{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T22:20:37Z","timestamp":1791584437510,"version":"4.3.4"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T00:00:00Z","timestamp":1722211200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T00:00:00Z","timestamp":1722211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Urol"],"DOI":"10.1007\/s00345-024-05173-0","type":"journal-article","created":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T08:57:37Z","timestamp":1722243457000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["A review of urinary bladder microbiome in patients with bladder cancer and its implications in bladder pathogenesis"],"prefix":"10.1007","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5828-8197","authenticated-orcid":false,"given":"Panagiotis Velissarios","family":"Stamatakos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charalampos","family":"Fragkoulis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ieronymos","family":"Zoidakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Ntoumas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zisis","family":"Kratiras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iraklis","family":"Mitsogiannis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanasios","family":"Dellis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,29]]},"reference":[{"key":"5173_CR1","doi-asserted-by":"publisher","first-page":"404","DOI":"10.18433\/jpps31525","volume":"23","author":"W Hayes","year":"2020","unstructured":"Hayes W, Sahu S (2020) The human microbiome: history and future. J Pharm Pharm Sci 23:404\u2013411","journal-title":"J Pharm Pharm Sci"},{"issue":"1","key":"5173_CR2","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.euf.2016.11.001","volume":"4","author":"I Arag\u03ccn","year":"2018","unstructured":"Arag\u03ccn I, Herrera-Imbroda B, Queipo-Ortuno MI et al (2018) The urinary tract Microbiome in Health and Disease. Eur Urol Focus 4(1):128\u2013138","journal-title":"Eur Urol Focus"},{"issue":"5","key":"5173_CR3","doi-asserted-by":"publisher","first-page":"569","DOI":"10.4111\/icu.20220124","volume":"63","author":"HK Ahn","year":"2022","unstructured":"Ahn HK, Kim K, Park J et al (2022) Urinary microbiome profile in men with genitourinary malignancies. Investig Clin Urol 63(5):569\u2013576","journal-title":"Investig Clin Urol"},{"issue":"1","key":"5173_CR4","first-page":"57","volume":"2","author":"W Xu","year":"2014","unstructured":"Xu W, Yang L, Lee P et al (2014) Mini-review: perspective of the microbiome in the pathogenesis of urothelial carcinoma. Am J Clin Exp Urol 2(1):57\u201361","journal-title":"Am J Clin Exp Urol"},{"issue":"1","key":"5173_CR5","doi-asserted-by":"publisher","first-page":"12157","DOI":"10.1038\/s41598-018-29054-w","volume":"8","author":"VB Popovi\u0107","year":"2018","unstructured":"Popovi\u0107 VB, \u0160itum M, Chow CET et al (2018) The urinary microbiome associated with bladder cancer. Sci Rep 8(1):12157","journal-title":"Sci Rep"},{"key":"5173_CR6","doi-asserted-by":"publisher","first-page":"167","DOI":"10.3389\/fcimb.2018.00167","volume":"8","author":"P Wu","year":"2018","unstructured":"Wu P, Zhang G, Zhao J et al (2018) Profiling the urinary microbiota in male patients with bladder Cancer in China. Front Cell Infect Microbiol 8:167","journal-title":"Front Cell Infect Microbiol"},{"key":"5173_CR7","doi-asserted-by":"crossref","unstructured":"Ma W, Zhang W, Shen L et al Can Smoking cause differences in urine microbiome in male patients with bladder Cancer? A retrospective study. Front Oncol 2021 Jun 8:11677605","DOI":"10.3389\/fonc.2021.677605"},{"issue":"10","key":"5173_CR8","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1099\/jmm.0.001058","volume":"68","author":"H Bi","year":"2019","unstructured":"Bi H, Tian Y, Song C et al (2019) Urinary microbiota \u2013 a potential biomarker and therapeutic target for bladder cancer. J Med Microbiol 68(10):1471\u20131478","journal-title":"J Med Microbiol"},{"issue":"1","key":"5173_CR9","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1097\/JU.0000000000001336","volume":"205","author":"B Oresta","year":"2021","unstructured":"Oresta B, Braga D, Lazzeri M et al (2021) The Microbiome of Catheter collected urine in males with bladder Cancer according to Disease Stage. J Urol 205(1):86\u201393","journal-title":"J