after the surgery to evaluate functional and long-term outcomes. Statistical analysis was performed with Statistical Package for the Social Sciences (SPSS\n                      <jats:sup>\u00ae<\/jats:sup>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The mean preoperative prostate volume was 105.6\u2009\u00b1\u200955.0\u00a0ml. Median enucleation speed was 4.1\u00a0g per minute (range 1.1\u20139.7). Short-term postoperative complications occurred in 21 patients (20.4%), but no high-grade complications (CDC\u2009\u2265\u2009IV) were observed. Five patients suffered gross haematuria and required reintervention (CDC IIIb; 4.9%). After 15 months, 76 patients (73.8%) participated in the follow-up interview, where seven patients (9.2%) reported complications, including two reinterventions for urethral strictures (CDC IIIb; 2.6%). Most patients reported an improvement in continence (54.0%) and urine stream (93.4%), but no difference in erectile function (81.6%). No persistent dysuria was reported. Patient satisfaction with the surgery results was very high (96.1%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Endoscopic enucleation of the prostate with the new pulsed solid-state Tm: YAG laser is a safe and effective option for surgical BPH treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>German Clinical Trials Register number: DRKS00031676. Registration date: 10 May 2023, retrospectively registered.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00345-024-05141-8","type":"journal-article","created":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T10:11:06Z","timestamp":1722593466000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Real-world experience with the new pulsed solid-state Thulium: YAG laser (Thulio) for endoscopic enucleation of the prostate"],"prefix":"10.1007","volume":"42","author":[{"given":"Maximilian Ferry","family":"von Bargen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Glienke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Tonyali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Sigle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Wilhelm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Schoenthaler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Gratzke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5894-9647","authenticated-orcid":false,"given":"A.","family":"Miernik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,2]]},"reference":[{"issue":"8","key":"5141_CR1","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1177\/1756287218779784","volume":"10","author":"GM Pirola","year":"2018","unstructured":"Pirola GM, Saredi G, Codas Duarte R et al (2018) Holmium laser versus thulium laser enucleation of the prostate: a matched-pair analysis from two centers. Ther Adv Urol 10(8):223\u2013233. https:\/\/doi.org\/10.1177\/1756287218779784","journal-title":"Ther Adv Urol"},{"issue":"1","key":"5141_CR2","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1007\/s00345-024-04958-7","volume":"42","author":"D Perri","year":"2024","unstructured":"Perri D, Pacchetti A, Morini E et al (2024) Evaluation of the learning curve for Thulium laser enucleation of the prostate in a contemporary cohort. World J Urol 42(1):246. https:\/\/doi.org\/10.1007\/s00345-024-04958-7","journal-title":"World J Urol"},{"issue":"4","key":"5141_CR3","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1016\/j.urology.2015.07.021","volume":"86","author":"O Brunckhorst","year":"2015","unstructured":"Brunckhorst O, Ahmed K, Nehikhare O, Marra G, Challacombe B, Popert R (2015) Evaluation of the learning curve for Holmium Laser Enucleation of the prostate using multiple outcome measures. Urology 86(4):824\u2013829. https:\/\/doi.org\/10.1016\/j.urology.2015.07.021","journal-title":"Urology"},{"issue":"1","key":"5141_CR4","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1159\/000019535","volume":"33","author":"MR Fraundorfer","year":"1998","unstructured":"Fraundorfer MR, Gilling PJ (1998) Holmium:YAG laser enucleation of the prostate combined with mechanical morcellation: preliminary results. Eur Urol 33(1):69\u201372. https:\/\/doi.org\/10.1159\/000019535","journal-title":"Eur Urol"},{"issue":"2","key":"5141_CR5","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.eururo.2023.04.008","volume":"84","author":"S Gravas","year":"2023","unstructured":"Gravas S, Gacci M, Gratzke C et al (2023) Summary Paper on the 2023 European Association of Urology Guidelines on the management of non-neurogenic male lower urinary tract symptoms. Eur Urol 84(2):207\u2013222","journal-title":"Eur Urol"},{"issue":"1","key":"5141_CR6","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1097\/JU.0000000000003698","volume":"211","author":"JS Sandhu","year":"2024","unstructured":"Sandhu JS, Bixler BR, Dahm P et al (2024) Management of lower urinary tract symptoms attributed to Benign Prostatic Hyperplasia (BPH): AUA Guideline Amendment 2023. J Urol 211(1):11\u201319. https:\/\/doi.org\/10.1097\/JU.0000000000003698","journal-title":"J Urol"},{"issue":"3","key":"5141_CR7","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1097\/MOU.0000000000000610","volume":"29","author":"C