{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T01:49:35Z","timestamp":1790300975975,"version":"4.1.0"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100002352","name":"Ain Shams University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002352","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Urol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To assess the safety, efficacy, and cost-effectiveness of flexible mini-percutaneous nephrolithotomy (F-mPCNL) in managing nephrolithiasis compared to retrograde intrarenal surgery (RIRS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>130 adult patients with renal stones (1.5\u20133\u00a0cm) were randomized to F-mPCNL or RIRS. The stone-free rate (SFR) was our primary outcome. Secondary outcomes were the operative time, fluoroscopy time, DJ stent insertion rate, auxiliary procedure needed, hospital stay, complications rate, total cost, and quality of life for both procedures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>out of 130 patients in our study, 125 were evaluated and completed the follow-up period. Preoperative data was similar in both groups including stone characteristics. F-mPCNL showed a better SFR of 95.1% compared to 77.8% in the RIRS group (p-value\u02c20.001), this was associated with less need for additional procedures. F-mPCNL was associated with a shorter operation time of 47.60\u2009\u00b1\u200914.54\u00a0min compared to 59.30\u2009\u00b1\u200920.10\u00a0min in the RIRS group (p-value\u02c20.001). F-mPCNL showed less radiational exposure and less need for DJ stent insertion than RIRS. The overall complication rate was comparable in both groups, postoperative pain, need for extra doses of analgesics, and hospital stay were higher in the F-mPCNL group. In our study, F-mPCNL was shown to be more cost-effective than RIRS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>F-mPCNL showed a superior SFR in treating renal stones compared to RIRS in a single session, with less need for auxiliary procedures, shorter operative time, less radiational exposure, and better quality of life. However, it was associated with slightly more hospital stay and postoperative pain compared to RIRS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00345-025-05689-z","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T04:19:50Z","timestamp":1748233190000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Flexible mini-percutaneous nephrolithotomy versus retrograde intra-renal surgery in the management of renal stones: a randomized controlled trial"],"prefix":"10.1007","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9679-4241","authenticated-orcid":false,"given":"Ahmed","family":"Higazy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"kandil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6140-6379","authenticated-orcid":false,"given":"Ahmed","family":"Elshafei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Esmat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2534-2261","authenticated-orcid":false,"given":"A. 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Our manuscript has not been published previously or is under consideration for publication elsewhere.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"the study was approved by the institutional research ethics committee before the recruitment process of our study was started and that has been conducted per the principles outlined in the Helsinki Declaration. The study was approved by the Research Ethics Committee of the Faculty of Medicine Ain Shams University, Cairo, Egypt. (FWA000017585) with ethical approval number: (MD 351\/2023). The study was registered at Clinicaltrial.gov, with a registration number: NCT06249100. (prospective registration)","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"<!--Emphasis Type='Bold' removed-->Ethical approval and consent to participate"}},{"value":"Written consent was obtained from all patients\u2019 parents or legal guardians before participation.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for participation"}},{"value":"Sample size was calculated using G-power 3.1.9.2 program, setting the type-1 error (\u03b1) at power at 80%. Results from a previous study (Abdulmecit Yavuz et al., 2020) showed that The SFR was 76% for the RIRS group compared to 94%; for the mini PCNL group (\n                      p\n                      \u2009<\u20090.001). Calculation according to these values produced a sample size of 61 cases in each group (122 total). However, the study will include 65 cases in each group (130 total) to account for dropout cases.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Sample size calculation"}}],"article-number":"328"}}