Urol"},{"issue":"2","key":"5173_CR10","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.urolonc.2022.09.018","volume":"41","author":"J Hrb\u00e1\u010dek","year":"2023","unstructured":"Hrb\u00e1\u010dek J, Tl\u00e1skal V, \u010cerm\u00e1k P et al (2023) Bladder cancer is associated with decreased urinary microbiota diversity and alterations in microbial community composition. Urol Oncol 41(2):107. e15-107.e22","journal-title":"Urol Oncol"},{"issue":"16","key":"5173_CR11","doi-asserted-by":"publisher","first-page":"6904","DOI":"10.1002\/cam4.2419","volume":"8","author":"F Liu","year":"2019","unstructured":"Liu F, Liu A, Lu X et al (2019) Dysbiosis signatures of the microbial profile in tissue from bladder cancer. Cancer Med 8(16):6904\u20136914","journal-title":"Cancer Med"},{"issue":"3","key":"5173_CR12","doi-asserted-by":"publisher","first-page":"809","DOI":"10.3390\/cancers15030809","volume":"15","author":"Y Zhang","year":"2023","unstructured":"Zhang Y, Wang W, Zhou H et al (2023) Urinary Eubacterium sp. CAG:581 promotes non-muscle invasive bladder Cancer (NMIBC) development through the ECM1\/MMP9 pathway. Cancers (Basel) 15(3):809","journal-title":"Cancers (Basel)"},{"key":"5173_CR13","doi-asserted-by":"crossref","unstructured":"Parra-Grande M, Or\u00e9-Arce M, Mart\u00ednez-Priego L et al Profiling the bladder microbiota in patients with bladder Cancer. Front Microbiol 2022 Feb 7:12718776","DOI":"10.3389\/fmicb.2021.718776"},{"issue":"6","key":"5173_CR14","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1016\/j.euo.2020.04.002","volume":"3","author":"F Pederzoli","year":"2020","unstructured":"Pederzoli F, Ferrarese R, Amato V et al (2020) Sex-specific alterations in the urinary and tissue microbiome in Therapy-na\u00efve urothelial bladder Cancer patients. Eur Urol Oncol 3(6):784\u2013788","journal-title":"Eur Urol Oncol"},{"key":"5173_CR15","doi-asserted-by":"crossref","unstructured":"Hussein AA, Elsayed AS, Durran M et al (2021) Investigating the association between the urinary microbiome and bladder cancer: An exploratory study. Urol Oncol. ;39(6):370.e9-370.e19","DOI":"10.1016\/j.urolonc.2020.12.011"},{"issue":"7","key":"5173_CR16","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1016\/j.urolonc.2020.04.014","volume":"38","author":"J Chipollini","year":"2020","unstructured":"Chipollini J, Wright JR, Nwanosike H et al (2020) Characterization of urinary microbiome in patients with bladder cancer: results from a single-institution, feasibility study. Urol Oncol 38(7):615\u2013621","journal-title":"Urol Oncol"},{"key":"5173_CR17","doi-asserted-by":"crossref","unstructured":"Zeng J, Zhang G, Chen C et al Alterations in Urobiome in patients with bladder Cancer and implications for clinical outcome: a single-Institution Study. Front Cell Infect Microbiol 2020 Dec 15:10555508","DOI":"10.3389\/fcimb.2020.555508"},{"issue":"1","key":"5173_CR18","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1186\/s40168-020-00875-0","volume":"8","author":"G Berg","year":"2020","unstructured":"Berg G, Rybakova D, Fischer D et al (2020) Microbiome definition re-visited: old concepts and new challenges. Microbiome 8(1):103","journal-title":"Microbiome"},{"issue":"6","key":"5173_CR19","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1080\/14789450.2018.1523724","volume":"16","author":"H Lin","year":"2019","unstructured":"Lin H, He QY, Shi L et al (2019) Proteomics and the microbiome: pitfalls and potential. Expert Rev Proteom 16(6):501\u2013511","journal-title":"Expert Rev Proteom"},{"issue":"6","key":"5173_CR20","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1002\/jobm.201900628","volume":"60","author":"CS Matilda","year":"2020","unstructured":"Matilda CS, Madhusudan I, Isola RG et al (2020) Potential of proteomics to probe microbes. J Basic Microbiol 60(6):471\u2013483","journal-title":"J Basic Microbiol"},{"issue":"7415","key":"5173_CR21","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1038\/nature11553","volume":"489","author":"GM Weinstock","year":"2012","unstructured":"Weinstock GM (2012) Genomic approaches to studying the human microbiota. Nature 489(7415):250\u2013256","journal-title":"Nature"},{"issue":"1","key":"5173_CR22","doi-asserted-by":"publisher","first-page":"84","DOI":"10.3390\/diagnostics13010084","volume":"13","author":"YN Gwon","year":"2022","unstructured":"Gwon YN, Park JJ, Lee KS et al (2022) Microbiome in bladder Cancer: a systematic review. Diagnostics (Basel) 13(1):84","journal-title":"Diagnostics (Basel)"},{"issue":"2","key":"5173_CR23","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.prnil.2022.03.004","volume":"10","author":"M Miyake","year":"2022","unstructured":"Miyake M, Tatsumi Y, Ohnishi K et al (2022) Prostate diseases and microbiome in the prostate, gut, and urine. Prostate Int 10(2):96\u2013107","journal-title":"Prostate Int"},{"issue":"7800","key":"5173_CR24","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1038\/s41586-020-2095-1","volume":"579","author":"GD Poore","year":"2020","unstructured":"Poore GD, Kopylova E, Zhu Q et al (2020) Microbiome analyses of blood and tissues suggest cancer diagnostic approach. Nature 579(7800):567\u2013574","journal-title":"Nature"},{"issue":"4","key":"5173_CR25","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/j.eururo.2018.12.043","volume":"75","author":"MC Markowski","year":"2019","unstructured":"Markowski MC, Boorjian SA, Burton JP et al (2019) The Microbiome and Genitourinary Cancer: a collaborative review. Eur Urol 75(4):637\u2013646","journal-title":"Eur Urol"},{"issue":"6","key":"5173_CR26","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1016\/j.gendis.2020.10.002","volume":"8","author":"X Huang","year":"2020","unstructured":"Huang X, Pan T, Yan L et al (2020) The inflammatory microenvironment and the urinary microbiome in the initiation and progression of bladder cancer. Genes Dis 8(6):781\u2013797","journal-title":"Genes Dis"},{"key":"5173_CR27","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.urology.2018.12.034","volume":"126","author":"P Bajic","year":"2019","unstructured":"Bajic P, Wolfe AJ, Gupta GN et al (2019) The urinary microbiome: implications in bladder Cancer pathogenesis and therapeutics. Urology 126:10\u201315","journal-title":"Urology"},{"issue":"19","key":"5173_CR28","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.21037\/atm-20-2976","volume":"8","author":"M Nicolaro","year":"2020","unstructured":"Nicolaro M, Portal DE, Shinder B et al (2020) The human microbiome and genitourinary malignancies. Ann Transl Med 8(19):1245","journal-title":"Ann Transl Med"},{"issue":"1","key":"5173_CR29","doi-asserted-by":"publisher","first-page":"e13012","DOI":"10.1016\/j.heliyon.2023.e13012","volume":"9","author":"W Zhang","year":"2023","unstructured":"Zhang W, Yang F, Mao S et al (2023) Bladder cancer-associated microbiota: recent advances and future perspectives. Heliyon 9(1):e13012","journal-title":"Heliyon"},{"issue":"2","key":"5173_CR30","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1002\/nau.23900","volume":"38","author":"JJJ Wyndaele","year":"2019","unstructured":"Wyndaele JJJ, Riedl C, Taneja R et al (2019) GAG replenishment therapy for bladder pain syndrome\/interstitial cystitis. Neurourol Urodyn 38(2):535\u2013544","journal-title":"Neurourol Urodyn"},{"key":"5173_CR31","doi-asserted-by":"crossref","unstructured":"Lou K, Chi J, Wu J et al Research progress on the microbiota in bladder cancer tumors. Front Cell Infect Microbiol 2024 Apr 8:141374944","DOI":"10.3389\/fcimb.2024.1374944"},{"issue":"9","key":"5173_CR32","doi-asserted-by":"publisher","first-page":"2068","DOI":"10.3390\/diagnostics12092068","volume":"12","author":"V Friedrich","year":"2022","unstructured":"Friedrich V, Choi HW (2022) The urinary microbiome: role in bladder Cancer and treatment. Diagnostics (Basel) 12(9):2068","journal-title":"Diagnostics (Basel)"},{"key":"5173_CR33","doi-asserted-by":"crossref","unstructured":"Sweis RF, Golan S, Steinberg GD et al Association of the commensal urinary microbiome with response to Bacillus Calmette-Gu\u00e9rin (BCG) immunotherapy in nonmuscle invasive bladder cancer. J Clin Oncol 37(7_suppl):423\u2013423","DOI":"10.1200\/JCO.2019.37.7_suppl.423"},{"key":"5173_CR34","doi-asserted-by":"publisher","first-page":"e725","DOI":"10.1097\/JU.0000000000002056.04","volume":"206","author":"J Knorr","year":"2021","unstructured":"Knorr J, Adler A, Agudelo J et al (2021) PD42-04 tumor microbiome associated with BCG response in non-muscle invasive bladder cancer. J Urol 206:e725\u2013e726","journal-title":"J Urol"},{"key":"5173_CR35","doi-asserted-by":"publisher","first-page":"e195","DOI":"10.1097\/JU.0000000000002538.01","volume":"207","author":"J Knorr","year":"2022","unstructured":"Knorr