Netsch","year":"2019","unstructured":"Netsch C, Gross AJ (2019) Thulium laser enucleation of the prostate. Curr Opin Urol 29(3):302\u2013303. https:\/\/doi.org\/10.1097\/MOU.0000000000000610","journal-title":"Curr Opin Urol"},{"key":"5141_CR8","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.euros.2022.07.012","volume":"48","author":"MR Socarr\u00e1s","year":"2023","unstructured":"Socarr\u00e1s MR, Del \u00c1lamo JF, Sancha FG (2023) Long live holmium! Eur Urol Open Sci 48:28\u201330. https:\/\/doi.org\/10.1016\/j.euros.2022.07.012","journal-title":"Eur Urol Open Sci"},{"issue":"1","key":"5141_CR9","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/s12894-021-00797-5","volume":"21","author":"G Bozzini","year":"2021","unstructured":"Bozzini G, Maltagliati M, Besana U et al (2021) Holmium laser enucleation of the prostate with virtual Basket mode: faster and better control on bleeding. BMC Urol 21(1):28. https:\/\/doi.org\/10.1186\/s12894-021-00797-5","journal-title":"BMC Urol"},{"key":"5141_CR10","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-022-04201-1","author":"G Bozzini","year":"2022","unstructured":"Bozzini G, Berti L, Maltagliati M et al (2022) Thulium: YAG vs continuous-wave thulium fiber laser enucleation of the prostate: do potential advantages of thulium fiber lasers translate into relevant clinical differences? World J Urol. https:\/\/doi.org\/10.1007\/s00345-022-04201-1","journal-title":"World J Urol"},{"issue":"Suppl 4","key":"5141_CR11","doi-asserted-by":"publisher","first-page":"S398","DOI":"10.21037\/tau.2019.08.01","volume":"8","author":"P Kronenberg","year":"2019","unstructured":"Kronenberg P, Traxer O (2019) The laser of the future: reality and expectations about the new thulium fiber laser-a systematic review. Transl Androl Urol 8(Suppl 4):S398\u2013S417. https:\/\/doi.org\/10.21037\/tau.2019.08.01","journal-title":"Transl Androl Urol"},{"key":"5141_CR12","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.urology.2023.05.013","volume":"178","author":"D Perri","year":"2023","unstructured":"Perri D, Mazzoleni F, Besana U et al (2023) Pulsed-wave vs continuous-wave Thulium Fiber Laser Enucleation of the prostate (ThuFLEP): a comparison of Perioperative outcomes. Urology 178:120\u2013124. https:\/\/doi.org\/10.1016\/j.urology.2023.05.013","journal-title":"Urology"},{"issue":"4","key":"5141_CR13","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1007\/s10103-018-02697-x","volume":"34","author":"K-W Xiao","year":"2019","unstructured":"Xiao K-W, Zhou L, He Q et al (2019) Enucleation of the prostate for benign prostatic hyperplasia thulium laser versus holmium laser: a systematic review and meta-analysis. Lasers Med Sci 34(4):815\u2013826. https:\/\/doi.org\/10.1007\/s10103-018-02697-x","journal-title":"Lasers Med Sci"},{"issue":"2","key":"5141_CR14","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/j.asjsur.2021.07.045","volume":"45","author":"C Meng","year":"2022","unstructured":"Meng C, Peng L, Li J, Li Y, Yang J, Wu J (2022) Comparison of enucleation between thulium laser and holmium laser for benign prostatic hyperplasia: a systematic review and meta-analysis. Asian J Surg 45(2):689\u2013697","journal-title":"Asian J Surg"},{"issue":"2","key":"5141_CR15","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/j.euf.2021.03.024","volume":"8","author":"FO Hartung","year":"2022","unstructured":"Hartung FO, Kowalewski KF, von Hardenberg J et al (2022) Holmium Versus Thulium Laser Enucleation of the prostate: a systematic review and Meta-analysis of Randomized controlled trials. Eur Urol Focus 8(2):545\u2013554. https:\/\/doi.org\/10.1016\/j.euf.2021.03.024","journal-title":"Eur Urol Focus"},{"issue":"1","key":"5141_CR16","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.euf.2021.01.012","volume":"7","author":"E Ventimiglia","year":"2021","unstructured":"Ventimiglia E, Villa L, Doizi S et al (2021) Laser lithotripsy: the importance of Peak Power and Pulse Modulation. Eur Urol Focus 7(1):22\u201325. https:\/\/doi.org\/10.1016\/j.euf.2021.01.012","journal-title":"Eur Urol Focus"},{"issue":"9","key":"5141_CR17","doi-asserted-by":"publisher","first-page":"3503","DOI":"10.1007\/s00345-021-03634-4","volume":"39","author":"S Huusmann","year":"2021","unstructured":"Huusmann S, Lafos M, Meyenburg I, Muschter R, Teichmann H-O, Herrmann T (2021) Tissue effects of a newly developed diode pumped pulsed Thulium:YAG laser compared to continuous wave Thulium:YAG and pulsed Holmium:YAG laser. World J Urol 39(9):3503\u20133508. https:\/\/doi.org\/10.1007\/s00345-021-03634-4","journal-title":"World J Urol"},{"issue":"2","key":"5141_CR18","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1007\/s00345-021-03825-z","volume":"40","author":"M Yilmaz","year":"2022","unstructured":"Yilmaz M, Esser J, Kraft L et al (2022) Experimental ex-vivo performance study comparing a novel, pulsed thulium solid-state laser, chopped thulium fibre laser, low and high-power holmium:YAG laser for endoscopic enucleation of the prostate. World J Urol 