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Aging-related inflammatory parameters including C-reactive protein (CRP), albumin, fibrinogen, cholesterol, platelet-to-lymphocyte ratio (PLR), and neutrophil-to-lymphocyte ratio (NLR) were analyzed before and at the end of RT, and 3 and 15 months after completion of the RT. Statistical analysis was performed using non-parametric variance analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall variance analysis showed a significant influence of RT on all inflammatory parameters (p\u2009&lt;\u20090.001) with the exception of CRP (p\u2009=\u20090.498). Pairwise analysis revealed a significant elevation of fibrinogen (p\u2009=\u20090.041), NLR (p\u2009&lt;\u20090.001), and PLR levels (p\u2009&lt;\u20090.001) as well as a significant decrease of albumin (p\u2009&lt;\u20090.001) and cholesterol levels (p\u2009&lt;\u20090.001) during the RT course. After completion of RT, a significant recovery was detected for NLR, PLR, albumin and cholesterol. However, 15 months after RT, PLR, fibrinogen, and cholesterol remained significantly lower when compared to the baseline (p\u2009&lt;\u20090.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our results indicate that radiation therapy triggers chronic inflammatory processes that could contribute to the development, acceleration or worsening of age-related alterations and conditions. Further investigations to estimate the long-term consequences of curative radiation therapy on clinical manifestations of aging are warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00345-024-05409-z","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T05:29:56Z","timestamp":1734499796000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Radiotherapy and inflammaging: the influence of prostate cancer radiotherapy on systemic inflammation"],"prefix":"10.1007","volume":"43","author":[{"given":"Katarzyna","family":"Paal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Stranz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva-Maria","family":"Thurner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Niedrist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilfried","family":"Renner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Langsenlehner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,18]]},"reference":[{"key":"5409_CR1","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1097\/00062752-200105000-00001","volume":"8","author":"H Bruunsgaard","year":"2001","unstructured":"Bruunsgaard H, Pedersen M, Pedersen BK (2001) Aging and proinflammatory cytokines. 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