J, Werneburg G, Adler A et al (2022) PD12-01 bladder tumor microbiome may augment response to BCG in non-muscle invasive bladder cancer. J Urol 207:e195","journal-title":"J Urol"},{"key":"5173_CR36","doi-asserted-by":"crossref","unstructured":"James C, Gomez K, Desai S et al Impact of intravesical Bacillus Calmette-Gu\u00e9rin and chemotherapy on the bladder microbiome in patients with non-muscle invasive bladder cancer. Front Cell Infect Microbiol 2023 Apr 5:131125809","DOI":"10.3389\/fcimb.2023.1125809"},{"issue":"12","key":"5173_CR37","doi-asserted-by":"publisher","first-page":"2270","DOI":"10.3390\/diagnostics11122270","volume":"11","author":"YC Wang","year":"2021","unstructured":"Wang YC, Ku WC, Liu CY et al (2021) Supplementation of Probiotic Butyricicoccus pullicaecorum mediates anticancer effect on bladder urothelial cells by regulating butyrate-responsive molecular signatures. Diagnostics (Basel) 11(12):2270","journal-title":"Diagnostics (Basel)"},{"key":"5173_CR38","doi-asserted-by":"publisher","first-page":"111619","DOI":"10.1016\/j.biopha.2021.111619","volume":"Jul","author":"R Mirzaei","year":"2021","unstructured":"Mirzaei R, Afaghi A, Babakhani S et al (2021) Role of microbiota-derived short-chain fatty acids in cancer development and prevention. Biomed Pharmacother Jul:139:111619","journal-title":"Biomed Pharmacother"},{"key":"5173_CR39","doi-asserted-by":"publisher","first-page":"2236","DOI":"10.1016\/S0022-5347(05)64362-5","volume":"168","author":"SW Seow","year":"2002","unstructured":"Seow SW, Rahmat JN, Mohamed AA et al (2002) Lactobacillus species is more cytotoxic to human bladder cancer cells than Mycobacterium bovis (bacillus Calmette-Guerin). J Urol 168:2236\u20132239","journal-title":"J Urol"},{"key":"5173_CR40","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/j.juro.2007.09.031","volume":"179","author":"S Naito","year":"2008","unstructured":"Naito S, Koga H, Yamaguchi A et al (2008) Prevention of recurrence with epirubicin and Lactobacillus casei after transurethral resection of bladder cancer. J Urol 179:485\u2013490","journal-title":"J Urol"},{"key":"5173_CR41","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1126\/science.aan3706","volume":"359","author":"B Routy","year":"2018","unstructured":"Routy B, Le Chatelier E, Derosa L et al (2018) Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors. Science 359:91\u201397","journal-title":"Science"},{"issue":"1","key":"5173_CR42","doi-asserted-by":"publisher","first-page":"11042","DOI":"10.1038\/s41598-020-67443-2","volume":"10","author":"B Mansour","year":"2020","unstructured":"Mansour B, Mony\u00f3k A, Makra N et al (2020) Bladder cancer-related microbiota: examining differences in urine and tissue samples. Sci Rep 10(1):11042","journal-title":"Sci Rep"}],"container-title":["World Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00345-024-05173-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00345-024-05173-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00345-024-05173-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T16:18:21Z","timestamp":1735834701000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00345-024-05173-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,29]]},"references-count":42,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["5173"],"URL":"https:\/\/doi.org\/10.1007\/s00345-024-05173-0","relation":{},"ISSN":["1433-8726"],"issn-type":[{"value":"1433-8726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,29]]},"assertion":[{"value":"6 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 July 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 July 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that there is no conflict of interest regarding the publication of this paper. Furthermore, there was no funding support for the conduction of this paper. Moreover, authors declare that human participants entered research freely after being fully informed about the research and that informed consent was obtained from all individual participants included in the study. In addition, authors declare that the study was approved by the appropriate institutional ethics committee (Scientific Council of GNA G. Gennimatas and Scientific Council of Medical School of University of Athens) and certify that the study was performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"457"}}