40(2):601\u2013606. https:\/\/doi.org\/10.1007\/s00345-021-03825-z","journal-title":"World J Urol"},{"issue":"2","key":"5141_CR19","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1089\/end.2021.0441","volume":"36","author":"L Kraft","year":"2022","unstructured":"Kraft L, Yilmaz M, Petzold R, Gratzke C, Suarez-Ibarrola R, Miernik A (2022) Dusting efficiency of a Novel Pulsed Thulium:Yttrium Aluminum Garnet Laser vs a Thulium Fiber laser. J Endourol 36(2):259\u2013265. https:\/\/doi.org\/10.1089\/end.2021.0441","journal-title":"J Endourol"},{"issue":"11","key":"5141_CR20","doi-asserted-by":"publisher","first-page":"3301","DOI":"10.1007\/s00345-023-04580-z","volume":"41","author":"E Ventimiglia","year":"2023","unstructured":"Ventimiglia E, Robesti D, Bevilacqua L et al (2023) What to expect from the novel pulsed thulium:YAG laser? A systematic review of endourological applications. World J Urol 41(11):3301\u20133308. https:\/\/doi.org\/10.1007\/s00345-023-04580-z","journal-title":"World J Urol"},{"issue":"4","key":"5141_CR21","doi-asserted-by":"publisher","first-page":"461","DOI":"10.23736\/S2724-6051.21.04315-9","volume":"74","author":"P Capogrosso","year":"2022","unstructured":"Capogrosso P, Fallara G, Pozzi E et al (2022) Rates and predictors of postoperative complications after Holmium laser enucleation of the prostate (HoLEP) at a high-volume center. Minerva Urol Nephrol 74(4):461\u2013466. https:\/\/doi.org\/10.23736\/S2724-6051.21.04315-9","journal-title":"Minerva Urol Nephrol"},{"issue":"3","key":"5141_CR22","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1007\/s00345-018-2418-0","volume":"37","author":"A Miernik","year":"2019","unstructured":"Miernik A, Schoeb DS (2019) Three horse shoe-like incision holmium laser enucleation of the prostate: first experience with a novel en bloc technique for anatomic transurethral prostatectomy. World J Urol 37(3):523\u2013528. https:\/\/doi.org\/10.1007\/s00345-018-2418-0","journal-title":"World J Urol"},{"issue":"5","key":"5141_CR23","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1159\/000496289","volume":"65","author":"S Madersbacher","year":"2019","unstructured":"Madersbacher S, Sampson N, Culig Z (2019) Pathophysiology of Benign Prostatic Hyperplasia and Benign Prostatic Enlargement: a Mini-review. Gerontology 65(5):458\u2013464. https:\/\/doi.org\/10.1159\/000496289","journal-title":"Gerontology"}],"container-title":["World Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00345-024-05141-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00345-024-05141-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00345-024-05141-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T16:18:45Z","timestamp":1735834725000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00345-024-05141-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,2]]},"references-count":23,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["5141"],"URL":"https:\/\/doi.org\/10.1007\/s00345-024-05141-8","relation":{},"ISSN":["1433-8726"],"issn-type":[{"value":"1433-8726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,2]]},"assertion":[{"value":"7 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 June 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the local ethics committee of Albert-Ludwigs-University of Freiburg, Germany (Approval number: 22-1465-S1-retro) as this was a retrospective study and all the procedures being performed were part of the routine care.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable for this section due to retrospective nature of the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable for this section.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"A. Miernik receives research funds of the German Federal Ministry of Education and Research, Berlin (D). He receives support for his travel activities from the European Society of Urology, Arnhem (NL), and the German Society of Urology, D\u00fcsseldorf (D). Furthermore, (A) Miernik is consulted for: KLS Martin, Tuttlingen (D), Avateramedical, Jena (D), LISA Laser Products GmbH, Katlenburg-Lindau (D), Schoelly fiberoptics GmbH, Denzlingen (D), Dornier MedTech Systems GmbH (D), Medi-Tate Ltd. (IL, USA) and (B) Braun New Ventures GmbH, Freiburg (D). A. Miernik is speaker for the companies Richard Wolf GmbH (D) and Boston Scientific (USA). Additionally, he performed expert activities for the Ludwig Boltzmann Gesellschaft, Wien (A). A. Miernik is involved in numerous patents and inventions in the field of medical technology. Prof. Dr. Christian Gratzke is adviser for Astellas Pharma GmbH, DE, Ipsen Pharma GmbH, DE, Steba Biotech S.A., LUX, Bayer Pharma, DE, Olympus Winter & Ibe GmbH, DE, Medi-Tate Ltd., IL, MSD, DE, Astra-Zeneca, UK and Roche, CH. He receives speaker fees from Amgen, USA, Astellas Pharma GmbH, DE, Ipsen Pharma GmbH, DE, Janssen-Cilag GmbH, BEL, Bayer Pharma, DE, Takeda Pharmaceuticals, JPN and medac GmbH, DE. M. von Bargen, M. Glienke, S. Tonyali, A. Sigle, K. Wilhelm, and M. Schoenthaler declare to have no conflicts of interest.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"467"}}